Patent application number | Description | Published |
20090143466 | Isolation of Atraric Acid, Synthesis of Atraric Acid Derivatives, and Use of Atraric Acid and the Derivatives Thereof for the Treatment of Benign Prostatic Hyperplasia, Prostate Carcinoma and Spinobulbar Muscular Atrophy - A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided. | 06-04-2009 |
20090159553 | Closure system for containers - A closure system for containers used for storing or administering substances in the form of liquids, pastes or powders, which system in one embodiment includes a cap, provided with a through-hole, and a closure element, wherein the cap holds the closure element with a force fit and/or form fit on the container, in the area of the container opening that is to be closed, by means of a catch element present on the container. For this purpose, the end face which surrounds the container opening, and on which the closure element bears, comprises a depression. The closure element is a virus-proof, bacteria-proof and spore-proof film that lies on the end face and, at least in some areas, over the depression. The cap is then fitted in place, an elastomer ring or adhesive ring is arranged between the closure element and the depression and fills the depression. With the present invention, a closure system for containers is provided that allows the container to be securely closed permanently and in a virus-proof, bacteria-proof and spore-proof manner. | 06-25-2009 |
20090166978 | Cylinder/piston unit with at least three sealing elements - A cylinder/piston unit is disclosed for pre-fill, storage and release when desired of an active substance, such as a medicament. The cylinder/piston unit is provided with a cylinder and with a piston which is guided therein and which is sealed off in a sterile manner by a rubber seal, the cylinder and the piston enclosing a chamber that can be filled at least temporarily with active substance, and the cylinder having at least one discharge element at its front end. For this purpose, the piston resting in a rear position is sealed off relative to the cylinder in a sterile manner by a static front sealing element and by a static rear sealing element. Arranged spatially behind each static sealing element, there is a parking area for receiving the respective sealing element. When the piston is actuated, the individual static sealing elements are transferred from their respective sealing position into a parked position located in the parking area, and each sealing element in the parked position touches only the cylinder wall or only the piston wall. With the present invention, a cylinder/piston unit is developed which can be pre-filled and in which, despite a sterile sealing of the piston, only a slight force has to be applied in order to accelerate and/or move the piston. | 07-02-2009 |
20090254036 | Single-use injector with at least one draw hook - A single-use injector is disclosed comprising a housing ( | 10-08-2009 |
20090281496 | Disposable injector with at least one central traction rod - A disposable injector having a housing ( | 11-12-2009 |
20100036326 | Disposable injector comprising at least one draw hook and a sliding wedge-type gear for unlocking a locking element - A disposable injector with a housing ( | 02-11-2010 |
20100076373 | Disposable injector with at least one support rod - A disposable injector with a housing ( | 03-25-2010 |
20100076379 | Disposable injector with at least one compression bar and a closure cap - A disposable injector with a housing that has at least one compression hook, which has at least one support surface respectively in the region of its free end. A piston-actuating plunger rests on the support surface. The locking position of the compression hook is secured by an actuating element positioned in a locked position. The actuating element has a locked position, in which it rests securely on a sealing cap. The actuating element has a triggering position, which effects lateral retreat of the compression hook when the piston-actuating plunger is released. | 03-25-2010 |
20100100040 | Disposable injector with at least one tension hook - A disposable injector with a housing ( | 04-22-2010 |
20100106084 | Disposable injector with at least one drawer hook which can be forcibly decoupled - A disposable injector with a housing ( | 04-29-2010 |
20100249697 | Disposable injector with dual-piston dual-chamber system - The invention relates to a disposable injector with a housing, an injector-side, first cylinder-piston unit—at least intermittently fillable—arranged thereon and an upstream detachable container adapter, wherein the container adapter bears a likewise at least intermittently fillable second cylinder-piston unit. A solvent is stored in the first cylinder-piston unit. In the second cylinder-piston unit there is a freeze-dried active pharmaceutical ingredient. Immediately before use of the disposable injector the solvent is conveyed to the second cylinder-piston unit to the active pharmaceutical ingredient, where a solution forms. This solution is transfer-pumped into the first cylinder-piston unit to then be administered. | 09-30-2010 |
