Robins, GB
Adrian Robins, Nottingham GB
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20110165180 | Polypeptides capable of binding to CD64 comprising one or more heterologous T cell epitopes and their uses - The invention relates to the use of a polypeptide that comprises i) a first portion comprising the part of human Fc that binds to CD64, and ii) a second portion comprising one or more heterologous T cell epitopes for stimulating a cytotoxic T cell response. The polypeptide may be an antibody that may be used to stimulate a cytotoxic T cell response against pathogens and tumour cells in patients in need of such treatment. | 07-07-2011 |
Alan C. Robins, Horley Surrey GB
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20120024086 | CRYOGENIC SPECIMEN HOLDER - An improved cryogenic specimen holder for imaging and analysis facilitates imaging at very high tilt angles with a large field of view. A retractable specimen holder tip protects the specimen during transport. An optimized Dewar design is positioned at a fixed, tilted angle with respect to the axis of the holder, providing a means of continuously cooling the specimen irrespective of the high tilt angle and the amount of liquid nitrogen present in the vessel. The Dewar neck design reduces the entrapment of nitrogen gas bubbles and its shape prevents the spilling of liquid nitrogen at high tilt angles. The specimen holder has a retractable tip that completely encapsulates the specimen within a shielded environment internal to the specimen holder body. The cooling and specimen transfer mechanisms reduce thermal drift and the detrimental effects of vibrations generated by both the evaporation of liquid nitrogen present in the Dewar as well as other environmental effects. | 02-02-2012 |
20130014528 | CRYOGENIC SPECIMEN HOLDER - An improved cryogenic specimen holder for imaging and analysis facilitates imaging at very high tilt angles with a large field of view. A retractable specimen holder tip protects the specimen during transport. An optimized Dewar design is positioned at a fixed, tilted angle with respect to the axis of the holder, providing a means of continuously cooling the specimen irrespective of the high tilt angle and amount of liquid nitrogen present in the vessel. The Dewar neck design reduces entrapment of nitrogen gas bubbles and its shape prevents the spilling of liquid nitrogen at high tilt angles. The specimen holder has a retractable tip that completely encapsulates the specimen within a shielded environment internal to the specimen holder body. The cooling and specimen transfer mechanisms reduce thermal drift and the detrimental effects of vibrations generated by both the evaporation of liquid nitrogen present in the Dewar and other environmental effects. | 01-17-2013 |
20140098380 | Method for Preparing Specimens for Microscopy - An apparatus for preparing specimens for microscopy including equipment for providing two or more of each of the following specimen processing activities under continuous vacuum conditions: plasma cleaning the specimen, ion beam or reactive ion beam etching the specimen, plasma etching the specimen and coating the specimen with a conductive material. Also, an apparatus and method for detecting a position of a surface of the specimen in a processing chamber, wherein the detected position is used to automatically move the specimen to appropriate locations for subsequent processing. | 04-10-2014 |
20140157914 | Apparatus for Preparing Specimens for Microscopy - An apparatus for preparing specimens for microscopy including equipment for providing two or more of each of the following specimen processing activities under continuous vacuum conditions: plasma cleaning the specimen, ion beam or reactive ion beam etching the specimen, plasma etching the specimen and coating the specimen with a conductive material. Also, an apparatus and method for detecting a position of a surface of the specimen in a processing chamber, wherein the detected position is used to automatically move the specimen to appropriate locations for subsequent processing. | 06-12-2014 |
Alan G. Robins, Guildford GB
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20110109464 | SENSING NETWORK AND METHOD - A system and method are described for detecting toxic gas releases in an urban environment. The system includes a series of repositionable remote sensor nodes that are located in an environment containing a toxic gas, the sensor nodes including a chemical sensor and/or a meteorological sensor. The sensor nodes gather data relating to the type of gas released and the surrounding atmospheric conditions and relay the information back to a data processing hub where the data is collated and analysed to produce an indication of the likely spread of the gas plume, the likely danger to the surrounding population and an indication of the release point of the gas. | 05-12-2011 |
Claire Louise Robins, Hoole GB
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20100024245 | Tumble Dryer Dispenser - A device for treating fabrics in a tumble dryer comprising a reservoir for storing a fabric treatment composition and transfer means to expose fabric treatment composition from the reservoir to airflow generated inside the tumble drier and/or to directly contact fabrics in the dryer, thereby transferring a portion of the fabric treatment composition into contact with fabrics in the tumble dryer during a tumble drying cycle; characterised in that the transfer means comprises compressed foam. | 02-04-2010 |
David Edward Robins, Cambridgeshire GB
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20100212804 | BRITTLE POLYMERIC FILM & TAMPER EVIDENT LABELS MADE THEREFROM - A process for the production of a polymeric film comprising a copolyester having an acid component and a diol component, said acid component comprising a dicarboxylic acid and a sulfomonomer containing a sulfonate group attached to the aromatic nucleus of an aromatic dicarboxylic acid, said process comprising the steps of: (i) melt-extruding a layer of said copolyester; (ii) stretching the extrudate in at least one direction; (iii) heat-setting the film by raising the temperature of the stretched film to a temperature T | 08-26-2010 |
