Ridgway, US
Brain Hugh Ridgway, Belmont, CA US
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20090186905 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE - The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R | 07-23-2009 |
Brian Hugh Ridgway, Belmont, CA US
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20080249079 | Pyrimidine Derivatives As Kinase Modulators and Method of Use - The invention provides compounds and methods for inhibition of kinases, more specifically IGF 1 R kinases. The invention also provides compounds and methods for inhibition of wildtype Abl. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein, V is NR | 10-09-2008 |
20090105211 | INHIBITORS OF HEDGEHOG PATHWAY - The present invention is directed to a compound of Formula I | 04-23-2009 |
20090298830 | 4-Aryl-2-Amino-Pyrimidnes or 4-Aryl-2-Aminoalkyl-Pyrimidines as Jak-2 Modulators and Methods of Use - This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R | 12-03-2009 |
20100136136 | JAK-2 Modulators and Methods of Use - This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention. | 06-03-2010 |
20110201599 | CDK Modulators - A compound according to Formula I: or a pharmaceutically-acceptable salt thereof, wherein R1, R3, A, B and D are as defined in the specification; pharmaceutical compositions thereof, and methods of use thereof. | 08-18-2011 |
20120238570 | INHIBITORS OF THE HEDGEHOG PATHWAY - The present invention is directed to a compound of Formula I | 09-20-2012 |
20120245139 | INHIBITORS OF THE HEDGEHOG PATHWAY - The present invention is directed to a compound of Formula I | 09-27-2012 |
Craig Ridgway, Jet, OK US
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20100071363 | Propane Injection System - A flow regulator valve having multiple stages is described herein. The flow regulator valve provides a base amount of propane when the engine is idling and provides additional propane to the engine based on the engine's requirements. | 03-25-2010 |
20120110999 | PROPANE INJECTION SYSTEM - A flow regulator valve having multiple stages is described herein. The flow regulator valve provides a base amount of propane when the engine is idling and provides additional propane to the engine based on the engine's requirements. | 05-10-2012 |
Don Ridgway, Spring, TX US
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20100179297 | REACTIVE AMINE CATALYSTS FOR POLYURETHANE FOAM - Polyurethanes made using compounds of formula A: | 07-15-2010 |
Donald Ridgway, Spring, TX US
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20150094387 | Use of Thickening Agents as Polyurethane Amine Catalyst Diluents - The present disclosure relates to an amine catalyst composition for producing polyurethane foam. The amine catalyst composition includes an amine catalyst and a diluent containing a thickening agent and water. The use of such a diluent, in place of conventional glycols, reduces raw material and processing costs as well as environmental concerns during the production of polyurethane foam. | 04-02-2015 |
Emily Ridgway, Bellevue, WA US
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20160124502 | SENSORY FEEDBACK SYSTEMS AND METHODS FOR GUIDING USERS IN VIRTUAL REALITY ENVIRONMENTS - Sensory feedback (“chaperoning”) systems and methods for guiding users in virtual/augmented reality environments such as walk-around virtual reality environments are described. Exemplary implementations assist with preventing collisions with objects in the physical operating space in which the user acts, among other potential functions and/or uses. | 05-05-2016 |
Jeff Ridgway, San Diego, CA US
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20100153050 | Autonomous Underwater Vehicle Borne Gravity Meter - Techniques and systems are disclosed for performing a gravity survey near the seafloor. In one aspect, a system includes an autonomous underwater vehicle that includes a sensor system holding area. The system includes a gravity sensor system to fit inside the sensor system holding area of the autonomous underwater vehicle. The gravity sensor system includes a motorized gimbal to provide a leveled sensor platform. Also, the gravity sensor system includes a gravimeter sensor mounted onto the motorized gimbal to measure gravity data. Further, the payload includes a motion sensor mounted onto the motorized gimbal to measure motion data associated with movements of the autonomous underwater vehicle. | 06-17-2010 |
John B. Ridgway, San Francisco, CA US
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20100254986 | METHOD FOR MAKING HETEROMULTIMERIC POLYPEPTIDES - The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins and antibody-immunoadhesin chimeras. The invention also relates to the heteromultimers prepared using the method. Generally, the method involves introducing a protuberance at the interface of a first polypeptide and a corresponding cavity in the interface of a second polypeptide, such that the protuberance can be positioned in the cavity so as to promote heteromultimer formation and hinder homomultimer formation. “Protuberances” are constructed by replacing small amino acid side chains from the interface of the first polypeptide with larger side chains (e.g. tyrosine or tryptophan). Compensatory “cavities” of identical or similar size to the protuberances are created in the interface of the second polypeptide by replacing large amino acid side chains with smaller ones (e.g. alanine or threonine). The protuberance and cavity can be made by synthetic means such as altering the nucleic acid encoding the polypeptides or by peptide synthesis. | 10-07-2010 |
