Patent application number | Description | Published |
20090286987 | METALLOPROTEIN INHIBITORS - The present invention relates to metalloprotein inhibitors comprising:
| 11-19-2009 |
20100041653 | COMPOSITION AND METHODS FOR THE DESIGN AND DEVELOPMENT OF METALLO-ENZYME INHIBITORS - The present disclosure provides compounds having the general structure A or pharmaceutically acceptable salts thereof: | 02-18-2010 |
20100098640 | Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation - Provided herein are chelating agents and metal chelates that are useful in diagnostic and therapeutic applications. The uses of metal chelates provided herein include their use as contrast agents in medical imaging modalities, such as magnetic resonance imaging (MRI). | 04-22-2010 |
20100173952 | METALLOPROTEIN INHIBITORS - The present invention relates to metalloprotein inhibitors comprising:
| 07-08-2010 |
20110312905 | STIMULUS-TRIGGERED PRODRUGS - Set forth herein, inter alia, are compositions and methods for treating diseases with prodrugs. Provided herein are prodrug compositions for inhibiting the function of proteins, compositions and methods for treating diseases associated with oxidative compounds, oxidatively-sensitive prodrugs of inhibitors of metalloproteases. and methods of inhibiting metalloproteases using oxidatively-sensitive prodrugs. | 12-22-2011 |
20120041032 | METALLOPROTEIN INHIBITORS - The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R | 02-16-2012 |
20120135959 | Metalloprotein inhibitors containing nitrogen based ligands - Provided herein metalloproteinase inhibitors containing nitrogen or mixed nitrogen/oxygen donating zinc binding groups. Also provided are pharmaceutical compositions containing the compounds and methods of treating preventing or ameliorating the diseases associated with metalloproteinase activity using the compounds and compositions. | 05-31-2012 |
20150147291 | Zinc Chelating Agents for Depleting Xiap and Sensitizing Tumor Cells to Apoptosis - The invention provides zinc chelating agents and formulations thereof that deplete XIAP in cancer cells and sensitize the cells to apoptosis-inducing agents. The invention provides methods for sensitizing apoptosis-resistant cancer cells to apoptosis-inducing agents, as well as methods for treating a subject with a combined therapy of a zinc chelating agent and an apoptosis-inducing agent. | 05-28-2015 |