20100262125 | Disposable injector with a manually actuated piston and with a twin chamber system - The invention relates to a disposable injector with a housing, with a cylinder/piston unit which is arranged thereon and has a manually movable piston, and with a detachable container adapter mounted upstream of this cylinder/piston unit, wherein the container adapter supports a container that is closed by an openable stopper. The piston of the cylinder/piston unit is movable via a pump rod. The container adapter engages at the front end around the cylinder of the piston/cylinder unit. The container adapter has an intermediate floor which supports a dual adapter having at least one through-channel. The container, which bears tightly with its stopper on the dual adapter, sits longitudinally displaceably in the rear of the container adapter. The container is opened by displacing it towards the intermediate floor and pushing the stopper into the container. | 10-14-2010 |
20110152758 | Injector and dual-chamber system having sterile components - The invention relates to a single-use injector ( | 06-23-2011 |
20110196292 | Injector and two-chamber system having sealing container adapter - The invention relates to a single-use injector and to a two-chamber system, wherein at least one first chamber is part of a cylinder-piston unit that can be received in the single-use injector, and wherein the second chamber is part of a container having at least one opening, and closed at least intermittently by means of a stopper and place in a container adapter releasably supported on the single-use injector. To this end, the stopper and the container adapter can be permanently latched to each other. When the container is inserted, the container adapter closes off the opening and displaces the stopper. When the container is inserted into the container adapter, the adapter connects the interior of the cylinder-piston unit to the interior of the container. By means of the present invention, a single-use injector and a two-chamber system having a reduced number of components is developed. | 08-11-2011 |
20110196342 | Disposable injector with dual-piston dual-chamber system - The invention relates to a method of making a solution for injection from a solvent and an active ingredient using a disposable injector with a housing, an injector-side, first cylinder-piston unit—at least intermittently fillable—arranged thereon and an upstream detachable container adapter, wherein the container adapter bears a likewise at least intermittently fillable second cylinder-piston unit. A solvent is stored in the first cylinder-piston unit. In the second cylinder-piston unit there is a freeze-dried active pharmaceutical ingredient. Immediately before use of the disposable injector the solvent is conveyed to the second cylinder-piston unit to the active pharmaceutical ingredient, where a solution forms. This solution is transfer-pumped into the first cylinder-piston unit to then be administered. | 08-11-2011 |
20110214777 | Method and device for filling a disposable injector - The invention relates to a method and a device for the sterile filling of a disposable injector with a defined dose of an injection solution, wherein the disposable injector comprises a cylinder/piston unit with a cylinder and with a piston that can be pulled back manually. The defined dose of the injection solution is stored in an interior of a container of a needle syringe held in a bored stopper. The cylinder interior is connected to the container interior in a gas-tight and liquid-tight manner through the bored stopper. The cylinder/piston unit is filled by pulling back the piston or by pressing the needle syringe piston. With the present invention, a method and a device for filling a disposable injector are developed in which, without intermediate weighing or risk of inaccurate readings, the disposable injector can be filled with a defined dose of an injection solution from a syringe with a fused-in needle. | 09-08-2011 |
20110238015 | Injector having a cylinder-piston unit and permanently sterile active piston skirt - A unidirectional injector having at least one cylinder-piston unit, the piston thereof being displaceable between two stroke end positions relative to the cylinder, wherein the cylinder-piston unit comprises at least one sealing system sealing a compensating space from the surroundings. To this end the piston is provided at its front surface with an axial annular groove for accommodating a seal ring or a permanently elastic seal material, that the cylinder is provided with a first seal element and a second seal element which are spaced by at least a piston stroke, or that the piston is provided with the first seal element and the second seal element which are spaced by at least a piston stroke, or the cylinder carries the first seal element and the piston carries the second seal element which is displaced with respect to the first by the piston stroke. | 09-29-2011 |
