Robl, US
James Robl, Belchertown, MA US
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20120076761 | Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including Parkinson's disease - Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease. | 03-29-2012 |
James Robl, Brandon, SD US
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20090092588 | Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease - Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease. | 04-09-2009 |
James M. Robl, Brandon, SD US
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20090165154 | Transgenic ungulates having reduced prion protein activity and uses thereof - The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and a safer source of agricultural products. | 06-25-2009 |
20090222935 | Transgenic animals and uses thereof - In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein. | 09-03-2009 |
20090276866 | Production of ungulates, preferably bovines that produce human immunoglobulins - The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and/or rag-2 eliminated from their genome are unable to conduct the gene rearrangements that are necessary to generate the antigen receptors of B- or T-lymphocytes, and therefore will not develop native B- or T-cells. Because they are unable to produce B- and T-lymphocytes, these IgM, rag-1, or rag-2 ungulates cannot reject human hematopoietic stem cell preparations, and B- and T-lymphocytes which develop therefrom. Therefore, the present invention also involves injecting into IgM, rag-1, and/or rag-2 deficient ungulates, in utero or shortly after birth, human B- and T-lymphocytes whose immune systems produce human immunoglobulin that can be processed for therapeutic uses in humans. | 11-05-2009 |
20110067122 | Expression of Xenogenous (Human) Immunoglobulins in cloned, transgenic ungulates - The present invention relates to the production of a transgenic ungulate which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies. | 03-17-2011 |
20110231943 | TRANSGENIC ANIMALS AND USES THEREOF - In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein. | 09-22-2011 |
James M. Robl, Canton, SD US
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20100291576 | IMPRINTED GENES AS EPIGENETIC MARKERS FOR USE IN CLONING AND REGENERATIVE CELL PROCEDURES - In general, the invention features methods of identifying and/or preparing a mammalian cell or a cell population (e.g., bovine or porcine cells) for use in cloning procedures or regenerative cell procedures using expression of one or more of the epigenetic markers, IGF2, p57, and NNAT. | 11-18-2010 |
James M. Robl, Belchertown, MA US
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20110287429 | USE OF HAPLOID GENOMES FOR GENETIC DIAGNOSIS, MODIFICATION AND MULTIPLICATION - Methods for propagating haploid genomes of male or female origina and genetic screening and modification thereof are provided. These haploid genomes may be used to produce haploid embryos, and embryonic stem-like cells and differentiated cells. Also, these haploid genomes and cells containing, may be used as nuclear transfer donors to produce diploid nuclear transfer units. These diploid NT units e.g., human NT units, may be used to obtain pluripotent cells and differentiated cells and tissues. | 11-24-2011 |
20130309206 | GYNOGENETIC OR ANDROGENETIC PRODUCTION OF PLURIPOTENT CELLS AND CELL LINES, AND USE THEREOF TO PRODUCE DIFFERENTIATED CELLS AND TISSUES - Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs. | 11-21-2013 |
James M. Robl, Sioux Falls, SD US
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20110293580 | GYNOGENETIC OR ANDROGENETIC PRODUCTION OF PLURIPOTENT CELLS AND CELL LINES, AND USE THEREOF TO PRODUCE DIFFERENTIATED CELLS AND TISSUES - Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs. | 12-01-2011 |
Ryan Robl, Ellinwood, KS US
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20150131275 | Decorative Lighting Assembly - A decorative lighting assembly incorporating at least a first rectangular sheet having upper and lower edges and having lateral edges; a plurality of fold scores impressed into the at least first rectangular sheet, the fold scores defining a laterally extending series of adjacent lantern wall faces; an adhesive pad fixedly attached to one of the edges among the pair of lateral edges, the adhesive pad being positioned for, upon folding of the at least first rectangular sheet creating angles between the lantern wall faces totaling 360°, holding the at least first rectangular sheet at an interior space defining configuration; perforate image indicia formed from at least a first aperture, the perforate image indicia, upon the holding of the at least first rectangular sheet at the interior space defining configuration, opening the interior space for light emission; and a first illuminator fitted for receipt within the interior space. | 05-14-2015 |
Thomas Robl, Sadieville, KY US
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20140311386 | HYBRID CEMENT CLINKER AND CEMENT MADE FROM THAT CLINKER - A hybrid cement clinker incorporates specific ranges of clinker phases and falls within specific modulus values as set forth and described in this document. | 10-23-2014 |
Thomas L. Robl, Sadieville, KY US
