Rast
Bryson Rast, Boulder, CO US
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20100063066 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF - Compounds of Formulas (I), (IIA) and (IIIA) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formulas (I), (IIA) and (IIIA) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 03-11-2010 |
Bryson Rast, Westminster, CO US
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20110144085 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS - Compounds of Formula (I), in which A, B, R | 06-16-2011 |
20120258952 | Substituted N-(1H-Indazol-4-yl)Imidazo[1,2-a]Pyridine-3-Carboxamide Compounds as cFMS Inhibitors - Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R | 10-11-2012 |
20130274244 | SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS - Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R | 10-17-2013 |
20140045817 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS - Provided herein is a method of treating a PIM-1 and/or PIM-2 and/or PIM-3 kinase-mediated condition in a mammal, which comprises administering to said mammal a therapeutically effective amount of a compound of Formula I: | 02-13-2014 |
Christopher Rast, San Diego, CA US
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20130345764 | DEVICE FOR FIXATION OF BONE FRACTURES - A device and method for fixation of bone fractures has a bone screw comprising a shank with a threaded end portion, on the outer surface. The screw has a through bore with two bore portions differing in diameter. A step in the diameter is formed between these bore portions and is located within the end of the screw having the thread. This step in diameter can support a metal insert which in turn supports a polymer pin when the latter if pressurized with a sonotrode in the bone screw. Together with an applied ultrasonic vibration the pressure fluidizes the polymer pin and presses the material through holes configured in the wall of the bone screw and into surrounding bone. | 12-26-2013 |
Christopher Rast, Gunten CH
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20140237714 | HEAT EXCHANGER, SHOWER TRAY AND METHOD FOR PRODUCING A SHOWER TRAY - A shower tray having a heat exchanger that is arranged beneath the shower tray for recovering heat from waste water in order to heat up clean water, wherein a first heat-exchanger surface is in contact with the waste water and a second heat-exchanger surface is in contact with the clean water, and the first heat-exchanger surface forms the floor, or part of the floor, of the shower tray. The shower tray here is produced from one metal material and, in the region of the tray floor, beneath the shower tray, a base plate made of some other metal is fastened on the tray floor, so as to form a heat-conducting connection to the tray floor is formed substantially over the entire surface of the base plate. Beneath the base plate, tubes are connected to the base plate in an integral manner. The tubes form the second heat-exchanging surface. | 08-28-2014 |
Christopher Rast, Biel CH
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20100023057 | DEVICE TO BE IMPLANTED IN HUMAN OR ANIMAL TISSUE AND METHOD FOR IMPLANTING AND ASSEMBLING THE DEVICE - An implant or endoprosthesis suitable to be implanted in human or animal tissue comprises two (or more than two) parts to be joined in situ. Each one of the parts comprises a joining location, the two joining locations facing each other when the device parts are positioned for being joined together, wherein one of the joining locations comprises a material which is liquefiable by mechanical vibration and the other one of the joining locations comprises a material which is not liquefiable by mechanical vibration and a structure (e.g. undercut cavities or protrusions) suitable for forming a positive fit connection with the liquefiable material. The joining process is effected pressing the two device parts against each other and by applying vibration, e.g. ultrasonic vibration, to one of the device parts when the two parts are positioned relative to each other such that the two joining locations are in contact with each other. Preferably, at least one of the device parts is fixed to the tissue before or during the joining process. Such fixing is advantageously effected with the aid of a further liquefiable material and mechanical vibration which results in an anchorage of the part by interpenetration of the tissue by the liquefiable material. | 01-28-2010 |
20150196378 | SURGICAL METHOD, KIT OF PARTS, AND IMPLANT - A surgical method is provided, the method including the steps of: providing an artificial or allograft flexible planar structure; providing an implant, the implant including material liquefiable by mechanical oscillation, exposing a surface region of hard tissue or hard tissue substitute material; positioning the implant on an exposed area of the hard tissue or hard tissue substitute material; and fastening the implant to the hard tissue or hard tissue substitute material by impinging the proximal end of the implant with mechanical oscillation and simultaneously pressing the implant against the hard tissue or hard tissue substitute material while the distal end of the implant protrudes into a cavity of the hard tissue or hard tissue substitute material and regions of the liquefiable material are in contact with the hard tissue or hard tissue substitute material, and thereby liquefying at least a portion of the liquefiable material, and letting the liquefiable material resolidify. | 07-16-2015 |
