Ryo Kubota
Ryo Kubota US
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20110044957 | METHODS AND SYSTEMS FOR EXTENDED IN VITRO CULTURE OF NEURONAL CELLS - A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided. | 02-24-2011 |
Ryo Kubota, Seattle, WA US
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20090170841 | Styrenyl Derivative Compounds for Treating Ophthalmic Diseases and Disorders - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. | 07-02-2009 |
20090197967 | COMPOSITIONS AND METHODS FOR TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS - Provided herein are compositions and methods for treating ophthalmic diseases and disorders. Compositions comprising retinylamine derivative compounds provided herein are useful for treating and preventing ophthalmic diseases and disorders, including diabetic retinopathy diabetic maculopathy, diabetic macular edema, retinal ischemia, ischemia-reperfusion related retinal injury, and metabolic optic neuropathy. | 08-06-2009 |
20090281149 | Amine Derivative Compounds for Treating Ophthalmic Diseases and Disorders - Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | 11-12-2009 |
20100093865 | SULPHUR-LINKED COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - Provided are sulphur-linked compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | 04-15-2010 |
20100113539 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | 05-06-2010 |
20110003895 | Pharmacology of Visual Cycle Modulators - Described herein are methods for the treatment of an ophthalmic disease or disorder comprising the administration of non-retinoid visual cycle modulators. | 01-06-2011 |
20120041038 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | 02-16-2012 |
20120041039 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | 02-16-2012 |
20120129860 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. | 05-24-2012 |
20130225619 | SUBSTITUTED HETEROCYCLIC COMPOUNDS FOR DISEASE TREATMENT - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted heterocyclic amine derivative compound and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. | 08-29-2013 |
20130253064 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. | 09-26-2013 |
20140039048 | METHODS FOR THE TREATMENT OF DIABETIC RETINOPATHY AND OTHER OPHTHALMIC DISEASES - Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions. | 02-06-2014 |
20140275043 | SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. | 09-18-2014 |
20140323530 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | 10-30-2014 |
20150238497 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. | 08-27-2015 |
Ryo Kubota, Kanagawa JP
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20080296729 | SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME - A semiconductor device is manufactured by forming a hole as being extended through a first insulating film and an insulating interlayer stacked over a semiconductor substrate, allowing side-etching of the inner wall of the hole to proceed specifically in a portion of the insulating interlayer, to thereby form a structure having the first insulating film projected out from the edge towards the center of the hole; forming a lower electrode film as being extended over the top surface, side face and back surface of the first insulating film, and over the inner wall and bottom surface of the hole; filling a protective film in the hole; removing the lower electrode film specifically in portions fallen on the top surface and side face of the first insulating film; removing the protective film; and forming a cylindrical capacitor in the hole. | 12-04-2008 |
20110256686 | SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME - A semiconductor device is manufactured by forming a hole as being extended through a first insulating film and an insulating interlayer stacked over a semiconductor substrate, allowing side-etching of the inner wall of the hole to proceed specifically in a portion of the insulating interlayer, to thereby form a structure having the first insulating film projected out from the edge towards the center of the hole; forming a lower electrode film as being extended over the top surface, side face and back surface of the first insulating film, and over the inner wall and bottom surface of the hole; filling a protective film in the hole; removing the lower electrode film specifically in portions fallen on the top surface and side face of the first insulating film; removing the protective film; and forming a cylindrical capacitor in the hole. | 10-20-2011 |
Ryo Kubota, Kawasaki JP
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20120102356 | INFORMATION PROCESSING APPARATUS, CONTROL APPARATUS, AND METHOD - An information processing apparatus includes a controller, a plurality of electric power supply units and a backup electric power supply unit that supply electric power to the controller. The controller detects a malfunction occurring in the plurality of electric power supply units, stops electric power supply from the plurality of electric power supply units, starts electric power supply from the backup electric power supply unit when a malfunction is detected, identifies an electric power supply unit having a malfunction from the plurality of electric power supply units, disconnects the identified electric power supply unit, resumes electric power supply from an electric power supply unit determined to function normally and stops the electric power supply from the backup electric power supply unit when the electric power supply unit having the malfunction is disconnected. | 04-26-2012 |
Ryo Kubota, Fukuoka JP