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20100056356 | METHODOLOGY AND TECHNOLOGY FOR THE PRODUCTION OF IMPROVED COAL DERIVED FLY ASH FOR THE PRODUCTION OF METAL MATRIX COMPOSITES - A method for preparing a metal-fly ash composite material includes classifying a fly ash-containing material to provide a classified fly ash material having a mean particle size of from about 4 μm to about 40 μm. The classified fly ash material is blended with a metal matrix whereby the fly ash material and the metal matrix form a substantially homogenous mixture. Suitable conditions of temperature and/or pressure are applied to form a metal-fly ash composite material is formed. The metal matrix may be provided as a liquid or as a powder. | 03-04-2010 |
20120145044 | CEMENTITIOUS COMPOSITIONS - The invention provides a cementitious composition comprising a cement component comprising (i) an accelerant, (ii) a calcium sulphate source and (iii) an ettringite forming cement; an aggregate; and optionally water; wherein the cement has a minimum unconfined compressive strength of 1500 psi when tested in accordance with ASTM C1140 and/or C1604 at 15 minutes after placement; methods for its use and concrete formed from it. | 06-14-2012 |
Thomas Lee Robl, Sadieville, KY US
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20150299560 | PROPPANT FOR USE IN HYDRAULIC FRACTURING TO STIMULATE A WELL - A proppant for use in hydraulic fracturing to stimulate a well is provided. The proppant is fly ash particles having a mean particle size (d50) of between 45 μm and 150 μm and a size distribution defined by (d10)≦5 μm and (d98)≦250 μm. | 10-22-2015 |
Troy Robl, St. George, KS US
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20140331663 | Quick Coupler Hydraulic Control System - A hydraulic system for an implement coupler assembly of a machine includes a coupler cylinder, a control valve connecting the coupler cylinder to a pressurized fluid source and a low pressure reservoir, and a sequence valve and a check valve connected in parallel between the coupler cylinder and the control valve. An implement cylinder provides a pilot pressure for the sequence valve. The coupler cylinder extends to a locked position when the control valve provides pressurized fluid through the check valve to a head end of the coupler cylinder. The coupler cylinder retracts to an unlocked position when the control valve provides pressurized fluid to a rod end of the coupler cylinder if the implement cylinder provides pilot pressure sufficient to open the sequence valve and connect the head end of the coupler cylinder to the low pressure reservoir. | 11-13-2014 |
Troy C. Robl, St. George, KS US
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20140294497 | LOCKING SYSTEM FOR QUICK COUPLER - A quick coupler for holding an implement is disclosed. The quick coupler includes a frame having a first plate and a second plate. The quick coupler includes a locking system adapted to lock the implement in the first plate and the second plate. The locking system includes a securing latch member and a hydraulic actuator is operatively connected to the securing latch member. The securing latch member is configured to move along a guide provided in each of the first plate and the second plate. The locking system further includes a set of grooves provided on at least one of the securing latch member and the guide. The set of grooves are adapted to lock the securing latch member in a latched position. | 10-02-2014 |
Troy C. Robl, Manhattan, KS US
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20090111549 | Combine harvester residue chopper active counter knife assembly - An active counter knife assembly for a material chopper assembly or construction that has a rotary chopper element disposed across a material flow path, including a chopper grate assembly, having a grate portion with spaced generally transverse slots therealong, positionable generally parallel to the rotary chopper element of the residue chopper assembly; a rotatable shaft positionable generally beneath and parallel to the grate portion of the chopper grate assembly, with a plurality of fixed or flail-type knife elements attached to such shaft and positioned thereon to be alignably rotatable through the spaced generally transverse slots of the grate portion of the chopper grate assembly; and a drive mechanism for effecting rotational movement of the counter knife assembly, which drive mechanism is preferably controllable to allow an operator to vary the rotational speed and direction of the rotatable shaft so that the rotatable shaft may be selectably either maintained in an essentially fixed or locked condition or operated to rotate either counter to the rotation of the rotary chopper element of the chopper assembly or in the same tangential direction as the rotary chopper element, thereby controlling to some extent both the throughput speed of the material at the chopper assembly and the quality of the chop by the chopper assembly. | 04-30-2009 |
20130322954 | QUICK COUPLER - A quick coupler for connecting an implement to an arm of a machine. The quick coupler includes a frame having a first plate and a second plate. A first and a second pair of recesses provided on the first and the second plates at a first end and a second end of the frame, respectively. A cover plate disposed between the first and the second plates and one or more lubrication lines having fittings attached to terminal ends of the lubrication lines. An external lubrication bank provided on at least one of the first or the second plate to support the fittings. | 12-05-2013 |
