Patent application number | Description | Published |
20110190474 | ANTIMICROBIAL PEPTIDES AND DERIVED METAPEPTIDES - The peptides and derivative metapeptides based upon natural antimicrobial peptides have potent and broad spectrum activity against pathogens exhibiting multiple antibiotic resistance. Specific peptides can also potentiate the antimicrobial functions of leukocytes, such as neutrophils. In addition, they exhibit lower inherent mammalian cell toxicities than conventional antimicrobial peptides, and overcome problems of toxicity, immunogenicity, and shortness of duration of effectiveness due to biodegradation, retaining activity in plasma and serum. The peptides and derivative metapeptides exhibit rapid microbicidal activities in vitro, can be used to potentiate conventional antimicrobial agents, to potentiate other antimicrobial peptides and are active against many organisms that exhibit resistance to multiple antibiotics currently in existence. | 08-04-2011 |
20130244928 | ANTIMICROBIAL PEPTIDES AND DERIVED METAPEPTIDES - The peptides and derivative metapeptides based upon natural antimicrobial peptides have potent and broad spectrum activity against pathogens exhibiting multiple antibiotic resistance. Specific peptides can also potentiate the antimicrobial functions of leukocytes, such as neutrophils. In addition, they exhibit lower inherent mammalian cell toxicities than conventional antimicrobial peptides, and overcome problems of toxicity, immunogenicity, and shortness of duration of effectiveness due to biodegradation, retaining activity in plasma and serum. The peptides and derivative metapeptides exhibit rapid microbicidal activities in vitro, can be used to potentiate conventional antimicrobial agents, to potentiate other antimicrobial peptides and are active against many organisms that exhibit resistance to multiple antibiotics currently in existence. | 09-19-2013 |
Patent application number | Description | Published |
20110263950 | SYSTEMS, DEVICES AND METHODS FOR PREVENTING, DETECTING AND TREATING PRESSURE-INDUCED ISCHEMIA, PRESSURE ULCERS, AND OTHER CONDITIONS - A system for monitoring medical conditions including pressure ulcers, pressure-induced ischemia and related medical conditions comprises at least one sensor adapted to detect one or more patient characteristic including at least position, orientation, temperature, acceleration, moisture, resistance, stress, heart rate, respiration rate, and blood oxygenation, a host for processing the data received from the sensors together with historical patient data to develop an assessment of patient condition and suggested course of treatment. In some embodiments, the system can further include a support surface having one or more sensors incorporated therein either in addition to sensors affixed to the patient or as an alternative thereof. The support surface is, in some embodiments, capable of responding to commands from the host for assisting in implementing a course of action for patient treatment. The sensor can include bi-axial or tri-axial accelerometers, as well as resistive, inductive, capactive, magnetic and other sensing devices, depending on whether the sensor is located on the patient or the support surface, and for what purpose. | 10-27-2011 |
Patent application number | Description | Published |
20090009752 | Method And Apparatus For Referencing A MEMS Device - A method and an apparatus for calibrating a MEMS actuator of a hybrid MEMS-PLC optical switch or router is described. Two calibrating waveguides, embedded monolithically adjacent to the waveguides that provide the PLC output functions, are used for referencing a MEMS mirror tilt angle by maximizing optical coupling of light, reflected off the MEMS mirror, into one or each of the two calibrating waveguides. The input light is provided by either a waveguide carrying a live optical signal, or by a special input waveguide, coupled to an LED, for providing a calibrating light. Two emitting waveguides, embedded monolithically adjacent to the waveguides that provide the PLC input functions, can be used. | 01-08-2009 |
20090046288 | Scanning Spectrometer With Multiple Photodetectors - A scanning optical spectrometer with a detector array is disclosed, in which position of focused spot of light at the input of a dispersive element such as arrayed waveguide grating (AWG) with a slab input, is scanned using a micro-electro-mechanical (MEMS) tiltable micromirror so as to make the dispersed spectrum of light scan over the detector array coupled to the AWG. Sub-spectra recorded using individual detectors are concatenated by a processor unit to obtain the spectrum of input light. | 02-19-2009 |
20090263142 | TUNABLE OPTICAL FILTER - A tunable PLC optical filter having sequentially connected thermally tunable Mach-Zehnder (MZ) interferometers is described. The MZ interferometers, having free spectral ranges matching ITU frequency grid spacing, are tuned so as to have a common passband centered on the frequency of the signal being selected, while having at least one of the stopbands centered on any other ITU frequency. Any other optical channel that may be present at any other ITU frequency is suppressed as a result. The PLC chip, including a zero-dispersion lattice-filter interleaver stage, a switchable fine-resolution stage and, or a retroreflector for double passing the filter, is packaged into a hot-pluggable XFP transceiver package. A compensation heater is used to keep constant the amount of heat applied to the PLC chip inside the XFP package, so as to lessen temperature variations upon tuning of the PLC optical filter. | 10-22-2009 |
20110052189 | OPTICAL DEVICE FOR REARRANGING WAVELENGTH CHANNELS - An optical device for rearranging wavelength channels in an optical network is disclosed. The optical device has a wavelength selective coupler having one input port and a plurality of output ports coupled to a plurality of input ports of an optical grating demultiplexor such as an arrayed waveguide grating. The wavelength channels in each of the input ports are dispersed by the demultiplexor and are directed to a plurality of output ports of the optical grating demultiplexor. As a result, at least one wavelength channel at each of the input ports of the optical grating demultiplexor is coupled into a common output port. The optical device is useful in passive optical networks wherein a same demultiplexor is used for simultaneous multiplexing and demultiplexing of wavelength channels. | 03-03-2011 |
20110096326 | SCANNING SPECTROMETER WITH MULTIPLE PHOTODETECTORS - A scanning optical spectrometer with a detector array is disclosed, in which position of focused spot of light at the input of a dispersive element such as arrayed waveguide grating (AWG) with a slab input, is scanned using a micro-electro-mechanical (MEMS) tiltable micromirror so as to make the dispersed spectrum of light scan over the detector array coupled to the AWG. Sub-spectra recorded using individual detectors are concatenated by a processor unit to obtain the spectrum of input light. | 04-28-2011 |
