Patent application number | Description | Published |
20100322927 | GLYCOSYLATED ANTIBODIES - The invention provides an antibody comprising human IgG1 or IgG3 heavy chain constant domains that are glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is at least 99%, and in addition the amount of NGNA is 1% or less and/or the amount of N-terminal alpha 1,3 galactose is 1% or less, and uses thereof. | 12-23-2010 |
20110117601 | Glycosylation Profile Analysis - The present invention provides a method for the production of a glycosylated heterologous polypeptide comprising the steps of obtaining a sample from a crude fermentation broth, incubation of the sample with magnetic affinity beads, releasing glycans from the immobilized glycosylated polypeptides, measuring a glycosylation profile, comparing the glycosylation profile with a desired glycosylation profile of the recombinant glycosylated polypeptide, modifying the culture conditions in accordance to the glycosylation profile obtained, and repeating the process in order to obtain a glycosylated heterologous polypeptide with the desired glycosylation profile. With a similar method diagnostic markers can be identified and quantified. | 05-19-2011 |
20120128664 | GLYCOSYLATED ANTIBODIES - The invention provides an antibody comprising human IgG1 or IgG3 heavy chain constant domains that are glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is at least 99%, and in addition the amount of NGNA is 1% or less and/or the amount of N-terminal alpha 1,3 galactose is 1% or less, and uses thereof. | 05-24-2012 |
20120129216 | ENZYMATIC ANTIBODY PROCESSING - The current invention comprises a method for producing an immunoglobulin or immunoglobulin fragment with defined glycostructure comprising the following steps: a) providing an affinity chromatography column eluate containing the immunoglobulin or immunoglobulin fragment, b) incubating the affinity chromatography column eluate with (α1,3)galactosidase of plant origin, e.g. from green coffee beans (EC 3.2.1.22), c) applying the incubated affinity chromatography column eluate to a protein A chromatography material and recovering the immunoglobulin or immunoglobulin fragment from the protein A chromatography material and thereby producing an immunoglobulin or immunoglobulin fragment with defined glycostructure. | 05-24-2012 |
20120172255 | ES-MS OF GLYCOPEPTIDES FOR ANALYSIS OF GLYCOSYLATION - Herein is reported a method for the determination of the glycosylation of an immunoglobulin with electrospray mass spectrometry but without the need for a chromatographic purification step after the digestion of the immunoglobulin and prior to the mass spectrometric analysis. | 07-05-2012 |
20140193404 | GLYCOSYLATED ANTIBODIES - The invention provides an antibody comprising human IgG1 or IgG3 heavy chain constant domains that are glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is at least 99%, and in addition the amount of NGNA is 1% or less and/or the amount of N-terminal alpha 1,3 galactose is 1% or less, and uses thereof. | 07-10-2014 |
20140234899 | PROCESS FOR ANTIBODY G1 GLYCOFORM PRODUCTION - The current invention comprises a method for producing an immunoglobulin or immunoglobulin fragment or immunoglobulin fusion with G1 glycostructure comprising incubating with a galactosyltransferase, a sialyltransferase, a beta-1,4-galactosidase and a sialidase, whereby the galactosyltransferase is added in more than one aliquot during the incubating. | 08-21-2014 |
Patent application number | Description | Published |
20100268358 | METHOD AND DEVICE FOR PROGRAMMING AN INDUSTRIAL CONTROLLER - An installation comprises at least one sensor for providing sensor data representing a real system state of the installation and at least one actuator for acting on the real system state. A controller for controlling the installation comprises a data memory for storing the sensor data and a program memory for storing a machine code program. A programming tool for programming the controller includes a program editor, a debugging tool and a compiler. A machine code program is executed on the controller while the debugging tool is activated, and the debugging tool determines a reverse relationship between the machine code running on the controller and at least one high level control instruction shown in the program editor. The debugging tool reads sensor data from a data memory in the controller and assigns the sensor data to the at least one high level control instruction, thereby linking the at least one high level control instruction to a real system state during the execution of the machine code program. | 10-21-2010 |
