Patent application number | Description | Published |
20100248237 | MINIATURIZED, HIGH-THROUGHPUT NUCLEIC ACID ANALYSIS - The present invention is directed to method for analyzing multiple nucleic acid molecules of interest comprising in the steps of (i) providing a plurality of beads, characterized in that each bead comprises at least two sequence specific amplification primers, further characterized in that at least one of the primers is bound to the bead via a cleavable linker, (ii) capturing the nucleic acid molecules of interest from a sample, (iii) clonally isolating the plurality of beads, (iv) cleaving the at least one primer, (v) clonally amplifying the nucleic acid thereby creating multiple amplification products, and (vi) analyzing the amplification products. | 09-30-2010 |
20100248991 | SOLID SUPPORT FOR HIGH-THROUGHPUT NUCLEIC ACID ANALYSIS - The present invention provides a solid support which is preferably a bead comprising at least two sequence specific amplification primers wherein at least one primer is bound to the support with an inducible cleavable linker. The present invention also provides various method for preparing a solid support comprising at least two sequence specific primers, further characterized in that at least one of the primers is cleavable. | 09-30-2010 |
20110177514 | INTEGRATED INSTRUMENT PERFORMING SYNTHESIS AND AMPLIFICATION, AND A SYSTEM AND METHOD THEREOF - An integrated instrument for oligonucleotide synthesis and PCR, and a system and method thereof are disclosed. The integrated instrument is basically composed of two independent modules. The first module is a unit for chemical de novo synthesis of oligonucleotides such as oligonucleotide primers and/or oligonucleotide hybridization probes. The second module is a unit for performing an analytical polymerase chain reaction amplification in real time, i.e. a qPCR. The two modules are operatively linked to each other in such a way that a user can load a nucleic sample to be analyzed into the integrated instrument and perform a PCR reaction by programming the instrument without a previous external synthesis of oligonucleotide amplification primers. | 07-21-2011 |
20110212861 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS - The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner. | 09-01-2011 |
20130190191 | MINIATURIZED, HIGH-THROUGHPUT NUCLEIC ACID ANALYSIS - The present invention is directed to method for analyzing multiple nucleic acid molecules of interest comprising in the steps of (i) providing a plurality of beads, characterized in that each bead comprises at least two sequence specific amplification primers, further characterized in that at least one of the primers is bound to the bead via a cleavable linker, (ii) capturing the nucleic acid molecules of interest from a sample, (iii) clonally isolating the plurality of beads, (iv) cleaving the at least one primer, (v) clonally amplifying the nucleic acid thereby creating multiple amplification products, and (vi) analyzing the amplification products. | 07-25-2013 |
20140017682 | HIGH RESOLUTION MELTING ANALYSIS AS A PRESCREENING TOOL - Compositions and methods for determining an increased likelihood of a response to a targeted treatment of a cancer disease including isolating genomic DNA from a patient sample, amplifying a fragment of DNA by means of PCR with a specific pair of amplification primers, determining if the amplified fragment comprises a wildtype sequence or a mutation by means of a High Resolution Melting Analysis (HRM), and correlating the presence or absence of a mutation with an increased likelihood of success of said targeted treatment. Respective primer pairs, compositions and kits are also claimed. | 01-16-2014 |
20140045719 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS - The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner. | 02-13-2014 |
20150152510 | HIGH RESOLUTION MELTING ANALYSIS AS A PRESCREENING TOOL - Compositions and methods for determining an increased likelihood of a response to a targeted treatment of a cancer disease including isolating genomic DNA from a patient sample, amplifying a fragment of DNA by means of PCR with a specific pair of amplification primers, determining if the amplified fragment comprises a wildtype sequence or a mutation by means of a High Resolution Melting Analysis (HRM), and correlating the presence or absence of a mutation with an increased likelihood of success of said targeted treatment. Respective primer pairs, compositions and kits are also claimed. | 06-04-2015 |