20120195544 | OPTICAL INTERFEROMETER - An optical interferometer for demodulating a differential phase shift keying optical signal includes a planar lightwave circuit and at least one free space delay line optically coupled to the planar lightwave circuit. The planar lightwave circuit has a waveguide splitter, a waveguide coupler, and a phase adjuster. In operation, the splitter splits the optical signal into equal portions, the phase adjuster adjusts the relative phase of the optical signal portions, and the free space delay line provides one-bit delay between the portions of the optical signal. The delayed signals are mixed in the waveguide coupler. The free space delay line can be made variable for adjustment of the bit delay for operation at different bit rates, and/or for optimization of the interferometer performance. | 08-02-2012 |
20130266313 | CHARACTERIZING A FREQUENCY CHANNEL IN AN OPTICAL NETWORK - A tunable optical filter is configured to take point measurements at a few optical frequencies per frequency channel of a DWDM optical network. The measurement frequencies are shifted by pre-determined amounts relative to the optical frequency channel being characterized. Since the spectral shape of the tunable optical filter is known, the center optical frequency, the modulation bandwidth, and the total optical power of the channel can be obtained from as few as three optical measurements. The center optical frequency and the total optical power can be continuously monitored by providing a tunable filter stage coupled to an interleaver stage, and computing a ratio and a weighted sum the optical signals at the two outputs of the interleaver stage. | 10-10-2013 |
20140112621 | REDUCING TEMPERATURE DRIFT OF AN ARRAYED WAVEGUIDE GRATING - A wavelength selective device including an arrayed waveguide grating is disclosed. The wavelength selective device includes a MEMS mirror, which couples light from an input port to an elongate aperture of an input star coupler or slab of the arrayed waveguide grating. A controller tilts the MEMS mirror in response to a sensed temperature change of the arrayed waveguide grating, thereby lessening a sensitivity of the arrayed waveguide grating to the temperature change. The MEMS mirror can also be tilted to shift wavelengths of the wavelength channels of the arrayed waveguide grating by pre-defined amounts upon receiving a corresponding remote command. | 04-24-2014 |
20140293393 | FLAT-TOP TUNABLE FILTER - A tunable PLC optical filter having sequentially connected thermally tunable Mach-Zehnder (MZ) interferometers is described. The cascade of MZ interferometers, each having a free spectral ranges matching ITU frequency grid spacing, are tuned so as to have a common passband centered on the frequency of the signal being selected, while having at least one of the stopbands centered on any other ITU frequency. Any other optical channel that may be present at any other ITU frequency is suppressed as a result. Another MZ interferometer in series with the cascade of interferometers including an asymmetric or variable coupler, is tuned to have low transmission at the center frequency of the selected optical channel. | 10-02-2014 |
Patent application number | Description | Published |
20080296173 | Electrolysis transistor - An electrolysis transistor for providing high-density electrochemistry and products utilizing the same, and high-efficiency electrolysis and electrochemical processes is disclosed. The electrolysis transistor may comprise an electrolyte, one or more working electrodes for transferring charge to or from said electrolyte, and one or more gate structures for altering electrode over-voltage and modifying the barrier at the electrode-electrolyte interface, reducing the voltage necessary for electrolysis. An electrochemical or photo-electrochemical cell may incorporate one or more of these electrolysis transistors. | 12-04-2008 |
20090230411 | INTERDIGITATED MULTIPLE PIXEL ARRAYS OF LIGHT-EMITTING DEVICES - The present invention discloses a plurality of interdigitated pixels arranged in an array, having a very low series-resistances with improved current spreading and improved heat-sinking. Each pixel is a square with sides of dimension l. The series resistance is minimized by increasing the perimeter of an active region for the pixels. The series resistance is also minimized by shrinking the space between a mesa and n-contact for each pixel. | 09-17-2009 |
20090267078 | Enhancement Mode III-N HEMTs - A III-N semiconductor device that includes a substrate and a nitride channel layer including a region partly beneath a gate region, and two channel access regions on opposite sides of the part beneath the gate. The channel access regions may be in a different layer from the region beneath the gate. The device includes an AlXN layer adjacent the channel layer wherein X is gallium, indium or their combination, and a preferably n-doped GaN layer adjacent the AlXN layer in the areas adjacent to the channel access regions. The concentration of Al in the AlXN layer, the AlXN layer thickness and the n-doping concentration in the n-doped GaN layer are selected to induce a 2DEG charge in channel access regions without inducing any substantial 2DEG charge beneath the gate, so that the channel is not conductive in the absence of a switching voltage applied to the gate. | 10-29-2009 |
20100140660 | Semiconductor Heterostructure Diodes - Planar Schottky diodes for which the semiconductor material includes a heterojunction which induces a 2DEG in at least one of the semiconductor layers. A metal anode contact is on top of the upper semiconductor layer and forms a Schottky contact with that layer. A metal cathode contact is connected to the 2DEG, forming an ohmic contact with the layer containing the 2DEG. | 06-10-2010 |
20110127541 | SEMICONDUCTOR HETEROSTRUCTURE DIODES - Planar Schottky diodes for which the semiconductor material includes a heterojunction which induces a 2DEG in at least one of the semiconductor layers. A metal anode contact is on top of the upper semiconductor layer and forms a Schottky contact with that layer. A metal cathode contact is connected to the 2DEG, forming an ohmic contact with the layer containing the 2DEG. | 06-02-2011 |