20110251549 | Single-use injector having a flexurally elastic housing - A housing of the injector is made from a thin-walled sheet-metal part. The sheet-metal part has at least two branches or legs. Each branch has, at the free end thereof, an angled retaining element or a recess as a means of receiving the cylinder of a cylinder/piston unit. The branches are elastic flexural beams which, in the middle area, are each bent in a Z-shape or S-shape to form a supporting portion for the piston-actuating ram. The contact zone situated between an individual supporting portion and the piston-actuating ram represents a wedge gear pairing that forces the respective branch outwards. The trigger unit comprises at least a trigger element which is slidably supported on the metal sheet, wherein the support section or, respectively the contact sections extend outwardly into longitudinal grooves. The branches may be provided with a locking tongue to engage corresponding openings in the trigger element to lock the housing in position as desired. | 10-13-2011 |
20110251550 | Single-use injector having a flexurally elastic metal housing - A single-use injector comprising a housing ( | 10-13-2011 |
20110251551 | Single-use injector capable of pumping and having a flexurally elastic housing - A single-use injector comprising a housing ( | 10-13-2011 |
20110270167 | Injector having a displaceable stopper part - A disposable injector ( | 11-03-2011 |
20110311593 | N-HYDROXYLATED AMIDINE-, GUANIDINE- AND/OR AMINOHYDRAZONE-TYPE PRODRUGS FOR APPLICATION ON THE SKIN - The invention relates to N-hydroxylated amidines, guanidines and aminohydrazones for application on the skin. In particular, the invention relates to transdermal therapeutic systems containing N-hydroxylated amidines, guanidines and aminohydrazones as a prodrug, and to methods for producing and using such systems. | 12-22-2011 |
20120067984 | DUAL-CHAMBER CYLINDER-PISTON UNIT FOR THE LYOPHILISATION, STORAGE, RECONSTITUTION AND APPLICATION OF INJECTION SOLUTIONS FOR AN INJECTOR, AND METHOD FOR FILLING THE CYLINDER-PISTON UNIT - A cylinder/piston unit ( | 03-22-2012 |
20120101431 | CYLINDER-PISTON UNIT SUITABLE FOR STORING INJECTION SOLUTIONS FOR A NEEDLE-FREE AUTOMATIC OR MANUAL FILLING OF THE CYLINDER-PISTON UNIT, ALSO UNDER ATMOSPHERIC PRESSURE - A pressure-stable cylinder/piston unit which blocks water vapor and oxygen and is designed for a needle-free injector, with a chamber arranged in a cylinder, which blocks water vapor and oxygen, and designed for long-term and sterile storage of an injection solution, an end wall with at least one nozzle bore or one outlet element, a pressure-stable outer cylinder, and a pressure-stable piston arranged movably in the chamber and blocking water vapor and oxygen. Methods for bubble-free, automatic or manual filling of the cylinder/piston unit, also at atmospheric pressure are also disclosed. | 04-26-2012 |
20120101450 | CYLINDER-PISTON UNIT OF A DISPOSABLE INJECTOR HAVING INCREASED OPERATIONAL SAFETY - The end face of a cylinder-piston unit has a press-in area, engaging around the mouth, and a press-on area, surrounding the press-in area. The press-in area comprises an inner web, delimiting the mouth, and an outer web. The webs delimit a recess, which surrounds the inner web and of which the depth measured parallel to the center axis of the cylinder-piston unit is at least a quarter of its width in a plane oriented normal thereto. The press-on area, at least during an injection, is offset counter to the injection direction relative to the end face of the press-in area. Moreover, the surface of the press-on area projected into a plane normal to the center axis is at least as large as the surface of the press-in area projected into the same plane. | 04-26-2012 |
20120197186 | DISPOSABLE INJECTOR COMPRISING AT LEAST ONE DRAW HOOK AND A SLIDING WEDGE-TYPE GEAR FOR UNLOCKING A LOCKING ELEMENT - A disposable injector with a housing ( | 08-02-2012 |
20120271279 | DISPOSABLE INJECTOR WITH A MANUALLY ACTUATED PISTON AND WITH A TWIN CHAMBER SYSTEM - A method for preparing a solution from a solvent and an active substance in and on a disposable injector with a housing, with an at least intermittently fillable cylinder/piston unit which is arranged thereon and has a manually movable piston, and with a detachable container adapter mounted upstream of the cylinder/piston unit, wherein the container adapter supports a container which can be filled at least temporarily with active substance and which is closable by an openable stopper. | 10-25-2012 |
20120273491 | CLOSURE SYSTEM FOR CONTAINERS - A closure system for containers used for storing or administering substances in the form of liquids, pastes or powders that allows the container to be securely closed permanently and in a virus-proof, bacteria-proof and spore-proof manner. The container having an opening that is to be closed, a cap provided with a through-hole, the cap including a substantially cylindrical securing area, and a closure element for sealing the opening. The container includes an end face which surrounds the opening and on which the closure element bears. The closure element comprises a virus-proof, bacteria-proof and spore-proof film, and the cap comprises at least one closed, elastic sealing lip bearing resiliently in a direction towards the closure element in the operative position. | 11-01-2012 |
20140005611 | DISPOSABLE INJECTOR WITH A FLEXURALLY ELASTIC PISTON-ACTUATING RAM | 01-02-2014 |
