Rom, IL
Alona Rom, Mazkeret Batiya IL
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20090011009 | Microspheres comprising nanocapsules containing a lipophilic drug - The present invention provides microspheres comprising a plurality of nanocapsules accommodated in a gel forming polymer, the plurality of nanocapsules comprising an oil core carrying a non hydrophilic active agent and a shell of polymeric coating. The invention also provides a method for preparing the microspheres of the invention, pharmaceutical compositions comprising the same as well as methods of use of the microspheres, specifically, in therapeutic, cosmetic and diagnostic applications. | 01-08-2009 |
Eran Rom, Tel Aviv IL
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20100005312 | Mutually Excluded Security Managers - Techniques for controlling access to at least one resource are provided. At least one shared key and at least one private key unique to one or more resource sets are generated. Each of the one or more resource sets identify the at least one resource. The at least one shared key and the at least one private key are transmitted to a security access point. The security access point controls access to the at least one resource. At least one resource key is generated. The resource key is a cryptographic function of the at least one private key and at least one resource identifier. The at least one resource key and the at least one shared key are transmitted to one or more local security managers. Each of the one or more local security managers is assigned to manage one of the one or more resource sets. In accordance with one or more policies, the one or more local security managers generate at least one credential using the at least one resource key and the at least one shared key. The at least one credential is distributed to one or more authenticated clients. Further, the at least one credential is used to grant the one or more authenticated clients access to the one or more resource sets through the security access point. | 01-07-2010 |
20120017030 | OPTIMIZING A FILE SYSTEM INTERFACE IN A VIRTUALIZED COMPUTING ENVIRONMENT - Systems and methods for optimizing write operations to a storage device in a virtualized computing environment comprise monitoring write operations issued by an application running on a virtual machine's (VM) operating system, wherein the VM is hosted by a hypervisor providing access to a storage device in a virtualized computing environment; and causing a virtual file system (VFS) supported by the operating system to call on a first para-virtualized file system (PVFS FE) supported by the operating system to execute a write operation, in response to determining that the write operation is to write data to the storage device, wherein data that is to be written to the storage device is first written to a VM memory area allocated to the VM and accessible to the hypervisor hosting the VM. | 01-19-2012 |
20120017209 | OPTIMIZING A FILE SYSTEM INTERFACE IN A VIRTUALIZED COMPUTING ENVIRONMENT - Systems and methods for optimizing read operations from a storage device in a virtualized computing environment are provided. One method comprises monitoring read operations issued by an application running on a virtual machine's (VM) operating system, wherein the VM is hosted by a hypervisor providing access to a storage device in a virtualized computing environment; and causing a virtual file system (VFS) supported by the operating system to call on a first para-virtualized file system (PVFS FE) supported by the operating system to execute a read operation, in response to determining that the read operation is for reading target data from the storage device. | 01-19-2012 |
20120330904 | EFFICIENT FILE SYSTEM OBJECT-BASED DEDUPLICATION - In accordance with one or more embodiments, an inode implemented file system may be utilized to support both offline and inline deduplication. When the first content is stored in the storage medium, one inode is used to associate a filename with the data blocks where the first content is stored. When a second content that is a duplicate of the first content is to be stored, then a parent inode is created to point to the data blocks in which a copy of the first content is stored. Further, two inodes are created, one representing the first content and the other representing the second content. Both inodes point to the same parent inode that points to the data blocks where the first content is stored. | 12-27-2012 |
20140181950 | Performance Optimization in a Secured Computing Environment - Systems and methods for associating a first process with a first state and a first computing environment initialized according to a first set of parameters, wherein a first task is to be performed under a first security context. The method further comprising associating a second process with a second state and a second computing environment initialized according to a second set of parameters; in response to the first process submitting a first request, the second process spawning a third process which has the second state; wherein the third process sets a security context for the third process to the first security context and the third process sets the computing environment for the third process according to a first a set of parameters; executing the third process under the first security context and in association with the second state; and executing the first task in the first computing environment. | 06-26-2014 |