20110156572 | INTERDIGITATED MULTIPLE PIXEL ARRAYS OF LIGHT-EMITTING DEVICES - The present invention discloses a plurality of interdigitated pixels arranged in an array, having a very low series-resistances with improved current spreading and improved heat-sinking. Each pixel is a square with sides of dimension l. The series resistance is minimized by increasing the perimeter of an active region for the pixels. The series resistance is also minimized by shrinking the space between a mesa and n-contact for each pixel. | 06-30-2011 |
20130015760 | INTERDIGITATED MULTIPLE PIXEL ARRAYS OF LIGHT-EMITTING DEVICES - The present invention discloses a plurality of interdigitated pixels arranged in an array, having a very low series-resistances with improved current spreading and improved heat-sinking Each pixel is a square with sides of dimension 1. The series resistance is minimized by increasing the perimeter of an active region for the pixels. The series resistance is also minimized by shrinking the space between a mesa and n-contact for each pixel. | 01-17-2013 |
20130316502 | Enhancement Mode III-N HEMTs - A III-N semiconductor device that includes a substrate and a nitride channel layer including a region partly beneath a gate region, and two channel access regions on opposite sides of the part beneath the gate. The channel access regions may be in a different layer from the region beneath the gate. The device includes an AlXN layer adjacent the channel layer wherein X is gallium, indium or their combination, and a preferably n-doped GaN layer adjacent the AlXN layer in the areas adjacent to the channel access regions. The concentration of Al in the AlXN layer, the AlXN layer thickness and the n-doping concentration in the n-doped GaN layer are selected to induce a 2DEG charge in channel access regions without inducing any substantial 2DEG charge beneath the gate, so that the channel is not conductive in the absence of a switching voltage applied to the gate. | 11-28-2013 |
20140054603 | Semiconductor Heterostructure Diodes - Planar Schottky diodes for which the semiconductor material includes a heterojunction which induces a 2DEG in at least one of the semiconductor layers. A metal anode contact is on top of the upper semiconductor layer and forms a Schottky contact with that layer. A metal cathode contact is connected to the 2DEG, forming an ohmic contact with the layer containing the 2DEG. | 02-27-2014 |
20140299900 | INTERDIGITATED MULTIPLE PIXEL ARRAYS OF LIGHT-EMITTING DEVICES - The present invention discloses a plurality of interdigitated pixels arranged in an array, having a very low series-resistances with improved current spreading and improved heat-sinking Each pixel is a square with sides of dimension 1. The series resistance is minimized by increasing the perimeter of an active region for the pixels. The series resistance is also minimized by shrinking the space between a mesa and n-contact for each pixel. | 10-09-2014 |
20140361309 | Enhancement Mode III-N HEMTs - A III-N semiconductor device that includes a substrate and a nitride channel layer including a region partly beneath a gate region, and two channel access regions on opposite sides of the part beneath the gate. The channel access regions may be in a different layer from the region beneath the gate. The device includes an AlXN layer adjacent the channel layer wherein X is gallium, indium or their combination, and a preferably n-doped GaN layer adjacent the AlXN layer in the areas adjacent to the channel access regions. The concentration of Al in the AlXN layer, the AlXN layer thickness and the n-doping concentration in the n-doped GaN layer are selected to induce a 2DEG charge in channel access regions without inducing any substantial 2DEG charge beneath the gate, so that the channel is not conductive in the absence of a switching voltage applied to the gate. | 12-11-2014 |
20150076533 | INTERDIGITATED MULTIPLE PIXEL ARRAYS OF LIGHT-EMITTING DEVICES - The present invention discloses a plurality of interdigitated pixels arranged in an array, having a very low series-resistance with improved current spreading and improved heat-sinking. Each pixel is a square with sides of dimension l. The series resistance is minimized by increasing the perimeter of an active region for the pixels. The series resistance is also minimized by shrinking the space between a mesa and n-contact for each pixel. | 03-19-2015 |
Patent application number | Description | Published |
20080261227 | Kinetic Pcr Assay for Quantification of Gene Amplification on Chromosome 17 - Provided is a kinetic PCR (“kPCR”) assay for determining gene copy number of a target gene located on chromosome 17. The kPCR assay uses the MMP-28 gene located at the 17q11.2-17q12 loci as a control and thus, is capable of detecting gene copy number of any gene on chromosome 17 in both singleplex and multiplex format without the need for a standard curve. The kPCR assay is useful for determining the gene copy number of the HER2/neu gene located at loci 17q12-17q21.32, which is a requirement for determining if a breast cancer patient is a candidate for anti-HER2/neu gene therapy. | 10-23-2008 |
20100047800 | Reagents and Methods for Detecting CYP2C9 Polymorphisms - The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the specific detection of clinically relevant CYP2C9 polymorphisms, in particular CYP2C9 polymorphisms associated with adverse drug response. The oligonucleotide sequences are also provided assembled as kits that can be used to predict how an individual will respond to drugs or other xenobiotic compounds that are metabolized, at least in part, by CYP2C9. | 02-25-2010 |
20100105041 | REAGENTS AND METHODS FOR DETECTING CYP2D6 POLYMORPHISMS - The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the specific detection of clinically relevant CYP2D6 polymorphisms, in particular CYP2D6 polymorphisms associated with adverse drug response. The oligonucleotide sequences are also provided assembled as kits that can be used to predict how an individual will respond to drugs or other xenobiotic compounds that are metabolized, at least in part, by CYP2D6. | 04-29-2010 |
20100255482 | Hepatitis B Virus (HBV) Specific Oligonucleotide Sequences - The present invention relates to oligonucleotide sequences for amplification primers and detection probes and to their use in nucleic acid amplification methods for the detection of HBV in biological samples. In particular, oligonucleotide sequences are provided for the sensitive qualitative or quantitative detection of all eight HBV genotypes. The invention also provides oligonucleotide primer sets and primer/probe sets in the form of kits for the diagnosis of HBV infection. | 10-07-2010 |
Patent application number | Description | Published |