Edward Robins, London GB
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20100105949 | RADIOSYNTHESIS OF ACID CHLORIDES - Radiolabelled acid chlorides may be synthesised by reacting a radiolabelled carboxylic acid with a solid-phase supported chlorinating agent. | 04-29-2010 |
20110206607 | IMIDAZOL (1,2-A)PYRIDINES AND RELATED COMPOUNDS WITH ACTIVITY AT CANNABINOID CB2 RECEPTORS - Disclosed herein are compounds of Formula (I), or a pharmaceutically acceptable salt, ester, amide, thereof; and methods of modulating the activity of a cannabinoid CB2 receptor comprising contacting a compound of Formula I with the cannabinoid CB2 receptor. Also disclosed are methods of imaging of a tissue by positron emission tomography, the method comprising administering to the subject a compound of Formula I, wherein the compound comprises a radioisotope. Also disclosed are methods of measuring the relative concentration of cannabinoid CB2 receptors in tissue of a subject, by using a compound of Formula I which comprises a radioisotope. In addition, method of diagnosing a disorder in a subject are disclosed. | 08-25-2011 |
Edward George Robins, London GB
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20080292552 | Pet Radiotracers - The invention relates to novel | 11-27-2008 |
20090220420 | TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR) - The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided. | 09-03-2009 |
20090317328 | TRICYCLIC OXAZEPINES AS IN VIVO IMAGING COMPOUNDS - Novel compounds of formula (I): suitable for use as in vivo imaging agents are provided as well as precursors suitable for the preparation of said compounds. The present invention also provides pharmaceuticals comprising the compounds and kits for the preparation of the pharmaceuticals. Furthermore, use of the compounds for imaging peripheral benzodiazepine receptors in a subject is provided, in particular for imaging pathological conditions in which PBR are upregulated, e.g. Parkinson's disease, multiple sclerosis, Alzheimer's disease and Huntington's disease, neuropathic pain, arthritis, asthma, atherosclerosis and cancer. | 12-24-2009 |
20100143252 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES - The invention provides a compound of formula (I); or a salt or solvate thereof, wherein: R | 06-10-2010 |
20120004404 | RADIOLABELLING METHODS - The present invention relates to the field of [ | 01-05-2012 |
20120130122 | PET RADIOTRACERS - The invention relates to novel | 05-24-2012 |
Ian Robins, Dorset GB
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20090301381 | Gas Detection System - The present invention provides a colorimetric gas detector comprising a substrate bearing a material that can react with a gas in an atmosphere being monitored and wherein the reaction causes the material to change the radiation at which the material absorbs or radiates radiation (the color-change material). The material is located in at least one discrete area of the substrate. By providing the color change material in discrete areas, the amount of such material can be reduced and different types of color-change material can be included on a common substrate to detect two or more gases simultaneously. | 12-10-2009 |
Lee Michael Robins, Cleveland GB
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20080290302 | Suspension System and Scanning Method - A method and apparatus for performing a radiation scan of a structure involve arranging a source of penetrating radiation and a radiation detector at opposed ends of a radiation path through the structure, oriented in such a way that the source emits radiation along the path through the structure and the detector is capable of detecting the radiation after it has passed through the structure and monitoring the radiation emitted from the source that is detected by the detector. At least one continuous loop of a cable is mounted on the structure between at least two fixed locations on the structure so that the cable is movable along its length relative to the structure, and the at least one of the source of penetrating radiation and the radiation detector are fixed to the cable. | 11-27-2008 |
Sean Robins, Guisborough GB
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20120208736 | Treatment of Hard Surfaces - Hard surfaces can be treated to improve soil resistance, particularly resistance to oily soils, by applying a composition of a quaternised, polyamine, polypropoxylate, polyethoxylate. The polyamine can be a polyethyleneimme, desirably having a molecular weight of from 10 to 50 kDa. The average length of the polypropylenoxy chains is desirably from 10 to 100 and the polyethylenoxy chains from 5 to 50 (each per NH group in the polyamine), particularly at a molar ratio of PO:EO of about 3:1. The degree of quaternisation of the nitrogen atoms in the polyamine is desirably from 70 to 100%. The polymer will usually be used in solution in water or an aqueous formulation, which may include detergent and other detergent formulation components. | 08-16-2012 |
Simon Robins, Aberdeen GB
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20140154241 | BINDING PEPTIDES I - A modified igNAR peptide sequence derived from a wild-type igNAR peptide sequence is diversified by mutating the amino acid sequence at 50% or more of the amino acids in the CDR3 loop region and optionally at 50% or more of the amino acids in the CDR3 loop region. The modified igNAR peptide may have the sequence of SEQ ID NO: 8, 10 or 50 to 85. The modified igNAR peptides have binding activity against albumin protein sequences, such as human serum albumin. These modified igNAR peptides may have utility in extending the in vivo half-life of biological molecules e.g. therapeutic agents, and so may be used in medicine. | 06-05-2014 |