20130089553 | METHOD FOR MAKING HETEROMULTIMERIC POLYPEPTIDES - The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins, heteromultimers and antibody-immunoadhesin chimeras. Generally, the method involves introducing a protuberance at the interface of a first polypeptide and a corresponding cavity in the interface of a second polypeptide, such that the protuberance can be positioned in the cavity so as to promote heteromultimer formation and hinder homomultimer formation. The protuberance and cavity can be made by synthetic means such as altering the nucleic acid encoding the polypeptides or by peptide synthesis. | 04-11-2013 |
Jon Robert Ridgway, Marietta, GA US
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20110052333 | Wire facing unit for retaining walls with strut attachment locator - A wire strut indicator facing unit for a retaining wall, such as a temporary retaining wall, having an upstanding face section and a rearwardly extending floor section, wherein the floor section is formed from pairs of parallel wire elements and transverse cross-wire elements, and otherwise substantially free of wire elements between the wire element pairs. The pairs of parallel wires define the attachment location for a wire strut that extends between the face section and floor section of the facing unit. | 03-03-2011 |
20110091290 | Combined strut and connector retaining wall system and method therefor - A retaining wall system formed from a wire facing unit having an upstanding face section and a rearwardly extending floor section the rear end of which is provided with aligned, transversely extending, openings defined by upstanding U-shaped protuberances. The apertures in the forward portion of a geogrid, preferably an integral, uniaxially-stretched, polymer geogrid, can be seated over the protuberances and a connector strut interconnects the face section and floor section for providing support therebetween and for securing the geogrid to the floor section. The connector strut is formed from an elongated rigid rod having a curved first end that extends to a substantially right-angled bend, and a connector rod portion extends from the bend to a free second end. The connector rod portion is threaded through the aligned openings of adjacent protuberances to secure the geogrid to the floor section and the curved first end of the connector strut is hooked to a transverse cross-wire element of the face section. | 04-21-2011 |
Lon Ridgway, Houston, TX US
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20140322356 | CTC BIOMARKER ASSAY TO COMBAT BREAST CANCER BRAIN METASTASIS - Embodiments of the present invention concern methods related to treating, prognosticating and/or diagnosing at least brain metastatic breast cancer. Embodiments of the methods include characterizing circulating tumor cells for the presence or absence of EpCAM and, upon identification of EpCAM negative cells and identification of the status of other markers (such as heparanase and/or Notch1, for example), treating the individual based on the determination of the characterization. | 10-30-2014 |
Michael Duane Ridgway, Bedford, TX US
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20130247480 | SERVICEABLE SOFFIT VENT - An attic soffit ventilator for a dwelling having a removable filter. The soffit ventilator includes a frame having a plurality of louvers on one side, wherein the frame is fixed to the underside surface or soffit structure of a roof. The frame includes a side openings or slot for receiving a filter media. The filter media is inserted into the frame by sliding it into the frame from the side opening or slot. Further, the filter media can be removed, cleaned, and re-inserted into the frame. | 09-26-2013 |
Philip Ridgway, Charlotte, NC US
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20140193063 | DUPLICATE CHECK IMAGE RESOLUTION - A system and method for comparing digital images, such as checks images used by banks, includes receiving and processing the images to be compared, including scaling the images to a common resolution, as well as filtering them to remove spot noise, background pels, and other non-information carrying elements. One or more regions of each image are selected for comparison. The selected regions are compared to one another by subtracting the pels of one image from the other's pels. A determination is made of whether the two or more images are duplicates of one another, or depict a substantially identical subject, based on the results of the subtractions. Furthermore, the amount of filtering and scaling may be adjusted to enhance the effects of the system to take advantage of common characteristics that may be known or detected in a particular set of images to be compared. | 07-10-2014 |
