Patent application number | Description | Published |
20080260721 | Nucleic acids encoding a mammalian raptor polypeptide and uses therefor - The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein. | 10-23-2008 |
20100173928 | Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex - In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity. | 07-08-2010 |
20110143370 | Nucleic Acids Encoding a Mammalian Raptor Polypeptide and Uses Therefor - The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein. | 06-16-2011 |
20110288091 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF - The present invention relates to small molecule modulators of mTORC1 and mTORC2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, autoimmune diseases, diabetic retinopathy) and metabolic diseases. Novel small molecules are provided that inhibit one or more of mTORC1, mTORC2, and PI3K-related proteins. Novel methods of providing soluble mTORC1 and mTORC2 complexes are discussed, as well as methods of using the soluble complexes in a high-throughput manner to screen for inhibitory compounds. | 11-24-2011 |
20130072485 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF - The present invention relates to small molecule modulators of mTORC1 and mTORC2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, autoimmune diseases, diabetic retinopathy) and metabolic diseases. Novel small molecules are provided that inhibit one or more of mTORC1, mTORC2, and PI3K-related proteins. Novel methods of providing soluble mTORC1 and mTORC2 complexes are discussed, as well as methods of using the soluble complexes in a high-throughput manner to screen for inhibitory compounds. | 03-21-2013 |
20130137633 | mTOR KINASE-ASSOCIATED PROTEINS - The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation. | 05-30-2013 |
20130178382 | Identification of Modulators of Autophagy - Methods for identifying compounds that inhibit or stimulate the autophagy pathway are described. Devices for detecting the expression of autophagy-related genes and kits for assaying the expression of autophagy-related genes are also described. Also described are methods for identifying individuals susceptible to or afflicted with a disease state associated with an autophagy pathway defect. | 07-11-2013 |
20140004532 | Nucleic Acids Encoding a Mammalian Raptor Polypeptide and Uses Therefor | 01-02-2014 |
20140087970 | SERINE BIOSYNTHESIS PATHWAY INHIBITION FOR TREATMENT OF CANCER - In some aspects, the invention provides compounds and methods of use for treating tumors. In some aspects, the methods comprise administering a serine biosynthesis pathway inhibitor to a subject, wherein the subject has a tumor that overexpresses PHGDH In some embodiments, the tumor is an ER negative breast cancer. In some aspects, the invention provides an in vivo RNAi-based negative selection screen of use to identify drug targets for treatment of tumors. | 03-27-2014 |
20140142180 | METHODS OF TREATING TUMORS HAVING ELEVATED MCT1 EXPRESSION - In some aspects, compositions and methods useful for classifying tumor cells, tumor cell lines, or tumors according to predicted sensitivity to 3-bromopyruvate (3-BrPA) are provided. In some aspects, methods of identifying subjects with cancer who are candidates for treatment with 3-BrPA are provided. In some aspects, compositions useful for subjects with cancers that express increased levels of MCT1 are provided. In some aspects, methods of treating subjects with cancers that express increased levels of MCT1 are provided. In some aspects, methods of identifying anti-tumor agents the efficacy of which is at least in part dependent on transporter-mediated uptake are provided. | 05-22-2014 |
20140348749 | IDENTIFICATION AND TREATMENT OF TUMORS SENSITIVE TO GLUCOSE LIMITATION - In some aspects, compositions and methods useful for classifying tumor cells, tumor cell lines, or tumors according to predicted sensitivity to glucose restriction are provided. In some aspects, compositions and methods useful for classifying tumor cells, tumor cell lines, or tumors according to predicted sensitivity to OXPHOS inhibitors are provided. In some aspects, compositions and methods useful for classifying tumor cells, tumor cell lines, or tumors according to predicted sensitivity to biguanides are provided. In some aspects, methods of identifying subjects with cancer who are candidates for treatment with an OXPHOS inhibitor are provided. In some aspects, methods of identifying subjects with cancer who are candidates for treatment with a biguanide are provided. In some aspects, methods of treating subjects with cancers that are sensitive to glucose restriction are provided. | 11-27-2014 |
20140357693 | METABOLIC GENE MESENCHYMAL SIGNATURES AND USES THEREOF - Aspects of the invention relate to methods and compositions for characterizing or modulating the expression of metabolic mesenchymal genes. In some embodiments, methods for assessing the expression of metabolic mesenchymal genes and related gene signatures are provided that are useful for cancer classification, prognosis, diagnosis, or treatment selection. | 12-04-2014 |
20150065556 | THERAPEUTIC TARGETS FOR MITOCHONDRIAL DISORDERS - In some aspects, compositions and methods for identifying therapeutic targets for treatment of mitochondrial disorders are provided. In some aspects compositions and methods for identifying therapeutic agents for treatment of mitochondrial disorders. In some aspects, the disclosure identifies ATPIF1 as a therapeutic target for mitochondrial disorders. | 03-05-2015 |
20150258124 | COMPOSITIONS AND METHODS FOR PROMOTING INTESTINAL STEM CELL FUNCTION - Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful for stimulating the proliferation of and/or self-renewal of intestinal stem cells, as well as for minimizing, preventing, or ameliorating cellular damage resulting from incidental or accidental exposure to radiation (e.g., cancer radiation therapy). | 09-17-2015 |
Patent application number | Description | Published |