20150058301 | EFFICIENT DATA DEDUPLICATION IN A DATA STORAGE NETWORK - Machines, systems and methods of uploading data files, the method comprising a first client machine dividing a first file into N data chunks to be uploaded to a server, wherein the N data chunks are of size kX, where k is an integer and X is size of a minimal size data chunk, wherein X is known by the server and by at least a second client machine used for uploading a second file to the server in data chunks of size k′X; and uploading the first file to the server, wherein a first unique signature is calculated for the first file based on applying a signature function to a collection of signatures calculated for the minimal size data chunks of size X that make up the data chunks of size kX in the first file, wherein the uploading of the first file is accomplished by uploading the data chunks of size kX to the server in any order. | 02-26-2015 |
Eran Rom, Rehovot IL
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20090175866 | TREATMENT OF B-CELL MALIGNANCIES - The present invention generally relates to a pharmaceutical composition and to an improved method of preventing, attenuating and treating multiple myeloma by administering to an individual in need thereof at least one antibody to fibroblast growth factor receptor 3 (FGFR3). In particular, the at least one FGR3 antibody induces apoptosis of myeloma cells expressing wild type FGFR3. | 07-09-2009 |
20090202547 | ANTIBODIES THAT BLOCK RECEPTOR PROTEIN TYROSINE KINASE ACTIVATION, METHODS OF SCREENING FOR AND USES THEREOF - Molecules comprising the antigen-binding portion of antibodies that block constitutive and/or ligand-dependent activation of a receptor protein tyrosine kinase, such as fibroblast growth factor receptor 3 (FGFR3), are found through screening methods, where a soluble dimeric form of a receptor protein tyrosine kinase is used as target for screening a library of antibody fragments displayed on the surface of bacteriophage. The molecules of the present invention which block constitutive activation can be administered to treat or inhibit skeletal dysplasia, craniosynostosis disorders, cell proliferative diseases or disorders, or tumor progression associated with the constitutive activation of a receptor protein tyrosine kinase. | 08-13-2009 |
20100047251 | ANTIBODIES BLOCKING FIBROBLAST GROWTH FACTOR RECEPTOR ACTIVATION AND METHODS OF USE THEREOF - The present invention is related to antibodies with binding affinity to fibroblast growth factor receptor 2 (FGFR2) optionally with binding affinity to other FGF receptors, which block both ligand-dependent and constitutive ligand independent receptor activation. Specifically, the present invention relates to antibodies with high affinity to more than one FGF receptor subtype, and fragments thereof, useful in treating disorders including cell proliferative diseases. | 02-25-2010 |
20110053841 | N-TERMINAL FGF VARIANTS HAVING INCREASED RECEPTOR SELECTIVITY AND USES THEREOF - The present invention relates to the design, manufacture and use of fibroblast growth factor (FGF) polypeptides having improved receptor specificity. In particular, the invention relates to isolated FGF2 and FGF4 polypeptides that include a truncated N-terminus and optionally N-terminal amino acid substitutions. The present invention provides polypeptides, nucleic acids encoding the polypeptides, compositions of the same and methods for use thereof. | 03-03-2011 |
20130225493 | FGF-18 Truncated Variants Having Increased Receptor Specificity And Uses Thereof - The present invention relates to fibroblast growth factor 18 (FGF-18) variants having various truncations beyond the signal peptide domain of the N-terminus, which activate FGFR3 with increased specificity. The invention further relates to polynucleotides encoding the variants, pharmaceutical compositions comprising same and methods for use thereof in treating cartilage and skeletal disorders. | 08-29-2013 |
Hillel Rom, Beit Zait IL
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20100182325 | APPARATUS AND METHOD FOR EFFICIENT ANIMATION OF BELIEVABLE SPEAKING 3D CHARACTERS IN REAL TIME - An apparatus for animating a moving and speaking enhanced-believability, character in real time, comprising a plurality of behavior generators, each for defining a respective aspect of facial behavior, a unifying scripter, associated with the behavior generators, the scripter operable to combine the behaviors into a unified animation script, and a renderer, associated with the unifying scripter, the renderer operable to render the character in accordance with the script, thereby to enhance believability of the character. | 07-22-2010 |
Hillel S. Rom, Ben Zait IL
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20090054117 | INDEPENDENTLY-DEFINED ALTERATION OF OUTPUT FROM SOFTWARE EXECUTABLE USING LATER-INTEGRATED CODE - A first executable, such as a computer game, is configured with a second independently operating executable that monitors events on a client operating the first executable. The second executable determines actions to be performed in response to monitored events, as defined by a business logic table. The second executable traps API calls to perform actions altering apparent output of the first executable. The business logic table may be distributed to the client separately. The second executable and the first executable may be combined in a single file. The second executable may be used to provide additional content, including advertising, in the context of an existing game or other software executable. | 02-26-2009 |
