Patent application number | Description | Published |
20090088702 | METHODS FOR MANUALLY INJECTING/ASPIRATING FLUIDS THROUGH SMALL DIAMETER CATHETERS AND NEEDLES AND MANUAL INJECTION/ASPIRATION SYSTEMS INCLUDING SMALL DIAMETER CATHETERS AND NEEDLES - A system for increasing rates at which fluids may be manually forced through injection/aspiration elements, such as catheters and needles, includes the injection/aspiration elements, as well as a syringe including a pair of crossed handles, one associated with the barrel of the syringe, the other associated with the plunger of the syringe, to provide a mechanical advantage. The system may include and injection/aspiration element of small (e.g., 0.052 inch or smaller) inner diameter. Such systems enable the use of a single hand to hold and operate a syringe in a variety or procedures, including angiography, angioplasty, discography, glue/cement injection, and a variety of aspiration procedures (e.g., biopsy, sampling, media removal, etc.). | 04-02-2009 |
20100030098 | LARGE SURFACE AREA TEMPERATURE SENSING DEVICE - A temperature probe for monitoring temperatures of a surface of a tissue or organ within the body of a subject includes a section with a substantially two-dimensional arrangement and a plurality of temperature sensors positioned across an area defined by the substantially two-dimensional arrangement. Such an apparatus may be used in conjunction with procedures in which thermal techniques are used to diagnose a disease state or treat diseased tissue. Specifically, a temperature probe may be used to monitor temperatures across an area of a surface of a tissue or organ located close to the treated tissue to prevent subjection of the monitored tissue or organ to potentially damaging temperatures. | 02-04-2010 |
20100100033 | DOUBLE BARREL SYRINGE AND HANDLES FOR USE WITH DOUBLE BARREL SYRINGES - An apparatus that includes two syringes, or a “double barrel syringe,” includes one syringe that injects or infuses while the other syringe aspirates. In the double barrel syringe, injection and aspiration may be effected by a single action. The double barrel syringe may include a handle with two members. A first member of such a handle includes one arm that pivotally couples to a plunger of a first syringe and another arm that pivotally couples to a barrel of a second syringe. A second member of the handle includes one arm that pivotally couples to a barrel of the first syringe and another arm that pivotally couples to a plunger of the second syringe. Methods for injecting or infusing simultaneously with aspirating are also disclosed. | 04-22-2010 |
20100249719 | Methods for Manually Injecting/Aspirating Fluids Through Small Diameter Catheters and Needles and Manual Injection/Aspiration Systems Including Small Diameter Catheters and Needles - A system for increasing rates at which fluids may be manually forced through injection/aspiration elements, such as catheters and needles, includes the injection/aspiration elements, as well as a syringe including a pair of crossed handles, one associated with the barrel of the syringe, the other associated with the plunger of the syringe, to provide a mechanical advantage. The system may include and injection/aspiration element of small (e.g., 0.052 inch or smaller) inner diameter and small outer diameter (e.g., 5 French or less). Such systems enable the use of a single hand to hold and operate a syringe in a variety or procedures, including angiography, angioplasty, discography, glue/cement injection, and a variety of aspiration procedures (e.g., biopsy, sampling, media removal, etc.). | 09-30-2010 |
20100268116 | SYRINGE WITH ROTATABLE ELEMENT, ASPIRATION SYSTEMS INCLUDING THE SYRINGE, AND ASSOCIATED METHODS - A syringe includes a barrel and a rotatable element on the barrel; for example at a proximal location along the length of the barrel. The rotatable element rotates at least partially around the barrel. When a handle is associated with the rotatable element, the barrel may rotate as the handle is held substantially stationary or the handle may be rotated while the barrel and any peripheral device secured thereto remain substantially stationary. When handles are associated with a rotatable element that may be removed from a barrel, a barrel that is disassembled from the rotatable element may be replaced with another barrel of the same or a different configuration. The barrel and plunger may be configured to cause the barrel to rotate as the plunger moves along the length of the barrel. Methods of using a syringe with a rotatable element on a barrel thereof are also disclosed. | 10-21-2010 |
