Patent application number | Description | Published |
20090252694 | Novel Chalcone Derivatives, Pharmaceutically Acceptable Salt, Method for Preparation and Uses Thereof - Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound. | 10-08-2009 |
20100068730 | METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS - The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient. | 03-18-2010 |
20120282619 | METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS - The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient. | 11-08-2012 |
20130146440 | PREPARATION METHOD OF CHROMENONE DERIVATIVES USING RADIATION - A preparation method of chromenone derivatives using radiation is provided. The preparation method exposes commercially-available silybin in reaction solvent to radiation, to thereby concurrently obtain both dehydrosilybin and apigenin compounds, which are chromenone compounds, in a simple reaction step and with high yield. Because the compounds are prepared at economic cost, the preparation method can be advantageously used particularly for the purpose of mass production. Further, in consideration of good cancer cell viability suppression effect thereof, dehydrosilybin and apigenin prepared according to the preparation method can be advantageously used as a pharmaceutical composition for prevention and treatment of cancer. | 06-13-2013 |
Patent application number | Description | Published |
20100259358 | HIGHLY DENSE AND NON-GRAINED SPINEL NTC THERMISTOR THICK FILM AND METHOD FOR PREPARING THE SAME - Disclosed herein are a highly dense and nano-grained NTC thermistor thick film and a method for preparing the same, and specifically, an NTC thermistor thick film vacuum deposited by spraying a spinel grained ceramic powder containing Ni and Mn on one side of the surface of a substrate using a room temperature powder spray in vacuum (AD) and a method for preparing the same. According to the present invention, a room temperature powder spray in vacuum (AD) may be used to perform a rapid deposition of NTC thermistor thick films and prepare a highly dense ceramic thick film, the NTC characteristic constant B which would be obtained by doping may be maximized without doping, demagnetization may be obtained without any additional heat treatment, and thus limitations on substrate that the conventional art has may be completely overcome. | 10-14-2010 |
20150236242 | SINGLE-CRYSTAL PIEZOELECTRIC FIBER COMPOSITE AND MAGNETOELECTRIC LAMINATE COMPOSITE INCLUDING THE SAME - A piezoelectric fiber composite and a magnetoelectric laminate composite including the same are disclosed. The piezoelectric fiber composite includes a first protective layer having a first electrode, a second protective layer having a second electrode, and a piezoelectric fiber layer formed between the first and the second electrode and having piezoelectric fibers arranged in the longitudinal direction of the composite, wherein the piezoelectric fibers include a single-crystal piezoelectric material and are configured such that a <011> direction of the single crystal is identical to a thickness direction of the composite and a <001> direction of the single crystal is identical to a longitudinal direction of the composite, thus exhibiting superior piezoelectric strain properties and sensing properties. Also, the magnetoelectric laminate composite includes the piezoelectric fiber composite and a magnetostrictive layer including a magnetostrictive material such as nickel (Ni) or Metglas (FeBSi alloy), thus ensuring significantly improved magnetoelectric properties. | 08-20-2015 |
Patent application number | Description | Published |
20090252694 | Novel Chalcone Derivatives, Pharmaceutically Acceptable Salt, Method for Preparation and Uses Thereof - Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound. | 10-08-2009 |
20100068730 | METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS - The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient. | 03-18-2010 |
20120107429 | Composition For The Prevention And Treatment Of Influenza Virus Infection And Composition For Suppressing Neuraminidase Activity Comprising Turmeric Extract - Disclosed is a composition comprising a turmeric extract for preventing and treating influenza virus infection and for inhibiting neuraminidase activity. A turmeric extract, its fraction, and a curcuminoid-based compound separated therefrom may inhibit neuraminidase activity and have antiviral and cell degeneration inhibitory effects on influenza virus, and may be useful in preventing and treating influenza virus infection. | 05-03-2012 |
20120282619 | METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS - The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient. | 11-08-2012 |