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20120128072 | IMAGE CONVERTING APPARATUS, IMAGE REPRODUCING APPARATUS, AND IMAGE CONVERTING METHOD - An image reproducing apparatus that achieves a higher readiness, high-speed backward reproduction, and a minimum amount of data, at a time of executing a backward reproduction. An encoder-side intra predictor transcodes decode images of a front end and a back end of a GOP of an image stream. An encoder-side motion compensator transcodes a decode image other than that of the front end of the GOP of the image stream by setting a motion vector to 0 and using an immediately preceding reference image. | 05-24-2012 |
Ryo Kubota, Honolulu, HI US
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20130171643 | Sequence Specific Real-Time Monitoring of Loop-Mediated Isothermal Amplification (LAMP) - Gene-based diagnostics capable of rapidly discriminating selected strains of a selected pathogen from other populations within the same species are disclosed. Sequence-specific, real-time monitoring of LAMP of DNA may be accomplished through the use of oglionucleotide probes, referred to as “assimilating probes.” The assimilating probes include two oglionucleotide strands, one which includes a quencher (referred to as the quenching probe) and another which includes a fluorophore (referred to as the fluorescent probe). A fluorescent signal results when the two strands are displaced from one another during the LAMP reaction. By monitoring the emitted fluorescence, sequence specific amplification may be detected. | 07-04-2013 |
Ryo Kubota, Hitachi JP
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20140254738 | ALTERNATIVE AIR SUPPLY AND EXHAUST PORT FOR AIR-OPERATED VALVE - The present invention is directed to remote operation of an operation valve such as an air operated valve even at the time of power loss. A gas supply apparatus of the present invention includes: an operation valve mounted in some midpoint of a piping for passing at least gas in a plant and operating a valve body by the gas flowing in the piping; an solenoid valve mounted in some midpoint of the piping and allowing/stopping flow of the gas to the operation valve; and a gas supply source for supplying gas to the solenoid valve. A switching valve for switching between exhaust from the solenoid valve and gas supply to the solenoid valve is mounted in an exhaust line of the solenoid valve and, at the time of power loss, the switching valve is switched to connection to the gas supply source for supplying gas to the solenoid valve. | 09-11-2014 |
20150117585 | Gas Supply Apparatus and Air or Nitrogen Supply Apparatus of Nuclear Plant - A gas supply apparatus of the present invention includes: an operating valve that is placed in the middle of a piping for letting at least gas in a plant flow and that operates a valve main body by the gas flowing in the piping; a first electromagnetic valve that is placed in the middle of the piping and that opens or closes a flow of the gas to the operating valve; and a gas supply source that supplies the first electromagnetic valve with the gas. A gas discharge line of the first electromagnetic valve has a switching valve placed therein and has a second electromagnetic valve placed between the switching valve and the gas supply source. The switching valve switches between a gas discharge from the first electromagnetic valve and a gas supply to the first electromagnetic valve. When a power source is lost, the switching valve is switched to connection to the gas supply source so as to supply the first electromagnetic valve with the gas. At the time of a normal operation, the second electromagnetic valve opens a gas discharge line side and closes a switching valve side, and when the power source is lost, the second electromagnetic valve opens the switching valve side and closes the gas discharge line side. In this way, even when the power source is lost, an operating valve such as an air-operated valve can not only be operated remotely but also be operated safely by a remote operator. | 04-30-2015 |
Ryo Kubota, Kitaku JP
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20150160299 | POWER SUPPLY APPARATUS AND POWER SUPPLY DEGRADATION DIAGNOSIS METHOD - A power supply apparatus includes a first electric accumulator, a second electric accumulator, and a control section which controls charge and discharge of the first electric accumulator and the second electric accumulator. When the control section does not carry out a degradation diagnosis of the first electric accumulator, the control section charges the first electric accumulator and makes the second electric accumulator discharge. When the control section carries out the degradation diagnosis of the first electric accumulator, the control section charges the second electric accumulator and then makes the first electric accumulator begin to discharge for the degradation diagnosis. | 06-11-2015 |
Ryo Kubota, Kita JP
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20160094023 | ELECTRONIC APPARATUS, POWER SUPPLY DEVICE, AND POWER SUPPLY MONITORING METHOD - An electronic apparatus includes: a power supply circuit that supplies power supply voltage to a load; an overcurrent detection circuit that performs output of detection information indicating the direction of current at a power supply path for the load in the power supply circuit when overcurrent occurs in the power supply path; and a determination circuit that performs output of notification information indicating whether or not a location at which a failure occurs exists within the power supply circuit or outside the power supply circuit, based on the detection information. | 03-31-2016 |