20100274197 | Hinge Assembly for an Injector - A locking hinge assembly for an injector is disclosed. The injector includes a forward handle member, a rear handle member and a hinge connecting the first and second members and defining an axis of rotation. The locking hinge assembly includes a hinge element slidable along the axis of rotation between a locked position and an unlocked position. The hinge element is coupled to the forward handle member and the rear handle member at the hinge, and the hinge element includes at least one groove. Additionally, a locking element is provided and positioned about the hinge. The locking element is configured to be received in the groove such that rotation of the forward handle member and rear handle member about the axis of rotation is prevented when the hinge element is in the locked configuration. | 10-28-2010 |
20110213245 | HAND-HELD, HAND-OPERATED POWER SYRINGE AND METHODS - A hand-held syringe includes a handle configured for suspending and using the syringe with a single hand. The handle includes pivotally connected first and second members. The members of the handle may be pivotally connected at intermediate positions along the lengths thereof or at or near ends thereof. The first member is associated with, and may be pivotally connected to, a syringe barrel, while the second member is associated with, and may be pivotally connected to, a syringe plunger. The syringe may be configured for a single-use (i.e., it may be disposable). Applications of use and methods of using a hand-held syringe are also disclosed. | 09-01-2011 |
20110224642 | SYRINGE WITH FLOW CONTROL VALVES AND ASSOCIATED METHODS - The present invention includes syringes with valves. The valves control communication between the interior of a barrel of the syringe and the exterior of the barrel. In syringes that include two valves, the valves may be oriented opposite one another, such that one of the valves may enable fluid to flow into the interior of the barrel of the syringe while preventing fluid from flowing in the opposite direction, while the other valve may enable fluid to flow out of the interior of the barrel while preventing fluid from flowing in the opposite direction. Alternatively, a syringe may include a single valve, which is carried at or near a distal end of its plunger. Methods for using such syringes, including, but not limited to, manual pulsed aspiration methods and manual pulsed delivery methods are also disclosed. | 09-15-2011 |
20110282338 | APPARATUS FOR MANUALLY MANIPULATING HOLLOW ORGANS - An apparatus for mechanically manipulating hollow organs within the body of a subject, or an organ manipulation apparatus, includes a manipulation section. The manipulation section may include a substantially two-dimensional element, which may have a width that exceeds a distance across a portion of the interior of a hollow organ within which the manipulation section is to be positioned. The manipulation section is configured to manipulate at least a portion of a hollow organ from within, which may modify at least one of a shape, orientation, or location of at least part of the hollow organ. Methods for manipulating hollow organs are also disclosed, as are operating techniques, such as left atrial ablation, in which the shapes, orientations, and/or locations of hollow organs are manipulated to move the hollow organs away from the site of the medical procedure, reducing the potential for damage to the hollow organs. | 11-17-2011 |
20120010524 | METHODS, APPARATUS AND SYSTEMS FOR FACILITATING INTRODUCTION OF SHAPED MEDICAL INSTRUMENTS INTO THE BODY OF A SUBJECT - A method for introducing an elongate medical instrument with a shaped portion into the body of a subject includes at least partially straightening the shaped portion from an exterior of the elongate medical instrument. A retention element may then be introduced into an interior of the shaped portion to maintain the shaped portion in an at least partially straightened configuration as the external force is removed from the shaped portion. With the retention element in place, the shaped portion may be introduced to a desired location within a hollow interior of an internal organ. The retention element may then be removed to enable the shaped portion to return to its desired shape. A straightening apparatus includes the retention element, as well as an external element that at least partially straightens the shaped portion of the elongate medical instrument from the outside. A system includes the elongate medical instrument and the straightening apparatus. | 01-12-2012 |
