Patent application number | Description | Published |
20100002929 | Image-based methods for measuring global nuclear patterns as epigenetic markers of cell differentiation - The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell colonies, individual cells, and/or cellular structures. | 01-07-2010 |
20100260406 | METHODS AND SYSTEMS FOR IMAGING CELLS - The invention generally provides methods and systems for determining characteristics of cellular structures. The methods include non-invasive, non-perturbing, automatable, and quantitative methods and may be applied to the examination of cells such as stem cells, embryos, and egg cells. | 10-14-2010 |
20110110577 | MATHEMATICAL IMAGE ANALYSIS BASED CELL REPROGRAMMING WITH APPLICATIONS FOR EPIGENETIC AND NON-EPIGENETIC BASE INDUCED PLURIPOTENT STEM CELL DERIVATION - Mathematical and statistical image analysis methods and systems are applied to enhance and refine the process of reprogramming cells, for example, to modify cells from patients into custom-matched stem cells. | 05-12-2011 |
20110170751 | SYSTEMS AND METHODS FOR DETECTING RETINAL ABNORMALITIES - The invention relates to methods and systems for detecting retinal abnormalities in fundus images by interdependently smoothing and segmenting the image, identifying retinal features in the smoothed and segmented image and analyzing the identified retinal features in the smoothed and segmented image to identify a retinal abnormality. | 07-14-2011 |
20110188728 | METHODS OF GENERATING TROPHECTODERM AND NEURECTODERM FROM HUMAN EMBRYONIC STEM CELLS - Methods for inducing differentiation of stem cells into trophectoderm, neurectoderm, or progeny cells thereof are described, and mathematical and statistical image analysis methods and systems, for example, to identify differentiated cells and screen for agents which modulate differentiation are provided for separate or combined use. | 08-04-2011 |
20110206262 | IMAGE-BASED METHODS FOR MEASURING GLOBAL NUCLEAR PATTERNS AS EPIGENETIC MARKERS OF CELL DIFFERENTIATION - The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell colonies, individual cells, and/or cellular structures. | 08-25-2011 |
20120065518 | SYSTEMS AND METHODS FOR MULTILAYER IMAGING AND RETINAL INJURY ANALYSIS - Systems and methods are provided for imaging an eye and identifying retinal or subretinal features that may be indicative of pathologies such as macular degeneration and traumatic brain injury. An infrared or near-infrared image of an eye is interdependently smoothed and segmented and attributes of the image are determined. The attributes are indicative of retinal or subretinal features. | 03-15-2012 |
20120127029 | CODED FILTER - A method and apparatus for estimating and compensating for a broad class of non-Gaussian sensor and process noise. In one example, a coded filter combines a dynamic state estimator (for example, a Kalman filter) and a non-linear estimator to provide approximations of the non-Gaussian process and sensor noise associated with a dynamic system. These approximations are used by the dynamic state estimator to correct sensor measurements or to alter the dynamic model governing evolution of the system state. Examples of coded filters leverage compressive sensing techniques in combination with error models based on concepts of compressibility and the application of efficient convex optimization processes. | 05-24-2012 |
20130183707 | STEM CELL BIOINFORMATICS - Ex vivo cell culture, especially the culture of stem cells, is a valuable and widely used technique. The appearance of unlabeled cultured cells contains significant information about the cell's identity, including its differentiation status and lineage. However, mere visual inspection of cells is a subjective process subject to inconsistencies between microscopists. This disclosure provides methods of quantifying cells' appearance, validating identity with known biomarkers, allowing automated classification of cells as well as automated segmentation and delineation of the borders of a cell colony. Also provided are systems and methods for comparing and standardizing cells cultured by different scientists using different cell culture methods. | 07-18-2013 |
20130207975 | SYSTEMS AND METHODS FOR SPATIO-TEMPORAL ANALYSIS - High resolution time sequences of 3D images that show the dynamics of a time varying changes are provided. The 3D time series of images representing an object that include time varying changes may be produced from lower dimensional image time sequences, such as 2D images. The 2D images may be generated using angiography and may include fluid flow information (e.g., arrival times). The fluid flow information may be provided, for example, by injecting a chemical into the fluid and analyzing its position in the object or body over time. A varying contrast model may be applied to determine the location of the chemical at different points in time which may assist in detecting an ailment. | 08-15-2013 |
20140369568 | Detecting Species Diversity by Image Texture Analysis - A method of measuring species diversity is provided. The method includes receiving a first image of a landscape and receiving a second image of a second landscape. The method also includes representing a portion of the first image as a first region of interest comprising a multiplicity of pixels and representing a portion of the second image as a second region of interest comprising a multiplicity of pixels. The method further includes comparing at least one textural feature of the first region of interest and the second region of interest and calculating the species diversity between the first landscape and the second landscape based on the comparison of the at least one textural features of the regions of interest. | 12-18-2014 |