Shaw, PA
Alan Shaw, Doylestown, PA US
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20090047303 | Method for improving the immunogenicity of plasmodium antigens - The present invention provides a Malaria antigen-carrier conjugate, which comprises a carrier protein and a plurality of | 02-19-2009 |
20130095130 | Methods and Compositions for Providing Protective Immunity in the Elderly - Compositions that include a flagellin/antigen protein comprising at least a portion of at least one flagellin and at least a portion of at least one antigen and methods of administering these compositions to humans at least 49 years old. The compositions stimulate immune response to the antigen, in particular, a protective immune response to the antigen, in the human, such as an elderly human. | 04-18-2013 |
Alan R. Shaw, Doylestown, PA US
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20110135680 | DELETION MUTANTS OF FLAGELLIN AND METHODS OF USE - Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one viral antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection. | 06-09-2011 |
Anthony Shaw, West Point, PA US
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20150203843 | NOVEL TETRAGALNAC CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES - Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents. | 07-23-2015 |
Anthony W. Shaw, Harleysville, PA US
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20080261972 | Cgrp Receptor Antagonists - Compounds of Formula (I), (where variables R | 10-23-2008 |
20080280857 | CGRP receptor antagonists - The present invention is directed to compounds of Formula I: | 11-13-2008 |
20090192139 | CGRP RECEPTOR ANTAGONISTS - The present invention is directed to compounds of Formula I: | 07-30-2009 |
20100298303 | CGRP RECEPTOR ANTAGONISTS - The present invention is directed to compounds of Formula I: | 11-25-2010 |
20110206783 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN - The subject invention relates to novel P2X | 08-25-2011 |
20130041133 | NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES - In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3′ and/or 5′ end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide. | 02-14-2013 |
20130253168 | NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES - In an embodiment the instant invention discloses a modular composition comprising 1) an oligonueleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at the 2′-position of the ribose rings and/or the terminal 3′- and/or 5′-positions of the oligonucleotide; 3) optionally, one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide. | 09-26-2013 |
Anthony W. Shaw, West Point, PA US
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20150246133 | NOVEL TETRAGALNAC AND PEPTIDE CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES - Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents. | 09-03-2015 |
Antony Shaw, Collegeville, PA US
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20110160227 | Prolyl Hydroxylase Inhibitors - The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I) | 06-30-2011 |
Antony Nicholas Shaw, Collegeville, PA US
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20110098324 | PROLYL HYDROXYLASE INHIBITORS - The invention described herein relates to certain pyrimidinedione N-substituted glycine derivatives of formula (I) | 04-28-2011 |
20130225524 | Chemical Compounds - The invention is directed to substituted quinoline derivatives. Specifically, the invention is directed to compounds according to Formula I: | 08-29-2013 |
Austin A. Shaw, Tyrone, PA US
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20110204639 | MODULAR POWER SYSTEM - The present invention in several embodiments is a modular power system for providing electrical and mechanical power to a variety of applications. This system may comprise an electric motor mechanically coupled to an electric generator or alternator, and a rechargeable battery. The rechargeable battery would store and provide electrical power for the system. Additional energy could be supplied to the battery and the system by means of electrical or mechanical connections. For example, a generator of the system could be mechanically connected to the moving wheels of a land vehicle or to the moving shaft of a piece of machinery to generate electrical power. The mechanical connection could be any know in the art, but preferably would comprise a means for efficiently transferring said mechanical energy. | 08-25-2011 |
David G. Shaw, Nazareth, PA US
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20120288084 | FAST ECHO GAIN CHANGE DETECTION - An apparatus generally having a first circuit and a second circuit is disclosed. The first circuit may be configured to synthesize a first vector by filtering a second vector based on a third vector. The second circuit may be configured to (i) generate a gain corresponding to a fourth vector, (ii) compare the gain to a plurality of thresholds and (iii) update the third vector as a function of the gain where the compare determines that the gain is not between the thresholds. The fourth vector may be received from a network as an echo of the second vector. | 11-15-2012 |
20130156210 | TRAINING AN ECHO CANCELLER IN SEVERE NOISE - An apparatus includes a non-adaptive filter, an adaptive filter, and a controller. The non-adaptive filter may have non-adaptive filter coefficients and be configured to develop a non-adaptive error signal as a function of the non-adaptive filter coefficients. The adaptive filter may have adaptive filter coefficients and be configured to develop an adaptive error signal as a function of the adaptive filter coefficients. The controller may be configured to monitor a quality of the non-adaptive and adaptive error signals and perform one or more of a full coefficient update, a partial coefficient update and a fractional coefficient update of the non-adaptive filter coefficients based on a comparison of the quality of the adaptive error signal to a determined current best-attained performance measurement. | 06-20-2013 |
