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| 20080248032 | COMPOSITIONS AND METHODS FOR PROTECTION AGAINST CARDIAC AND/OR CENTRAL NERVOUS SYSTEM TISSUE INJURY BY INHIBITING SPHINGOSINE-1-PHOSPHATE LYASE - The present invention relates generally to the prevention and/or treatment of cardiac and stroke injury. In particular, the present invention provides compositions and methods for preventing and treating tissue injury in cardiac and stroke settings and injury due to ischemia/reperfusion, hypoxia, cardiotoxicity of certain therapeutic regimens, and other causes, by administering an agent that inhibits sphingosine-1-phosphate lyase (SPL) activity. | 10-09-2008 |
| 20090202551 | IMMUNOMODULATION BY ALTERING SPHINGOSINE 1-PHOSPHATE LYASE (SPL) ACTIVITY - Compositions and methods for modulating immune function are provided based on the unexpected discovery that inhibition of sphingosine-1-phosphate lyase (SPL) activity confers useful immunosuppressive effects, for example to modulate immune function in treatment or prevention of inflammation, transplant graft rejection, autoimmune disease, allergy, or other conditions, including therapeutic alteration of immune system cell survival and/or proliferation. Altering SPL activity by direct or indirect pharmacological intervention, or alternatively by molecular genetic methods to alter SPL expression levels, are also contemplated. | 08-13-2009 |
| 20090203044 | SPHINGOSINE-1-PHOSPHATE LYASE POLYPEPTIDES, POLYNUCLEOTIDES AND MODULATING AGENTS AND METHODS OF USE THEREFOR - Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided. | 08-13-2009 |
| 20110098317 | USE OF UNSATURATED SPHINGOSINE COMPOUNDS AS CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER - The present invention is directed to unsaturated sphingosine compounds which are useful as therapeutic agents for the treatment of cancer and for the treatment of other diseases including diabetes and infection with intracellular bacteria. This invention is also directed to methods of using the compounds and pharmaceutical compositions comprising the compounds in treating these diseases. | 04-28-2011 |
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| 20090152287 | Vending Machine Improvement - A vending machine system includes a control module for controlling a cooling system. The cooling system, which includes an evaporator, may omit a heating element for defrosting the evaporator. In operation, the control module cycles an evaporator fan in conjunction with a compressor based on a required set temperature to help keep products within a specified range. In an embodiment, the evaporator fan is turned on and off at substantially the same time as the compressor is turned on and off. In another embodiment, there is a predetermined delay after the compressor is turned on and off before the evaporator is respectively turned on and off. Other variations are contemplated. | 06-18-2009 |
| 20100018233 | COOLER MERCHANDISER WITH CUSTOMIZABLE GRAPHICS - A display unit may be a cooler merchandiser for displaying products, such as food and beverages. The cooler merchandiser may have a housing that contains a display portion for displaying one or more products and a cooling portion that may be configured to cool the products in the display portion. A frame may be attached to the housing and may extend along at least a portion of the perimeter of a surface of the housing. A removable insert may slide into the frame so that it is positioned adjacent to a surface of the housing. The removable insert may include a cardboard material and the housing may include a rigid styrene material. The removable insert may display a graphics that may be customized. An opening may be provided in the housing to provide access to the display portion and a thermo-protective barrier may be provided to cover the opening. | 01-28-2010 |
| 20110132921 | VENDING MACHINE IMPROVEMENT - A vending machine system includes a control module for controlling a cooling system. The cooling system, which includes an evaporator, may omit a heating element for defrosting the evaporator. In operation, the control module cycles an evaporator fan in conjunction with a compressor based on a required set temperature to help keep products within a specified range. In an embodiment, the evaporator fan is turned on and off at substantially the same time as the compressor is turned on and off. In another embodiment, there is a predetermined delay after the compressor is turned on and off before the evaporator is respectively turned on and off. Other variations are contemplated. | 06-09-2011 |
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| 20080275979 | System and method for clustering of group-centric networks - Exemplary systems and methods for managing a plurality of group-centric networks are provided. In exemplary embodiments, a plurality of group-centric networks is established within a network cluster. Each group-centric network comprises one or more groups having a common interest. Once established, the group-centric network defines customized administrative components for the group-centric network. In exemplary embodiments, the administrative component comprises roles and relationship definitions which define what data and functionality may be provided to a user accessing a group within the group-centric network. | 11-06-2008 |
| 20090019062 | System and method for providing universal profiles for networked clusters - Exemplary systems and methods for providing universal profiles for networked clusters are provided. In exemplary embodiments, membership in a first cluster is established for a member. A profile for the member is then generated that comprises profile segments associated with the first cluster. Membership in a second or subsequent cluster may also be established for the member. After which, a profile extension is provided that indicates additional profile segments associated with the second or subsequent cluster. Based on the profile extension, the profile is appended. | 01-15-2009 |
| 20090193356 | Systems and methods for providing a zoomable user interface - Systems and methods for providing a zoomable user interface are provided. Objects associated with content may be graphically presented to a user. The graphical presentation may be initially based on a first browsing mode of a plurality of browsing modes. A selection of a portion of the objects of the graphical presentation may be received. In addition, a second or successive browsing mode may be determined. The selected portion may then be mapped based on the second browsing mode. Subsequently, the selected portion may be graphically presented based on the second browsing mode to the user. | 07-30-2009 |
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| 20080275969 | System and method for managing a plurality of network clusters - Exemplary systems and methods for managing a plurality of network clusters are provided. In exemplary embodiments, a network cluster is established within a super cluster. Each network cluster comprises one or more groups/organizations having a common interest. Once established, the network cluster defines customized administrative components for the network cluster. These administrative components may define how groups are organized within the network cluster and individual's roles and functionalities within the network cluster. The administrative components may also define what components may be provided to a user associated with the network cluster. | 11-06-2008 |
| 20090055545 | Roles and relationship based security in a group-centric network - Exemplary systems and methods for providing security in a group-centric network are provided. In exemplary embodiments, a request to access a webpage associated with a group or individual is received. The user security level for a user requesting access to the webpage is then determined. One or more security settings associated with data on the webpage is also determined. Based on the user security level and the one or more security settings, an appropriate level of access and functionality for data on the webpage is provided to the user. | 02-26-2009 |
| 20090198815 | Criteria-based creation of organizational hierarchies in a group-centric network - Exemplary systems and method for creating organizational hierarchies in a group-centric network are provided. In exemplary embodiments, a request from a user to establish a new group within the organization on the group-centric network is received by the group-centric network host. The group-centric network host retrieves an applicable, predetermined set of criteria for group creation, and determines if terms in the request match the predetermined set of criteria. If there is a match, the new group is created and one or more relationships of the new group may be activated. | 08-06-2009 |
