Shafren
Darren R. Shafren, The Hill AU
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20100062020 | Method of Treating a Malignancy in a Subject Via Direct Picornaviral-Mediated Oncolysis - There are provided methods for treatment of abnormal cells such as cancer cells in a mammal. The methods involve treating the mammal with virus selected from echoviruses and modified forms and combination thereof, which recognize α | 03-11-2010 |
Darren R. Shafren, New Lambton AU
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20090123427 | Method of Treating a Malignancy in a Subject and a Pharmaceutical Composition for Use in Same - There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF. | 05-14-2009 |
20150037287 | Method of Treating a Malignancy in a Subject and a Pharmaceutical Composition for Use in Same - There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF. | 02-05-2015 |
Darren Raymond Shafren, Newcastle AU
Patent application number | Description | Published |
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20100104578 | METHOD AND COMPOSITION FOR TREATMENT OF NEOPLASMS - The invention relates to methods of treating a neoplasm in an animal, in particular treating a neoplasm in a human, through the use of isolated nucleic acid sequence, including synthetic viral RNA and complementary DNA, derived from one or more Picornaviruses. The invention also relates to compositions of isolated nucleic acids derived from one or more Picornaviruses, and to the use of isolated nucleic acids derived from one or more Picornaviruses for the manufacture of a medicament for the treatment of neoplasms in a mammal. | 04-29-2010 |
Darren Raymond Shafren, The Hill AU
Patent application number | Description | Published |
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20120328575 | Modified Oncolytic Viruses - The present invention provides an isolated selected Picornavirus capable of lytically infecting or inducing apoptosis in a cell substantially in the absence of intercellular adhesion molecule-1 (ICAM-1), and methods for treating subjects. | 12-27-2012 |
20130164330 | Methods and Compositions for Treatment of Hematologic Cancers - The present invention relates to oncolytic Picornaviruses and methods and compositions for treating subjects having hematologic cancers. These include methods and compositions for treatment of myeloma, using disclosed Picornavirus such as Coxsackievirus, in methods of direct or indirect administration to subjects and ex vivo purging of malignant cells within auto grafts prior to transplantation. | 06-27-2013 |
20150273002 | METHODS AND COMPOSITIONS FOR TREATMENT OF HEMATOLOGIC CANCERS - The present invention relates to oncolytic Picornaviruses and methods and compositions for treating subjects having hematologic cancers. These include methods and compositions for treatment of myeloma, using disclosed Picornavirus such as Coxsackievirus, in methods of direct or indirect administration to subjects and ex vivo purging of malignant cells within auto grafts prior to transplantation. | 10-01-2015 |
Darren Raymond Shafren, Merewether, Nsw AU
Patent application number | Description | Published |
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20160136211 | METHODS FOR THE TREATMENT OF BLADDER CANCER - The present invention relates to methods of treating bladder cancer with human enterovirus C (HEC) in combination with chemotherapy or radiation therapy. The present invention also relates to methods for increasing susceptibility of a cancer cell to infection by HEC. | 05-19-2016 |