Georg Rast, Ingelheim Am Rhein DE
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20130289050 | INHIBITORS OF BETA-SECRETASE - The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. | 10-31-2013 |
20150150872 | INHIBITORS OF BETA-SECRETASE - The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. | 06-04-2015 |
Georg Rast, Singen DE
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20100261687 | SUBSTITUTED PIPERIDINES AS CCR3 ANTAGONISTS - Object of the present invention are novel substituted compounds of the formula 1, | 10-14-2010 |
20130023517 | Therapeutic methods employing substituted piperidines which are CCR3 antagonists - Object of the present invention are novel substituted compounds of the formula 1, | 01-24-2013 |
Keith Rast, Yacolt, WA US
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20100192113 | METHOD AND APPARATUS FOR MANAGING VIOLATIONS AND ERROR CLASSIFICATIONS DURING PHYSICAL VERIFICATION - Some embodiments provide a system for managing violations during physical verification. The system may identify a design-rule-check (DRC) violation by applying a set of DRC rules to a layout. The system can then receive an error classification from the user which specifies how the DRC violation is to be handled. Next, the system can store the DRC violation, the user-selected error classification, and a user identifier associated with the user in a database. If the user is not authorized to approve the error classification, the database can indicate that the error classification has not been approved. Later, a user who is authorized to approve the error classification can approve the error classification. The system can determine if a cell is known, and if so, the system can use the violations and error classifications stored in the database to speed up the verification process. | 07-29-2010 |
Markus Rast, Konstanz DE
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20140120086 | METHOD FOR PREPARATION OF A HIGH CONCENTRATION LIQUID FORMULATION OF AN ANTIBODY - The present invention provides a method for preparation of a high concentration liquid formulation (HCLF) of an antibody or a fragment thereof. The present invention also relates to a method for stabilizing an anti-CD20 antibody or a fragment thereof in a liquid pharmaceutical formulation. Furthermore, the present invention relates to a liquid pharmaceutical formulation of a veltuzumab antibody or a fragment thereof comprising at least 155 mg/mL of a veltuzumab antibody or a fragment thereof. | 05-01-2014 |
20140271636 | FORMULATION OF AN ANTIBODY AND USE THEREOF - The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient. | 09-18-2014 |
Markus Rast, Radolfzell DE
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20130142782 | HUMIDIFIED PARTICLES COMPRISING A THERAPEUTICALLY ACTIVE SUBSTANCE - The invention relates to aerosolized and humidified particles comprising a therapeutically active substance which can be obtained by suspending dry inhalable particles in a carrier gas, adding water vapor and causing condensation of water on the particles. The invention further relates to methods to generate these particles, and apparatus useful to carry out such methods. | 06-06-2013 |
20150266965 | Method for Preparation of a High Concentration Liquid Formulation of an Antibody - The present invention provides a method for preparation of a high concentration liquid formulation (HCLF) of an antibody or a fragment thereof. The present invention also relates to a method for stabilizing an anti-CD20 antibody or a fragment thereof in a liquid pharmaceutical formulation. Furthermore, the present invention relates to a liquid pharmaceutical formulation of a veltuzumab antibody or a fragment thereof comprising at least 155 mg/mL of a veltuzumab antibody or a fragment thereof. | 09-24-2015 |
Markus Rast, Radofzell DE
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20150266965 | Method for Preparation of a High Concentration Liquid Formulation of an Antibody - The present invention provides a method for preparation of a high concentration liquid formulation (HCLF) of an antibody or a fragment thereof. The present invention also relates to a method for stabilizing an anti-CD20 antibody or a fragment thereof in a liquid pharmaceutical formulation. Furthermore, the present invention relates to a liquid pharmaceutical formulation of a veltuzumab antibody or a fragment thereof comprising at least 155 mg/mL of a veltuzumab antibody or a fragment thereof. | 09-24-2015 |
Oliver Rast, Wielenbach DE
