Patent application number | Description | Published |
20080269255 | 4-Phenylpiperidine Derivatives as Renin Inhibitors - Compounds of the present invention having the formula (I) exhibit inhibitory activity on the natural enzyme renin. Thus, compounds of formula (I) may be employed for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders. | 10-30-2008 |
20090281069 | ORGANIC COMPOUNDS - The present invention relates to compounds of the formula; | 11-12-2009 |
20090318463 | Indolylmaleimide Derivatives - Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer. | 12-24-2009 |
20100240679 | 4-Phenylpiperidine Derivatives as Renin Inhibitors - Compounds of the present invention having the formula | 09-23-2010 |
20110034462 | ORGANIC COMPOUNDS - The present invention relates to compounds of the formula; and their use in therapy. | 02-10-2011 |
20120035168 | N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES - The invention relates to compound of the formula I | 02-09-2012 |
20130012485 | ORGANIC COMPOUNDS - Compounds of the formula (I) are provided: | 01-10-2013 |
20150126492 | Complement Pathway Modulators and Uses Thereof - The present invention provides a compound of formula I a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitor of the complement alternative pathway and particularly as inhibitor of Factor B for the treatment of e.g. age-related macular degeneration and diabetic retinopathy. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition. | 05-07-2015 |