Patent application number | Description | Published |
20090074834 | METHOD AND SYSTEM FOR MODIFYING THE WETTABILITY CHARACTERISTICS OF A SURFACE OF A MEDICAL DEVICE BY THE APPLICATION OF GAS CLUSTER ION BEAM TECHNOLOGY AND MEDICAL DEVICES MADE THEREBY - Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas cluster ion beam. Improvements in wettability of a surface by the invention exceed those obtained by conventional plasma cleaning or etching. The improvements may be applied to surfaces of medical devices, such as vascular stents for example, and may be used to enable better wetting of medical device surfaces with liquid drugs in preparation for adhesion of the drug to the device surfaces. A mask may be used to limit processing to a portion of the surface. Medical devices formed by using the methods of the invention are disclosed. | 03-19-2009 |
20090098186 | METHOD AND SYSTEM FOR COATING A SURFACE OF A MEDICAL DEVICE WITH A THERAPEUTIC AGENT AND DRUG ELUTING MEDICAL DEVICES MADE THEREBY - A multi-layer drug coated medical device such as for example an expandable vascular drug eluting stent is formed by vacuum pulse spray techniques wherein each layer is irradiated to improve adhesion and/or drug elution properties prior to formation of subsequent layers. Layers may be homogeneous or of diverse drugs. Layers may incorporate a non-polymer elution-retarding material. Layers may alternate with one or more layers of non-polymer elution-retarding materials. Polymer binders and/or matrices are not used in the formation of the coatings, yet the pure drug coatings have good mechanical and elution rate properties. Systems, methods and medical device articles are disclosed. | 04-16-2009 |
20090198264 | Method and System for Improving Surgical Blades by the Application of Gas Cluster Ion Beam Technology and Improved Surgical Blades - Methods and systems for the improvement of a crystalline and/or poly-crystalline surgical blade include gas cluster ion beam irradiation of the blades in order to smooth; or to sharpen; or to reduce the brittleness and thus reduce susceptibility of the blade to crack, chip, or fracture; or to render the blades hydrophilic. Crystalline or poly-crystalline surgical blade (silicon for example) having a thin film cutting edge with improved properties. | 08-06-2009 |
20090321658 | METHOD AND SYSTEM FOR STERILIZING OBJECTS BY THE APPLICATION OF GAS-CLUSTER ION-BEAM TECHNOLOGY - Methods and systems for sterilization of objects by gas-cluster ion-beam (GCIB) irradiation are disclosed. The sterilization may be in conjunction with other beneficial GCIB surface processing of the objects. The objects may be medical devices or surgically implantable medical prostheses. | 12-31-2009 |
20100036482 | DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF - A medical device for surgical implantation adapted to serve as a drug delivery system has one or more drug loaded holes with barrier layers to control release or elution of the drug from the holes or to control inward diffusion of fluids into the holes. The barrier layers are non-polymers and are formed from the drug material itself by ion beam processing. The holes may be in patterns to spatially control drug delivery. Flexible options permit combinations of drugs, variable drug dose per hole, multiple drugs per hole, temporal control of drug release sequence and profile. Methods for forming such a drug delivery system are also disclosed. | 02-11-2010 |
20100226897 | METHOD FOR MODIFYING THE WETTABILITY AND/OR OTHER BIOCOMPATIBILITY CHARACTERISTICS OF A SURFACE OF A BIOLOGICAL MATERIAL BY THE APPLICATION OF GAS CLUSTER ION BEAM TECHNOLOGY AND BIOLOGICAL MATERIALS MADE THEREBY - The invention provides methods for surgical grafting of a tissue. The method comprises the steps of explanting a graft tissue from a donor, irradiating at least a first portion of the graft tissue with an ion beam, and surgically grafting the graft tissue into a recipient. | 09-09-2010 |
20100226958 | METHOD FOR MODIFYING THE WETTABILITY AND/OR OTHER BIOCOMPATIBILITY CHARACTERISTICS OF A SURFACE OF A BIOLOGICAL MATERIAL BY THE APPLICATION OF GAS CLUSTER ION BEAM TECHNOLOGY AND BIOLOGICAL MATERIALS MADE THEREBY - The invention provides a method for preparing a biological material for implanting. The invention also provides a biological material for surgical implantation. The invention further provides a biological composition for surgical implantation. | 09-09-2010 |
20100227523 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - The invention provide for a method of improving bioactivity of a surface of an object. The invention further provides for a method of preparing an object for medical implantation. The invention even further provide for an article made by a method comprising the steps of forming a gas-cluster ion-beam in a reduced-pressure chamber, introducing the article into the reduced-pressure chamber, and irradiating at least a portion of the surface of the object with the gas-cluster ion-beam. The invention still further provides for an article for medical or surgical implantation made by a method comprising selecting at least a portion of a surface of the object for increased bioactivity, forming a gas-cluster ion-beam in a reduced-pressure chamber, introducing the object into the reduced-pressure chamber, and irradiating the selected at least a portion with the gas-cluster ion-beam to increase the bioactivity of the at least a portion. | 09-09-2010 |
20100234948 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provide a method of attaching cells to an object. The invention even further provides for a method of preparing an object for medical implantation. The invention also provides for an article with attached cells, and for an article for medical implantation. | 09-16-2010 |
20110029068 | DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF - Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas cluster ion beam. Improvements in wettability of a surface by the invention exceed those obtained by conventional plasma cleaning or etching. The improvements may be applied to surfaces of medical devices, such as vascular stents for example, and may be used to enable better wetting of medical device surfaces with liquid drugs in preparation for adhesion of the drug to the device surfaces. A mask may be used to limit processing to a portion of the surface. Medical devices formed by using the methods of the invention are disclosed. | 02-03-2011 |