20140198968 | DUPLICATE CHECK IMAGE RESOLUTION - A system and method for comparing digital images, such as checks images used by banks, includes receiving and processing the images to be compared, including scaling the images to a common resolution, as well as filtering them to remove spot noise, background pels, and other non-information carrying elements. One or more regions of each image are selected for comparison. The selected regions are compared to one another by subtracting the pels of one image from the other's pels. A determination is made of whether the two or more images are duplicates of one another, or depict a substantially identical subject, based on the results of the subtractions. Furthermore, the amount of filtering and scaling may be adjusted to enhance the effects of the system to take advantage of common characteristics that may be known or detected in a particular set of images to be compared. | 07-17-2014 |
20150287168 | DUPLICATE CHECK IMAGE RESOLUTION - A system and method for comparing digital images, such as checks images used by banks, includes receiving and processing the images to be compared, including scaling the images to a common resolution, as well as filtering them to remove spot noise, background pels, and other non-information carrying elements. One or more regions of each image are selected for comparison. The selected regions are compared to one another by subtracting the pels of one image from the other's pels. A determination is made of whether the two or more images are duplicates of one another, or depict a substantially identical subject, based on the results of the subtractions. Furthermore, the amount of filtering and scaling may be adjusted to enhance the effects of the system to take advantage of common characteristics that may be known or detected in a particular set of images to be compared. | 10-08-2015 |
Randal Sewell Ridgway, Spokane, WA US
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20140078174 | AUGMENTED REALITY CREATION AND CONSUMPTION - Architectures and techniques for augmenting content on an electronic device are described herein. In particular implementations, a user may use a portable device (e.g., a smart phone, tablet computer, etc.) to capture images of an environment, such as a room, outdoors, and so on. As the images of the environment are captured, the portable device may send information to a remote device (e.g., server) to determine whether augmented reality content is associated with a textured target in the environment (e.g., a surface or portion of a surface). When such a textured target is identified, the augmented reality content may be sent to the portable device. The augmented reality content may be displayed in an overlaid manner on the portable device as real-time images are displayed. | 03-20-2014 |
20140079281 | AUGMENTED REALITY CREATION AND CONSUMPTION - Architectures and techniques for augmenting content on an electronic device are described herein. In particular implementations, a user may use a portable device (e.g., a smart phone, tablet computer, etc.) to capture images of an environment, such as a room, outdoors, and so on. As the images of the environment are captured, the portable device may send information to a remote device (e.g., server) to determine whether augmented reality content is associated with a textured target in the environment (e.g., a surface or portion of a surface). When such a textured target is identified, the augmented reality content may be sent to the portable device. The augmented reality content may be displayed in an overlaid manner on the portable device as real-time images are displayed. | 03-20-2014 |
Regina S. Ridgway, Williamsburg, VA US
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20100270195 | BIOME IN A BOX SYSTEM - Some of the exemplary embodiments provide a biome in a box system comprising a transparent external container having a first size and a top edge and a transparent internal container having a second size configured to fit within the external container. The internal container is for placement of a habitat and has at least one handle configured to hang over and suspend from the top edge of the external container. The system further includes a hinged lid having a side wall extending over the at least one handle and the top edge and a drain assembly under the transparent internal container. | 10-28-2010 |
Richard Ridgway, Westerville, OH US
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20080199124 | OPTICAL DEVICE FOR GENERATING AND MODULATING THz AND OTHER HIGH FREQUENCY SIGNALS - Optical generation and modulation is carried out in the optical domain and converted to, for example, the THz band using suitable optical/electrical conversion hardware. In accordance with one embodiment of the present invention, an electrooptic modulator is significantly overdriven to create sidebands on an optical carrier signal. An arrayed waveguide grating or other suitable filter is then used to filter the optical signal and remove the carrier signal and unwanted sidebands. The desired sidebands are then combined to create an optical signal that can be encoded with data through suitable modulation. Additional embodiments are disclosed. | 08-21-2008 |
