Rogoff
Gerald L. Rogoff, Framingham, MA US
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20100033813 | 3-D Display Requiring No Special Eyewear - A display system enables viewing a stereo pair of images without any special eyewear. In one embodiment an array of micro-lens elements are mounted in front of a pixel-based image display. Lens elements in the micro-lens array can have differing fixed optical properties and in one embodiment the micro-lens array can have differing focal lengths to provide flexibility as to the location of a viewer, reduced optical distortion, and more comfortable viewing due to balanced horizontal and vertical resolution. | 02-11-2010 |
Harry Rogoff, Wrentham, MA US
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20100286378 | Composition of Asymmetric RNA Duplex As MicroRNA Mimetic or Inhibitor - The present invention provides double-stranded RNA molecules that are asymmetrical in strand length. The RNA molecule of the invention, the asymmetric RNA duplex, has one or two overhangs at the end. In one aspect, these novel RNA duplex molecules serve as effective mimetics of miRNA. In another aspect, they are designed to function as effective inhibitors of miRNA. Accordingly, the RNA molecules of the present invention can be used to modulate miRNA pathway activities, with tremendous implications for research, drug discovery and development, and treatment of human diseases. | 11-11-2010 |
20120252763 | NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS - The present invention relates to the use of a novel class of cancer stem cell pathway (CSCP) inhibitors; to methods of using such compounds to treat refractory, recurrent, or metastatic cancers; to methods of selective killing cancer cells by using such compounds with specific administration regimen; to methods of targeting cancer stem cells by inhibiting Stat3 pathway; to methods of using novel compounds in the treatment of conditions or disorders in a mammal related to aberrant Stat3 pathway activity; and to processes for preparing such compounds and intermediates thereof, and to the pharmaceutical composition of relevant compounds, and to the specific methods of administration of these compounds. | 10-04-2012 |
20120321622 | Compositions of Kinase Inhibitors and Their Use for Treatment of Cancer and Other Diseases Related to Kinases - The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof. | 12-20-2012 |
20140275033 | INHIBITORS OF KINASES AND CANCER STEM CELLS, AND METHODS OF PREPARATION AND USE THEREOF - The invention provides novel inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, and methods of making such compounds and compositions. | 09-18-2014 |
Harry Rogoff, Norwood, MA US
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20090208564 | Compositions of asymmetric interfering RNA and uses thereof - The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5′-overhang, 3′-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics. | 08-20-2009 |
Harry Rogoff, Worcester, MA US
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20100285006 | Compositions of Kinase Inhibitors and Their Use for Treatment of Cancer and Other Diseases Related to Kinases - The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof. | 11-11-2010 |
Martin R. Rogoff, Houston, TX US
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20130007306 | DATA STORAGE METHODS AND DATA STORAGE SYSTEMS - Data storage methods and data storage systems are disclosed. An example method includes detecting a presence of a target device on a port; collecting detailed drive information associated with the target device; and preventing an initiator device from creating an affiliation with the target device until the drive information is collected. | 01-03-2013 |
20140018972 | ENCLOSURE TEMPERATURE SCRIPT INTERPRETER - In an enclosure to house computing components, the enclosure includes a temperature control processor, and temperature control script interpreter logic. The temperature control script interpreter logic causes the processor to maintain the interior temperature of the enclosure in accordance with the temperature control script. | 01-16-2014 |
Scott Rogoff, Fullerton, CA US
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20140187388 | ANKLE STRENGTHENING EXERCISE DEVICE - An ankle strengthening exercise device is disclosed. The device is intuitive and simple to use by a patient even without professional medical supervision since the device indicates a specific movement of a foot by pivoting an ankle of the patient. In particular, the device may have an extension member that can be positioned on a frame of the device. The foot of the patient may engage the device. An elastic member may be secured to the extension member and the foot. The direction of the elastic member indicates the direction the foot of the patient should move by pivoting his or her ankle to specifically work or strengthen and exercise a particular ankle muscle of the patient. | 07-03-2014 |
Stephen Rogoff, Glendale, AZ US
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20120268852 | SYSTEMS AND METHODS FOR TESTABLE CURRENT LIMITING WITH HICCUP RESET - Testable current limiting with hiccup reset is provided. In one embodiment, a current limiter comprises: a current regulating circuit having a pass-transistor wherein a load current delivered to a load side flows through the pass-transistor, the current regulating circuit clamps the load current when the load current exceeds a threshold; a latch regulating circuit coupled to the current regulating circuit, and further coupled to a line side through a semiconductor having a turn-on voltage threshold higher than the pass-transistor; and a current limit test circuit configured to apply a reference impedance to the load side output. The latch regulating circuit compares a voltage from the current regulating circuit to a voltage measured at the semiconductor to determine when the load current exceeds the threshold. When the load current exceeds the threshold for a period of time exceeding a predetermined duration, the latch regulating circuit temporarily shuts off the pass-transistor. | 10-25-2012 |
Stephen Forrest Rogoff, Glendale, AZ US
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20140100816 | FILTER ACTIVATION AND DEACTIVATION BASED ON COMPARATIVE RATES - A system includes a plurality of sensors measuring a physical parameter; a processing unit communicatively coupled to the plurality of sensors and configured to receive sensor data from each of the plurality of sensors; wherein the processing unit is further configured to compare rates of change between sensor data for each individual sensor of the plurality of sensors and each of the other individual sensors of the plurality of sensors; wherein the processing unit is further configured to perform a first action when the rate of change of each of the plurality of sensors is within a first threshold of all of the other plurality of sensors; and wherein the processing unit is further configured to perform a second action when the rate of change of at least one of the plurality of sensors is not within the first threshold of at least another of the plurality of sensors. | 04-10-2014 |
20140215278 | SYSTEM AND METHOD FOR THREE INPUT VOTING - An embodiment described herein includes a method for input channel voting. The method includes steps for sorting the three input values by magnitude into a high input value, a middle input value, and a low input value. The three input values are then tested. The testing includes subtracting the middle input value form the high input value to calculate a first difference, and comparing an absolute value of the first difference to a failure threshold. A first intermediate value is determined based on the comparison of the first difference to the failure threshold. The testing also includes subtracting the middle input value from the low input value to calculate a second difference, and comparing the second difference to the failure threshold. A second intermediate value is determined based on this comparison. The first intermediate value and second intermediate value are averaged to produce an output based on the three input values. | 07-31-2014 |