Patent application number | Description | Published |
20100223281 | FINDING RELATIVES IN A DATABASE - Determining relative relationship includes receiving recombinable deoxyribonucleic acid (DNA) information of a first user and recombinable DNA information of a second user, determining, based at least in part on the recombinable DNA information of the first user and recombinable DNA information of the second user, a predicted degree of relationship between the first user and the second user, and in the event that the expected degree of relationship between the first user and the second user at least meets the threshold, notifying at least the first user about a relative relationship with the second user. | 09-02-2010 |
20110159499 | METHODS AND COMPOSITIONS FOR DETECTING GENETIC MATERIAL - This invention provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some cases, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). The methods and materials described apply techniques for allowing detection of small, but statistically significant, differences in polynucleotide copy number. | 06-30-2011 |
20120322058 | Analysis of nucleic acids - Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles. | 12-20-2012 |
20130345988 | SUMMARIZING AN AGGREGATE CONTRIBUTION TO A CHARACTERISTIC FOR AN INDIVIDUAL - Summarizing an aggregate contribution to a phenotypic characteristic for an individual includes: receiving information pertaining to the phenotypic characteristic of an individual; identifying, using one or more computer processors, a set of one or more markers associated with the phenotypic characteristic; obtaining a set of one or more marker measurements of the individual that corresponds to the set of one or more markers; obtaining a set of one or more statistical factors that measure associations between the set of one or more markers and the phenotypic characteristic; determining an aggregate contribution to the phenotypic characteristic of the individual based at least in part on the retrieved set of one or more statistical factors; and outputting a display characteristic to be displayed that is associated with the aggregate contribution to the phenotypic characteristic for the individual. | 12-26-2013 |
20140006433 | FINDING RELATIVES IN A DATABASE | 01-02-2014 |
20140156605 | PROCESSING DATA FROM GENOTYPING CHIPS - Processing genetic data includes receiving two or more genetic data sets for an individual from one or more genetic data sources, wherein the genetic data sets comprises data pertaining to the individual's deoxyribonucleic acid (DNA); merging the genetic data sets from the one or more genetic data sources to obtain a set of merged genetic data for the individual, including: identifying data in the genetic data sets that is conflicting, the identified data corresponding to a genetic marker associated with a variation that occurs at a region in the individual's genome; analyzing the identified data to resolve a discrepancy attributed to the identified conflicting data and automatically determine an appropriate value that corresponds to the genetic marker, the analysis and the determination being based at least in part on contextual information; and storing the appropriate value in the set of merged genetic data. | 06-05-2014 |
Patent application number | Description | Published |
20090118131 | Genetic comparisons between grandparents and grandchildren - Displaying a comparison of genotypic information between relatives is disclosed, including receiving an indication that a first individual is a grandparent, receiving an indication that a second individual is a grandchild of the first individual, comparing the genotypic information of the first individual and the second individual and calculating a similarity score, and displaying an indication of the similarity score graphically using colors. | 05-07-2009 |
20090119083 | Family inheritance - Displaying a comparison of genetic data is disclosed, including receiving an indication of a first individual, receiving an indication of a second individual, retrieving the genotypic information for the first individual and the second individual, comparing the genotypic information of the first individual and the second individual, displaying an indication of the comparison of the genotypic information of the first individual and the second individual graphically. A first graphical symbol is used to display an indication of the genome regions for which the first individual and the second individual are identical. A second graphical symbol is used to display an indication of the genome regions for which the first individual and the second individual are half identical. | 05-07-2009 |
20100057374 | Genotype calling - Determining a genetic sequence for a particular site on an individual's genome is disclosed, including: receiving a measurement associated with a particular sequence for the particular site on the individual's genome, receiving contextual information associated with a context of the individual within a larger collection of genetic information, and using the measurement associated with the particular sequence and the contextual information to compute an improved determination of the genetic sequence at the particular site on the individual's genome. | 03-04-2010 |
