Patent application number | Description | Published |
20090078134 | Flexographic Printing Press - A flexographic printing press is comprised of at least four printing cylinders which are each driven by a respective drive motor. These at least four printing cylinders cooperate directly with a common satellite cylinder during the printing of a web of material. Each of these printing cylinders supports at least one flexographic printing plate. Each end journal of such printing cylinder is mounted in at least one linear bearing that is located on a lateral frame, and which can be moved perpendicularly to the axis of rotation of the respective cylinder. A stator of each driving motor can be moved along with the associated linear bearing, or along with the printing cylinder. Each such drive motor is configured as a synchronous motor which is excited by a permanent magnet. An independent hydraulic actuator is assigned to each printing cylinder, to change the position of that printing cylinder. At least one linear bearing is arranged in a bearing unit which is placed on the interior wall of the respective lateral frame. The journals of each printing cylinder do not penetrate the lateral frames. | 03-26-2009 |
20090266256 | Doctor blade system - A doctor blade system utilizes a lightweight doctor blade chamber to apply ink to an inking roller. The doctor blade chamber is removably positioned on a support plate which is, in turn, carried by linear guides on pivotable end plates. A rigid box beam is also attached to the end plates and is spaced from the support plate. A plurality of membrane cylinders are mounted on the rigid box beam and engage a surface of the support plate opposite to the surface that supports the doctor blade chamber. Through the application of suitable force, the support plate and its supported doctor blade chamber can be moved, by sliding motion on the linear slides, into uniform engagement with the surface of the ink roller. The system uses pivotable end plates which are supported by exterior plates that are, in turn, pivotably supported by press side frames. The chamber doctor blade and its support plate and box beam can be moved into several different positions, with respect to the cooperating ink roller, to facilitate doctor blade chamber cleaning or replacement or ink roller replacement. | 10-29-2009 |
Patent application number | Description | Published |
20080199467 | Immunoglobulin fusion proteins and methods of making - Disclosed are immunoglobulin fusion proteins and methods of making such proteins. In certain embodiments, the fusion protein may include a non-immunoglobulin polypeptide linked to an immunoglobulin polypeptide. In certain embodiments, the non-immunoglobulin polypeptide may comprise a region that replaces an immunoglobulin Fc hinge region, but that allows for correct assembly of the immunoglobulin chains. | 08-21-2008 |
20090004190 | Rage Fusion Proteins And Methods Of Use - Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin C | 01-01-2009 |
20090035302 | Rage Antagonists As Agents To Reverse Amyloidosis And Diseases Associated Therewith - Disclosed are RAGE antagonist compounds that have the ability to reverse pre-existing amyloidosis. Treatment with the RAGE antagonist compounds described herein may be used to reduce plaque size and improve cognition for subjects in the later stages of Alzheimer's disease. Additionally, the RAGE antagonists described herein may be used to reduce the onset of plaque formation and thereby prevent loss of cognition and other symptoms associated with Alzheimer's Disease and other diseases of amyloid deposition. | 02-05-2009 |
20090060925 | Rage Fusion Proteins and Methods of Use - Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies. | 03-05-2009 |
20110110945 | Immunoglobulin Fusion Proteins and Methods of Making - Disclosed are immunoglobulin fusion proteins and methods of making such proteins. In certain embodiments, the fusion protein may include a non-immunoglobulin polypeptide linked to an immunoglobulin polypeptide. In certain embodiments, the non-immunoglobulin polypeptide may comprise a region that replaces an immunoglobulin Fc hinge region, but that allows for correct assembly of the immunoglobulin chains. | 05-12-2011 |
20110124102 | Rage Fusion Proteins And Methods Of Use - Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin C | 05-26-2011 |
20110244516 | Rage Fusion Proteins And Methods Of Use - Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin C | 10-06-2011 |
20110282035 | Rage Fusion Proteins, Formulations And Methods Of Use Thereof - Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin C | 11-17-2011 |
20120171202 | Rage Fusion Proteins And Methods Of Use - Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin C | 07-05-2012 |