Scolaro
Alessandra Scolaro, Bresso IT
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20090099221 | PYRIDYL-AND PYRIMIDINYL-SUBSTITUTED PYRROLE-, THIOPHENE-AND FURANE-DERIVATIVES AS KINASE INHIBITORS - The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R | 04-16-2009 |
20140336192 | 3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS - There are provided substituted 3-phenyl-isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly(ADP-ribose) polymerase PARP-1 with respect to poly(ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. | 11-13-2014 |
Alessandra Scolaro, Bresso, Milan IT
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20100075998 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES - The present invention provides tricyclic indoles and (4,5-dihydro) indoles of the formula (I) or a pharmaceutically acceptable salt thereof: wherein the ring A represents a fused pyrazole, pyridine or pyrimidine, | 03-25-2010 |
Alessandra Scolaro, Bresso (milano) IT
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20130217715 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS - Substituted pyrazolophenyl-benzenesulfonamide compounds of formula (I) are described, wherein m, R1, R2, R3, and R4 are defined in the description, which modulate the activity of protein kinases, These compounds find utility in treating diseases caused by deregulated protein kinase activity, such as cancer and cell proliferative disorders. | 08-22-2013 |
Alessandra Scolaro, Bresso (mi) IT
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20120157454 | ISOQUINOLIN-1 (2H) -ONE DERIVATIVES AS PARP-1 INHIBITORS - There are provided substituted isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. A screening method for the identification of compounds capable of binding several PARP proteins, as well the probes used in such method, are further objects of the invention. | 06-21-2012 |
20120245143 | 3-0X0-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES WITH SELECTIVE PARP-1 INHIBITION - There are provided substituted 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide derivatives (I) which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. | 09-27-2012 |
20120295906 | PYRIDYL-AND PYRIMIDINYL-SUBSTITUTED PYRROLE-, THIOPHENE-AND FURANE-DERIVATIVES AS KINASE INHIBITORS - The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R | 11-22-2012 |
20130324551 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS - Thiazolylphenyl-benzenesulfonamido derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. | 12-05-2013 |
20140045846 | ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS - There are provided substituted isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. A screening method for the identification of compounds capable of binding several PARP proteins, as well the probes used in such method, are further objects of the invention. | 02-13-2014 |
20150051237 | PYRIDYL-AND PYRIMIDINYL-SUBSTITUTED PYRROLE-, THIOPHENE- AND FURANE-DERIVATIVES AS KINASE INHIBITORS - The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R | 02-19-2015 |
Alessandro Scolaro, Bresso (mi) IT
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20100056556 | ISOQUINOLINOPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS - Heteroarylpyridinone derivatives represented by formula (I) wherein R | 03-04-2010 |
Christopher P. Scolaro, Bloomfield Township, MI US
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20120161414 | Eccentric Steering Axis Strut Top Mount - An eccentric steering axis strut top mount providing a reduced spindle length. An axes eccentricity is provided by laterally shifting the steering axis with respect to the strut rod axis in a direction toward a vertical ray passing through the wheel center. The axes eccentricity results in an upper point of the kingpin axis being laterally shifted toward the vertical ray with the consequence of the spindle length being shortened. | 06-28-2012 |
George Scolaro, Sunnyvale, CA US
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20110169409 | Led motorcycle lighting system - The LED motorcycle lighting system is designed to help improve visibility of riders during night and day riding. The system includes an array of LED lights disposed in a housing adapted for mounting on a weight-balanced bracket. The weight-balanced bracket is adapted for mounting on a motorcycle's caliper mount to secure the LED lamp to the vehicle. Using two weight-balanced mounting brackets, a first LED lamp is mounted on the left front of the motorcycle, while a second LED lamp is mounted on the right front of the motorcycle. The system uses pulse width modulated current drivers fed by an adjustable PWM signal to allow brightness adjustment of the lights by the user to suit a particular riding situation. A handlebar-mounted potentiometer adapted for adjusting the PWM signal provides easy access to the user for brightness control of the lights. | 07-14-2011 |
James M. Scolaro, Racine, WI US
