Patent application number | Description | Published |
20080248549 | GLUTATHIONE S-TRANSFERASE SEQUENCE VARIANTS - Isolated GSTO2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as GSTO2 allozymes. Methods for determining if a subject contains a GSTO2 sequence variant also are described. | 10-09-2008 |
20090023136 | HSD3B1 sequence variants - Isolated HSD3B1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as are HSD3B1 allozymes. Methods for determining whether a subject contains an HSD3B1 sequence variant also are provided. | 01-22-2009 |
20090029399 | METHOD FOR RAPID DETERMINATION OF THIOPURINE METHYLTRANSFERASE ACTIVITY - This document provides methods and materials related to rapid, quantitative determination of TPMT activity in biological samples. Also featured are compositions and kits useful for determination of TPMT activity in biological samples. | 01-29-2009 |
20090197242 | Lipidomic Approaches to Determining Drug Response Phenotypes in Cardiovascular Disease - The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. | 08-06-2009 |
20090208944 | ASSESSING OUTCOMES FOR BREAST CANCER PATIENTS TREATED WITH TAMOXIFEN - This document provides methods and materials related to assessing the likely outcome for mammals (e.g., humans) with cancer (e.g., breast cancer). For example, methods and materials that involve assessing a breast cancer patient's cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) genotype to determine the likelihood of the beast cancer patient to experience breast cancer relapse or death are provided. Methods and materials that involve assessing the likelihood that a breast cancer patient being treated with tamoxifen will experience side effects such as hot flashes also are provided. | 08-20-2009 |
20090221053 | SULFOTRANSFERASE SEQUENCE VARIANTS - Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to thyroid disease or cancer also are described. | 09-03-2009 |
20100047803 | BIOMARKERS FOR ACETAMINOPHEN TOXICITY - Materials and methods for evaluating cellular responses to acetaminophen and assessing susceptibility to liver damage. | 02-25-2010 |
20100311606 | PHARMACOGENOMIC CELL LINE PANEL AND USE THEREOF - Materials and methods for evaluating cellular response to therapeutic agents. | 12-09-2010 |
20110014678 | SULFOTRANSFERASE 1E1 SEQUENCE VARIANTS - Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described. | 01-20-2011 |
20110244547 | SULFOTRANSFERASE 1E1 SEQUENCE VARIANTS - Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described. | 10-06-2011 |
20120021920 | RADIATION THERAPY BIOMARKERS - Materials and methods related to using biomarkers for prediction of response to radiation therapy. | 01-26-2012 |