20110301720 | SAFETY CONTROLLER AND METHOD FOR CONTROLLING AN AUTOMATED INSTALLATION - A safety controller for controlling an automated installation which has a plurality of sensors and a plurality of actuators, comprises a control unit to which a plurality of control input signals are supplied by the sensors. The control unit produces a plurality of control output signals in an automatic mode on the basis of the control input signals in accordance with a user program running in said control unit. The plurality of control output signals is used to actuate the plurality of actuators. The safety controller also has a diagnosis evaluation unit to which a number of diagnoses input signals are supplied. The diagnosis evaluation unit takes the diagnosis input signals as a basis for ascertaining which of a plurality of operating states is present at a defined instant of time. The diagnosis evaluation unit produces an operating state data record which represents an ascertained operating state. The safety controller also has an interface for a display unit in order to display diagnosis reports. The operating state data record includes a plurality of diagnosis data and a Boolean status indicator. The control unit actuates at least one actuator on the basis of the Boolean status indicator contained in the operating state data record. | 12-08-2011 |
20120004744 | METHOD AND PROGRAMMING TOOL FOR CREATING A USER PROGRAM FOR A SAFETY CONTROLLER - A new method and to a new programming tool for creating a user program for a safety controller is disclosed. The new method and programming tool exploit a matrix-type organization of occurring programming tasks. Itemized software components allocated to specific hardware components are combined with aspect blocks that enable programming grouped according to functional control aspects of the system to be controlled. | 01-05-2012 |
20120036493 | METHOD AND APPARATUS FOR CREATING A USER PROGRAM FOR A SAFETY CONTROLLER - A method for creating a user program for a safety controller designed to control an automated installation having a plurality of sensors and a plurality of actuators involves several programming steps. The user program comprises a first program portion, in which safety-related program variables are processed in failsafe fashion, and comprises at least one second program portion, in which non-safety-related program variables are processed, wherein failsafe processing is not necessary for the non-safety-related program variables within the second program portion. The method steps involve a step of defining a number of safety-related program variables, a step of defining a number of non-safety-related program variables, a step of selecting a safety-related program variable from the number of safety-related program variables, a step of selecting a first non-safety-related program variable from the number of non-safety-related program variables, wherein the first non-safety-related program variable is repeatedly assigned an instantaneous value when the user program is executed, a step of defining at least one assignment condition which is processed when the user program is executed, a step of defining an association which associates the selected first non-safety-related program variable with the selected safety-related program variable, wherein the instantaneous value of the selected first non-safety-related program variable is assigned to the selected safety-related program variable depending on the assignment condition, when the user program is executed. | 02-09-2012 |
20120078392 | SAFETY CONTROLLER FOR CONTROLLING AN AUTOMATED INSTALLATION AND METHOD FOR GENERATING A USER PROGRAM FOR A SAFETY CONTROLLER - A safety controller for controlling an automated installation in accordance with a user program has a plurality of control components. At least some of the control components have a respective data bus interface. The data bus interface is designed to receive and send data. The safety controller also has a data bus to which the plurality of control components are connected via the respective data bus interfaces for the purpose of interchanging data. A configuration interface is designed to receive configuration data ascertained on the basis of association data generated by a programming tool. The configuration data determine at least one characteristic of the data bus or of at least one data bus interface. | 03-29-2012 |
20120096428 | METHOD AND APPARATUS FOR GENERATING AN APPLICATION PROGRAM FOR A SAFETY-RELATED CONTROL UNIT - A safety controller designed to control an automated installation having a plurality of sensors and a plurality of actuators. A method for generating a user program for the safety controller comprises the step of generating a source code having a number of control instructions for controlling the actuators and having a number of diagnosis instructions for producing diagnosis reports. Safety-related program variables are processed in failsafe fashion during execution of the control instructions. A machine code is generated on the basis of the source code. At least one checksum is determined for at least some of the machine code. The diagnosis instructions are ignored for the determination of the checksum. | 04-19-2012 |
