Patent application number | Description | Published |
20090169576 | INFLUENZA COMBINATORIAL ANTIGEN VACCINE - The invention provides a combinatorial influenza vaccine composition for use in providing prophylactic protection in humans against influenza viruses or animals, and a method of producing the vaccine. | 07-02-2009 |
20090176654 | Universal fibronectin type III binding-domain libraries - Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens. | 07-09-2009 |
20090318297 | Antibody Ultrahumanization by Predicted Mature CDR Blasting and Cohort Library Generation and Screening - Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed. | 12-24-2009 |
20100068224 | Method for Producing Viral Vaccine and Therapeutic Peptide Antigens - A method of producing viral antigens for use in a vaccine or therapeutic composition against infection by a virus, and a composition produced thereby, are disclosed. The method is applicable to viruses having a plurality of subtypes whose protein sequences for at least one viral protein or polyprotein are known. Regions of a selected viral protein that (i) are known or predicted to bind to MHC proteins in host antigen-presenting cells, and (ii) have a moderate amino acid variability within the virus subtypes are systematically varied in amino acid sequence, and tested for enhanced binding to MHC proteins. The composition includes those peptides having the highest binding affinity for MHC proteins. | 03-18-2010 |
20100152063 | UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES - Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens. | 06-17-2010 |
20110021746 | UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES - Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having hign binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins. | 01-27-2011 |
20110124527 | UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES - Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens. | 05-26-2011 |
20110245108 | Universal Antibody Libraries - Universal antibody libraries are described which are synthetic and derived from expressed human antibody sequences selected accordingly to certain criteria, for example, that the sequences are derived from naturally-occurring antibodies expressed in response to a certain antigen class (e.g., small molecule, polysaccharide, peptide, or protein) and having CDR regions engineered for optimal diversity. Methods for making and screening such libraries for isolating therapeutics suitable for treating disease are also disclosed. | 10-06-2011 |
20120107871 | METHOD OF PRODUCING HUMAN IGG ANTIBODIES WITH ENHANCED EFFECTOR FUNCTIONS - A method for generating human IgG | 05-03-2012 |
20120315374 | Maintaining A Fixed Distance By Laser Or Sonar Assisted Positioning During Coating Of A Medical Device - System and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A positioning device is provided to determine the distance to the surface of the expandable member at a corresponding location and relays the information to a controller or the like to maintain a substantially fixed distance between the outlet of the applicator and the surface of the expandable member when in alignment with the corresponding location. | 12-13-2012 |
20120315375 | Maintaining A Fixed Distance By Providing An Air Cushion During Coating Of A Medical Device - System and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A positioning device maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by ejecting a pressurized medium against the surface of the expandable member. | 12-13-2012 |
20140113059 | MAINTAINING A FIXED DISTANCE BY PROVIDING AN AIR CUSHION DURING COATING OF A MEDICAL DEVICE - System and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A positioning device maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by ejecting a pressurized medium against the surface of the expandable member. | 04-24-2014 |
20140135474 | UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES - Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins. | 05-15-2014 |
20140206576 | UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES - Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens. | 07-24-2014 |