20100056062 | Beamforming by Sector Sweeping - A method for beamforming in a communication system includes receiving a first plurality of training data units via a plurality of antennas, applying a different steering vector as each training data unit is received, generating a first plurality of quality indicators based on the first plurality of received training data units, such that each of the first plurality of quality indicators corresponds to a respective one of the first plurality of received training data units, and selecting a steering vector based on the different steering vectors and the first plurality of quality indicators. | 03-04-2010 |
20130242968 | PHYSICAL LAYER DATA UNIT FORMAT - A beamforming training (BFT) data unit for transmission via a communication channel in a wireless personal area network is generated, and in particular, is for transmitting beamforming training information. A physical layer header and first BFT data are encoded using block encoding to generate a first block. Second BFT data are encoded using block encoding to generate a second block. The BFT data unit is generated with a fixed-length payload, such that the BFT data unit includes only i) a preamble, ii) the first block, and iii) the second block. | 09-19-2013 |
20140078961 | METHOD AND SYSTEM FOR DETECTING SYNCHRONIZATION SIGNALS IN A MOBILE COMMUNICATIONS PROTOCOL - A method of detecting a secondary synchronization signal in a received signal having desired primary and secondary synchronization signals, and interfering primary and secondary synchronization signals, includes providing information regarding primary synchronization signal location and, based on the information regarding primary synchronization signal location, performing successive interference cancellation to remove the interfering secondary synchronization signals for detecting the desired secondary synchronization signal, without performing successive interference cancellation on the primary synchronization signals. Apparatus for detecting a secondary synchronization signal in a received signal having (i) desired primary and secondary synchronization signals and (ii) interfering primary and secondary synchronization signals includes a source of information regarding primary synchronization signal location, and successive interference cancellation circuitry. The successive interference cancellation circuitry uses the information regarding primary synchronization signal location to remove interfering secondary synchronization signals for detecting the desired secondary synchronization signal, without performing successive interference cancellation on the primary synchronization signals. | 03-20-2014 |
20140206304 | BEAMFORMING BY SECTOR SWEEPING - A first plurality of training data units are transmitted via a plurality of antennas of a first station as part of a first transmit beamforming training procedure. Subsequently, a second plurality of training data units are received via the plurality of antennas as part of second transmit beamforming procedure while the first station applies a single receive antenna configuration. The second plurality of training data units includes an information element that specifies a feedback from a second station, the feedback including an identifier corresponding to one of the training data units in the first plurality of data units. The first station transmits a feedback message to the second station, that includes (i) one or more indicators of one or more training data units selected from the second plurality of training data units, and (ii) a request to perform a subsequent beamforming training procedure. | 07-24-2014 |
Patent application number | Description | Published |
20080242555 | MULTIPLEX NUCLEIC ACID REACTIONS - The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously. | 10-02-2008 |
20120122737 | METHODS FOR SELECTING AND AMPLIFYING POLYNUCLEOTIDES - The invention provides methods for controlling the density of different molecular species on the surface of a solid support. A first mixture of different molecular species is attached to a solid support under conditions to attach each species at a desired density, thereby producing a derivatized support having attached capture molecules. The derivatized support is treated with a second mixture of different molecular species, wherein different molecular species in the second mixture bind specifically to the different capture molecules attached to the solid support. One or more of the capture molecules can be reversibly modified such that the capture molecules have a different activity before and after the second mixture of molecular species are attached. In particular embodiments, the different molecular species are nucleic acids that are reversibly modified to have different activity in an amplification reaction. | 05-17-2012 |
20130071879 | AMPLIFICATION METHODS TO MINIMISE SEQUENCE SPECIFIC BIAS - Methods for amplifying nucleic acids are provided. The methods can be used to minimise sequence specific bias caused by the preferential amplification of certain nucleic acid sequences. Methods are described which can lower the efficiency of AT rich templates relative to GC rich templates, thereby minimising GC bias during amplification reactions with multiple templates of different sequence. The methods are suited to solid phase amplification, for example, utilising flow cells. | 03-21-2013 |
20130079232 | METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING - The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected. | 03-28-2013 |
20140080721 | METHODS FOR REDUCING NUCLEIC ACID DAMAGE - Provided herein is a method of inhibiting degradation of nucleic acids during a nucleic acid processing step selected from fragmentation and detection comprising contacting the nucleic acids with a solution comprising gallic acid, analogues, derivatives thereof or mixtures thereof, during the processing step, wherein the contacting inhibits degradation of the nucleic acids. Also provided herein is a method of inhibiting light-induced degradation of nucleic acids. Additionally, provided herein is a method of reducing or inhibiting nucleic acid damage during preparation of a nucleic acid sample comprising fragmenting the nucleic acid sequences in the sample in a solution comprising one of more compounds, the compounds inhibiting degradation of the nucleic acid sequences in the sample. | 03-20-2014 |
20140329246 | AMPLIFICATION METHODS TO MINIMISE SEQUENCE SPECIFIC BIAS - Methods for amplifying nucleic acids are provided. The methods can be used to minimise sequence specific bias caused by the preferential amplification of certain nucleic acid sequences. Methods are described which can lower the efficiency of AT rich templates relative to GC rich templates, thereby minimising GC bias during amplification reactions with multiple templates of different sequence. The methods are suited to solid phase amplification, for example, utilising flow cells. | 11-06-2014 |
Patent application number | Description | Published |