20120116541 | SAFETY CONTROLLER AND METHOD FOR CONTROLLING AN AUTOMATED INSTALLATION - A safety controller controls an automated installation on the basis of project data representing an individual application running. The safety controller has a plurality of controller hardware components. At least some controller hardware components have a respective project data memory. The project data memories each are designed to store project data supplied to them. The safety controller includes a connecting unit, such as a communication network, which connects the controller hardware components to one another. The safety controller also has a distribution unit for distributing at least some of the project data via the connecting unit to at least some of the project data memories. | 05-10-2012 |
Patent application number | Description | Published |
20150034930 | ORGANIC LIGHT-EMITTING DEVICE - An organic light-emitting component is specified, comprising a translucent substrate ( | 02-05-2015 |
20150053951 | ORGANIC LIGHT-EMITTING DEVICE AND METHOD FOR PRODUCING AN ORGANIC LIGHT-EMITTING DEVICE - The invention relates to an organic light-emitting part having a functional layer stack ( | 02-26-2015 |
20150123093 | Organic Light-Emitting Component and Method for Producing an Organic Light-Emitting Component - According to at least one embodiment, an organic light-emitting component includes a substrate, a first electrode arranged on the substrate, and a second electrode. An organic light-generating layer stack is arranged between the first and second electrodes and includes a first organic OLED functional material. A first organic coupling-out layer is in optical contact with the organic light-generating layer stack and includes an organic material containing a second organic OLED functional material. One of the first and second electrodes is translucent, and the first organic coupling-out layer is arranged on that side of the electrode that faces away from the organic light-generating layer stack. | 05-07-2015 |
20150200378 | OPTOELECTRONIC COMPONENT AND METHOD FOR PRODUCING AN OPTOELECTRONIC COMPONENT - Various embodiments may relate to an optoelectronic component, including a first organic functional layer structure, a second organic functional layer structure and a charge generating layer structure between the first organic functional layer structure and the second organic functional layer structure. The charge generating layer structure includes a hole-conducting charge generating layer and a first electron-conducting charge generating layer. The hole-conducting charge generating layer includes or is formed from an inorganic substance or an inorganic substance mixture. The first electron-conducting charge generating layer includes or is formed from an organic substance or an organic substance mixture. The first electron-conducting charge generating layer includes or is formed from an organic, intrinsically electron-conducting substance. | 07-16-2015 |
20150207101 | DEVICE AND METHOD FOR PRODUCING HERMETICALLY-SEALED CAVITIES - An apparatus may include a first support covered with at least one ALD precursor and/or at least one MLD precursor, and a second support covered with at least one ALD precursor and/or at least one MLD precursor which is/are complementary to the ALD precursor and/or MLD precursor of the first support. The first support is at least partly joined to the second support by an atomic bond between the ALD precursor of the first support and the ALD precursor of the second support or between the MLD precursor of the first support and the MLD precursor of the second support in such a way that an ALD layer or an MLD layer is formed. | 07-23-2015 |
20150243923 | Optoelectronic component and method for producing an optoelectronic component - Various embodiments may relate to an optoelectronic component, including a glass substrate, a glass layer on the glass substrate, and encapsulation, which includes a glass fit, wherein the glass frit is arranged on the glass layer. The glass frit is fastened on the glass substrate by the glass layer. The glass layer is configured as an adhesion promoter for the glass frit on the glass substrate. The glass frit is configured in such a way that a laterally hermetically tight seal of the optoelectronic component is formed by the glass frit. | 08-27-2015 |
Patent application number | Description | Published |
20120132953 | Thin-Layer Encapsulation for an Optoelectronic Component, Method for the Production Thereof, and Optoelectronic Component - A thin-layer encapsulation ( | 05-31-2012 |
20120175668 | Electronic Component and Electrical Contact - An electronic component ( | 07-12-2012 |