20090016729 | FREQUENCY SELECTIVE MMW SOURCE - The present invention relates to the design and operation of a frequency selective electrooptic source. In accordance with one embodiment of the present invention, the electrooptic source comprises an optical signal generator, optical circuitry, and at least one optical/electrical converter wherein the optical signal generator comprises a plurality of optical outputs characterized by distinct output frequencies and the optical circuitry is configured to permit the selection and combination of different ones of the distinct-frequency optical outputs to generate a modulated optical signal, which is converted to a millimeter or sub-millimeter wave. Additional embodiments are disclosed and claimed. | 01-15-2009 |
Richard Eugene Ridgway, Fort Wayne, IN US
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20140130622 | BARRIER ASSEMBLY - A barrier assembly for a motor vehicle having a shift lever and a kit for assembling the barrier assembly are disclosed. The barrier assembly has a retainer, a lever plate, seals and spacers. The retainer has a retainer aperture extending from a first surface to a second surface. The lever plate is moveable and has a lever opening extending from a first face to a second face. A gliding surface allows the lever plate to move in a planar motion parallel to the retainer while supported on the retainer. A first seal is located on the first face of the lever plate proximal to the lever opening. A second seal is located on the first face of the lever plate distal to the lever opening. Spacers project from the retainer distal to the retainer aperture. | 05-15-2014 |
Richard W. Ridgway, Westerville, OH US
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20100263001 | OPTICAL-TO-MILLIMETER WAVE CONVERSION - A method of converting a modulated optical signal to an encoded electrical signal is provided. The method utilizes a device comprising an electrooptic sideband generator, an optical filter, and an optical/electrical converter. Initially, the modulated optical signal, which carries encoded optical data, is directed to an optical input of the electrooptic sideband generator. The electrooptic sideband generator is driven to generate frequency sidebands about a carrier frequency of the input optical signal. The optical filter is utilized to discriminate between the frequency sidebands and the carrier frequency and combine sidebands-of-interest to yield at least one frequency-converted optical signal comprising a millimeter wave modulation frequency. The frequency converted optical signal carries the encoded optical data and the modulation frequency is a function of the spacing of the sidebands-of-interest. The frequency-converted optical signal is directed to the optical/electrical converter where it is converted to an encoded electrical signal. Additional embodiments are disclosed and claimed. | 10-14-2010 |
20110038640 | SPECTRALLY EFFICIENT DIGITAL DATA TRANSMISSION UTILIZING PHASE ENCODED MMW - A digital data transmission device is provided comprising optical waveguide architecture, a sideband generator, a modulation controller, an optical filter, a data mapping unit, and a phase controller. The optical waveguide architecture is configured to direct an optical signal through the sideband generator and the optical filter. The sideband generator comprises an electrooptic interferometer comprising first and second waveguide arms. The modulation controller is configured to generate an electrical drive signal to drive the sideband generator at a control voltage that is substantially larger than Vπ to generate optical frequency sidebands about a carrier frequency of the optical signal. The optical filter is configured to discriminate between the optical frequency sidebands and the optical carrier frequency such that optical sidebands of interest can be directed through the optical waveguide architecture as an optical millimeter wave signal. The data mapping unit is configured to generate an encoded data signal representing a digital data input received by the data mapping unit. The phase controller is configured to alter the phase of the electrical drive signal in response to the encoded data signal generated by the data mapping unit. The sideband generator is configured such that encoded alterations in the phase of the electrical drive signal are manifested as encoded alterations in the phase of the optical millimeter wave signal, creating an encoded representation of the digital data input in the optical millimeter wave signal. Methods of transmitting digital data are also provided. | 02-17-2011 |