20150055774 | ECHO CANCELLATION WITH QUANTIZATION COMPENSATION - An apparatus having a first circuit and a second circuit is disclosed. The first circuit is configured to generate a first intermediate signal by expanding a first input signal subjected to a quantization. The second circuit is configured to generate a second intermediate signal based on a second input signal. The second intermediate signal approximates an echo in the first input signal caused by the second input signal. The second circuit is also configured to generate a third intermediate signal by companding the second intermediate signal to compensate the quantization of the first input signal. | 02-26-2015 |
Dolores A. Shaw, Collegeville, PA US
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20090163445 | Synergistic microbicidal compositions - This invention relates to synergistic combinations of selected microbicides in combination with a second microbicide or formulation ingredient or raw material. The combinations have greater efficacy than would be expected from combinations of the individual components. The combinations include mixtures of (a) 5-Chloro-2-methyl-4-isothiazolin-3-one+2-Methyl-4-isothiazolin-3-one, :(b) Methyl-4-isothiazolin-3-one, or (c) 1,2-Benzisothiazolin-3-one with one or more of a variety of other compounds. | 06-25-2009 |
20110224270 | SYNERGISTIC MICROBICIDAL COMPOSITIONS - This invention relates to synergistic combinations of selected microbicides in combination with a second microbicide or formulation ingredient or raw material. The combinations have greater efficacy than would be expected from combinations of the individual components. The combinations include mixtures of (a) 5-Chloro-2-methyl-4-isothiazolin-3-one+2-Methyl-4-isothiazolin-3-one, :(b) Methyl-4-isothiazolin-3-one, or (c) 1,2-Benzisothiazolin-3-one with one or more of a variety of other compounds. | 09-15-2011 |
Dolores Ann Shaw, Collegeville, PA US
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20110028525 | Synergistic Microbicidal Compositions - This invention relates to synergistic combinations of selected isothiazolin-3-one microbicides in combination with a second microbicide or formulation ingredient or raw material. The combinations have greater efficacy than would be expected from combinations of the individual components. The combinations include mixtures of (a) Methyl-4-isothiazolin-3-one or (b) 1,2-Benzisothiazolin-3-one with one or more of a variety of other compounds. | 02-03-2011 |
Edmund Arnliot Shaw, Pittsburgh, PA US
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20130289401 | METHOD AND APPARATUS FOR DIAGNOSING OBSTRUCTIVE SLEEP APNEA WITH AN AWAKE PATIENT - An apparatus for use in diagnosing the presence of obstructive sleep apnea (OSA) in a patient includes a sensing module structured to measure a parameter indicative of a tremor in the patient's neck, tongue and/or throat muscles while the patient is awake, the parameter not being airflow through the patient's airway. The sensing module generates one or more electrical signals based on the measured parameter. The apparatus also includes a processor operatively coupled to the sensing module, the processor being structured to receive the one or more electrical signals, perform an analysis of the one or more electrical signals, and based on the analysis determine whether the transducer tremor has a frequency in at least one predetermined frequency range that is indicative of OSA. | 10-31-2013 |
George M. Shaw, Philadelphia, PA US
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20140248301 | METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES - The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method. | 09-04-2014 |
Jeffrey J. Shaw, New Kensington, PA US
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20110100579 | METHOD OF UNIDIRECTIONAL SOLIDIFICATION OF CASTINGS AND ASSOCIATED APPARATUS - Molten metal is injected uniformly into a horizontal mold from a feed chamber in a horizontal or vertical direction at a controlled rate, directly on top of the metal already within the mold. A cooling medium is applied to the bottom surface of the mold, with the type and flow rate of the cooling medium being varied to produce a controlled cooling rate throughout the casting process. The rate of introduction of molten metal and the flow rate of the cooling medium are both controlled to produce a relatively uniform solidification rate within the mold, thereby producing a uniform microstructure throughout the casting, and low stresses throughout the casting. A multiple layer ingot product is also provided comprising a base alloy layer and at least a first additional alloy layer, the two layers having different alloy compositions, where the first additional alloy layer is bonded directly to the base alloy layer by applying the first additional alloy in the molten state to the surface of the base alloy while the surface temperature of the base alloy is lower than the liquidus temperature and greater than eutectic temperature of the base alloy −50 degrees Celsuis. | 05-05-2011 |
Jeffrey J. Shaw, Lower Burrell, PA US
