Patent application number | Description | Published |
20080206886 | Large stoke shift dye used for optical imaging - The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate. | 08-28-2008 |
20080241266 | AMINE POLYMER-MODIFIED NANOPARTICULATE CARRIERS - There are disclosed colloids containing polymer-modified core-shell particle carrier. The described colloids containing core-shell nanoparticulate carrier particles wherein the shell contains a polymer having amine functionalities. The described carrier particles are stable under physiological conditions. The carriers can be bioconjugated with biological, pharmaceutical or diagnostic components. | 10-02-2008 |
20090079783 | MEMS PRINTHEAD BASED COMPRESSED FLUID PRINTING SYSTEM - A method and apparatus for delivering a mixture of compressed fluid and marking material and depositing the marking material in a pattern onto a substrate, includes a high pressure source of a mixture of compressed fluid and marking material. A micro-machined manifold includes a plurality of micro-nozzles, a fluid chamber, and an entrance port with portions of a first surface of the micro-machined manifold defining the entrance port with the entrance port being connected in fluid communication with the fluid chamber. Each of the micro-nozzles having an inlet and an outlet with the inlet being connected in fluid communication with the fluid chamber and the outlet being located on the second surface of the micro-machined manifold. Each micro-nozzle is shaped to produce a directed beam of the mixture of compressed fluid and marking material beyond the outlet of the micro-nozzle. A housing is connected in fluid communication with the high pressure source and the entrance port of the micro-machined manifold with the connection being a sealed connection. Optionally, a device operable to capture marking material that does not adhere to the substrate can be included. | 03-26-2009 |
20090086908 | APPARATUS AND METHOD FOR MULTI-MODAL IMAGING USING NANOPARTICLE MULTI-MODAL IMAGING PROBES - An apparatus for multimodal imaging of an object includes a support stage for receiving an object to be imaged; an object supported on the stage, the object having been treated with a biocompatible imaging probe comprising nanoparticles carrying one or more targeting moieties and one or more diagnostic components for enabling capture of images of the object; a light source for producing a beam to illuminate the object; a filter positioned to receive and pass the beam toward the object; and a lens and camera system for capturing an image of the object. The apparatus may include a tiltable filter for filtering light from the source. The apparatus may include a mechanism for selectively directing light from the light source through a first filter assembly to produce a first beam of light of a first frequency range for illuminating an object on the stage in a first imaging mode or through a second filter assembly to produce a second beam of light of a second frequency range for illuminating an object on the stage in a second imaging mode, so that the lens and camera system captures light from the object illuminated by either the first or second beam of light to produce a first image in response to the first beam and a second image, different from the first image, in response to the second image. An x-ray source and phosphor plate may be included to provide an additional imaging mode. | 04-02-2009 |
20090098057 | SILICA-CORED CARRIER PARTICLE - A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core. | 04-16-2009 |
20090169482 | SILICA-CORED CARRIER PARTICLE - A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core. | 07-02-2009 |
20090269699 | ON-PRESS DEVELOPABLE ELEMENTS AND METHODS OF USE - A negative-working imageable element has an imageable layer that includes an infrared radiation absorbing dye that upon exposure to thermal irradiation, changes from colorless to a visible color or from one visible color to another visible color, providing a ΔE of at least 5 between the exposed and non-exposed regions of the imageable layer within 3 hours of its exposure to 300 mJ/cm | 10-29-2009 |
20100075258 | ON-PRESS DEVELOPABLE IMAGEABLE ELEMENTS - On press developable negative-working, on-press developable imageable elements have improved printout qualities with an incorporated infrared radiation absorbing compound that has a cyanine dye chromophore that is represented by the following Structure (CHROMOPHORE): | 03-25-2010 |
20120045720 | DEVELOPERS AND METHOD OF COLORING LITHOGRAPHIC PRINTING MEMBERS - A color contrast image in imaged lithographic printing precursors can be obtained by contacting the imaged precursor with a coloration solution containing a colorless form of a photochromic compound. Residual amounts of this compound attached to the oleophilic surface of the imaged precursor can be changed to its colored form when exposed to UV light. The coloration solution can be an alkaline or acidic developer or an alkaline or acidic solution used separately after development. The coloration solution can also be a gum solution. | 02-23-2012 |
20120058050 | LOADED LATEX OPTICAL MOLECULAR IMAGING PROBES CONTAINING LIPOPHILIC LARGE STOKES SHIFT DYES - The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent. | 03-08-2012 |
20130101938 | ON-PRESS DEVELOPABLE LITHOGRAPHIC PRINTING PLATE PRECURSORS - A negative-working lithographic printing plate precursor is designed for improved printout or contrast between exposed and non-exposed regions in its imageable layer. The imaged precursor can be developed on-press. The improvement in printout is achieved by using a combination of at least two infrared radiation absorbing cyanine dyes. At least one of these cyanine dyes comprises a methine chain substituent that comprises a group represented by Structure (I): | 04-25-2013 |