20100015626 | MULTIPLEX NUCLEIC ACID REACTIONS - The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously. | 01-21-2010 |
20100151473 | METHODS AND COMPOSITIONS FOR HYBRIDIZING NUCLEIC ACIDS - Methods and compositions for hybridizing nucleic acids are disclosed herein. Also disclosed herein are methods and compositions to detect a nucleic acid provided to an array. | 06-17-2010 |
20100311064 | MULTIPLEX NUCLEIC ACID REACTIONS - The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously. | 12-09-2010 |
20120196758 | METHOD FOR NUCLEOTIDE DETECTION - A method of inhibiting light-induced degradation of nucleic acids includes irradiating a portion of the nucleic acids in the presence of a detection solution comprising a polyphenolic compound. A method of detecting a nucleic acid having a fluorescent tag includes irradiating at least a portion of the nucleic acid with light of a suitable wavelength to induce a fluorescence emission and detecting the fluorescence emission. Optionally, the polyphenolic compound is gallic acid, a lower alkyl ester thereof, or mixtures thereof. A kit includes one or more nucleotides, an enzyme capable of catalyzing incorporation of the nucleotides into a nucleic acid strand and a polyphenolic compound suitable for preparing a detection solution. | 08-02-2012 |
20130116128 | INTEGRATED SEQUENCING APPARATUSES AND METHODS OF USE - Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing. | 05-09-2013 |
20130244882 | MULTIPLEX NUCLEIC ACID REACTIONS - A method for detecting nucleic acids by (a) providing a sample having target nucleic acids, each nucleic acid having contiguous first, second, and third domains; (b) contacting the sample with probe sets to form hybridization complexes, wherein each probe set includes (i) a first probe having a sequence that is complementary to the first domain; and (ii) a second probe having a sequence substantially complementary to the third domain; (c) extending the first probes along the second domains of the complexes while the complexes are immobilized on a solid support; (d) ligating the extended first probes to the second probes to form templates; (e) amplifying the templates with primers that are complementary to the first and second priming sequences to produce amplicons; and (f) detecting the amplicons on the surface of a nucleic acid array. | 09-19-2013 |
20130274148 | PORTABLE GENETIC DETECTION AND ANALYSIS SYSTEM AND METHOD - A portable detector is disclosed for detecting certain analytes of interest, such as genetic material (e.g., nucleic acids). The detector includes a reading component for the detection of the analytes, and control circuitry for controlling operation of the reading component. Processing circuitry may be included to perform both primary analysis of acquired data, and where desired, secondary analysis. Where desired, some or all of the computationally intensive tasks may be off-loaded to enhance the portability and speed of the device. The device may incorporate various types of interface, technologies for reading and analysis, positioning system interfaces, and so forth. A number of exemplary use cases and methods are also disclosed. | 10-17-2013 |
20130338042 | KINETIC EXCLUSION AMPLIFICATION OF NUCLEIC ACID LIBRARIES - A method including (a) providing an amplification reagent including an array of sites, and a solution having different target nucleic acids; and (b) reacting the amplification reagent to produce amplification sites each having a clonal population of amplicons from a target nucleic acid from the solution. The reacting can include simultaneously transporting the nucleic acids to the sites at an average transport rate, and amplifying the nucleic acids that transport to the sites at an average amplification rate, wherein the average amplification rate exceeds the average transport rate. The reacting can include producing a first amplicon from a nucleic acid that transports to each of the sites, and producing subsequent amplicons from the nucleic acid or from the first amplicon, wherein the average rate at which the subsequent amplicons are generated exceeds the average rate at which the first amplicon is generated. | 12-19-2013 |
20140073514 | INTEGRATED SEQUENCING APPARATUSES AND METHODS OF USE - Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing. | 03-13-2014 |
20140127792 | SEQUENCE SCHEDULING AND SAMPLE DISTRIBUTION TECHNIQUES - A technique is disclosed for sample management for use in conjunction with sequencing devices that sequence biological samples, e.g., DNA and RNA. A sequencing device or a network of sequencing devices may be scheduled according to the characteristics of the samples in queue and the capabilities and availability of sequencing devices. Biological samples may be automatically queued and loaded via a sample distribution system. A sample distribution system may be used to reduce operator intervention. | 05-08-2014 |
20140214579 | METHODS AND SYSTEMS FOR USING A CLOUD COMPUTING ENVIRONMENT TO SHARE BIOLOGICAL RELATED DATA - The present disclosure provides a novel approach for shifting or distributing various information (e.g., protocols, analysis methods, sample preparation data, sequencing data, etc.) to a cloud-based network. For example, the techniques relate to a cloud computing environment configured to receive this information from one or more individual sample preparation devices, sequencing devices, and/or computing systems. In turn, the cloud computing environment may generate information for use in the cloud computing environment and/or to provide the generated information to the devices to guide a genomic analysis workflow. Further, the cloud computing environment may be used to facilitate the sharing of sample preparation protocols for use with generic sample preparation cartridges and/or monitoring the popularity of the sample preparation protocols. | 07-31-2014 |
20150080230 | KINETIC EXCLUSION AMPLIFICATION OF NUCLEIC ACID LIBRARIES - A method including (a) providing an amplification reagent including an array of sites, and a solution having different target nucleic acids; and (b) reacting the amplification reagent to produce amplification sites each having a clonal population of amplicons from a target nucleic acid from the solution. The reacting can include simultaneously transporting the nucleic acids to the sites at an average transport rate, and amplifying the nucleic acids that transport to the sites at an average amplification rate, wherein the average amplification rate exceeds the average transport rate. The reacting can include producing a first amplicon from a nucleic acid that transports to each of the sites, and producing subsequent amplicons from the nucleic acid or from the first amplicon, wherein the average rate at which the subsequent amplicons are generated exceeds the average rate at which the first amplicon is generated. | 03-19-2015 |