20120022404 | ASPIRATION APPARATUS AND METHODS - An aspiration apparatus includes handles with two members. Each of the handle members includes a proximal actuation end and an opposite distal connection end. The members of the handles are associated with one another (e.g., pivotally, etc.) in such a way that movement of the proximal actuation ends in first directions (e.g., toward one another, away from one another) causes the distal connection ends to move in opposite second directions (e.g., away from one another, toward one another). The distal connection end of the first member may configured for association with the barrel of a syringe, while the distal connection end of the second member may be configured for association with the plunger of the syringe. Association of one or both of the distal connection ends with its respective syringe element may be pivotal. Aspiration methods, including, but not limited to, methods of using such an aspiration apparatus, are also disclosed. | 01-26-2012 |
20120071838 | RAPID EXCHANGE ASPIRATION CATHETERS WITH LUMENS CONFIGURED FOR OPTIMIZED FLOW - A rapid exchange aspiration catheter includes a distal portion with a round cross-sectional shape, taken transverse to a longitudinal axis of the catheter. A primary lumen through the catheter has a size and a shape, and extends through the catheter at a location that are optimized for aspiration. In particular, the size of the primary lumen is maximized relative to the outer diameter of the catheter by minimizing the thicknesses of interior walls of the catheter. Such optimization maximizes the rate at which fluid flows through the aspiration catheter without compromising the ability of the catheter to withstand negative pressure (i.e., a vacuum). The present invention also includes systems in which the catheter is used in conjunction with a guide catheter and a wire, systems in which the catheter is used in conjunction with an aspiration element, and methods of using the catheter. | 03-22-2012 |
20120095447 | APPARATUS FOR ROTATING MEDICAL DEVICES, SYSTEMS INCLUDING THE APPARATUS, AND ASSOCIATED METHODS - A rooter includes a rotatable element, an actuator for causing the rotatable element to rotate, and a coupling feature for rotatably coupling an elongate medical instrument to the rotatable element. The rotatable element may be at least partially contained within the interior of a housing or another element that remains substantially stationary as the actuator causes the rotatable element to rotate. The rooter may be used with a variety of elongate medical instruments, such as needles, drill bits, trocars, wires, catheters, tubes, and other elongate instruments that are used to enable or effect medical procedures within the body of a subject. The rooter may be used for a variety of purposes, including, without limitation, the introduction of an elongate medical instrument into the body of a subject or its removal from the subject's body; removing, breaking up, or eliminating obstructions (e.g., blood clots, plaques, etc.) from the body of a subject; and obtaining samples from a subject's body. | 04-19-2012 |
20120179111 | ELONGATE MEDICAL INSTRUMENTS WITH REMOVABLE CORE GUIDE WIRE EXTENDERS, GUIDE WIRE EXTENDERS, SYSTEMS AND METHODS - A guide wire extender includes a coupling element for coupling to a proximal portion of a guide wire. Such a configuration enables the introduction of elongate medical instruments that lack rapid exchange features to be introduced into the body of a subject over short, rapid exchange-length guide wires. Assemblies that include a guide wire extender within an elongate medical device are also disclosed. Such an assembly may include a configuration that enables a single user to effectively lengthen a guide wire and introduce the elongate medical instrument into a subject's body without significant risk of contaminating the elongate medical instrument. Systems that include a guide wire extender and an elongate medical instrument are also disclosed, as are methods of using the guide wire extender to introduce an elongate medical instrument into the body of a subject. | 07-12-2012 |
20120179140 | ELONGATE MEDICAL INSTRUMENTS WITH REMOVABLE CORE GUIDE WIRE EXTENDERS, GUIDE WIRE EXTENDERS, SYSTEMS AND METHODS - A guide wire extender includes a coupling element for coupling to a proximal portion of a guide wire. Such a configuration enables the introduction of elongate medical instruments that lack rapid exchange features to be introduced into the body of a subject over short, rapid exchange-length guide wires. Assemblies that include a guide wire extender within an elongate medical device are also disclosed. Such an assembly may include a configuration that enables a single user to effectively lengthen a guide wire and introduce the elongate medical instrument into a subject's body without significant risk of contaminating the elongate medical instrument. Systems that include a guide wire extender and an elongate medical instrument are also disclosed, as are methods of using the guide wire extender to introduce an elongate medical instrument into the body of a subject. | 07-12-2012 |