20140096865 | CYLINDER-PISTON UNIT SUITABLE FOR STORING INJECTION SOLUTIONS FOR A NEEDLE-FREE INJECTOR AND METHOD FOR THE BUBBLE-FREE AUTOMATIC OR MANUAL FILLING OF THE CYLINDER-PISTON UNIT, ALSO UNDER ATMOSPHERIC PRESSURE - A pressure-stable cylinder/piston unit which blocks water vapor and oxygen and is designed for a needle-free injector, with a chamber arranged in a cylinder, which blocks water vapor and oxygen, and designed for long-term and sterile storage of an injection solution, an end wall with at least one nozzle bore or one outlet element, a pressure-stable outer cylinder, and a pressure-stable piston arranged movably in the chamber and blocking water vapor and oxygen. Methods for bubble-free, automatic or manual filling of the cylinder/piston unit, also at atmospheric pressure are also disclosed. | 04-10-2014 |
20140243740 | CYLINDER-PISTON UNIT WITH ADHESIVE DISC I - A cylinder-piston unit of a needle-free injector, with at least one cylinder accommodating an injection solution, at least one piston, and an adhesive coating arranged in the area of the free end face of the cylinder. The cylinder has a bottom portion, on which a discharge tube is arranged. An adhesive disc, which is displaceable in the direction of the centre line of the cylinder-piston unit between an installation position and an application position, is arranged on the discharge tube and/or on the bottom portion. The adhesive disc has an adhesive coating on each of the two end faces. In the installation position, the discharge tube can be sealed off in the adhesive disc. In the application position, the front edge of the discharge nozzle lies in the plane of the front adhesive coating or protrudes beyond this plane by at least 0.5 mm. A needle-free cylinder-piston unit of an injector whose discharge system is suitable for safely penetrating the outer layers of skin, covered by the term “dermis”, in order to convey the injection solution into or under the skin. | 08-28-2014 |
20140245882 | CYLINDER-PISTON UNIT WITH SHORT CANNULA - A cylinder-piston unit, with at least one cylinder accommodating an injection solution and having an outlet opening, and with at least one piston. The cylinder, or a component mounted upstream of the cylinder, has an end face from which, during correct emptying of the cylinder-piston unit, a short cannula protrudes, which has an outlet opening at its free end. The outlet opening has a surface with a border which has a point near the bottom or an edge near the bottom. The point near the bottom or the edge near the bottom lies 0.15-0.3 mm away from the end face or the front-most point or edge thereof. A cylinder-piston unit is developed which is intended for a disposable injector and which is suitable for virtually painless penetration of the human skin, among other reasons for the administration of highly viscous injection solutions. | 09-04-2014 |
20140249470 | CYLINDER-PISTON UNIT WITH MULTI-PART PISTON - A cylinder-piston unit, of a needle-free injector, with at least one cylinder accommodating an injection solution, and with at least one piston. The piston is composed of a drive body and of a sealing body. The sealing body is at least one elastic disc, which bears under a radial clamping action against the inner wall of the cylinder. The drive body is a pot-shaped body with a peripheral elastic skirt. At least one area of the skirt bears under a radial clamping action against the inner wall of the cylinder. The cylinder chamber areas located in front of and behind the drive body communicate with each other via at least one recess. The drive body is arranged behind the sealing body in the cylinder, and the skirt faces towards the sealing body. A piston is developed which, at ambient pressure, can be set down on the liquid level of a filled cylinder in a bubble-free, sterile and gas-tight manner and which nevertheless withstands a high compression pressure without leakage during the targeted emptying of the cylinder-piston unit. | 09-04-2014 |
20140249471 | CYLINDER-PISTON UNIT WITH ADHESIVE DISC II - A cylinder-piston unit, with at least one cylinder accommodating an injection solution, at least one piston, and an adhesive coating arranged in the area of the free end face of the cylinder. The cylinder has a bottom portion, on which a discharge tube is arranged. An adhesive disc, which is displaceable in the direction of the centre line of the cylinder-piston unit between an installation position and an application position, is arranged on the discharge tube and/or on the bottom portion. On its end face directed away from the bottom portion, the adhesive disc has an adhesive coating. In the storage position, the adhesive disc has at least one sealing element or a sealing area for closing the discharge tube, the effect of which sealing element or sealing area is no longer present in the application position. In the application position, the front edge of the end face of the discharge tube protrudes at least 0.5 mm beyond the adhesive coating of the adhesive disc. A cylinder-piston unit of an injector is developed whose discharge system is suitable for safely penetrating the outer layers of skin, covered by the term “dermis”, in order to convey the injection solution into or under the skin and keep it there for a definable period of time. | 09-04-2014 |