Regamey
Alexandre Regamey, Lausanne CH
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20110061117 | MATRIX ATTACHMENT REGIONS (MARS) FOR INCREASING TRANSCRIPTION AND USES THEREOF - Isolated and purified MAR sequences of human and non-human animal origin are disclosed as are nucleotide sequences corresponding to or based on them. In particular, MARs and MAR constructs with high transcription and/or protein production enhancing activities are disclosed and so are methods for identifying such MARs, designing such MAR constructs and employing them, e.g., for high yield production of proteins. | 03-10-2011 |
Alexandre Regamey, Plan-Les-Ouates CH
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20120231449 | PRODUCTS AND METHODS FOR ENHANCED TRANSGENE EXPRESSION AND PROCESSING - Disclosed are methods and eukaryotic host cells for transgene expression. The cells may be treated and/or modified to increase homologous recombination (HR), decrease non homologous end joining (NHEJ) and/or to enhance a HR/NHEJ ratio in said cell. Such cells can be transfected with vectors comprising the transgene, which advantageously integrates into the genome of the cell to form a concatemeric structure which may comprise more than 200 transgene copies. Certain expression enhancing elements such as MARs are advantageously provided to further enhance and/or facilitate transgene expression. Disclosed is also a recombinant eukaryotic host cell, in particular a non-primate host cell, comprising a transgenic sequence encoding a protein and/or a RNA, in particular a primate protein and/or RNA, involved in translocation across the ER membrane and/or secretion across the cytoplasmic membrane. | 09-13-2012 |
Francis Regamey, Vancouver CA
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20140194687 | FILTER FOR USE WITH IMAGING ENDOSCOPES - A fluorescence endoscopy video system includes a multi-mode light source that produces light for white light and fluorescence imaging modes. A filter is positioned at the distal end of an imaging endoscope so that the endoscope can produce fluorescence and white light images of a tissue sample. | 07-10-2014 |
Yves-Julien Regamey, Yverdon-Les-Bains CH
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20140049576 | INK JET PRINTING METHOD - An ink jet printing method includes providing an ensemble of dots to be printed. A current run is made of through the ensemble of dots to be printed, which includes, for each of dot of the ensemble of dots, deleting all neighboring dots from the current run having a distance less than at least one predetermined value and keeping non-deleted dots as remaining dots in the current run. The remaining dots are assigned to a certain layer corresponding to the current run. The remaining dots of the current run are then removed from the ensemble of dots. The foregoing steps are repeated until there are no further dots in the ensemble of dots. | 02-20-2014 |