20120239008 | APPARATUS FOR ROTATING MEDICAL DEVICES, SYSTEMS INCLUDING THE APPARATUS, AND ASSOCIATED METHODS - A rooter includes a rotatable element, an actuator for causing the rotatable element to rotate, and a coupling feature for rotatably coupling an elongated medical instrument to the rotatable element. The rotatable element may be at least partially contained within the interior of a housing or another element that remains substantially stationary as the actuator causes the rotatable element to rotate. The rooter may be used with a variety of elongated medical instruments, such as needles, drill bits, trocars, wires, catheters, tubes, and other elongated instruments that are used to enable or effect medical procedures within the body of a subject. The rooter may be used for a variety of purposes, including, without limitation, the introduction of an elongated medical instrument into the body of a subject or its removal from the subject's body; removing, breaking up, or eliminating obstructions (e.g., blood clots, plaques, etc.) from the body of a subject; and obtaining samples from a subject's body. | 09-20-2012 |
20130110036 | DOUBLE BARREL SYRINGE AND HANDLES FOR USE WITH DOUBLE BARREL SYRINGES | 05-02-2013 |
20130345644 | Hinge Assembly for an Injector - A locking hinge assembly for an injector is disclosed. The injector includes a forward handle member, a rear handle member and a hinge connecting the first and second members and defining an axis of rotation. The locking hinge assembly includes a hinge element slidable along the axis of rotation between a locked position and an unlocked position. The hinge element is coupled to the forward handle member and the rear handle member at the hinge, and the hinge element includes at least one groove. Additionally, a locking element is provided and positioned about the hinge. The locking element is configured to be received in the groove such that rotation of the forward handle member and rear handle member about the axis of rotation is prevented when the hinge element is in the locked configuration. | 12-26-2013 |
20140005634 | ASPIRATION APPARATUS AND METHODS | 01-02-2014 |
20140142594 | Apparatus for rotating medical devices, systems including the apparatus, and associated methods - A rooter includes a rotatable element, an actuator for causing the rotatable element to rotate, and a coupling feature for rotatably coupling an elongated medical instrument to the rotatable element. The rotatable element may be at least partially contained within the interior of a housing or another element that remains substantially stationary as the actuator causes the rotatable element to rotate. The rooter may be used with a variety of elongated medical instruments, such as wires, mascerators, needles, drill bits, trocars, catheters, tubes and other elongated instruments that are used to enable or effect medical procedures within the body of a subject. The rooter may be used for a variety of purposes, including, without limitation, the introduction of an elongated medical instrument into the body of a subject or its removal from the subject's body; removing, breaking up, or eliminating obstructions (e.g., blood clots, plaques, etc.) from the body of a subject; and obtaining samples from a subject's body. | 05-22-2014 |
20140200483 | SYRINGE WITH ROTATABLE ELEMENT, ASPIRATION SYSTEMS INCLUDING THE SYRINGE, AND ASSOCIATED METHODS - A syringe includes a barrel and a rotatable element on the barrel; for example at a proximal location along the length of the barrel. The rotatable element rotates at least partially around the barrel. When a handle is associated with the rotatable element, the barrel may rotate as the handle is held substantially stationary or the handle may be rotated while the barrel and any peripheral device secured thereto remain substantially stationary. When handles are associated with a rotatable element that may be removed from a barrel, a barrel that is disassembled from the rotatable element may be replaced with another barrel of the same or a different configuration. The barrel and plunger may be configured to cause the barrel to rotate as the plunger moves along the length of the barrel. Methods of using a syringe with a rotatable element on a barrel thereof are also disclosed. | 07-17-2014 |
20150032081 | HAND-HELD, HAND-OPERATED POWER SYRINGE AND METHODS - A hand-held syringe includes a handle configured for suspending and using the syringe with a single hand. The handle includes pivotally connected first and second members. The members of the handle may be pivotally connected at intermediate positions along the lengths thereof or at or near ends thereof. The first member is associated with, and may be pivotally connected to, a syringe barrel, while the second member is associated with, and may be pivotally connected to, a syringe plunger. The syringe may be configured for a single-use (i.e., it may be disposable). Applications of use and methods of using a hand-held syringe are also disclosed. | 01-29-2015 |
