Patent application number | Description | Published |
20090027693 | Optical interrogation system and microplate position correction method - An optical interrogation system and method are described herein that are capable of detecting and correcting a positional misalignment of a label independent detection (LID) microplate so that the LID microplate can be properly interrogated after being removed from and then re-inserted back into a microplate holder/XY translation stage. | 01-29-2009 |
20090247427 | LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD - A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays. | 10-01-2009 |
20100118315 | REFERENCE MICROPLATES AND METHODS FOR MAKING AND USING THE REFERENCE MICROPLATES - A reference microplate is described herein which can be used to help calibrate and troubleshoot an optical interrogation system. In one embodiment, the reference microplate has a frame with an array of wells each of which contains an optical biosensor and each optical biosensor is at least partially coated with a substance (e.g., elastomer, optical epoxy). In another embodiment, the reference microplate in addition to having its optical biosensors at least partially covered with a substance (e.g., elastomer, optical epoxy) also has a controllable heating device attached thereto which is used to heat the optical biosensors. | 05-13-2010 |
20100225921 | Screening system and method for analyzing a plurality of biosensors - A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers. | 09-09-2010 |
20110142092 | SCREENING SYSTEM AND METHOD FOR ANALYZING A PLURALITY OF BIOSENSORS - A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers. | 06-16-2011 |
20120010105 | LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD - A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays. | 01-12-2012 |
Patent application number | Description | Published |
20150178395 | SYSTEM AND METHOD FOR IDEMPOTENT INTERACTIVE DISPARATE OBJECT DISCOVERY, RETRIEVAL AND DISPLAY - The present invention is a system that performs a real time on-demand searching for items such as goods or services with specific search criteria, and returns a set of search results that are deduped and can be updated when modifications to the search results occur. The functionality is provided by a idempotence search system having a user agent that asynchronously receives search results from user's remote computing devices, a set of fetchers for retrieving search results from associated external site and organizing the results in a results queue, a plurality of parser operating in parallel, a broadcaster wherein the user agent includes retrieving the difference from the delta queue, retrieving the results associated with the difference and displaying the results for the user. | 06-25-2015 |
20150178746 | SYSTEM AND METHOD FOR NEAR REAL-TIME, UNSOLICITED, UNBIASED DEMAND COLLECTION FOR DISTRIBUTING CONSUMER ITEMS - This invention is a system for determining non-abstract consumer demand for an item comprising: a user agent, an aggregator and a sales agent for transmitting the quantity price demand information to a supplier computer system, receiving an initial price and quantity of the discrete item being offered by the supplier from the supplier computer system, setting the current price to the initial price, (a) transmitting the discrete item information to remote computer systems that represent the user's desire for the discrete item, (b) waiting an predetermined period of time, (c) reducing the quantity of items available by the number sold during the predetermined period of time, (d) reducing the current price and performing steps (a), (b), (c) and (d) until: (i) the quantity of items available is reduced to zero or (ii) a sale termination period is reached or (iii) a maximum price reduction has been reached. | 06-25-2015 |
20150178747 | SYSTEM AND METHOD FOR DETERMINING AND DISTRIBUTING CONSUMER ITEMS ACCORDING TO DYNAMIC DEMAND LEVELS - This invention is directed to a computerized system for asynchronously receiving persistent query requests, selecting a subset from the plurality of persistent query requests for a particular item, ordering the subset of persistent query requests into a plurality of equal range brackets between the highest desired price to the lowest desired price, receiving a set of sales program criteria from the vendor computer system created in response to the vendor computer system previously receiving the subset of persistent query requests having available quantity and available price information for the items available for sale from the vendor, determining the number of available items from the sales program criteria having available prices that are within a first desired range bracket, and transmitting a notification to the remote computer devices associated with the query results having available prices in the first range bracket. | 06-25-2015 |
20150178807 | SYSTEM AND METHOD FOR ASYNCHRONOUS CONSUMER ITEM SEARCHING REQUESTS WITH SYNCHRONOUS PARALLEL SEARCHING - This invention is a system for providing persistence searching for consumer items that performs the steps of: retrieving a set of get requests uniquely associated with external vendor sites wherein each get request is specifically formatted for its external vendor site and simultaneously transmitting the set of get requests to the respective external vendor sites. Asynchronously receiving current results from the external vendor sites, extracting the price from the current results for each item contained in the current results received from the external vendor sites, comparing the extracted price of the current results with the price of a previously stored results, generating a notification and including in the notification, a link to the external vendor site to provide a purchasing opportunity to a user where the price of the current results is lower than the price of the stored results. | 06-25-2015 |
Patent application number | Description | Published |
20120324911 | DUAL-LOOP COOLING SYSTEM - Disclosed are methods and apparatuses for cooling a work piece surface using a dual-loop cooling system. The system includes a vapor-compression loop and a liquid-evaporation loop. The loops are configured to prepare a coolant at or approximately at saturation for delivery into a chamber for cooling the surface. A preferred liquid-evaporation loop includes a chamber, a phase separator, a liquid pressurizer, and a vapor mixer that heats the coolant to or near its saturation temperature. A preferred vapor-compression loop includes the phase separator, a compressor, a condenser, an expansion valve, and a return line. The vapor mixer preferably heats the coolant by mixing liquid coolant with vapor coolant derived from the vapor-compression loop. A two-phase flow detector may be disposed downstream of the vapor mixer and be in communication with a vapor valve disposed upstream of the vapor mixer to ensure that an appropriate amount of vapor is fed into the vapor mixer to induce evaporation. Methods include cooling a surface by cycling a coolant through the liquid-evaporation loop and preparing the coolant at saturation with vapor derived from the vapor-compression loop. | 12-27-2012 |
20120325436 | HIGH EFFICIENCY THERMAL MANAGEMENT SYSTEM - Disclosed are methods and apparatuses for cooling a work piece surface using two-phase impingement, such as direct jet impingement. Preferred methods include flowing a coolant through a chamber comprising a surface to be cooled by projecting a jet stream of coolant against the surface while maintaining pressure in the chamber to permit at least a portion of coolant contacting the surface to boil. Preferred apparatuses include a chamber comprising the surface and tubular nozzles configured to project a stream of coolant against the surface, a pump for forcing coolant through the tubular nozzles, a pressurizer for maintaining an appropriate pressure in the chamber, and a heat exchanger for cooling the coolant exiting the chamber. The apparatuses may further include a pressure regulator for detecting changes in temperature of the coolant exiting the chamber and communicating with the pressurizer to adjust the maintained pressure accordingly. The methods and apparatuses disclosed herein provide for effective and efficient cooling of work piece surfaces. | 12-27-2012 |