Patent application number | Description | Published |
20100278055 | Apparatus and Method of Compensating for Clock Frequency and Phase Variations by Processing Packet Delay Values - An apparatus and method are described for compensating for frequency and phase variations of electronic components by processing packet delay values. In one embodiment, a packet delay determination module determines packet delay values based on time values associated with a first and a second electronic component. A packet delay selection module selects a subset of the packet delay values based on the maximum frequency drift of the first electronic component. A statistical parameter determination module evaluates a first and a second parameter based on portions of the subset of packet delay values A validation module validates the parameters when each portion the subset of packet delay values includes a minimum of at least two packet delay values. An adjustment module compensates for at least one of a frequency variation and a phase variation of the first electronic component based on the parameters if the parameters are both validated. | 11-04-2010 |
20110128976 | Apparatus and Method of Scheduling Timing Packets to Enhance Time Distribution in Telecommunication Networks - An apparatus and method of scheduling timing packets to enhance time distribution includes an improved apparatus in a system in which at least one of time and frequency information is derived based on information distributed in timing packets, at least some of the timing packets being transmitted by or received by the apparatus. The improvement includes a scheduling module that determines a first packet transmission time offset of a first timing packet based on a first predetermined identifier associated with the apparatus, and a second packet transmission time offset of a second timing packet based on the first packet transmission time offset and a timing packet spacing that is independent of the first predetermined identifier. The improvement further includes a transmission module that transmits the first timing packet based on the first packet transmission time offset, and the second timing packet based on the second packet transmission time offset. | 06-02-2011 |
20110310766 | APPARATUS AND METHOD OF COMPENSATING FOR CLOCK FREQUENCY AND PHASE VARIATIONS BY PROCESSING PACKET DELAY VALUES - An apparatus and method are described for compensating for frequency and phase variations of electronic components by processing packet delay values. In one embodiment, a packet delay determination module determines packet delay values based on time values associated with a first and a second electronic component. A packet delay selection module selects a subset of the packet delay values based on the maximum frequency drift of the first electronic component. A statistical parameter determination module evaluates a first and a second parameter based on portions of the subset of packet delay values. A validation module validates the parameters when each portion the subset of packet delay values includes a minimum of at least two packet delay values. An adjustment module compensates for at least one of a frequency variation and a phase variation of the first electronic component based on the parameters if the parameters are both validated. | 12-22-2011 |
20130010815 | Apparatus and Method of Compensating for Clock Frequency and Phase Variations by Processing Packet Delay Values - An apparatus and method are described for compensating for frequency and phase variations of electronic components by processing packet delay values. In one embodiment, a packet delay determination module determines packet delay values based on time values associated with a first and a second electronic component. A packet delay selection module selects a subset of the packet delay values based on the maximum frequency drift of the first electronic component. A statistical parameter determination module evaluates a first and a second parameter based on portions of the subset of packet delay values. A validation module validates the parameters when each portion the subset of packet delay values includes a minimum of at least two packet delay values. An adjustment module compensates for at least one of a frequency variation and a phase variation of the first electronic component based on the parameters if the parameters are both validated. | 01-10-2013 |
20130301660 | Apparatus and Method of Compensating for Clock Frequency and Phase Variations by Processing Packet Delay Values - An apparatus and method are described for compensating for frequency and phase variations of electronic components by processing packet delay values. In one embodiment, a packet delay determination module determines packet delay values based on time values associated with a first and a second electronic component. A packet delay selection module selects a subset of the packet delay values based on the maximum frequency drift of the first electronic component. A statistical parameter determination module evaluates a first and a second parameter based on portions of the subset of packet delay values. A validation module validates the parameters when each portion the subset of packet delay values includes a minimum of at least two packet delay values. An adjustment module compensates for at least one of a frequency variation and a phase variation of the first electronic component based on the parameters if the parameters are both validated. | 11-14-2013 |
Patent application number | Description | Published |
20080299612 | FUSION PROTEINS WITH CLEAVABLE SPACERS AND USES THEREOF - A polypeptide comprising a first protein domain, a second protein domain, and a dithiocyclopeptide spacer containing at least one protease cleavage site, wherein the dithiocyclopeptide is exogenous relative to the first or second protein domain, and wherein the first and second protein domains are operably linked by the dithiocyclopeptide. Also disclosed are methods of producing the polypeptide and delivering the protein domains into a cell. | 12-04-2008 |
20090042777 | G-CSF Transferrin Fusion Proteins - A polypeptide comprising a G-CSF domain operably linked to a Tf domain, wherein the ability of the polypeptide to be transported into a cell expressing a TfR gene or the ability of the polypeptide to be transported across a cell expressing a TfR gene via transcytosis is higher than that of the G-CSF domain alone. | 02-12-2009 |
20090170163 | SPACERS TO INCREASE THE EXPRESSION OF RECOMBINANT FUSION PROTEINS - The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin (Tf)-based fusion proteins by inserting a helical linker between two protein domains. | 07-02-2009 |
