Patent application number | Description | Published |
20090088573 | BIOLOGICALLY ACTIVE PEPTIDES AND COMPOSITIONS, THEIR USE - This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, | 04-02-2009 |
20090264487 | HEMIASTERLIN ANALOGS - This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as a cytotoxic anti-mitotic agents. | 10-22-2009 |
20100168225 | Small-Molecule Hepatitis C Virus (HCV) NS3/4A Serine Protease Inhibitors - Compounds of Formula 5 and prodrug compounds of Formula 5 wherein G | 07-01-2010 |
20100280004 | SMALL MOLECULE CORRECTORS OF DELTAF508 CFTR TRAFFICKING - This invention provides compounds of Formula I. The compounds are correctors of ΔF508 CFTR trafficking. Also provided are uses of compounds of Formula I for treatment, as well as methods of treatment, of cystic fibrosis. | 11-04-2010 |
20100311094 | Allosteric Modulation Of Ship Polypeptides And Uses Thereof - This invention provides a method for identifying allosteric modulators of a SHIP polypeptide, wherein said SHIP polypeptide is contacted with a test compound, and wherein said SHIP polypeptide comprises an allosteric site selected from the group consisting of a SHIP C2 domain and a SHIP PH domain. | 12-09-2010 |
20100323990 | SHIP 1 MODULATOR PRODRUGS - The present invention provides the use of prodrugs of pelorol and homopelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions. | 12-23-2010 |
20110189107 | ALPHA-AMYLASE INHIBITORS: THE MONTBRETINS AND USES THEREOF - Particular naturally occurring glycosylated acyl-flavonols, e.g. montbretin A (of the formula below wherein R | 08-04-2011 |
20110263539 | SHIP 1 MODULATOR COMPOUNDS - The present invention provides the use of pelorol analogs of Formula, (I) and pharmaceutical compositions thereof as modulators of SHIP 1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions. | 10-27-2011 |
20120129925 | SHIP 1 MODULATORS - The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof. | 05-24-2012 |
20130217674 | SHIP1 MODULATORS AND RELATED METHODS - Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R | 08-22-2013 |