20130292655 | Method for producing an electronic component and electronic component - A method for producing an electronic component may include: applying an electrode growth layer on or above a layer structure by means of an atomic layer deposition method; and applying an electrode on the electrode growth layer, wherein the electrode growth layer is applied with a layer thickness in a range of approximately 1.5 nm to approximately 28 nm. | 11-07-2013 |
20140138662 | LIGHT-EMITTING COMPONENTS AND METHOD FOR PRODUCING A LIGHT-EMITTING COMPONENT - A light-emitting component may include: a first electrode; an organic electroluminescent layer structure on or over the first electrode; a second translucent electrode on or over the organic electroluminescent layer structure; and a mirror layer structure on or over the second electrode, wherein the mirror layer structure has a lateral thermal conductance of at least 1*10 | 05-22-2014 |
20140210112 | ENCAPSULATION STRUCTURE FOR AN OPTOELECTRONIC COMPONENT AND METHOD FOR ENCAPSULATING AN OPTOELECTRONIC COMPONENT - An encapsulation structure for an optoelectronic component may include: a barrier thin-film layer for protecting an optoelectronic component against chemical impurities; a cover layer applied above the barrier thin-film layer and serving for protecting the barrier thin-film layer against mechanical damage; and an intermediate layer applied on the barrier thin-film layer between barrier thin-film layer and cover layer and including a curable material designed such that when the non-cured intermediate layer is applied to the barrier thin-film layer, particle impurities at the surface of the barrier thin-film layer are enclosed by the intermediate layer and the applied intermediate layer has a substantially planar surface, and that after the intermediate layer has been cured, mechanical loads on the barrier thin-film layer as a result of particle impurities during the application of the cover layer are reduced by the intermediate layer. | 07-31-2014 |
20140264316 | Organic Light-Emitting Device - An organic light-emitting device includes a substrate, on which a transparent electrode and a further electrode are applied. An organic light-emitting layer is arranged between the electrodes. At least one optical scattering layer is arranged on a side of the transparent electrode facing away from the organic light-emitting layer. | 09-18-2014 |
20140319482 | LIGHT-EMITTING COMPONENT AND METHOD FOR PRODUCING A LIGHT-EMITTING COMPONENT - A light-emitting component may include: a first electrode; an organic electroluminescent layer structure on or above the first electrode; a second translucent electrode on or above the organic electroluminescent layer structure; an optically translucent layer structure on or above the second electrode, wherein the optically translucent layer structure includes photoluminescence material; and a mirror layer structure on or above the optically translucent layer structure. | 10-30-2014 |
20140374729 | METHOD FOR PRODUCING AN OPTOELECTRONIC COMPONENT, AND OPTOELECTRONIC COMPONENT - Various embodiments relate to a method for producing an optoelectronic component includes applying a planarization medium to a surface of a substrate, wherein the planarization medium comprises a material which absorbs electromagnetic radiation having wavelengths of a maximum of 600 nm, applying a first electrode on or above the material, forming an organic functional layer structure on or above the first electrode, and forming a second electrode on or above the organic functional layer structure. | 12-25-2014 |
20150014668 | RADIATION-EMITTING ORGANIC COMPONENT - The invention relates to a radiation-emitting, organic component comprising a radiation-permeable carrier body ( | 01-15-2015 |
20150076451 | ORGANIC LIGHT-EMITTING COMPONENT - An organic light-emitting component includes a translucent substrate, on which an optical coupling-out layer is applied. A translucent electrode overlies the coupling-out layer and an organic functional layer stack having organic functional layers overlies the translucent electrode. The organic functional layer stack includes a first organic light-emitting layer on the translucent electrode and a second organic light-emitting layer on the first organic light-emitting layer. The first organic light-emitting layer includes arbitrarily arranged emitter molecules and the second organic light-emitting layer includes anisotropically oriented emitter molecules having an anisotropic molecular structure. | 03-19-2015 |
20150076452 | ORGANIC LIGHT-EMITTING COMPONENT - An organic light-emitting component includes a substrate, on which are applied an optical coupling-out layer, a translucent electrode on the coupling-out layer, an organic hole-conducting layer or an organic electron-conducting layer on the translucent electrode, an organic light-emitting layer thereon, an organic electron-conducting layer or an organic hole-conducting layer on the organic light-emitting layer, and a reflective electrode. The organic light-emitting layer is at a distance of greater than or equal to 150 nm from the reflective electrode. | 03-19-2015 |