20150094570 | LARGE SURFACE AREA TEMPERATURE SENSING - A temperature probe for monitoring temperatures of a surface of a tissue or organ within the body of a subject includes a section with a substantially two-dimensional arrangement and a plurality of temperature sensors positioned across an area defined by the substantially two-dimensional arrangement. Such an apparatus may be used in conjunction with procedures in which thermal techniques are used to diagnose a disease state or treat diseased tissue. Specifically, a temperature probe may be used to monitor temperatures across an area of a surface of a tissue or organ located close to the treated tissue to prevent subjection of the monitored tissue or organ to potentially damaging temperatures. | 04-02-2015 |
20150245829 | EXPANDABLE DEVICES FOR POSITIONING ORGANS - A positioning device is configured to selectively position or otherwise manipulate one or more organs within the body of a subject. The positioning device includes a shaped expandable element that is configured to be selectively transitioned between an unexpanded, or collapsed, state and an expanded state. While in the expanded state, the expandable element repositions or otherwise manipulates an organ. Systems that include positioning devices are also disclosed, as are methods for positioning or otherwise manipulating organs. | 09-03-2015 |
20150305765 | TISSUE RESECTORS WITH CUTTING WIRES, HAND OPERATED TISSUE RESECTING SYSTEMS AND ASSOCIATED METHODS - A tissue resector includes an outer cannula with a cutting wire disposed therein. The outer cannula includes an opening that is configured to be associated with a cutting element of the cutting wire in such a way that when tissue is drawn into the opening of the cannula, a cutting element of the cutting wire can be rotated past the opening to engage and cut into and through the tissue. The outer cannula and the cutting wire may also be configured to enable aspiration of the tissue. A tissue resector according to this disclosure may be used with a hand-held, hand-operated rooter. | 10-29-2015 |
20160029897 | LARGE SURFACE AREA TEMPERATURE SENSING DEVICE - A temperature probe for monitoring temperatures of a surface of a tissue or organ within the body of a subject includes a section with a substantially two-dimensional arrangement and a plurality of temperature sensors positioned across an area defined by the substantially two-dimensional arrangement. Such an apparatus may be used in conjunction with procedures in which thermal techniques are used to diagnose a disease state or treat diseased tissue. Specifically, a temperature probe may be used to monitor temperatures across an area of a surface of a tissue or organ located close to the treated tissue to prevent subjection of the monitored tissue or organ to potentially damaging temperatures. | 02-04-2016 |
20160089497 | ROTATABLE FINGER LOOP FOR SYRINGE, SYRINGE CONFIGURED TO RECEIVE THE ROTATABLE FINGER LOOP AND ASSOCIATED METHODS - Finger control handles for conventional syringes are disclosed. The finger control handles may be configured to be assembled with a hand-held syringe, to be secured in place on a proximal portion of the barrel of the syringe and, when secured in place, to rotate freely about a circumference of the proximal portion of the barrel of the syringe. Systems that include the finger control handles and a hand-held syringe that is configured to capture the finger control handles are also disclosed, as are various methods of use, including methods for assembling the finger control handles with the syringe and methods for connecting the syringe to an elongated medical instrument, such as a catheter. | 03-31-2016 |
Patent application number | Description | Published |
20090123472 | DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS1 - A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided. | 05-14-2009 |
20090155234 | DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, MX1 - A method for detecting a mutation related to the gene encoding MxA. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the wild-type and mutated genes, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human MxA, including antisense oligonucleotides, methods, and compositions specific for human MxA, are also provided. | 06-18-2009 |
20090186028 | Detection of mutations in a gene associated with resistance to viral infection - A method for detecting a mutation related to the gene encoding LDLR. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the wild-type and mutated genes, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human LDLR, including antisense oligonucleotides, methods, and compositions specific for human LDLR, are also provided. | 07-23-2009 |