20160083804 | HIGH RESOLUTION MELTING ANALYSIS AS A PRESCREENING TOOL - Compositions and methods for determining an increased likelihood of a response to a targeted treatment of a cancer disease including isolating genomic DNA from a patient sample, amplifying a fragment of DNA by means of PCR with a specific pair of amplification primers, determining if the amplified fragment comprises a wildtype sequence or a mutation by means of a High Resolution Melting Analysis (HRM), and correlating the presence or absence of a mutation with an increased likelihood of success of said targeted treatment. Respective primer pairs, compositions and kits are also claimed. | 03-24-2016 |
Patent application number | Description | Published |
20080284246 | Multi-Voltage Vehicle Electrical Supply System for a Motor Vehicle and Method for Operating the Same - A multi-voltage vehicle electrical system for a motor vehicle is provided, including at least one multi-voltage generator, a first energy store, whose energy may be fed into a first low-voltage vehicle electrical system branch having low-voltage consumers, and a second energy store, whose energy may be fed into a second high-voltage vehicle electrical system branch having high-voltage consumers, as well as at least one controllable switching device, using which the energy generated by the multi-voltage generator may be distributed to the first and the second vehicle electrical system branches, the first and the second energy stores being connected in series to one another and the first vehicle electrical system branch being connected to a node between the first and the second energy store and to a reference potential of the first energy store. | 11-20-2008 |
20090273236 | System and Method for Supplying Voltage to Electrical Loads of a Motor Vehicle by Using a Supercap - A system and method for supplying voltage to electrical loads in the onboard electrical system of a motor vehicle are provided. The onboard electrical system consists of at least two onboard electrical system regions. The first onboard electrical system region has an electric generator, a vehicle battery, as well as one or more first electrical loads. The second onboard electrical system region has a double-layer capacitor or a so-called supercap and one or more second electrical loads. Between the two onboard electrical system regions, a blocking device is provided, in particular, a semiconductor diode or a power switch, which permits a current flow from the first onboard electrical system region into the second electrical system region and largely prevents a reverse current flow from the second onboard electrical system region into the first onboard electrical system region. The output voltage of the electric generator is raised and the supercap is charged when a first threshold value of the electric voltage in the second onboard electrical system region is undershot. | 11-05-2009 |
Patent application number | Description | Published |
20080210133 | System of Interference Pigments - The present invention provides a system of N≧3 interference pigments, which is distinguished in that it exhibits a maximum colour gamut through specification of the optimum pigment hue angle h | 09-04-2008 |
20130118380 | SYSTEM OF INTERFERENCE PIGMENTS - A system of N≧3 interference pigments, which is distinguished in that it exhibits a maximum color gamut through specification of the optimum pigment hue angle h | 05-16-2013 |
20130164356 | EFFECT PIGMENTS - The present invention relates to effect pigments which are based on flake-form substrates having a circular form factor of 1.2-2 and are coated with at least one high-refractive-index layer, and to the use thereof, inter alia in paints, coatings, printing inks, plastics and in cosmetic formulations. | 06-27-2013 |
20160068683 | EFFECT PIGMENTS - The present invention relates to effect pigments which are based on flake-form substrates having a circular form factor of 1.2-2 and are coated with at least one high-refractive-index layer, and to the use thereof, inter alia in paints, coatings, printing inks, plastics and in cosmetic formulations. | 03-10-2016 |
Patent application number | Description | Published |
20110271426 | Industrial Impact Protection Helmet - The impact protection cap manufactured from a bendable synthetic material comprises at least one middle shell ( | 11-10-2011 |
20130062234 | PACKAGING CONTAINER OF VARIABLE LENGTH - A packaging container ( | 03-14-2013 |
20130068645 | PACKAGING CASE WITH CLAMP-TYPE HOLDER FOR OBLONG OBJECTS - A packaging case ( | 03-21-2013 |
20140014653 | STACKABLE PACKING BOX - A packing box ( | 01-16-2014 |
20140021086 | PACKAGING BOX WITH A MULTITUDE OF INDIVIDUAL BOXES - Packaging system ( | 01-23-2014 |
