Patent application number | Description | Published |
20110087155 | TRANSMUCOSAL DRUG DELIVERY DEVICE AND METHOD INCLUDING ELECTRICALLY-ACTUATED PERMEATION ENHANCEMENT - Intralumenal devices and methods are provided for transmucosal drug delivery. The device may comprise a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion. | 04-14-2011 |
20110087192 | TRANSMUCOSAL DRUG DELIVERY DEVICE AND METHOD INCLUDING CHEMICAL PERMEATION ENHANCERS - Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance. | 04-14-2011 |
20110087195 | TRANSMUCOSAL DRUG DELIVERY DEVICE AND METHOD INCLUDING MICRONEEDLES - Devices and methods for transmucosal drug delivery are provided. A device includes a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and a plurality of microneedles extending, or being extendable from, the housing, the plurality of microneedles being configured to disrupt at least one region of a mucosal barrier adjacent the housing at a selected time after being intralumenally deployed in the human or animal subject. The device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the plurality of microneedles. | 04-14-2011 |
20120271218 | DRUG DELIVERY DEVICES AND METHODS WITH COLLIMATED GAS STREAM AND RELEASE-ACTIVATABLE TAPE - Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape having the drug disposed thereon. The device also includes a first collimator fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas. | 10-25-2012 |
20120271221 | DELIVERY DEVICES AND METHODS WITH COLLIMATED GAS STREAM AND PARTICLE SOURCE - Delivery devices, methods and systems are provided for the delivery of particles into a biological tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas; a first particle source comprising a first plurality of particles; a first collimator fluidly connected with the gas source and adapted to form a collimated stream of the first plurality of particles entrained in the gas. The device also includes a tissue-interfacing surface adapted to interface with a surface of the tissue and orient the first collimator with the tissue such that the collimated stream of the first plurality of particles will penetrate the tissue in a direction substantially perpendicular to the surface of the tissue. | 10-25-2012 |
20120271224 | DRUG DELIVERY DEVICES AND METHODS WITH COLLIMATED GAS STREAM AND DRUG RESERVOIR - Drug delivery device and methods are provided for transdermal drug delivery through a skin. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a first collimator fluidly connected with the gas source adapted to form a first plurality of collimated gas streams comprising the gas. The first collimator has an inlet end and an outlet end. The device further includes a first drug source comprising a drug. The first drug source is configured to release the drug into the first plurality of collimated gas streams between the inlet end and outlet end of the first collimator. | 10-25-2012 |
20150065997 | TRANSMUCOSAL DRUG DELIVERY DEVICE AND METHOD INCLUDING CHEMICAL PERMEATION ENHANCERS - Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance. | 03-05-2015 |
20150285622 | MONITOR FOR PARTICLE INJECTOR - Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal. | 10-08-2015 |