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20100125964 | MOP WITH RECEPTACLE - Some aspects of the present invention are related to a mop and/or mop head that allows larger debris to pass over at least a portion of the mop head and into a receptacle of the mop head. In some embodiments, the mop head and the receptacle are integrally formed. The mop has debris collecting material coupled to the mop head to collect dust, dirt, and other relatively small debris as the mop moves over a floor. In one particular embodiment, the debris collecting material is a non-woven material. The debris collecting material of the mop can be connected to the mop many different ways. However, in some embodiments, the material is connected via several projections extending from a top surface of the mop head. The projections pass through apertures in the dust collecting material. | 05-27-2010 |
20120042901 | MOP WITH RECEPTACLE - Some aspects of the present invention are related to a mop and/or mop head that allows larger debris to pass over at least a portion of the mop head and into a receptacle of the mop head. In some embodiments, the mop head and the receptacle are integrally formed. The mop has debris collecting material coupled to the mop head to collect dust, dirt, and other relatively small debris as the mop moves over a floor. In one particular embodiment, the debris collecting material is a non-woven material. The debris collecting material of the mop can be connected to the mop many different ways. However, in some embodiments, the material is connected via several projections extending from atop surface of the mop head. The projections pass through apertures in the dust collecting material. | 02-23-2012 |
James Michael Scolaro, Ponte Vedra Beach, FL US
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20140028973 | METHOD AND APPARATUS FOR ENGAGING AND PROVIDING VISION CORRECTION OPTIONS TO PATIENTS FROM A REMOTE LOCATION - A method and system for providing vision correction to a patient is disclosed. The method and system employ a vision care POD to engage and provide vision diagnostics and correction options to a patient. More specifically, method and system may include educating the population of a geographic area through sources that target particular identified groups in need of vision correction; providing an eye examination to patients using a vision care POD to generate a personalized vision correction ID card; providing one or more vision correction solution(s) to the patient; supplying the patient with the one or more vision correction solution(s) and the corresponding training for the solution(s); and providing ongoing care and support to the patient. | 01-30-2014 |
Mauro Scolaro, Cernusso Sul Naviglio IT
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20120297729 | DEVICE FOR VACUUM PACKAGING, PARTICULARLY OF FOOD PRODUCTS - A packaging device, particularly for manually or automatically packaging trays containing food products or technical materials which can be inserted, by means of a loading platform, between longitudinally folded parts of a single-folded film and comprising elements for thermal bonding or heat-sealing for sealing, and at least one nozzle for producing a vacuum and/or for introducing the gas or mixture, and a vacuum chamber. The single-folded film is fixed and the vacuum chamber is movable and comprises at least one movable presser arranged above the single-folded film. The presser is forced on top of the tray and is provided with elements adapted to convey the streams of air and/or gas. The return of air into the vacuum chamber occurs by means of a series of holes provided between a transverse heat-sealing bar and the wall of the vacuum chamber that is parallel thereto. | 11-29-2012 |
Mauro Scolaro, Cernusco Sul Naviglio IT
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20130263559 | DEVICE FOR VACUUM PACKAGING, PARTICULARLY OF FOOD PRODUCTS - A packaging device, particularly for packaging trays containing food products or technical materials in a controlled atmosphere and by means of a film of plastic material, comprising an upper chamber and a lower chamber, which can be fastened by mutually superimposing them and are each provided internally with a plurality of heat-sealing and/or cutting and/or die-cutting elements arranged concentrically, the lower chamber being provided centrally with a plurality of supporting elements for a tray. | 10-10-2013 |
Michael J. Scolaro, Los Angeles, CA US
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20140234400 | Targeted Lipid-Drug Formulations for Delivery of Drugs to Myeloid and Lymphoid Immune Cells - A method of preferentially delivering an active agent to an immune cell, such as a myeloid progenitor cell, a dendritic cell, a monocyte, a macrophage or a T-lymphocyte, or other cell type restricted to a functional organ system or an anatomic entity, of a mammalian subject by administering a lipid-drug complex to the subject. The lipid-drug complex is comprised of an active agent, such as a drug, and an outer surface with a targeting ligand that binds a marker on the surface of the immune cell or other cell type that is infected with or susceptible to infection with an infectious agent. The other cell type that is infected with or susceptible to infection with an infectious agent may belong to a malignant tumor or a part of the immune system contributing to the development, maintenance, or exacerbation of an autoimmune disease or chronic inflammatory disease. | 08-21-2014 |