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20100247954 | SYSTEM AND METHOD OF PRODUCING MULTI-LAYERED ALLOY PRODUCTS - System and method of producing multi-layered aluminum alloy products are disclosed. A multi-layered aluminum alloy product may be formed by first heating a first aluminum alloy to a first temperature where the first temperature is at least about 5° C. lower than the eutectic temperature of the first aluminum alloy, second heating a second aluminum alloy to a second temperature where the second temperature is at least about 5° C. higher than the liquidus temperature of the second aluminum alloy, and coupling the second aluminum alloy to the first aluminum alloy to produce a multi-layered aluminum alloy product. | 09-30-2010 |
20130337177 | SYSTEM AND METHOD OF PRODUCING MULTI-LAYERED ALLOY PRODUCTS - System and method of producing multi-layered aluminum alloy products are disclosed. A multi-layered aluminum alloy product may be formed by first heating a first aluminum alloy to a first temperature where the first temperature is at least about 5° C. lower than the eutectic temperature of the first aluminum alloy, second heating a second aluminum alloy to a second temperature where the second temperature is at least about 5° C. higher than the liquidus temperature of the second aluminum alloy, and coupling the second aluminum alloy to the first aluminum alloy to produce a multi-layered aluminum alloy product. | 12-19-2013 |
20140178590 | SYSTEM AND METHOD OF PRODUCING MULTI-LAYERED ALLOY PRODUCTS - System and method of producing multi-layered aluminum alloy products are disclosed. A multi-layered aluminum alloy product may be formed by first heating a first aluminum alloy to a first temperature where the first temperature is at least about 5° C. lower than the eutectic temperature of the first aluminum alloy, second heating a second aluminum alloy to a second temperature where the second temperature is at least about 5° C. higher than the liquidus temperature of the second aluminum alloy, and coupling the second aluminum alloy to the first aluminum alloy to produce a multi-layered aluminum alloy product. | 06-26-2014 |
Leslie M. Shaw, Audubon, PA US
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20100290994 | O-Methylated Rapamycin Derivatives For Alleviation And Inhibition Of Lymphoproliferative Disorders - The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapamycin) to the mammal. Further, the invention provides a method for identifying agents which are useful for alleviating and inhibiting a lymphoproliferative disorders, as well as a method for identifying agents which are capable of inhibiting metastasis of lymphatic tumors in a mammal. | 11-18-2010 |
20100305151 | O-Methylated Rapamycin Derivatives For Alleviation And Inhibition Of Lymphoproliferative Disorders - The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapamycin) to the mammal. Further, the invention provides a method for identifying agents which are useful for alleviating and inhibiting a lymphoproliferative disorders, as well as a method for identifying agents which are capable of inhibiting metastasis of lymphatic tumors in a mammal. | 12-02-2010 |
20110104304 | O-Methylated Rapamycin Derivatives For Alleviation And Inhibition Of Lymphoproliferative Disorders - The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapamycin) to the mammal. Further, the invention provides a method for identifying agents which are useful for alleviating and inhibiting a lymphoproliferative disorders, as well as a method for identifying agents which are capable of inhibiting metastasis of lymphatic tumors in a mammal. | 05-05-2011 |
Louis Carl Shaw, Saxonburg, PA US
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20100170321 | BANDOLIER WITH LATERALLY OFFSET AND SPACED WORK PIECE - A method of operating a progressive die wherein the progressive die acts on a work piece having an elongated body with a blank at one end. The work piece is supported by a bandolier which is also formed in the progressive die. The progressive die acts on each blank. | 07-08-2010 |
20120137861 | BANDOLIER WITH LATERALLY OFFSET AND SPACED WORK PIECE - A method of operating a progressive die wherein the progressive die acts on a work piece having an elongated body with a blank at one end. The work piece is supported by a bandolier which is also formed in the progressive die. The progressive die acts on each blank. | 06-07-2012 |
Louis Cart Shaw, Saxonburg, PA US
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20090183628 | DUAL SIDED AND DUAL PROCESS BANDOLIER - A method of making bullets on a progressive die wherein the progressive dies acts on a work piece having an elongated body with blanks at each end. The work piece is supported by a bandolier which is also formed in the progressive die. The progressive die forms each blank into a bullet, effectively doubling the output of the progressive die relative to a progressive die that acts upon a work piece that supports, or is, a single blank. | 07-23-2009 |
Mari M. Shaw, Philadelphia, PA US
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20080275118 | HEALTH AND COSMETIC COMPOSITION AND REGIME FOR STIMULATING HAIR GROWTH AND THICKENING ON THE HEAD, INCLUDING THE SCALP, EYELASHES, AND EYEBROWS, AND WHICH DISCOURAGES HAIR LOSS - This invention relates to compositions and processes for stimulating the growth of mammalian hair comprising the topical application of compositions comprising a hair growth stimulating and/or hair loss prevention agent, and a hair and/or skin lightening and/or neutralization agent, in association with a topical pharmaceutical carrier. Unlike other products, the composition of the invention can be used with dyed/treated hair so as to not affect the color of the hair. | 11-06-2008 |
Michael Shaw, Horsham, PA US