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20150141087 | MOBILE TELEPHONE INTEGRATION SYSTEM - A mobile telephone integration system including an adapter having a main body and a clip which, from an edge of the main body, projects, in a clamping position under prestress in the direction of the bearing surface, over the bearing surface such that a mobile telephone can be pushed into a holding position between a free end of the clip and the bearing surface. A noise-generating means generates a warning noise when the clip is deflected in the opening direction into an overload position by virtue of a rotation process in which the clip is moved out of its release position owing to an increased action of force in the opening direction. The clip pivots back into the release position again by virtue of a return rotation process in which the clip is moved from its overload position owing to an action of force in the closing direction. | 05-21-2015 |
Rodger H. Rast, Gold River, CA US
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20110090083 | Systems and methods of searching based on trademarks - A system and method of searching the world wide web for relevant web sites by a user. The system provides a means for indexing relationship information, such as owners of trademarks, in the search engine and retrieval thereof. The user can select particular relationship elements to rank at the top of the web list, and/or the search engine can automatically retrieve one or more categories of relationship information. New classes of META tags are defined in one embodiment for supporting the invention while third party data can be utilized, or in conjunction with META tag information. | 04-21-2011 |
Slavko Rast, Zagreb HR
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20100190764 | Novel compounds - This invention relates to novel Spiro cyclopentane derivatives of formula (I) or a pharmaceutically acceptable salt thereof, for treating diseases and conditions of the central nervous system (CNS), in particular sleep disorders. | 07-29-2010 |
Valérie Rast, Basel CH
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20110015315 | PROCESS FOR THE SYNTHESIS OF N-ALKOXYAMINES - The present invention relates to novel processes for the preparation of sterically hindered amine ethers by the transformation of a corresponding oxo-piperidin to a hydroxy or amino substituted sterically hindered amine ether and the preparation of a N-propoxy or N-propenoxy substituted sterically hindered amine and some novel compounds obtainable by these processes. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers. | 01-20-2011 |
Valérie Rast, Basel CH
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20090069470 | Process for the synthesis of n-alkoxyamines - The present invention relates to novel processes for the preparation of a sterically hindered amine ethers by the transformation of a corresponding oxo-piperidin to a hydroxy or amino substituted sterically hindered amine ether and the preparation of a N-propoxy or N-propenoxy substituted sterically hindered amine and some novel compounds obtainable by these processes. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers. | 03-12-2009 |
20110015315 | PROCESS FOR THE SYNTHESIS OF N-ALKOXYAMINES - The present invention relates to novel processes for the preparation of sterically hindered amine ethers by the transformation of a corresponding oxo-piperidin to a hydroxy or amino substituted sterically hindered amine ether and the preparation of a N-propoxy or N-propenoxy substituted sterically hindered amine and some novel compounds obtainable by these processes. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers. | 01-20-2011 |
20130041148 | PROCESS FOR THE SYNTHESIS OF N-ALKOXYAMINES - The present invention relates to novel processes for the preparation of sterically hindered amine ethers by the transformation of a corresponding oxo-piperidin to a hydroxy or amino substituted sterically hindered amine ether and the preparation of a N-propoxy or N-propenoxy substituted sterically hindered amine and some novel compounds obtainable by these processes. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers. | 02-14-2013 |
20150031879 | PROCESS FOR THE SYNTHESIS OF N-ALKOXYAMINES - The present invention relates to novel processes for the preparation of sterically hindered amine ethers by the transformation of a corresponding oxo-piperidin to a hydroxy or amino substituted sterically hindered amine ether and the preparation of a N-propoxy or N-propenoxy substituted sterically hindered amine and some novel compounds obtainable by these processes. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers. | 01-29-2015 |
Walker M. Rast, Colubia, SC US
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20100158983 | METHOD FOR INCREASING THE PERMEABILITY OF POLYMER FILM - Polymer membranes are disclosed having increased permeability. The process of the present disclosure, for instance, can increase the ion permeability of membranes and/or the gas permeability of membranes. In one embodiment, for instance, a precursor polymer is subjected to energy in an amount sufficient to form damage tracks through the thickness of the polymer. The damage tracks are then oxidized to form free radical groups. The precursor polymer is then hydrolyzed causing ion groups to form that cluster along the damage tracks. In one embodiment, sulfonated tetrafluoroethylene-based copolymer ionomer membranes are formed that have increased conductivity. Other ionomer membranes that may be formed according to the present disclosure include copolymers of a vinyl hydrocarbon and a vinyl carboxylic acid. | 06-24-2010 |