Patent application number | Description | Published |
20100015139 | METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH FACTOR Ba SPECIFIC ANTIBODIES AND USE THEREOF - A method of inhibiting the adverse effects of alternative complement pathway activation products in a subject comprising administering to the subject an amount of anti-factor Ba antibody effective to selectively inhibit formation of an alternative complement pathway activation products C3a, C5a, and C5b-9, and activation of neutrophils, monocytes, and platelets. | 01-21-2010 |
20100087393 | METHODS AND COMPOSITIONS OF INHIBITING COMPLEMENT AND CELLULAR ACTIVATION WITH DEXTRAN SULFATE - A method of inhibiting the adverse effects of complement pathway, activation products in a subject comprising administering to the subject an amount of Dextran Sulfate effective to inhibit formation of alternative complement pathway activation product. | 04-08-2010 |
20100111946 | INHIBITING ACTIVATION WITH HUMAN ANTI-FACTOR C3 ANTIBODIES AND USE THEREOF - A method of inhibiting complement activation mediated by C3b inhibitors in a subject includes administering a C3B inhibitor to the subject to inhibit at least one of C3b binding to factors B and properdin, inhibit C3 cleavage, inhibit the activation of neutrophils, monocytes, platelets, and endothelium; or inhibit the formation of C3a, C5a, and MAC. | 05-06-2010 |
20100239573 | METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH FACTOR Bb SPECIFIC ANTIBODIES - A process of inhibiting the adverse effects of alternative complement pathway activation products in a subject includes administering to the subject an amount of anti-factor Bb antibody effective to selectively inhibit formation of an alternative complement pathway activation products C3a, C5a, and C5b-9, and activation of neutrophils, monocytes, and platelets. | 09-23-2010 |
20100322921 | METHOD OF INHIBITING COAGULATION ACTIVATION WITH HUMAN ANTI-FACTOR Va ANTIBODIES AND USE THEREOF - The present invention also discloses the novel use of factor Va inhibitors in the treatment of various disorders caused by the formation of blood clots. | 12-23-2010 |
20110082126 | METHOD FOR TREATING INFLAMMATORY CONDITIONS - A method for treating an autoimmune disease in a subject includes administering to the subject a therapeutically effective amount of an agent comprising an imidazole, an estrogen receptor agonist, or pharmaceutically acceptable salts thereof. | 04-07-2011 |
20110160636 | DEVICE AND METHOD FOR INHIBITING COMPLEMENT ACTIVATION - An extracorporeal device for inhibiting alternative complement pathway activation includes a support structure an anti-complement antibody disposed on or within the support structure and a first conduit for conducting blood of the subject to the anti-complement antibody. The anti-complement antibody can bind to the complement protein and remove the complement protein from the blood. | 06-30-2011 |
20110195974 | METHODS OF TREATING INFLAMMATORY CONDITIONS WITH ADRENERGIC ANTAGONISTS - A method of treating inflammation and joint deterioration in mammals includes administering a therapeutically effective dose of alpha 1A receptor antagonists alone or in combination with a beta 2 adrenergic antagonists or beta 2 adrenergic antagonists and beta 2 adrenergic agonists. | 08-11-2011 |
20110262456 | METHOD OF TREATING ISCHEMIA REPERFUSION INJURY - A method of treating an ischemic reperfusion injury of a subject comprising administering to the subject a therapeutically effective amount of at least one of an adenosine receptor agonist or a protein kinase C activator and a therapeutically effective amount of a complement inhibitor. | 10-27-2011 |
20110311532 | INHIBITION OF COMPLEMENT AND CELLULAR ACTIVATION - A method of inhibiting Fc mediated platelet activation in a subject induced by administration of a therapeutic antibody or fragment thereof includes administering to the subject an amount of anti-platelet agent effective to inhibit Fc induced platelet activation in the subject. | 12-22-2011 |
20120040928 | METHODS AND COMPOSITIONS FOR INHIBITING CELLULAR PROLIFERATION AND SURGICAL ADHESION - A method for inhibiting cellular proliferation of fibroblasts and/or blioma cells in a mammal includes administering a composition to a mammal wherein the composition includes an amount of an anionic polymer and an anti-platelet agent effective to inhibit cellular proliferation of fi- broblasts and gliomas in the mammal | 02-16-2012 |
20120288493 | METHOD OF INHIBITNG COMPLEMENT ACTIVATION WITH HUMAN ANTI-FACTOR C3 ANTIBODIES AND USE THEREOF - A method of inhibiting complement activation mediated by C3b inhibitors in a subject includes administering a C3B inhibitor to the subject to inhibit at least one of C3b binding to factors B and properdin, inhibit C3 cleavage, inhibit the activation of neutrophils, monocytes, platelets, and endothelium; or inhibit the formation of C3a, C5a, and MAC. | 11-15-2012 |
20130004485 | HUMANIZED AND CHIMERIC ANTI-PROPERDIN ANTIBODIES - An isolated anti-properdin antibody or antigen binding portion thereof includes a heavy chain variable domain including the 3CDRs in SEQ ID NO: 1 and light chain variable domain including the 3 CDRS in SEQ ID NO: 9. | 01-03-2013 |
20130039925 | ALTERNATIVE PATHWAY SPECIFIC ANTIBODIES FOR TREATING ARTHRITIS - A method of selecting a genus of therapeutic antibodies includes selecting antibodies with the following criteria; a) do inhibit cell lysis under conditions wherein the alternative pathway is isolated from the classical pathway; and b) do not inhibit cell lysis under conditions wherein the classical pathway is isolated from the alternative pathway; and c) do not inhibit cell lysis under conditions wherein the classical pathway and alternative pathway are active; and d) do inhibit C3b produced exclusively by the alternative pathway; | 02-14-2013 |
20130071396 | METHOD OF INHIBITING COAGULATION ACTIVATION WITH HUMAN ANTI-FACTOR V ANTIBODIES AND USE THEREOF - The present invention also discloses the novel use of factor Va inhibitors in the treatment of various disorders caused by the formation of blood clots. | 03-21-2013 |
20140056808 | NEOANTIBODIES FOR DIAGNOSING TISSUE INJURY - A method for diagnosing the development of a tissue injury in a subject comprising administering a sample of neoantibodies to the subject's tissue for the purpose of detecting the presence of neoepitopes bearing complement proteins. | 02-27-2014 |
20140127204 | ANTI-PROPERDIN ANTIBODIES - A method of inhibiting alternative complement pathway activation in a mammal includes administering an amount of an antibody and/or fragment thereof that specifically binds to an epitope of the N terminus end of properdin effective to the inhibit alternative complement pathway in the subject. | 05-08-2014 |
20140328846 | ANTI-PROPERDIN ANTIBODIES - A method of inhibiting alternative complement pathway activation in a mammal includes administering an amount of an antibody and/or fragment thereof that specifically binds to an epitope of the N terminus end of properdin effective to the inhibit alternative complement pathway in the subject. | 11-06-2014 |
20150064202 | HUMANIZED AND CHIMERIC ANTI-FACTOR C3 ANTIBODIES AND USES THEREOF - A method of inhibiting complement activation mediated by C3b inhibitors in a subject includes administering a C3b inhibitor to the subject to inhibit at least one of C3b binding to factors B and properdin, inhibit C3 cleavage, inhibit the activation of neutrophils, monocytes, platelets, and endothelium; or inhibit the formation of C3a, C5a, and MAC. | 03-05-2015 |