20150102310 | ORGANIC OPTOELECTRONIC COMPONENT AND USE OF A TRANSPARENT INORGANIC SEMICONDUCTOR IN A CHARGE CARRIER PAIR GENERATING LAYER SEQUENCE - Various embodiments may relate to an organic optoelectronic component with a layer structure for generating and separating charge carriers of a first charge carrier type and charge carriers of a second charge carrier type, the layer structure including a hole-conducting transparent inorganic semiconductor. | 04-16-2015 |
20150207097 | COMPONENTS AND METHOD FOR PRODUCING COMPONENTS - Various embodiments may relate to a component, including a carrier, a first electrode on or over the carrier, an organic functional layer structure on or over the first electrode, a second electrode on or over the organic functional layer structure, and thin film encapsulation. The first electrode and the second electrode are configured in such a way that an electrical connection of the first electrode to the second electrode is established only through the organic functional layer structure. The first electrode and/or the second electrode is electrically coupled to the carrier. The thin-film encapsulation together with the carrier forms a structure which seals the organic functional layer structure as well as at least one electrode out of the first electrode and the second electrode hermetically against water and/or oxygen. | 07-23-2015 |
Patent application number | Description | Published |
20090214574 | Anti-cd16 binding molecules - The present invention relates to binding molecules that specifically bind to the human Fc gamma receptor expressed on the surface of natural killer (NK) cells and macrophages (i.e. FcγRIIIA), and in particular binding molecules that specifically bind the A form FcγRIII but do not bind to the B form of FcγRIII, as well as to the use of such binding molecules in the diagnosis and treatment of disease. The invention further extends to polynucleotides encoding such binding molecules, host cells comprising such polynucleotides and methods of producing binding molecules of the invention using such host cells. | 08-27-2009 |
20130115213 | HUMAN CD3-SPECIFIC ANTIBODY WITH IMMUNOSUPPRESSIVE PROPERTIES - Described are mono- and multivalent scFv-antibodies comprising the binding sites specific for the human T cell marker CD3. These antibodies are strongly immunosuppressive and do not cause a significant release of cytokines. Furthermore, polynucleotides encoding said antibodies are described as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Pharmaceutical compositions containing any of the above mentioned polynucleotides, antibodies or vectors are useful for immunotherapy, preferably against acute transplant rejections. | 05-09-2013 |
20140220041 | COMPOUNDS FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE - The invention relates to a method of modulating concentration of Alzheimer's Disease (AD) relevant proteins amyloid precursor protein (APP), beta (β) and gamma (γ) secretases and amyloid beta peptide (Aβ), and also relates to a method of reducing Aβ shedding. Furthermore, this invention extends to a compound for use in the treatment of AD, and also to a method of treating AD. | 08-07-2014 |
20150218275 | ANTI-CD16 BINDING MOLECULES - The present invention relates to binding molecules that specifically bind to the human Fc gamma receptor expressed on the surface of natural killer (NK) cells and macrophages (i.e. FcγRIIIA), and in particular binding molecules that specifically bind the A form FcγRIII but do not bind to the B form of FcγRIII, as well as to the use of such binding molecules in the diagnosis and treatment of disease. The invention further extends to polynucleotides encoding such binding molecules, host cells comprising such polynucleotides and methods of producing binding molecules of the invention using such host cells. | 08-06-2015 |
20160002333 | Bispecific CD33 and CD3 Binding Proteins - Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33 | 01-07-2016 |
20160039934 | CD3 BINDING DOMAINS - The invention relates to a humanized CD3 binding site, which comprises (a) a variable heavy chain domain (VH) as depicted in SEQ ID NO:8 and a variable light chain domain (VL) as depicted in SEQ ID NO:3; or (b) a variable heavy chain domain (VH) as depicted in SEQ ID NO:9 and a variable light chain domain (VL) as depicted in SEQ ID NO:4, or c) a variable heavy chain domain (VH) as depicted in SEQ ID NO:7 and a variable light chain domain (VL) as depicted in SEQ ID NO:2; or (d) a variable heavy chain domain (VH) as depicted in SEQ ID NO:6 and a variable light chain domain (VL) as depicted in SEQ ID NO:1. The CD3 binding sites have an increased stability, while the binding affinity has been retained due to mutations at positions VH111 and VL49. | 02-11-2016 |