20090193718 | Snap-in Lifter Plate - The invention is a lifter plate for a window regulator adapted for the insertion of a window glass. The lift plate includes a main body portion adapted for translational movement by the window regulator. A flange jaw is spaced apart from the main body portion and connected to the main body portion by a flexible joint interconnecting the body portion and the flange jaw. The flexible joint is integrally formed as part of the lifter plate and is shaped in an undulating waveform pattern. | 08-06-2009 |
20140299642 | POWERED BICYCLE RACKING SYSTEM - A powered bicycle racking system is disclosed for use with a motor vehicle and which is configured to be concealed within or beneath a rear bumper area of the motor vehicle. The system includes a power-operated presenter unit that can be controlled to move a folding bicycle attachment assembly that is mounted to a mounting structure between retracted and extended position. In the retracted position, the bicycle attachment assembly is folded and concealed within the bumper. In the extended position, the bicycle attachment assembly can be unfolded for mounting a bicycle thereto. | 10-09-2014 |
20140338129 | BED WITH USER-ASSIST MECHANISM - A bed, comprising: a user support structure including a body support member having a head region and a foot region, and a foot support member positioned proximate the foot region of the body support member and projecting laterally from the body support member; a frame for supporting the user support structure on a support surface; a coupling mechanism coupling the user support structure to the frame and providing for relative movement there-between; and an actuator that is configured to move the user support structure relative to the frame between a user rest position and a user reception/departure position, such that when in the user rest position the body support member is oriented to support the body of a user lying at least indirectly thereon, and when in the user reception/departure position, the body support member is oriented laterally to the foot support member such that the foot support member is oriented to support the user standing thereon. | 11-20-2014 |
20140345963 | COMPONENTS FOR ACTIVE PEDESTRIAN SAFETY MECHANISM - A latch assembly for driving a closure panel from a closed panel position to an open panel position. The latch assembly comprises: a latch mechanism having a first latch element for retaining a mating latch component in a latched position and for moving the mating latch component from the latched position to an unlatched position when released, the movement of the first latch element biased towards the unlatched position by a latch biasing element; and an actuation system having: a mechanical energy storage system having a device for storing mechanical potential energy for assisting the latch biasing element in moving the mating latch component from the latched position to the unlatched position; a mechanical advantage system having a plurality of advantage elements for engaging the device, such that movement of the plurality of advantage elements is associated with a trigger force and cooperation of the plurality of advantage elements provides for amplification of the trigger force as an initiating force to release the stored mechanical potential energy; and a trigger system configured to provide the trigger force to release the stored mechanical potential energy. | 11-27-2014 |
20150059250 | POWER DOOR ACTUATION SYSTEM - A power door actuation system for moving a vehicle door relative to a vehicle body between an open position and a closed position includes a motor assembly connectable to one of the vehicle door and the vehicle body that is configured to generate a rotational force. A drive shaft is interconnected to the motor assembly and extends from a first end disposed adjacent the motor assembly to a second end. The second end of the drive shaft is rigidly attached to one of a body strap or a door strap of a hinge for transferring the rotational force from the motor assembly to the respective rigidly attached strap to rotate the respective rigidly attached strap relative to the other of the door strap and the body strap for automatically moving the vehicle door between the open and closed positions. | 03-05-2015 |
20160023630 | COMPONENTS FOR ACTIVE PEDESTRIAN SAFETY MECHANISM - A latch assembly for driving a closure panel from a closed panel position to an open panel position. The latch assembly comprises: a latch mechanism having a first latch element for retaining a mating latch component in a latched position and for moving the mating latch component from the latched position to an unlatched position when released, the movement of the first latch element biased towards the unlatched position by a latch biasing element; and an actuation system having: a mechanical energy storage system having a device for storing mechanical potential energy for assisting the latch biasing element in moving the mating latch component from the latched position to the unlatched position; a mechanical advantage system having a plurality of advantage elements for engaging the device, such that movement of the plurality of advantage elements is associated with a trigger force and cooperation of the plurality of advantage elements provides for amplification of the trigger force as an initiating force to release the stored mechanical potential energy; and a trigger system configured to provide the trigger force to release the stored mechanical potential energy. | 01-28-2016 |
20160075224 | MODULAR HYBRID SYSTEM - An electric propulsion system for use with a vehicle including a pair of first wheels, a pair of second wheels, and a gas propulsion system. The electric propulsion system includes a first electric traction motor mounted to one of the first wheels, and a second electric traction motor mounted to the other one of the first wheels. The electric propulsion system includes pair of electric motor controllers each in electrical communication with a respective one of the first or second electric traction motors. Each of the electric motor controllers are also in electrical communication with the system controller and configured to receive vehicle signals from the system controller to control the respective electric traction motors accordingly. Put another way, the pair of electric motor controllers react to vehicle conditions to provide vehicle assist power to the gas propulsion system as needed. | 03-17-2016 |