Troy Curtis Robl, Manhattan, KS US
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20090007465 | QUICK COUPLER ASSEMBLY - A quick coupler for connecting and disconnecting an implement such as a bucket to and from a machine such as an excavator. In an example, the quick coupler includes a frame having recesses configured to receive pins located on the implement. The quick coupler includes first and second securing latches that are movable between latched and unlatched positions for removably latching the pins of the implement in the recesses. A rocker assembly and a connector link are provided for moving the second latch between latched and unlatched positions. | 01-08-2009 |
20110209608 | TOOL COUPLER ASSEMBLY - A tool coupler assembly for a machine is disclosed. The tool coupler assembly may have a coupler frame, a first latch, a second latch, and a hydraulic actuator connected to move the second latch relative to the first latch and the coupler frame. The hydraulic actuator may have a first chamber, a second chamber, and a pressure valve with a check element movable to allow a flow of fluid into the first chamber based on a pressure of fluid in the first chamber, and a pressure regulating element movable to allow a flow of fluid out of the first chamber based on a pressure of fluid in the second chamber. The tool coupler assembly may additionally have a first pilot passage configured to communicate fluid from the second chamber with the pressure-regulating element, and a second pilot passage configured to communicate fluid from the first chamber with the pressure-regulating element. | 09-01-2011 |
20130008153 | TOOL COUPLER ASSEMBLY - A tool coupler assembly for a machine is disclosed. The tool coupler assembly may have a coupler frame, a first latch, a second latch, and a hydraulic actuator connected to move the second latch relative to the first latch and the coupler frame. The hydraulic actuator may have a first chamber, a second chamber, and a pressure valve with a check element movable to allow a flow of fluid into the first chamber based on a pressure of fluid in the first chamber, and a pressure regulating element movable to allow a flow of fluid out of the first chamber based on a pressure of fluid in the second chamber. The tool coupler assembly may additionally have a first pilot passage configured to communicate fluid from the second chamber with the pressure-regulating element, and a second pilot passage configured to communicate fluid from the first chamber with the pressure-regulating element. | 01-10-2013 |
20130318841 | TOOL COUPLER SYSTEM HAVING MULTIPLE PRESSURE SOURCES - A tool coupler system is disclosed for use with a machine. The tool coupler system may have a tool coupler with a hydraulic actuator configured to selectively lock a tool to a machine. The tool coupler system may also have a first hydraulic pump configured to generate a first flow of pressurized fluid, and a second hydraulic pump configured to generate a second flow of pressurized fluid. The tool coupler system may further have a valve configured to selectively direct the first or second flows of pressurized fluid to the hydraulic actuator of the tool coupler. | 12-05-2013 |
20130322959 | TOOL COUPLER HAVING ANTI-RELEASE MECHANISM - A tool coupler for a machine is disclosed. The tool coupler may have a coupler frame, a hook coupled to the coupler frame and configured to receive a first pin of a tool, and a wedge operatively connected to the coupler frame. The tool coupler may also have an actuator connected to move the wedge away from the hook to bias a second pin of the tool against the coupler frame, and a latch associated with the wedge. The latch may be movable between a first position at which the wedge is allowed to move away from the second pin, and a second position at which the wedge is constrained from moving away from the second pin. | 12-05-2013 |
Troy Curtis Robl, St. George, KS US
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20140212210 | TOOL COUPLER HAVING A MODULAR FRAME CONSTRUCTION - A tool coupler for connecting a machine to a tool is disclosed. The tool coupler may have a first frame module having a first pair of side plates and a pair of aligned bores passing through the first pair of side plates. The aligned bores may be configured to receive pins that are connectable to a linkage of the machine. The tool coupler may also have a second frame module releasably attached to the first frame module. The second frame module may have a second pair of side plates and a pair of hooks fixedly connected to the second pair of side plates. The pair of hooks may be configured to receive corresponding pins that are connectable to the tool. | 07-31-2014 |
20140308061 | Method and System for Detecting Engagement with a Work Tool Accessory - The present disclosure is in the field of construction and mining machinery and is directed to a quick coupler, a machine incorporating a quick coupler, and a method for detecting positive engagement between a quick coupler and a work tool accessory. The various embodiments involve detecting the strain exerted on an engagement mechanism of the quick coupler by an attachment mechanism of a work tool accessory or determining the proximity between the engagement mechanism and the attachment mechanism in order to determine if the work tool accessory is positively coupled with the quick coupler. | 10-16-2014 |