Patent application number | Description | Published |
20130244332 | TAREGTED INTEGRATION AND EXPRESSION OF EXOGENOUS NUCLEIC ACID SEQUENCES - Disclosed herein are methods and compositions for targeted integration of a exogenous sequence into a predetermined target site in a genome for use, for example, in protein expression and gene inactivation. | 09-19-2013 |
20130253040 | METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE - Disclosed herein are methods and compositions for treating or preventing Huntington's Disease. | 09-26-2013 |
20140017212 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES - Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of a lysosomal storage disease. | 01-16-2014 |
20140080216 | METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION - Methods and compositions for a genetic disease are provided. | 03-20-2014 |
20140093913 | METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION - Methods and compositions for a genetic disease are provided. | 04-03-2014 |
20140112896 | METHODS AND COMPOSITIONS FOR THE PROVISION OF PROTEINS DEFICIENT IN LYSOSOMAL STORAGE DISEASES - Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for the provision of proteins lacking or deficient in subjects with a lysosomal storage disease and treatment and/or prevention of lysosomal storage diseases. | 04-24-2014 |
20140134723 | NOVEL DNA-BINDING PROTEINS AND USES THEREOF - Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences. | 05-15-2014 |
20140134740 | NOVEL DNA-BINDING PROTEINS AND USES THEREOF - Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences. | 05-15-2014 |
20140134741 | NOVEL DNA-BINDING PROTEINS AND USES THEREOF - Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences. | 05-15-2014 |
20140287500 | COMPOSITIONS FOR LINKING ZINC FINGER MODULES - Disclosed herein are compositions for linking DNA binding modules to allow for specific and selective binding to module subsites separated by 1 or more base pairs. Also described are methods of making and using compositions comprising these linkers. | 09-25-2014 |
20140336133 | METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE - Disclosed herein are methods and compositions for treating or preventing Huntington's Disease. | 11-13-2014 |
20150056705 | METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION - Methods and compositions for genetic alteration of cells are provided. | 02-26-2015 |
Patent application number | Description | Published |
20110082093 | Methods and compositions for treating trinucleotide repeat disorders - Disclosed herein are methods and compositions for treating trinucleotide repeat disorders. | 04-07-2011 |
20110281937 | Methods and compositions for treating neuropathic and neurodegenerative conditions - Disclosed herein are engineered zinc finger proteins which modulate transcription of the gene encoding vascular endothelial growth factor-A (VEGF-A) and other genes encoding products with neurotrophic activities. Also disclosed are methods for the use of these engineered zinc finger proteins in the treatment of neuropathy (including diabetic neuropathy), and other types of neural injury and neurodegeneration. | 11-17-2011 |
20110301073 | Novel DNA-binding proteins and uses thereof - Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences. | 12-08-2011 |
20120060230 | METHODS AND COMPOSITIONS FOR MODIFICATION OF A HLA LOCUS - Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator. | 03-08-2012 |
20130122591 | METHODS AND COMPOSITIONS FOR MODIFICATION OF THE HPRT LOCUS - Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals. | 05-16-2013 |
20130123484 | POSITION DEPENDENT RECOGNITION OF GNN NUCLEOTIDE TRIPLETS BY ZINC FINGERS - The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid sequences for recognition of triplet target subsites having the nucleotide G in the 5′-most position of the subsite, that have been optimized with respect to the location of the subsite within the target site. Accordingly, the disclosure provides finger position-specific amino acid sequences for the recognition of GNN target subsites. This allows the construction of multi-finger zinc finger proteins with improved affinity and specificity for their target sequences, as well as enhanced biological activity. | 05-16-2013 |
20130137104 | METHODS AND COMPOSITIONS FOR MODIFICATION OF THE HPRT LOCUS - Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals. | 05-30-2013 |
20130177960 | METHODS AND COMPOSITIONS FOR REGULATION OF TRANSGENE EXPRESSION - Nucleases and methods of using these nucleases for expressing a transgene from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom. | 07-11-2013 |
20130177983 | METHODS AND COMPOSITIONS FOR REGULATION OF TRANSGENE EXPRESSION - Nucleases and methods of using these nucleases for expressing a transgene from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom. | 07-11-2013 |
20130196373 | MODIFIED DNA-BINDING PROTEINS AND USES THEREOF - Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences. | 08-01-2013 |