20110300599 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provides a method of attaching cells to an object. The invention even further provides for a method of preparing an object for medical implantation. The invention also provides for an article with attached cell, and for an article for medical implantation. Improvements result from the application of gas-cluster ion beam technology and from the application of neutral beam technology, wherein neutral beams are derived from accelerated gas-cluster ion beams. | 12-08-2011 |
20120045615 | METHOD AND APPARATUS FOR NEUTRAL BEAM PROCESSING BASED ON GAS CLUSTER ION BEAM TECHNOLOGY - An apparatus, method and products thereof provide an accelerated neutral beam derived from an accelerated gas cluster ion beam for processing materials. | 02-23-2012 |
20130022494 | METHOD AND SYSTEM FOR STERILIZING OBJECTS BY THE APPLICATION OF BEAM TECHNOLOGY - Methods and systems for sterilization of objects by gas-cluster ion-beam (GCIB) irradiation or by accelerated Neutral Beam are disclosed. The sterilization may be in conjunction with other beneficial GCIB surface processing of the objects. The objects may be medical devices or surgically implantable medical prostheses. The accelerated Neutral Beam is derived from an accelerated GCIB. | 01-24-2013 |
20130024004 | METHOD AND SYSTEM FOR STERILIZING OR DISINFECTING BY THE APPLICATION OF BEAM TECHNOLOGY AND BIOLOGICAL MATERIALS TREATED THEREBY - A method of disinfecting a biological material provides disposing at least a portion of the biological material in the path of the gas cluster ion beam or in the path of the accelerated neutral beam so as to irradiate at least a portion of the biological material to disinfect the irradiated portion. | 01-24-2013 |
20130105710 | DIAGNOSTIC METHOD AND APPARATUS FOR CHARACTERIZATION OF A NEUTRAL BEAM AND FOR PROCESS CONTROL THEREWITH | 05-02-2013 |
20130213933 | METHODS AND APPARATUS FOR EMPLOYING AN ACCELERATED NEUTRAL BEAM FOR IMPROVED SURFACE ANALYSIS - Apparatus and methods are disclosed for employing an accelerated neutral beam derived from an accelerated gas cluster ion beam as a physical etching beam for providing reduced material mixing at the etched surface, compared to previous techniques. This results in the ability to achieve improved depth profile resolution in measurements by analytical instruments such as SIMS and XPS (or ESCA) analytical instruments. | 08-22-2013 |
20130218264 | DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF - A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby. | 08-22-2013 |
20130282136 | METHOD FOR MODIFYING THE WETTABILITY AND OTHER BIOCOMPATIBILITY CHARACTERISTICS OF A SURFACE OF A BIOLOGICAL MATERIAL BY THE APPLICATION OF BEAM TECHNOLOGY AND BIOLOGICAL MATERIALS MADE THEREBY - A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated. | 10-24-2013 |
20140021343 | METHOD AND APPARATUS FOR NEUTRAL BEAM PROCESSING BASED ON GAS CLUSTER ION BEAM TECHNOLOGY - An apparatus, method and products thereof provide an accelerated neutral beam derived from an accelerated gas cluster ion beam for processing materials. | 01-23-2014 |
20140074159 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - A method for improving bioactivity of a surface of a surgical suture and sutures prepared thereby provides forming a gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing a surgical suture into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said surgical suture with a GLIB derived beam. | 03-13-2014 |
20140236286 | DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF - A medical device for surgical implantation adapted to serve as a drug delivery system has one or more drug loaded holes with barrier layers to control release or elution of the drug from the holes or to control inward diffusion of fluids into the holes. The barrier layers are non-polymers and are formed from the drug material itself by beam processing. The holes may be in patterns to spatially control drug delivery. Flexible options permit combinations of drugs, variable drug dose per hole, multiple drugs per hole, temporal control of drug release sequence and profile. Methods for forming such a drug delivery system are also disclosed. Gas cluster ion beam and/or accelerated Neutral Beam derived from an accelerated gas cluster ion beam may be employed. | 08-21-2014 |
20140236295 | METHOD FOR MODIFYING BIOCOMPATIBILITY CHARACTERISTICS OF A SURFACE OF A BIOLOGICAL MATERIAL WITH GAS CLUSTER ION BEAM - A method for preparing a biological material for implanting provides irradiating at least a portion of the surface of the material with an accelerated Neutral Beam. | 08-21-2014 |
20140315271 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam. | 10-23-2014 |
20140336125 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - A method for improving bioactivity and/or biodegradation time of a collagen surgical implant and collagen surgical implants having such improved properties. A gas-cluster ion-beam (GCIB) is formed in a reduced-pressure chamber, a collagen surgical implant is introduced into the reduced-pressure chamber, and at least a first portion of the surface of said collagen surgical implant is irradiated with a GCIB-derived beam. | 11-13-2014 |
20140363678 | METHOD FOR NEUTRAL BEAM PROCESSING BASED ON GAS CLUSTER ION BEAM TECHNOLOGY AND ARTICLES PRODUCED THEREBY - A method for Neutral Beam irradiation derived from gas cluster ion beams and articles produced thereby including optical elements. | 12-11-2014 |
20150024020 | DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF - An apparatus and method provides a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate. | 01-22-2015 |
20150038899 | MEDICAL DEVICE FOR BONE IMPLANT AND METHOD FOR PRODUCING SUCH A DEVICE - A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of accelerated Neutral Beam irradiation, wherein the Neutral Beam is derived from an accelerated gas cluster ion beam irradiation for improving bone integration. | 02-05-2015 |