Settembre
Carmine Settembre, Napoli IT
Patent application number | Description | Published |
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20140038897 | TFEB VARIANTS AND USES THEREOF - The invention refers to TFEB related molecules, as variants, mutants, truncated proteins, chimeras etc. that are constitutively localized in the nucleus of a eukaryote cell. Such molecules have a therapeutic applicability in all of disorders that need of an induction of the cell authophagic/lysosomal system, as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases. | 02-06-2014 |
20140038920 | TFEB PHOSPHORYLATION INHIBITORS AND USES THEREOF - The invention refers to TFEB phosphorylation inhibitors. Such molecules have a therapeutic applicability in all disorders that need induction of the cell authophagic/lysosomal system, such as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases. | 02-06-2014 |
Ethan Settembre, Lexington, MA US
Patent application number | Description | Published |
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20130171185 | NOROVIRUS DERIVED IMMUNOGENIC COMPOSITIONS AND METHODS - The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions. | 07-04-2013 |
20130273109 | METHOD FOR GENERATING A PARVOVIRUS B19 VIRUS-LIKE PARTICLE - The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids. | 10-17-2013 |
20140170187 | COMPOSITIONS AND METHODS FOR ASSESSING FUNCTIONAL IMMUNOGENICITY OF PARVOVIRUS VACCINES - The present invention is directed to mutant parvovirus VP1 unique region polypeptides, compositions comprising such polypeptides, methods of making such compositions, as well as methods for identifying the likely presence of parvovirus-neutralizing antibodies, and methods for assessing the functional immunogenicity of parvovirus vaccines and measuring a correlate of efficacy to assess a treatment for parvovirus infection. | 06-19-2014 |
Kurt Settembre, Syracuse, NY US
Patent application number | Description | Published |
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20110258889 | Snow And Water Clearing Device - A snow, slush, and water removal device comprising a blade with top and bottom working edges. The blade can be straight, curved, or V-shaped when viewed from above or from the side. The bottom edge of the blade is comprised of a flexible material. The reverse side of the blade contains attachment points and bracing for the main long handle pole, the main handle being connected at the first end to the reverse side of the blade. The novel combination of features provides superior results both in terms of less energy required, and faster and safer removal of snow, slush, water, or other matter. | 10-27-2011 |
Marina Settembre, Roma IT
Patent application number | Description | Published |
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20110176415 | OPTIMIZED CONNECTION ADMISSION CONTROL FOR SYSTEMS USING ADAPTIVE MODULATION AND CODING TECHNIQUES - A method is proposed for controlling the admission of connections in a wireless communication system between a base station and a subscriber unit, in which the modulation and coding scheme of the uplink and downlink can be varied over time. The method comprises the steps of receiving a request for a connection and of admitting the connection and updating the available bandwidth, if the available bandwidth corresponding to the current AMC scheme is greater than the admission bandwidth of the connection. Moreover the method periodically evaluates if the current admission bandwidth can be changed for a plurality of active connections: if this is the case, and there is not enough bandwidth to allow the change, the method stops the admission of new connections, suspends at least one active connection of said plurality of active connections or changes the AMC scheme of such at least one active connection. On the other hand, if the current admission bandwidth can be changed and there is enough bandwidth to allow the change, the method updates the current admission bandwidth for the plurality of active connections and updates the available bandwidth. | 07-21-2011 |
Richard Settembre, Liverpool, NY US
Patent application number | Description | Published |
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20110258889 | Snow And Water Clearing Device - A snow, slush, and water removal device comprising a blade with top and bottom working edges. The blade can be straight, curved, or V-shaped when viewed from above or from the side. The bottom edge of the blade is comprised of a flexible material. The reverse side of the blade contains attachment points and bracing for the main long handle pole, the main handle being connected at the first end to the reverse side of the blade. The novel combination of features provides superior results both in terms of less energy required, and faster and safer removal of snow, slush, water, or other matter. | 10-27-2011 |