Patent application number | Description | Published |
20080260736 | Methods and Compositions to Regulate Iron Metabolism - The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders. | 10-23-2008 |
20120064076 | METHODS AND COMPOSITION TO REGULATE IRON METABOLISM - The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders. | 03-15-2012 |
20120258105 | METHODS AND COMPOSITIONS TO REGULATE IRON METABOLISM - The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders. | 10-11-2012 |
20130149304 | USE OF MODULATORS OF COMPOUNDS OF TGF-BETA SUPERFAMILY TO REGULATE HEPCIDIN-MEDIATED IRON METABOLISM - The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders. | 06-13-2013 |
20150072927 | METHODS AND COMPOSITIONS TO REGULATE HEPCIDIN EXPRESSION - The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders. | 03-12-2015 |
Patent application number | Description | Published |
20090024870 | SYSTEM AND METHOD FOR MANAGING APPLICATION SERVER RESPONSES IN IP MULTIMEDIA SUBSYSTEM - In an Internet Protocol Multimedia Subsystem (IMS), a user profile is provided with an extended schema that provides one or more error code definitions and associated error handling instructions. Response codes received in response to requests to an application server are processed to determine if a matching response code is defined in the user profile. If a match is found, the associated response handling instructions are performed. If no match is found, a default response handling is performed. | 01-22-2009 |
20100008254 | METHOD AND APPARATUS FOR INSTANCE IDENTIFIER BASED ON A UNIQUE DEVICE IDENTIFIER - A method and apparatus for use in a communications network whereby an Instance Identifier (ID) is created to uniquely identify a device such as a mobile device or User Equipment (UE) in the communications network. | 01-14-2010 |
20100009681 | METHOD AND APPARATUS FOR INSTANCE IDENTIFIER BASED ON A UNIQUE DEVICE IDENTIFIER - A method and apparatus for use in a communications network whereby an Instance Identifier (ID) is created to uniquely identify a device such as a mobile device or User Equipment (UE) in the communications network. | 01-14-2010 |
20100037045 | METHOD AND APPARATUS FOR CREATING AN INSTANCE ID BASED ON A UNIQUE DEVICE IDENTIFIER - A method and apparatus for signaling between a device and network. The method comprises the step of generating, by a device, an Instance Identification (ID) that matches an Instance ID used by a network. The apparatus of the present invention includes a means of generating an ID that matches the Instance ID used by the network. | 02-11-2010 |
20110219431 | SYSTEM AND METHOD OF QUALITY OF SERVICE ENABLEMENT FOR OVER THE TOP APPLICATIONS IN A TELECOMMUNICATIONS SYSTEM - A system, method, and node providing a predefined Quality of Service (QoS) level to an Over The Top (OTT) service provider in a telecommunications network. A User Equipment (UE) initiates an IP-based application session (e.g., Hyper Text Transfer Protocol (HTTP) session) with the OTT service provider by sending an application-dependent message toward an OTT application server. The method begins with a proxy node in the telecommunications network intercepting the application-dependent message. The proxy node then modifies the application-dependent message by adding a subscriber identification to the header of the application-dependent message. The proxy node forwards the modified application-dependent message to the OTT application server. The OTT application server then sends a request having the subscriber identification to the telecommunications network with a QoS requirement for the HTTP session. Next, a network policy node determines an appropriate QoS level for the subscriber. A network gateway then enforces the determined QoS level for the HTTP session with the OTT service provider. | 09-08-2011 |
20140073296 | METHOD AND APPARATUS FOR INSTANCE IDENTIFIER BASED ON A UNIQUE DEVICE IDENTIFIER - A method and apparatus for use in a communications network whereby an Instance Identifier (ID) is created to uniquely identify a device such as a mobile device or User Equipment (UE) in the communications network. | 03-13-2014 |