Ram, MA
J. Rajeev Ram, Cambridge, MA US
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20110195260 | METHOD OF HYDROLYTICALLY STABLE BONDING OF ELASTOMERS TO SUBSTRATES - Active devices such as pumps and mixers have been fabricated in plastic-PDMS hybrid devices. By utilizing functionalized bis-silane primers, bond strength between Polycarbonate or PMMA and PDMS improved in dry and aqueous environments. Plastic-primer-PDMS layers exposed to acid and base solutions at 70° C. for 2 hours showed no signs of delamination at 30 psi for pH −1 to 15 and 60 psi for pH 0 to 15. A peristaltic pump fabricated in polycarbonate achieved consistent flow rates up to peristaltic cycle frequencies of 10 Hz in water, 1OM HCl, and 1OM NaOH solutions. | 08-11-2011 |
Oren Ram, Chestnut Hill, MA US
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20150057163 | SYSTEMS AND METHODS FOR EPIGENETIC SEQUENCING - The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation (“ChIP”). In some cases, the DNA sequences may also be aligned with genomes, e.g., to determine which portions of the genome were epigenetically modified, e.g., via methylation. | 02-26-2015 |
Rajeev Ram, Boston, MA US
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20080299539 | Parallel integrated bioreactor device and method - In one embodiment, the present invention introduces integrated fluid injection and mixing devices to enable pH control in a miniature parallel integrated bioreactor array system. In another embodiment, the environmental conditions of the growth chamber is enabled through fluidic injections in a miniature parallel cell culture system. In still another embodiment, the present invention utilizes gas switches to control oxygen concentration within a miniature parallel integrated bioreactor array. | 12-04-2008 |
Rajeev Ram, Arlington, MA US
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20090274418 | REDUCTION OF SUBSTRATE OPTICAL LEAKAGE IN INTEGRATED PHOTONIC CIRCUITS THROUGH LOCALIZED SUBSTRATE REMOVAL - Structures including optical waveguides disposed over substrates having a chamber or trench defined therein, and methods for formation thereof. | 11-05-2009 |
20090297017 | HIGH RESOLUTION MULTIMODAL IMAGING FOR NON-DESTRUCTIVE EVALUATION OF POLYSILICON SOLAR CELLS - A non-destructive evaluation system for evaluating an article such as a test sample, the system comprising: | 12-03-2009 |
20100316327 | Surface Plasmon Enhanced Optical Devices for Integrated Photonics - An optical device for integrated photonic applications includes a substrate, a dielectric waveguide and a surface plasmon waveguide. The dielectric waveguide includes a dielectric waveguide core disposed relative to a dielectric waveguide cladding and a common cladding. The surface plasmon waveguide includes a surface plasmon waveguide core disposed relative to the common cladding and a surface plasmon waveguide cladding. The common cladding couples the dielectric waveguide and the surface plasmon waveguide. | 12-16-2010 |
20130019916 | SOLAR CONCENTRATOR ASSEMBLY AND METHODS OF USING SAME - A solar concentrator assembly includes a tripod, a base, a reflective dish, a receptacle, and a thermoelectric module or a heat transfer module. The tripod includes legs and a top tripod connector coupled to top portions thereof. The base includes a rod coupled to the tripod; a bottom support structure coupled to the rod; a top support structure coupled to the bottom support structure; an extension coupled to the bottom support structure and the top support structure; and a cap with recesses mounted to the top support structure. The reflective dish includes support rods received within the recesses; a pliable material forms panels, wherein the support rods are inserted into seams between the panels; and a reflective material disposed on the pliable material. The receptacle is connected to the base and disposed within the reflective dish. The thermoelectric module or the heat transfer module is partially disposed within the receptacle. | 01-24-2013 |
Rajeev J. Ram, Arlington, MA US
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20090245322 | OPTICAL CHARACTERIZATION OF PHOTONIC INTEGRATED CIRCUITS - In one aspect, the present invention provides techniques and apparatus for optical characterization of photonic devices and/or circuits. By way of example, the techniques can be used to identify damaged devices in photonic integrated circuits. In some embodiments, thermal imaging is employed as a diagnostic tool for characterizing the devices/circuits under investigation. For example, in one embodiment, integrated cascaded semiconductor amplifiers can be characterized using amplified spontaneous emission from one amplifier as a thermal modulation input to another amplifier. A thermoreflectance image of the second amplifier can reveal flaws, if present. Further, in some embodiments, thermal imaging in conjunction with a total energy model can be employed to characterize the elements of photonic circuits optically and/or to map the optical power distribution throughout the circuits. | 10-01-2009 |
Rajeev Jagga Ram, Arlington, MA US
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20130084622 | DEVICE AND METHOD FOR CONTINUOUS CELL CULTURE AND OTHER REACTIONS - Devices, systems, and methods for continuous cell culture and other reactions are generally described. In some embodiments, chambers (e.g., cell growth chambers) including at least a portion of a wall formed of a flexible member are provided. A retaining structure can be incorporated outside and proximate to the chamber such that when liquid is added to the chamber, the flexible member is consistently and predictably deformed, and a consistent volume of liquid is added. The flexible member can be formed of, in some embodiments, a gas-permeable medium. In some embodiments, reaction chambers can be arranged in a fluidic loop, and a bypass channel can be used to introduce and/or extract fluid from the loop without affecting loop operation. | 04-04-2013 |
20140120609 | HUMIDITY CONTROL IN CHEMICAL REACTORS - Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described. | 05-01-2014 |
20140127802 | CONTROL OF CARBON DIOXIDE LEVELS AND PH IN SMALL VOLUME REACTORS - Strategies to control the level of dissolved carbon dioxide (CO | 05-08-2014 |
20140159582 | THERMO-ELECTRICALLY PUMPED LIGHT-EMITTING DIODES - Contrary to conventional wisdom, which holds that light-emitting diodes (LEDs) should be cooled to increase efficiency, the LEDs disclosed herein are heated to increase efficiency. Heating an LED operating at low forward bias voltage (e.g., V06-12-2014 | |
Sanjay Ram, Worcester, MA US
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20100240075 | COMPLEMENT FACTOR H-BASED ASSAYS FOR SERUM BACTERICIDAL ACTIVITY AGAINST NEISSERIA MENINGITIDIS - Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fHBp) are provided, as well as non-human animal models of Neisserial infection. | 09-23-2010 |
20110229522 | METHODS, COMPOSITIONS AND VACCINES RELATING TO NEISSERIA MENINGITIDIS ANTIBODIES - The invention provides compositions and methods for screening subjects at risk for contracting meningococcal disease and/or at risk for failing to elicit an immunogenic response to a vaccine against | 09-22-2011 |
Siya Ram, Winchester, MA US
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20090209530 | INHIBITORS OF CYCLIN-DEPENDENT KINASES, COMPOSITIONS AND USES RELATED THERETO - The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation. | 08-20-2009 |
20100004207 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto - The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation. | 01-07-2010 |
20100144707 | Pharmacokinetically improved compounds - The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease. | 06-10-2010 |
20120202793 | RHO KINASE INHIBITORS - The present invention relates to inhibitors of ROCK1 and ROCK2, which may be selective for ROCK2, and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and/or ROCK2. Also provided are treatments combining inhibitors of ROCK1 and/or ROCK2 with statins. | 08-09-2012 |
20130131047 | PHARMACOKINETICALLY IMPROVED COMPOUNDS - The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease. | 05-23-2013 |