Seil
Seil Jang, Yuseong-Gu Daejeon KR
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20140072558 | Activin Receptor Type II B Inhibitors Comprising DLK1 Extracellular Water-Soluble Domain - The present invention relates to an activin receptor type II B (ACVR2B) inhibitor which comprises the delta-like 1 homolog (DLK1) extracellular water-soluble domain. More specifically, the present invention relates to an extracellular soluble domain of DLK1; fragments of the extracellular soluble domain of DLK1; mutants of the extracellular soluble domain of DLK1; a composition for suppressing ligand linkage with the ACVR2B receptor, which includes a fragment of the mutants as an active ingredient; and a pharmaceutical composition for prevention and treatment of diseases which comprises the same. The composition of the present invention competitively binds to the ACVR2B receptor and inhibits the binding of an ACVR2B ligand to the ACVR2B receptor, which inhibits protein signalling associated with such ligands, and will be useful for prevention and treatment of diseases associated therewith. | 03-13-2014 |
Seil Jang, Daejeon KR
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20160108118 | Anti-TNF-alpha/CXCL10 Double-Targeting Antibody and Use Thereof - The present invention relates to a TNF-α (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXCL10 specific antibody links to the C-terminus of the heavy chain constant domain of the TNF-α specific antibody, is a bispecific antibody that effectively binds to both TNF-α and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-α/CXCL10. A composition of the present invention comprises a TNF-α/CXCL-10 double targeting antibody which effectively binds to both TNF-α and CXCL10. The double targeting antibody of the present invention has excellent TNF-α inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-α or CXCL10 single targeting antibody. The composition of the present invention can be used in preventing or treating immunological disease. | 04-21-2016 |
Seil Jeon, Seocho-Gu KR
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20100103856 | METHOD OF TRANSMITTING MULTICAST DATA BASED ON PROXY MOBILE IPv6 DURING HANDOFF - Provided is a method of transmitting multicast data based on proxy mobile Internet protocol version 6 (PMIPv6) during handoff. The method includes, when a first access router detects that a mobile node in the region of the first access router moves out of the region, transmitting, at the first access router, a context message informing a second access router adjacent to the first access router of handoff, when the second access router receives the context message, transmitting, at the second access router, a multicast membership report message about the mobile node to a multicast router, and receiving, at the second access router, multicast data from the multicast router and holding the received multicast data. | 04-29-2010 |
Seil Jung, Seoul KR
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20150084178 | INTEGRATED CIRCUIT PACKAGING SYSTEM WITH HEAT SPREADER AND METHOD OF MANUFACTURE THEREOF - An integrated circuit packaging system, and method of manufacture therefor, includes: a substrate; a mold cap formed on the substrate; fiducial mark inscribed in the mold cap; a thermal interface material applied over the substrate and referenced by the fiducial mark; and a heat spreader, mounted on the thermal interface material, precisely positioned by a position notch aligned relative to the fiducial mark. | 03-26-2015 |
Seil Kim, Suwon-Si KR
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20120080861 | STEERING APPARATUS FOR VEHICLE - A steering apparatus for a vehicle may include a steering pinion rotated by operation of a steering wheel, and a steering rack bar having a rack engaged with the steering pinion to move straight in a longitudinal direction thereof, wherein a tooth gap in a gear of the rack changes such that a steering gear ratio corresponding to a linear displacement of the steering rack bar according to rotation of the steering pinion increases and then decreases in both sections from the center of the rack to both ends thereof. | 04-05-2012 |
Seil Oh, Seoul KR
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20110087210 | MAGNETICALLY-COUPLED BIPOLAR RADIOFREQUENCY ABLATION CATHETER - The present invention provides a bipolar radiofrequency ablation catheter comprising a working catheter and a magnetic catheter. The magnetic catheter comprises a first tube; a magnet; a first electrode; and a first electrode connector, and the working catheter comprises a second tube; a metallic element; a second electrode; and a second electrode connector. According to the present invention, it is possible to create transmural lesions more completely and easily at a thick myocardial region such as left ventricle in which a transmural lesion could not be easily created by using conventional radiofrequency ablation catheters and thus it is expected to increase the treatment efficiency for tachycardia such as ventricular tachycardia and atrial fibrillation. | 04-14-2011 |