20100303761 | Lipidized Interferon and Uses Thereof - The present invention is directed to methods and compositions useful in increasing in mammals the absorption and retention of polypeptides. The invention provides lipid-conjugated interferon having increased liver uptake and increased plasma half-life. | 12-02-2010 |
20110275120 | Fusion Proteins With Cleavable Spacers and Uses Thereof - A polypeptide comprising a first protein domain, a second protein domain, and a dithiocyclopeptide spacer containing at least one protease cleavage site, wherein the dithiocyclopeptide is exogenous relative to the first or second protein domain, and wherein the first and second protein domains are operably linked by the dithiocyclopeptide. Also disclosed are methods of producing the polypeptide and delivering the protein domains into a cell. | 11-10-2011 |
20110288269 | Design of Spacers To Increase The Expression of Recombinant Fusion Proteins - The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin (Tf)-based fusion proteins by inserting a helical linker between two protein domains. | 11-24-2011 |
20120004398 | Method for Uses of Protein Precursors as Prodrugs - The present invention provides compositions useful as prodrugs and methods for making the same. The compositions include a fusion protein having a first delivery domain and a second protein precursor domain linked together via a linker sequence. The delivery domain is a protein capable of facilitating entry to a target cells via the endocytotic pathway, such as transferrin. The protein precursor is a prohormone or a profactor, such as proinsulin. Methods of this invention include the steps of selecting a protein suitable as the delivery domain, constructing a vector to encode the fusion protein, and expressing the fusion protein in a suitable expression host. | 01-05-2012 |
20130130967 | Method for Uses of Protein Precursors as Prodrugs - The present invention provides compositions useful as prodrugs and methods for making the same. The compositions include a fusion protein having a first delivery domain and a second protein precursor domain linked together via a linker sequence. The delivery domain is a protein capable of facilitating entry to a target cells via the endocytotic pathway, such as transferrin. The protein precursor is a prohormone or a profactor, such as proinsulin. Methods of this invention include the steps of selecting a protein suitable as the delivery domain, constructing a vector to encode the fusion protein, and expressing the fusion protein in a suitable expression host. Also disclosed is a method for targeted-delivery of prodrugs to livers and a method of reducing hepatic glucose production. | 05-23-2013 |
20130143949 | G-CSF Transferrin Fusion Proteins - A polypeptide comprising a G-CSF domain operably linked to a Tf domain, wherein the ability of the polypeptide to be transported into a cell expressing a TfR gene or the ability of the polypeptide to be transported across a cell expressing a TfR gene via transcytosis is higher than that of the G-CSF domain alone. | 06-06-2013 |
20140206596 | Design of pH-Sensitive Oligopeptide Complexes For Drug Release Under Mildly Acidic Conditions - The present invention discloses a design for a molecular delivery vehicle capable of delivering a molecular payload to a target cell and its intracellular compartments. Also disclosed are highly pH-sensitive nanoconstruct that takes advantage of the requirement of cationic charge for internalization of CPPs to mask the non-specific internalization, compositions containing nanoconstruct, and methods for forming the same. | 07-24-2014 |
Patent application number | Description | Published |
20100232462 | Thermally Optimized Mechanical Interface for Hybrid Integrated Wavelength Division Multiplexed Arrayed Transmitter - An apparatus comprising a plurality of laser dice and a heat sink positioned between the laser dice and thermally coupled to the laser dice. Also included is an apparatus comprising a chip comprising a laser core, a stopper at least partially defining a groove, wherein the stopper and the groove are positioned adjacent to the chip, and a heater located between the laser core and the groove. | 09-16-2010 |
20110085794 | Wavelength Locker for Simultaneous Control of Multiple Dense Wavelength Division Multiplexing Transmitters - An apparatus comprising a plurality of optical transmitters coupled to a fiber, a signal generator coupled to the optical transmitters and configured to provide a single pilot tone to the optical transmitters, and a processor positioned within a feedback loop between the fiber and the optical transmitters, the processor configured to adjust a wavelength for each of the optical transmitters to lock the wavelengths. An apparatus comprising at least one processor configured to implement a method comprising receiving an optical signal comprising a pilot tone, detecting an amplitude and a phase of the pilot tone, calculating a quadrature term using the amplitude and the phase, and wavelength locking the optical signal using the quadrature term. | 04-14-2011 |
20110129192 | Efficient Thermoelectric Cooling of Photonic Integrated Circuits - An apparatus comprising a carrier comprising at least one heat-generating component and a thermoelectric cooler (TEC) coupled to a surface of the carrier, wherein the cross-sectional area of the TEC is less than the cross-sectional area of the carrier, and wherein the TEC is aligned with the heat-generating component. Included is an apparatus comprising a carrier comprising a plurality of optical transmitters and an active component, at least one TEC coupled to the surface of the carrier, and a support post coupled to the surface of the carrier, wherein the support post has a higher thermal resistivity than the TEC, wherein the cross-sectional area of the TEC is less than the cross-sectional area of the carrier, and wherein the TEC is aligned with the optical transmitters, the active component, or both. | 06-02-2011 |
20120008955 | Use of Multiple Shared Wavelength Lockers to Stabilize Transponders in a Wavelength Division Multiplexing (WDM) Network - An apparatus comprising at least one processor configured to receive a wavelength-division-multiplexed (WDM) signal from a remote node, wherein the WDM signal comprises a first channel carrying a first remotely generated signal, a second channel carrying a second remotely generated signal, and a third channel, adapt the WDM signal into a composite WDM signal by: dropping the first remotely generated signal from the first channel; adding a first locally generated signal to the first channel; and adding a second locally generated signal to the third channel, and provide wavelength locking to the first locally generated signal and the second locally generated signal without providing wavelength locking to the second remotely generated signal. | 01-12-2012 |
