Patent application number | Description | Published |
20130011919 | Mammalian alpha-kinase proteins, nucleic acids and diagnostic and therapeutic uses thereof - The present invention provides novel mammalian alpha-kinase proteins: melanoma alpha-kinase (MK), heart alpha-kinase (HK), kidney alpha-kinase (KK), skeletal muscle alpha-kinase (SK), and lymphocyte alpha-kinase (LK). In particular, a novel kinase type is herein provided, characterized by the presence of an alpha-kinase catalytic domain and an ion channel domain. Isolated nucleic acids of the alpha-kinases MK, HK, KK, SK and LK are provided. Methods for making the novel alpha-kinases, cells that express the alpha-kinases and methods for treating an animal in need of either increased or decreased activity of the alpha-kinases are provided. | 01-10-2013 |
20140134722 | Mammalian alpha-kinase proteins, nucleic acids and diagnostic and therapeutic uses thereof - The present invention provides novel mammalian alpha-kinase proteins: melanoma alpha-kinase (MK), heart alpha-kinase (HK), kidney alpha-kinase (KK), skeletal muscle alpha-kinase (SK), and lymphocyte alpha-kinase (LK). In particular, a novel kinase type is herein provided, characterized by the presence of an alpha-kinase catalytic domain and an ion channel domain. Isolated nucleic acids of the alpha-kinases MK, HK, KK, SK and LK are provided. Methods for making the novel alpha-kinases, cells that express the alpha-kinases and methods for treating an animal in need of either increased or decreased activity of the alpha-kinases are provided. | 05-15-2014 |
20150204890 | MICROARRAYS OF G PROTEIN COUPLED RECEPTORS - Microarrays encompassing GPCRs, methods of making such microarrays, and methods of using such microarrays are described. | 07-23-2015 |
Patent application number | Description | Published |
20090163578 | NOVEL MODIFICATION OF IMMUNOMODULATORY PROTEIN - Methods of inhibiting annexin I induced apoptosis by contacting a cell population containing a TRPM7/ChaK1 kinase with an effective amount of a composition containing an inhibitor for the kinase. | 06-25-2009 |
20110020842 | eEF2K Assays for Identifying Compounds that Inhibit eEF2K Activity - Assays for identifying novel compounds for inhibiting eEF2 kinase and consequence peptides employed therein. | 01-27-2011 |
20110183942 | Methods and Compositions for Treating Alzheimer's Disease - A method is disclosed for inhibiting the build-up of amyloid plaques in the brain of a patient with at least one risk factor for, or a diagnosis of, Alzheimer's Disease by administering to the patient an amount of one or more compounds effective to inhibit the phosphorylative activity of eEF2K, thereby inhibiting amyloid plaque deposition. | 07-28-2011 |
20120178769 | NOVEL COMPOUNDS FOR INHIBITING EEF-2 KINASE ACTIVITY - The present invention discloses novel compounds for inhibiting eEF2 kinase and methods of use thereof. | 07-12-2012 |
20130041009 | Methods and means for increasing resistance to cell damage - Methods are provided to increase resistance to cell damage in a subject. The increase in resistance to cell damage in a subject in the subject is accomplished by decreasing activity of eEF2 kinase in the subject. The eEF2 kinase activity can be decreased by decreasing the amount of functional eEF2 kinase produced by the subject, including contacting the eEF2 kinase with a compound that inhibits phosphorylation of eEF2 kinase substrate or decreasing the amount of functional eEF2 kinase is decreased by reducing expression of a gene encoding the eEF2 kinase. | 02-14-2013 |
20130131313 | EEF2K ASSAYS FOR IDENTIFYING COMPOUNDS THAT INHIBIT EEF2K ACTIVITY - Assays for identifying novel compounds for inhibiting eEF2 kinase and consequence peptides employed therein. | 05-23-2013 |
20140378424 | ESTROGEN RECEPTOR MODULATORS FOR REDUCING BODY WEIGHT - The present invention relates to a method of reducing the body weight of a subject by administering an effective amount of an estrogen receptor modulator (ERM), optionally, in combination with an anti-obesity or weight loss agent. | 12-25-2014 |