20110122477 | Methods and Systems for Modulating and Demodulating Millimeter-Wave Signals - A system comprises an optical processor comprising a sideband generator, an optical filter, and a phase-shift-keying (PSK) modulator, wherein: the sideband generator generates optical frequency sidebands about a carrier frequency of an optical signal; the optical filter discriminates between the optical frequency sidebands and the optical carrier frequency such that optical sidebands of interest can be used to generate an optical millimeter-wave signal; the PSK modulator comprises an optical splitter, an optical phase delay unit, two or more optical gates, and an optical combiner; the optical splitter divides the optical millimeter-wave signal into two or more intermediate signals; the optical phase delay unit delays one or more of the intermediate signals to create distinct phase relationship between them; the optical gates modulate each intermediate signal individually, based on a control input; and the optical combiner combines the gated intermediate signals into a single, PSK-modulated optical millimeter-wave signal. | 05-26-2011 |
20110311231 | SUBMERSIBLE VESSEL DATA COMMUNICATIONS SYSTEM - A data communications system is provided comprising a submersible home vessel, a submersible satellite vessel, and a flexible dielectric waveguide cable. The flexible dielectric waveguide cable comprises an exposed dielectric face configured to transmit electromagnetic millimeter wave radiation. The submersible home vessel comprises a transparent pressure boundary that is configured to be functionally transparent to electromagnetic millimeter wave radiation and to permit unguided propagation of the electromagnetic millimeter wave radiation. The submersible home vessel further comprises a coupling portion that is configured to secure the dielectric face in a position that enables the transmission of unguided millimeter wave radiation across the transparent pressure boundary to a MMW detector within the submersible home vessel. Additional embodiments are disclosed and claimed. | 12-22-2011 |
Robert K. Ridgway, Northbrook, IL US
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20110089643 | Fuel Line Gasket For Use With A Diesel Fuel Injector - Disclosed is a gasket for sealing a fuel connection for a diesel fuel injector. The gasket resides between the filter caps and the jumper block. The gasket includes a pair of holes having frustoconical shaped sidewalls designed to fit within the chamfer walls of the filter caps. The gasket further includes an aperture designed to fit over the threaded injector stud. | 04-21-2011 |
Robert William Ridgway, Schenectady, NY US
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20120134803 | METHOD FOR SHUT DOWN OF A WIND TURBINE HAVING ROTOR BLADES WITH FAIL-SAFE AIR BRAKES - A method for shutdown of a wind turbine having one or more wind turbine blades includes detecting an operational condition of the wind turbine that calls for an expedited or emergency shutdown of the wind turbine by means other than normal pitch control shutdown. Upon detection of the operational condition, one or more air brake flaps configured on each of the turbine blades is deployed by removing power to a fail-safe actuator operatively coupled to each of the air brake flaps. The fail-safe actuator is configured to hold the respective air brake flap at a retracted position relative to a suction side of the turbine blade in a powered state of the fail-safe actuator and to release the air brake flap for automatic deployment to an open position upon loss of power to the fail-safe actuator. | 05-31-2012 |
20120134814 | WIND TURBINE ROTOR BLADE WITH FAIL-SAFE AIR BRAKE FLAPS - A wind turbine blade includes an air brake flap flush mounted within a recess in the suction side of the blade. The air brake flap is actuatable from a retracted position within the recess to an open position wherein the air brake flap extends transversely or vertically from the suction side. A fail-safe actuator is operatively coupled to the air brake flap and is configured to hold the air brake flap at the retracted position in a powered state of the actuator and to release the air brake flap to the open position upon loss of power to the actuator. | 05-31-2012 |
20140110940 | SYSTEMS AND METHODS FOR USE IN OPERATING POWER GENERATION SYSTEMS - A control system is provided. The control system includes a turbine controller that is configured to generate at least a first signal that is representative of pitch control commands for a plurality of turbine blades and a second signal that is representative of the pitch control commands for the turbine blades. A first pitch controller is coupled to the turbine controller, wherein the first pitch controller is configured to receive the first signal and to implement the pitch control commands for each of the turbine blades in response to receiving the first signal. A second pitch controller is coupled to the turbine controller and to the first pitch controller, wherein the second pitch controller is configured to receive the second signal and to implement the pitch control commands to each of the turbine blades when the first pitch controller is unable to implement the pitch control commands. | 04-24-2014 |
William Ridgway, Cincinnati, OH US
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20130101610 | Therapeutic Uses of CD137 in Treating Autoimmune Disease - A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of soluble CD137 or CD137 | 04-25-2013 |
20140154277 | Pharmaceutical Compositions Comprising Soluble CD137 - A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of soluble CD137 or CD137 | 06-05-2014 |