20090054140 | INDEPENDENTLY-DEFINED ALTERATION OF OUTPUT FROM SOFTWARE EXECUTABLE USING DISTRIBUTED ALTERATION ENGINE - A first executable, such as a computer game, operates co-extensively with a second independently operating executable that monitors events on a client operating the first executable. The second executable determines actions to be performed in response to monitored events, as defined by a business logic table. The second executable traps API calls to perform actions altering apparent output of the first executable. The business logic table may be distributed to the client separately. The second executable and the first executable may be configured to execute during the same times on the client node. The second executable may be used to provide additional content, including advertising, in the context of an existing game or other software executable. | 02-26-2009 |
Hillel S. Rom, Beit Zait IL
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20090025024 | AUDIENCE DETERMINATION FOR MONETIZING DISPLAYABLE CONTENT - The present disclosure relates to the measurement of the audience characteristics or demographics which is or can be exposed to displayed interactive content depicted on a screen. The audience can include persons who are engaged in interacting with the interactive content as well as persons who are observers of the interactive content and/or the active participants. The content can include one or more targeted advertisements contained in or associated with interactive content, and can be varied based on the audience characteristics or demographics. The audience characteristics or demographics can be used to accurately charge advertisers for the impressions created by the content displayed and can also or alternatively be used to determine and/or trigger what content is actually displayed. | 01-22-2009 |
20110093877 | AUDIENCE DETERMINATION FOR MONETIZING DISPLAYABLE CONTENT - The present disclosure relates to the measurement of the audience characteristics or demographics which is or can be exposed to displayed interactive content depicted on a screen. The audience can include persons who are engaged in interacting with the interactive content as well as persons who are observers of the interactive content and/or the active participants. The content can include one or more targeted advertisements contained in or associated with interactive content, and can be varied based on the audience characteristics or demographics. The audience characteristics or demographics can be used to accurately charge advertisers for the impressions created by the content displayed and can also or alternatively be used to determine and/or trigger what content is actually displayed. | 04-21-2011 |
Israel Rom, Reut IL
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20090306892 | OPTICAL DISTANCE VIEWING DEVICE HAVING POSITIONING AND/OR MAP DISPLAY FACILITIES - An optical distance viewing device has position and/or map display facilities that can be shown simultaneously with the optical view. The device includes a remote view acquisition module for acquiring a remote view; a location module for acquiring a location; a map module for generating a map in accordance with the acquired location; and an output module for outputting an image which shows the optical view together with the map, or current location co-ordinates or both. An enhancement projects the view onto a 3D map. | 12-10-2009 |
Li-Raz Rom, Netanya IL
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20130212440 | SYSTEM AND METHOD FOR VIRTUAL SYSTEM MANAGEMENT - A system and method for virtual system management. A set of data received from a plurality of data sensors may be analyzed, each sensor monitoring performance at a different system component. Sub-optimal performance may be identified associated with at least one component based on data analyzed for that component's sensor. A cause of the sub-optimal performance may be determined using predefined relationships between different value combinations including scores for the set of received data and a plurality of causes. An indication of the determined cause may be sent, for example, to a management unit. A solution to improve the sub-optimal performance may be determined using predefined relationships between the plurality of causes of problems and a plurality of solutions to correct the problems. | 08-15-2013 |
Rami Rom, Zichron Yaakov IL
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20090292334 | OPTIMIZING AND MONITORING ADAPTIVE CARDIAC RESYNCHRONIZATION THERAPY DEVICES - A system for remotely monitoring cardiac resynchronization therapy (CRT) devices and for optimizing location of implanted leads. The system displays a graph of the right ventricle pacing interval (PRV) vs. left ventricle pacing interval (PLV) diagram at maximal stroke volume and or a graph of a responder curve that demonstrates the stroke volume obtained beat after beat by the implanted hemodynamic sensor with dynamically optimized AV and VV parameters. The system lends itself easily to be used as a remote monitoring means for active and resting patients. | 11-26-2009 |
20120071943 | SYSTEM AND METHOD FOR THE VISUALIZATION AND OPTIMIZATION OF CARDIAC RESYNCHRONIZATION THERAPY - A system and method for optimizing cardiac resynchronization therapy and visualizing cardiac pacing intervals. The system comprises at least one hemodynamic sensor; at least one electrode; a learning module; a micro controller; and at least one graphical interface for showing at least one of a PRV vs. PLV diagram and a responder curve. | 03-22-2012 |
Rami Rom, Zichron Yaacov IL
