Patent application number | Description | Published |
20080214515 | Process for Preparing 3a(Beta)-7a(Beta)-Dihydroxy-6a(Beta)-Alkyl-5Beta-Cholanic Acid - Process for preparing 3α-7α(β)-di-hydroxy-6α(β)-alkyl-5β-cholanic acid (I) in which R is a linear or branched C | 09-04-2008 |
20090318442 | THIAZOLYL-AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM - The present invention relates to substituted thiazolyl- and oxazoyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders. | 12-24-2009 |
20090325951 | THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM - The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders. | 12-31-2009 |
20100022498 | STEROIDS AS AGONISTS FOR FXR - The invention relates to compounds of formula (I): | 01-28-2010 |
20100063018 | BILE ACID DERIVATIVES AS FXR LIGANDS FOR THE PREVENTION OR TREATMENT OF FXR-MEDIATED DISEASES OR CONDITIONS - The present invention relates to compounds of formula (I) | 03-11-2010 |
20100152151 | TGR5 MODULATORS AND METHODS OF USE THEROF - The invention relates to compounds of Formula A: | 06-17-2010 |
20110003782 | 23-Substituted Bile Acids as TGR5 Modulators and Methods of Use Thereof - The invention relates to compounds of Formula A: (A) or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including obesity, insulin sensitivity, inflammation, cholestasis, and bile desaturation. | 01-06-2011 |
20110144064 | Inhibitors of Kynurenine Aminotransferase and Uses Therefor - Provided herein are methods of decreasing a level of kynurenic acid in a cell and of treating a pathophysiological condition in a subject associated with an increase in kynurenic acid in a subject. In these methods the inhibitory action of dicarboxylic acids or derivatives or analogs thereof are effective to inhibit activity of kynurenine aminotransferase II. Also provided is a method of screening for potential inhibitory compounds for kynurenine aminotransferase II. The dicarboxylic acids or derivatives or analogs thereof may have the structural formula, where R | 06-16-2011 |
20110172198 | TGR5 Modulators And Methods Of Use Thereof - The invention relates to compounds of Formula A: (A) or a salt, solvate, or hydrate thereof. The compounds of formula A are TGR5 modulators useful for the treatment of disease. | 07-14-2011 |
20110237617 | THIENO[2,3-C] ISOQUINOLINES FOR USE AS INHIBITORS OF PARP - The present invention relates to compounds for the inhibition of poly(ADP-ribose) polymerase (PARP). In some embodiments, the compounds have the Formula: | 09-29-2011 |
20110263555 | TGR5 Modulators and Methods of Use Thereof - The invention relates to compounds of Formula (A): (A) or a salt, solvate, hydrate, or amino acid conjugate thereof. The compounds of formula A are TGR5 modulators useful for the prevention and treatment of disease. | 10-27-2011 |
20120115832 | TGR5 Modulators and Methods of Use Thereof - The invention relates to compounds of Formula A: | 05-10-2012 |
20120283234 | Bile Acid Derivatives As FXR Ligands For The Prevention Or Treatment Of FXR-Mediated Diseases Or Conditions - The present invention relates to compounds of formula (I): | 11-08-2012 |
20130059843 | Thiazolyl- and Oxazolyl-Isoquinolinones and Methods for Using Them - The present invention relates to substituted thiazolyl- and oxazolyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders. | 03-07-2013 |
20140024631 | Steroids as Agonists for FXR - The invention relates to compounds of formula (I): | 01-23-2014 |
20140057886 | Bile Acid Derivatives as FXR Ligands for the Prevention or Treatment of FXR-Mediated Diseases or Conditions - The present invention relates to compounds of formula (I): | 02-27-2014 |
20140094443 | TGR5 Modulators and Methods of Use Thereof - The invention relates to compounds of Formula A: | 04-03-2014 |
20140100209 | TGR5 Modulators and Methods of Use Thereof - The invention relates to compounds of Formula A: | 04-10-2014 |
20140107117 | Thienyl- and Furanyl-Isoquinolinones and Methods for Using Them - The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders. | 04-17-2014 |
20140371190 | Farnesoid X receptor modulators - The present invention provides a compound of formula (I): | 12-18-2014 |