20100057807 | Processing data from genotyping chips - Processing genetic data is disclosed, including: receiving two or more genetic data sets for an individual from one or more genetic data sources; merging the genetic data sets from the one or more genetic data sources, including identifying a duplicate SNP between the genetic data sets and determining one or more data values to be stored for the duplicate SNP; and storing a single set of merged genetic data for the individual. | 03-04-2010 |
Patent application number | Description | Published |
20120252015 | METHODS AND COMPOSITIONS FOR DETECTING GENETIC MATERIAL - The present disclosure provides methods and compositions for detecting polynucleotides in a sample and for quantifying polynucleotide load in a sample. The polynucleotides can be associated with a disease, disorder, or condition. In some applications, methylated DNA is quantified, e.g., in order to determine the load of polynucleotides in a sample. The present disclosure also provides methods and compositions for determining the load of fetal polynucleotides in a biological sample, e.g., the load of fetal polynucleotides (e.g., DNA, RNA) in maternal plasma. The present disclosure provides methods and compositions for detecting cellular processes such as cellular viability, growth rates, and infection rates. This disclosure also provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some embodiments, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). | 10-04-2012 |
20120316074 | METHODS AND COMPOSITIONS FOR NUCLEIC ACID ANALYSIS - Provided herein are methods, compositions, and kits for assays, many of which involve amplification reactions such as digital PCR or droplet digital PCR. The assays may be used for such applications as sequencing, copy number variation analysis, and others. In some cases, the assays involve subdividing a sample into multiple partitions (e.g., droplets) and merging the partitions with other partitions that comprise adaptors with barcodes. | 12-13-2012 |
20120329664 | MULTIPLEXED DIGITAL ASSAYS WITH COMBINATORIAL USE OF SIGNALS - System, including methods, apparatus, and compositions, for performing a multiplexed digital assay on a greater number of targets through combinatorial use of signals. | 12-27-2012 |
20130040841 | DIGITAL ASSAYS WITH MULTIPLEXED DETECTION OF TWO OR MORE TARGETS IN THE SAME OPTICAL CHANNEL - System, including methods and apparatus, for performing a digital assay with multiplexed detection of two or more distinct targets in the same optical channel. | 02-14-2013 |
20130045875 | LIBRARY CHARACTERIZATION BY DIGITAL ASSAY - Methods of characterizing a nucleic acid library by digital assay. | 02-21-2013 |
20130189700 | BREAKAGE OF AN EMULSION CONTAINING NUCLEIC ACID - Methods of processing an emulsion of aqueous droplets containing nucleic acid. The methods may include breakage of the emulsion with a destabilizing fluid including a halogen-substituted hydrocarbon. | 07-25-2013 |
20140155295 | CAPSULE ARRAY DEVICES AND METHODS OF USE - This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis. | 06-05-2014 |
20140171341 | MULTIPLEXED DIGITAL ASSAYS - System, including methods and apparatus, for performing a multiplexed digital assay. | 06-19-2014 |
20140200164 | SYSTEM FOR DETECTION OF SPACED DROPLETS - System, including methods and apparatus, for detection of spaced droplets. | 07-17-2014 |
20140206554 | Methods and Systems for Processing Polynucleotides - The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. | 07-24-2014 |
20140235506 | POLYNUCLEOTIDE BARCODE GENERATION - The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. In some cases, this disclosure provides methods for the generation of polynucleotide barcode libraries, and for the attachment of such polynucleotides to target polynucleotides. | 08-21-2014 |
20140287963 | Capsule Array Devices and Methods of Use - This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis. | 09-25-2014 |
20140378322 | COMPOSITIONS AND METHODS FOR SAMPLE PROCESSING - This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device. | 12-25-2014 |
20140378345 | COMPOSITIONS AND METHODS FOR SAMPLE PROCESSING - This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device. | 12-25-2014 |
20140378349 | COMPOSITIONS AND METHODS FOR SAMPLE PROCESSING - This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device. | 12-25-2014 |
20140378350 | COMPOSITIONS AND METHODS FOR SAMPLE PROCESSING - This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device. | 12-25-2014 |
20150031034 | METHODS AND COMPOSITIONS FOR DETECTING GENETIC MATERIAL - This invention provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some cases, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). The methods and materials described apply techniques for allowing detection of small, but statistically significant, differences in polynucleotide copy number. | 01-29-2015 |
20150066385 | SEQUENCING METHODS - The invention described herein solves challenges in providing a proficient, rapid and meaningful analysis of sequencing data. Methods and computer program products of the invention allow for a system to receive, analyze, and display sequencing data in real-time. The invention provides solutions to several difficulties encountered in assembling short sequencing-reads, and by doing so the invention improves the worth and significance of sequencing data. | 03-05-2015 |