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20110213435 | OPTIMAL CARDIAC PACING WITH Q LEARNING - A cardiac pacemaker control system constituted of: a means for receiving input from a hemodynamic sensor; an adaptive control system in communication with the means for receiving input from the hemodynamic sensor; and an interface arranged to provide cardiac stimulation responsive to the adaptive control system; the adaptive control system comprising a learning module operative to converge to patient specific cardiac pacing stimulation timing using a machine learning scheme in cooperation with a probabilistic replacement scheme, the probabilistic replacement scheme arranged to replace inputs from the hemodynamic sensor with online calculated values. | 09-01-2011 |
20120016435 | OPTIMAL DEEP BRAIN STIMULATION THERAPY WITH Q LEARNING - A closed loop Deep Brain Stimulation (DBS) system constituted of: a physiological sensor; a multi-electrode DBS lead; an adaptive control system in communication with the physiological sensor; and an implantable pulse generator (IPG) responsive to the adaptive control system, the adaptive control system comprising a learning module operable to learn to find the optimal stimulation parameters, classify and associate patient conditions responsive to the physiological sensor with optimal stimulation parameters in a plurality of patient conditions. The adaptive DBS device control system learns to deliver the optimal stimulation parameters based on Watkins and Dayan Q learning recursive formula, the closed loop adaptive DBS control system thus finds the optimal stimulation parameters online. | 01-19-2012 |
Rami Rom, Zikhron Ya'Akov IL
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20130123869 | VENTRICLE PACING DURING ATRIAL FIBRILLATION EPISODES - An adaptive dual chamber pacemaker and/or cardioverter defibrillator for delivering ventricular stimulation to the heart correlated with hemodynamic performance of the heart, including a hemodynamic sensor for monitoring the hemodynamic performance of the heart, an atrial electrode and a ventricular electrode for sensing ventricular and atrial signals, and a learning module having a spiking neural network processor for learning to associate the ventricular-atrial intervals sensed by the electrodes with the hemodynamic performance sensed by the hemodynamic sensor, calculating ventricular-atrial intervals, replacing the ventricular-atrial intervals calculated from the sensed ventricular and atrial signals with the learned associated ventricular-atrial intervals, and causing delivery according to the learned associated ventricular-atrial intervals of a ventricular stimulation to the heart during atrial fibrillation episodes. | 05-16-2013 |
Rami Rom, Pardes Hanna IL
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20130131528 | METHOD OF DETECTING AND CLASSIFYING ARRHYTHMIAS - A method of detecting and classifying cardiac arrhythmias, comprising: receiving a hemodynamic wave signal from at least one hemodynamic sensor by a processor; receiving a cardiac electrical wave signal from a cardiac stimulation device by the processor; integrating, by the processor, the received hemodynamic wave signal and the received cardiac electrical wave signal; determining if a heart arrhythmia is present via examination of the regularity of the hemodynamic signal; and if a heart arrhythmia is determined, classifying the arrhythmia according to a time correlation between the hemodynamic signal and the electrical signal. | 05-23-2013 |
Rami Rom, Or-Akiva IL
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20100145402 | INTELLIGENT CONTROL SYSTEM FOR ADAPTIVE CARDIAC RESYNCHRONIZATION THERAPY DEVICE - An adaptive CRT control system that achieves optimal AV delay and VV pacing intervals associated with temporal patterns of stroke volumes that represent internally the heart conditions is disclosed. The adaptive CRT control system includes: (a) at least two implanted electrodes in patient heart and at least additional one hemodynamic sensor able to indicate the stroke volume heartbeat after heartbeat; (b) an input pre processing stage synchronizer priority classifier that synchronize on the sensed atrial event, classify heart conditions and associate the learned optimal pacing intervals according to prioritized operational modes and learning schemes; (c) a learning module that with the input stage synchronizer priority classifier processes the inputs of the implanted electrodes and hemodynamic sensor and using a reinforcement learning scheme learns to achieve and to associate optimal pacing intervals at each heart condition with temporal patterns of stroke volumes; (d) an algorithmic micro-controller module that supervises the learning module and control a pulse generator module, and (f) a pulse generator that delivers therapeutic stimulation to the patient heart. | 06-10-2010 |
20100185250 | VENTRICLE PACING DURING ATRIAL FIBRILLATION EPISODES - An adaptive cardiac resynchronization therapy system delivers biventricular stimulation to the heart with dynamic AV delay and VV interval. The stimulation is modified continuously in correlation with the hemodynamic performance of the heart. The system uses a spiking neural network comprising spike controller ( | 07-22-2010 |
20100198285 | CARDIAC STIMULATION WITH HEMODYNAMIC SENSOR GUARD - A method and system for regulating the operation of a cardiac pacemaker or defibrillator are disclosed. A processor receives signals of both an implanted hemodynamic sensor and intracardiac electrograms and digitizes them. The digitized signal of the hemodynamic sensor is used to prevent inappropriate cardiac stimulation and erroneous cardiac detection. The hemodynamic signal is also used to define arrhythmias. | 08-05-2010 |