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20120071652 | Novel Piperazines, Pharmaceutical Compositions and Methods of Use Thereof - Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds. | 03-22-2012 |
20120108569 | 8-AZA Tetracycline Compounds - The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use. | 05-03-2012 |
20120115819 | Pentacycline Compounds - The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use. | 05-10-2012 |
20120135968 | Tetracycline Compounds - The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use. | 05-31-2012 |
20120302527 | C7-Fluoro Substituted Tetracycline Compounds - The present invention is directed to a compound represented by Structural Formula (A): | 11-29-2012 |
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20130345178 | 8-AZA Tetracycline Compounds - The present invention is directed to a compound represented by Structural Formula (I): | 12-26-2013 |
20140343059 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF - Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds. | 11-20-2014 |