20090291074 | MUTATIONS IN OAS1 GENES - Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided. | 11-26-2009 |
20110071073 | Detection of mutations in a gene associated with resistance to viral infection, OAS1 - A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided. | 03-24-2011 |
20110237501 | Detection of Mutations in a Gene Associated with Resistance to Viral Infection, OAS1 - A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided. | 09-29-2011 |
20110262482 | ANTI-VIRAL COMPOUNDS - Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway. | 10-27-2011 |
20120070424 | Mutations on OAS1 Genes - Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided. | 03-22-2012 |
20120253027 | DETECTION OF MUTATIONS IN A GENE ASSOCIATED WTIH RESISTANCE TO VIRAL INFECTION, OAS1 - A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided. | 10-04-2012 |
20120258908 | OLIGOADENYLATE SYNTHETASE (OAS) - The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention. | 10-11-2012 |
20120321608 | DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS1 - A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided. | 12-20-2012 |
20130035382 | Anti-Viral Compounds - Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway. | 02-07-2013 |
20130035397 | Anti-Viral Compounds - Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway. | 02-07-2013 |
20130039887 | Methods of Identifying and Using Anti-Viral Compounds - Disclosed herein are methods for identifying compounds for the treatment of viral infection, including RNA viral infection and uses of the compounds as pharmaceutical compositions. The identified compounds modulate the RIG-I pathway in vertebrate cells. | 02-14-2013 |
20130039944 | Anti-Viral Compounds - Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway. | 02-14-2013 |
20130039945 | Anti-Viral Compounds - Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway. | 02-14-2013 |
20130045229 | Anti-Viral Compounds - Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway. | 02-21-2013 |
20130142773 | Mutations in OAS1 Genes - Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided. | 06-06-2013 |
20130336929 | METHODS AND CELLS FOR IDENTIFYING RIG-I PATHWAY REGULATORS - Disclosed herein are methods for identifying compounds for the treatment of viral infection, including RNA viral infection and uses of the compounds as pharmaceutical compositions. The identified compounds modulate the RIG-I pathway in vertebrate cells. | 12-19-2013 |
20140005101 | Oligoadenylate Synthetase (OAS) | 01-02-2014 |
20140005102 | Oligoadenylate Synthetase (OAS) | 01-02-2014 |
20140037717 | Detection of Mutations in a Gene Associated with Resistance to Viral Infection, OAS1 - A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided. | 02-06-2014 |
20140199348 | Anti-Viral Compounds - Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway. | 07-17-2014 |
20140221271 | SHK-BASED PHARMACEUTICAL COMPOSITIONS AND METHODS OF MANUFACTURING AND USING THE SAME - Disclosed herein are pharmaceutical compositions having the sequence Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Xaa-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys (SEQ ID NO: 1). The disclosed compositions can include an acid or amide at the C-terminus of SEQ ID NO: 1 and the polypeptide can be attached to an organic or inorganic chemical entity that has an anionic charge. The polypeptide can be detectably labeled for diagnostic purposes. Methods of manufacturing and using the pharmaceutical compounds are also disclosed. | 08-07-2014 |
20150342932 | ANTI-VIRAL COMPOUNDS - Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway. | 12-03-2015 |
20160000869 | METHODS OF TREATING IPEX SYNDROME USING TOXIN-BASED PHARMACEUTICAL COMPOSITIONS - Disclosed herein are methods of treating immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) comprising administering a toxin-based therapeutic peptide, such as an ShK-based peptide. The peptide can include an acid or amide at the C-terminus and/or the peptide can be attached to an organic or inorganic chemical entity that has an anionic charge. | 01-07-2016 |
20160045627 | SHK-BASED PHARMACEUTICAL COMPOSITIONS AND METHODS OF MANUFACTURING AND USING THE SAME - Disclosed herein are pharmaceutical compositions having the sequence Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Xaa-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys (SEQ ID NO:1). The disclosed compositions can include an acid or amide at the C-terminus of SEQ ID NO: 1 and the polypeptide can be attached to an organic or inorganic chemical entity that has an anionic charge. The polypeptide can be detectably labeled for diagnostic purposes. Methods of manufacturing and using the pharmaceutical compounds are also disclosed. | 02-18-2016 |
20160102099 | ANTI-VIRAL COMPOUNDS - Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway. | 04-14-2016 |