Patent application number | Description | Published |
20130199459 | HERBAL CUSHION ATTACHABLE TO A DOG HARNESS - A herbal cushion attachable to a dog harness, comprising a middle part in the intersection of the longitudinal axis and the transverse axis, and rounded side parts on both sides of the transverse axis in the continuation of the middle part, which side parts and the middle part are bordered by the same edging zone, furthermore a part containing herbs is included in the herbal cushion attachable to a dog harness, in such a way that the herbal cushion attachable to a dog harness ( | 08-08-2013 |
20130209734 | STRUCTURAL ARRANGEMENT FOR A TEXTILE STRAP WITH FLUORESCENT COATING - A structural arrangement for a textile strap with fluorescent coating, wherein the textile strap is made of at least one layer of synthetic-based fibres, it is preferably belt-shaped, and has a plastic-containing coating covering 100% of its surface, in a such way that at least one synthetic-based fibre ( | 08-15-2013 |
20130291805 | PROTECTIVE CUSHION - A protective cushion to be used in dog training, having an outer and an inner covering, made of a material reinforced with synthetic fibres, furthermore bordered by a sewn edge line, wherein the inner covering ( | 11-07-2013 |
20130327282 | DOG HARNESS EQUIPPED WITH A COVERING COVER - The invention relates to a dog harness equipped with a covering cover comprising a blanketing saddle part covered by a covering cover, within that a middle portion hollow on one side and domed on the other side, and two side portions, on which side portions a chest strap is attached to trace straps, connecting the two side portions at the height of the trace straps, furthermore a back strap crossing the trace straps is attached directly to the covering cover in the continuation of a belly strap, wherein the covering cover ( | 12-12-2013 |
20140041599 | SWIMMING VEST FOR DOGS - The object of the invention is a swimming vest for dogs comprising an outer covering, at least one swimming pad placed into an openable pocket portion, an inner covering, and a strap closing element enclosing the body of the dog, these together forming a blanket, close-fitting on the body of the dog like a diving suit, which allows the water training, rehabilitation treatment of dogs unable to swim due to bodily injury or breed characteristics, and can also be used as a life vest. | 02-13-2014 |
Patent application number | Description | Published |
20090208961 | COMPOSITIONS AND METHODS FOR USE IN ANALYTICAL REACTIONS - Compositions, methods, substrates and systems for use in analysis of single molecule reactions and particularly single molecule nucleic acid sequence analysis. Compositions that include non-reactive, distinguishable or undetectable competitive substrates for the reaction system of interest are provided, as well as their use in systems and substrates for such applications, such compounds typically preferably polyphosphate chains or analogous structures. | 08-20-2009 |
20100136592 | Photo-Induced Damage Mitigating Agents and Preparation and Methods of Use Thereof - Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photo-induced damage mitigating agents to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period. | 06-03-2010 |
20110212437 | SINGLE MOLECULE SEQUENCING WITH TWO DISTINCT CHEMISTRY STEPS - Methods, Compositions, and Systems are provided for nucleic acid sequencing where the sequential incorporation of nucleotides uses two distinct chemical steps. A plurality of nucleotide analogs, each having a labeled leaving group at its 3′ hydroxyl can be sequentially added to a growing strand in the presence of a selective cleaving activity that cleaves the 3′ hydroxyl leaving group preferentially after it has been incorporated. The selective cleaving agent can comprise an exonuclease activity, and the exonuclease activity can be a polymerase-associated exonuclease activity. Nucleotide analogs having labels on both a cleavable polyphosphate portion and on a 3′ hydroxyl leaving group can provide signals characteristic of nucleotide analog incorporation. Systems having illumination optics, collection optics, and substrates observe signals from the labels as they are being incorporated into a growing nucleic acid strand, allowing for the sequencing of template nucleic acids. | 09-01-2011 |
20120058473 | Molecular Adaptors for Dye Conjugates - In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an adaptor moiety. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an adaptor. An adaptor can be a component of a linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention. | 03-08-2012 |
20120077189 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES - The invention provides a novel class of scaffold-based labeled polymerase enzyme substrates. The polymerase enzyme substrates have a multivalent core or scaffold to which is attached fluorescent dye moieties and nucleoside phosphate moities. The polymerase enzyme substrates have multiple fluorescent dye moities and/or multiple nucleoside phosphate moieties. Preferred multivalent cores comprise trifunctional six membered aromatic moities. The invention also provides for sequencing methods and kits with scaffold-based labeled polymerase enzyme substrates. | 03-29-2012 |
20130316912 | POLYMERASE ENZYME SUBSTRATES WITH PROTEIN SHIELD - Compositions and methods are provided for nucleotide analogs comprising protein shields for improving enzyme photostability in single molecule real time sequencing. Nucleotide analogs of the invention have a protein shield between the dye moieties and nucleotide moieties of the analog. The protein prevents the direct interaction of the dye moiety with the enzyme carrying out nucleotide synthesis preventing photodamage to the enzyme. The nucleotide analogs of the invention can have multiple dyes and multiple nucleotide moieties. | 11-28-2013 |
20140127680 | SINGLE MOLECULE SEQUENCING WITH TWO DISTINCT CHEMISTRY STEPS - Methods, Compositions, and Systems are provided for nucleic acid sequencing where the sequential incorporation of nucleotides uses two distinct chemical steps. A plurality of nucleotide analogs, each having a labeled leaving group at its 3′ hydroxyl can be sequentially added to a growing strand in the presence of a selective cleaving activity that cleaves the 3′ hydroxyl leaving group preferentially after it has been incorporated. The selective cleaving agent can comprise an exonuclease activity, and the exonuclease activity can be a polymerase-associated exonuclease activity. Nucleotide analogs having labels on both a cleavable polyphosphate portion and on a 3′ hydroxyl leaving group can provide signals characteristic of nucleotide analog incorporation. Systems having illumination optics, collection optics, and substrates observe signals from the labels as they are being incorporated into a growing nucleic acid strand, allowing for the sequencing of template nucleic acids. | 05-08-2014 |
20150050659 | PROTECTED FLUORESCENT REAGENT COMPOUNDS - Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. | 02-19-2015 |