20130084073 | Shared Wavelength Locker With A Periodic Transmission Filter In A Network Communication Path - An apparatus comprising a plurality of optical transmitters and a wavelength locker shared by the plurality of optical transmitters. A periodic transmission filter used for wavelength locker operations is in a network communication path and shapes optical transmissions from the plurality of optical transmitters to a network. An apparatus comprising at least one processor configured to receive a pre-filter signal corresponding to part of an optical signal comprising a pilot tone and to receive a post-filter signal corresponding to a part of the optical signal that passes through a period transmission filter, wherein a filtered part of the optical signal is directed into a network. The processor is also configured to perform wavelength locking based on a quadrature detection technique that aligns an adiabatic logical one position of a modulated transmission signal with a spectral transmission peak of the period transmission filter. | 04-04-2013 |
20130202312 | Arrayed Optical Device Block for Photonic Integration - Included is an apparatus comprising a first circuit component comprising a plurality of optical devices each having an optical input port and an optical output port. All of the optical input ports and all of the optical output ports are positioned on a first side of the circuit component. Also included is a circuit component comprising a plurality of optical devices. The circuit component further comprises a plurality of electrical inputs coupled to the optical devices and positioned on a first side of the circuit component. The circuit component also comprises a plurality of optical input ports coupled to the optical devices and positioned on a second side of the circuit component that does not share any edges with the first side. | 08-08-2013 |
20140185978 | HYBRID INTEGRATION USING FOLDED MACH-ZEHNDER MODULATOR ARRAY BLOCK - An apparatus comprising a modulation block comprising a plurality of modulators, wherein each of the plurality of modulators comprises an optical input port and an optical output port, and wherein all of the optical input ports and all of the optical output ports are positioned on one face of the modulation block. Another apparatus comprising a modulation block comprising one or more Mach-Zehnder modulators (MZMs), wherein each MZM is coupled to an optical input port, an optical output port, and at least one electrical trace, wherein all of the optical input ports and all of the optical output ports are positioned on a first side of the modulation block, and wherein all of the electrical traces are positioned on a second side of the modulation block, and a planar lightwave circuit (PLC) coupled to the modulation block via an optical interface. | 07-03-2014 |
20140185980 | Silicon-On-Insulator Platform for Integration of Tunable Laser Arrays - An apparatus comprising a silicon-on-insulator (SOI) platform comprising an optical component network. An apparatus comprising an optical component network monolithically grown on a SOI platform, and an optical device coupled to the optical component network. A method comprising generating an optical signal using a silicon-based optical component, applying an electrical signal to the optical component, and tuning a wavelength of the optical signal based on the electrical signal. | 07-03-2014 |
20150071314 | Obtaining Narrow Line-width, Full C-band Tunability Mirror for Monolithic or Hybrid Integrated Lasers - An apparatus comprising an optical medium, a power splitter coupled to the optical medium, a first delay line coupled to the power splitter such that the power splitter is positioned between the first delay line and the optical medium, a first comb reflector coupled to the first delay line such that the first delay line is positioned between the first comb reflector and the power splitter, and a second comb reflector coupled to the power splitter but not the first comb reflector and not the first delay line. A method comprising receiving an optical signal, splitting the optical signal into a first split optical signal and a second split optical signal, delaying the first split optical signal, tuning the delayed first split optical signal, tuning the second split optical signal, and delaying the tuned second split optical signal. | 03-12-2015 |
Patent application number | Description | Published |
20090070130 | REPUTATION SCORING - In one example embodiment, a system and method is shown that includes receiving a feedback score relating to a transaction engaged in by a user. The system and method also includes applying a weight to the feedback score based on weighting criteria to create a weighted feedback score. Further, generating a reputation score for the user based on the weighted feedback score may also be implemented. In an additional example embodiment, the system and method includes identifying a reputation score relating at least one neighbor of a user, the at least one neighbor of the user including another user with whom the user has engaged in a transaction. Further, the system and method includes ordering the reputation score relating to at least one neighbor of the user to create an ordered reputation score. Moreover, the system and method includes displaying the ordered reputation score. | 03-12-2009 |
20090070460 | METHOD AND SYSTEM FOR SOCIAL NETWORK ANALYSIS - Methods and system for social network analysis are described. In one embodiment, a strongly connected component value, an in-component value, an out-component value, a disconnected component value, a tendril value, and a tube value of a social network for a time period may be accessed. A social strength of the social network for the time period may be calculated by combining the strongly connected component value, the in-component value, the out-component value, the disconnected component value, the tendril value, and the tube value. The social strength of the social network for the time period may be utilized for analysis of the social network. The strongly connected component value may have a greatest weight and the disconnected component value may have the lowest weight in the combining. | 03-12-2009 |
20090070679 | METHOD AND SYSTEM FOR SOCIAL NETWORK ANALYSIS - Methods and system for social network analysis are described. In one embodiment, user interaction data of a time period for a plurality of users in a social network may be accessed. Network analysis may be performed on the user interaction data. A necktie-shaped graph may be generated from the user interaction data in accordance with the performing of the network analysis. The necktie-shaped graph may be utilized for analysis of the social network. | 03-12-2009 |