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20090089083 | SYSTEM AND METHOD FOR MANAGING HEALTH CARE COMPLEXITY VIA AN INTERACTIVE HEALTH MAP INTERFACE - To empower a member to make informed health care decisions, a health care organization (HCO) graphically presents the member with a manageable closed universe of health care information via an online interactive visual interface. The online interactive interface comprises a custom category node display of member health care data based on analyzing the member profile in light of the overall health care data taxonomy built by the HCO. Upon identifying the subset of relevant health care data categories, HCO initiates the display of the identified categories by way of a dynamically linked category node interface. To enhance the member's understanding of the relationships between the category nodes, the HCO preferably employs a ring node topology by displaying the online interface as a closed network or map, such as by locating each category node along one or more closed, loop-shaped wireframes, which connect the interrelated categories. | 04-02-2009 |
Peter Shaw, Yardley, PA US
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20080318228 | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents - Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone. | 12-25-2008 |
20100190172 | GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF - The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. | 07-29-2010 |
20140221484 | GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF - The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. | 08-07-2014 |
Stephen J. Shaw, Pittsburgh, PA US
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20080313002 | METHOD, SYSTEM, AND APPARATUS FOR OPERATING A REGISTRY - Various embodiments of the present invention relate to a method for operating a registry of service providers in a given service sector, an apparatus for operating a registry of service providers in a given service sector, and a system for operating a registry of service providers in a given service sector. In one embodiment, a method of operating a registry of service providers in a given service sector comprises providing a plurality of service providers in the given sector with input access to an electronic database to which each participating service supplies information, and validating the supplied information. | 12-18-2008 |
Venson M. Shaw, Washington, PA US
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20140019235 | CLASSIFICATION ENGINE FOR DYNAMIC E-ADVERTISEMENT CONTENT INSERTION - A way to modify a media file to include an advertisement is described herein. A media includes, but is not limited to, broadcast television, video, or music. The content of the media is analyzed to determine an appropriate advertisement to be inserted into the media content. For example, the advertisement may be a pizza commercial inserted into media that is popular among college age individuals. The content of the media may be further analyzed to determine an appropriate position within the media to insert the advertisement. For example, the pizza commercial may be inserted after a scene in which the characters are eating. Another example may be the insertion of a dating service commercial in a movie immediately following a dating scene in the movie. | 01-16-2014 |
Wayne Shaw, Glen Mills, PA US
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20090020218 | METHOD OF REINFORCING FIBER MAT FOR BUILDING INSULATION - Reinforced fiber insulation is formed by depositing a mixture of textile fiber segments and rotary and/or flame attenuated segments on a surface, mixing a binder with the fibers, and heating the binder to join the fibers together. The low cost process provides a mixed fiber insulation product with improved strength after compression. | 01-22-2009 |
Wayne E. Shaw, Glenn Mills, PA US
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20110017278 | ROOFING PRODUCTS, PHOTOVOLTAIC ROOFING ELEMENTS AND SYSTEMS USING THEM - The present invention relates generally to roofing products. The present invention relates more particularly to roofing products for use with photovoltaic elements, and to photovoltaic systems that include one or more photovoltaic elements is joined to a roofing substrate. In one embodiment, a roofing product includes a flexible roofing substrate having a top surface having an exposure area, the exposure area having one or more receptor zones thereon, each receptor zone being adapted to receive one or more photovoltaic elements, each receptor zone having a different surfacing than the area of the top surface adjacent to it, wherein the one or more receptor zones and/or the exposure area have a height of about eight inches. In another embodiment, a photovoltaic roofing element includes a flexible roofing substrate having a top surface, the top surface having an exposure area having a height of about eight inches; and one or more photovoltaic elements disposed in the exposure area of the top surface of the flexible roofing substrate, each photovoltaic element having a height of about eight inches. | 01-27-2011 |
20120017972 | ROOFING PRODUCTS, PHOTOVOLTAIC ROOFING ELEMENTS AND SYSTEMS USING THEM - The present invention relates more particularly to roofing products for use with photovoltaic elements, and to photovoltaic systems that include one or more photovoltaic elements joined to a roofing substrate. In one aspect, the invention provides a roofing product including: a bituminous roofing substrate having a top surface; and roofing granules embedded in the top surface of the roofing substrate, wherein in at least one over-pressed zone of the roofing product, the roofing granules are embedded so that (a) the over-pressed zone exhibits a 0.20 gram loss or less in a rub test as described in ASTM D-4977; or (b) in the over-pressed zone the average granule embed volume fraction is at least 0.5; or (c) in the over-pressed zone, the average distance between the top of the roofing granules and the top surface of the bituminous roofing substrate is 1.0 mm or less. | 01-26-2012 |