Raimundo
Brian Raimundo, San Francisco, CA US
Patent application number | Description | Published |
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20110059976 | PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds having the formula: | 03-10-2011 |
20120040951 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 02-16-2012 |
Nuno Das Neves Raimundo, Portalegre PT
Patent application number | Description | Published |
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20120064091 | DYSFUNCTION OF THE MITOCHONDRIAL RESPIRATORY CHAIN, METHODS FOR DIAGNOSIS, TREATMENT AND FOLLOW-UP - The invention relates to a method, of assessing whether a subject is affected with or at risk for developing a dysfunction of the mitochondrial respiratory chain, the method comprising determining the concentration of fibroblast growth factor 21 (FGF21) in a biological sample from the subject, and comparing it to the concentration of FGF21 in a biological sample from at least one normal control, wherein an increase in the concentration of FGF21 in the biological sample from the subject when compared to the concentration of FGF21 in the biological sample from at least one normal control is indicative of occurrence of the dysfunction of the mitochondrial respiratory chain in said subject, or of risk for developing said dysfunction. The invention also relates to a method for follow-up of a dysfunction of the mitochondrial respiratory chain in a subject diagnosed with but not being treated for said dysfunction, to a method for treating a subject having a dysfunction of the mitochondrial respiratory chain, to a method for determining whether a dysfunction of the mitochondrial respiratory chain in a subject diagnosed with and being treated for said dysfunction is responding to the treatment, and for selecting patients for clinical trials. | 03-15-2012 |
Sebastian Raimundo, Bernried DE
Patent application number | Description | Published |
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20120270948 | POLYMORPHISIMS IN THE HUMAN CYP2D6 GENE PROMOTER REGION AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - Provided are polynucleotides of molecular variant promoters of the CYP2D6 gene which, for example, are associated with abnormal drug response or individual predisposition to several common diseases and disorders caused by drug under- or over-metabolization, and vectors comprising such polynucleotides. Furthermore, methods of diagnosing the status of disorders related to intermediate metabolization of drugs are described. In addition, kits comprising oligonucleotides hybridizing to the CYP2D6 promoter and/or being capable of being extended into this region useful for diagnosing subjects that are ultrarapid or intermediate metabolizer of drugs are provided. | 10-25-2012 |