20140251845 | Methods of Packaging and Packaging for Sharp-Edged Tools - Packaging and methods for packaging tools having a sharp or cutting edge, such as surgical tools, in which the tool is packaged under sterile conditions. The tool may be packaged first—at least partially—and in particular with its sensitive cutting edges and working surfaces packaged in a protective package. The protective package containing at least the cutting or working surfaces of the tool may then be secured in a fixed position in an outer blister pack, which may be sealed with a sealing film. | 09-11-2014 |
20140251846 | Package for Elongated Sharp-Edged Tools - Package for elongated sharp-edged objects, in particular for tools useful for surgical applications, which are secured in a fixed position in a package consisting at least partially of plastic, wherein the package comprises an a first enlarged package part which defines an interior into which the object that is to be protected and secured protrudes with its sharp edges in a noncontact manner and a second package part in which the shaft of the object is accommodated and held in a fixed position by holding elements. | 09-11-2014 |
20140305829 | ORGANIZING SYSTEM WITH PACKING BOXES - An organizing system with packing boxes formulated as containers, each packing box having a floor wall and one or more legs attached thereto which are adapted to interlock with retainers on a catch plate. The retainers may have undercuts which may match a convex outward orientation of the legs. Further, the retainers and the legs may be elastically flexible so that engagement of the two may be through elastic deformation to form a strong but releasable latching engagement. | 10-16-2014 |
20150076140 | PACKAGING CONTAINER WITH A BAYONET TWIST CLOSURE AND FREE RUNNING - A packaging container for elongated objects that includes an outer sleeve ( | 03-19-2015 |
20150076149 | PACKAGING SLEEVE WITH LATCHING CAP - A packaging sleeve ( | 03-19-2015 |
20150101721 | FLEXIBLE SAFETY CAP FOR ACCOMMODATING SHAFTS OF DIFFERENT DIAMETERS - A flexible safety cap ( | 04-16-2015 |
Patent application number | Description | Published |
20080252396 | Electroacoustic Component - A component working with guided bulk acoustic waves includes a first substrate, a second substrate, and a layer system between the first and second substrates. The layer system includes a metal layer and a dielectric layer. A ratio of the acoustic impedance of the metal layer to the acoustic impedance of the dielectric layer is greater than or equal to 4.5. | 10-16-2008 |
20080266024 | Component Operated by Guided Acoustic Waves - A component working with guided acoustic waves includes a layer system configured to guide waves in a lateral plane. The layer system includes a piezoelectric layer, electrodes on the piezoelectric layer for exciting the wave, a dielectric layer with an acoustic impedance, and an adjustment layer with an acoustic impedance. A ratio of the acoustic impedance of the adjustment layer to the acoustic impedance of the dielectric layer is greater than 1.5. | 10-30-2008 |
20080292127 | Electroacoustic Component - An electroacoustic component includes a carrier substrate and a piezosubstrate having piezoelectric properties. The electroacoustic component also includes a layer system between the carrier substrate and the piezosubstrate. | 11-27-2008 |
20090108961 | Electroacoustic Component - An electroacoustic component operates with guided acoustic waves and includes a first substrate, a second substrate, a metallic layer and an intermediate layer. The first substrate (S | 04-30-2009 |
20100109485 | ELECTROACOUSTIC COMPONENT - An electroacoustic component includes a substrate that includes a quartz single crystal. The quartz single crystal has a first Euler angle λ: −5°≦λ≦5°, a second Euler angle μ, and a third Euler angle θ. A contiguous region of the quartz single crystal has the following vertices P | 05-06-2010 |
20100225201 | Electroacoustic Component - An electroacoustic component that includes a substrate made of monocrystalline LiNbO | 09-09-2010 |
20100231330 | Component Working with Guided Bulk Acoustic Waves - A component working with guided bulk acoustic waves is disclosed with at least one substrate and a layer system that is connected to this substrate and suitable for wave propagation. The layer system includes a metallization layer, a first dielectric layer, and a second dielectric layer. The velocity of the acoustic wave is greater in the second dielectric layer than in the first dielectric layer. At least one of the dielectric layers contains TeO | 09-16-2010 |