| Patent application number | Description | Published |
|---|
| 20090087403 | REVERSAL OF VIRAL-INDUCED SYSTEMIC SHOCK AND RESPIRATORY DISTRESS BY BLOCKADE OF THE LYMPHOTOXIN BETA PATHWAY - This invention provides methods of inducing an antiviral response in an individual comprising administering to the individual an effective amount of a LT-B blocking agent and a pharmaceutically acceptable carrier. In particular this invention provides methods for treating viral-induced systemic shock and respiratory distress. | 04-02-2009 |
| 20100040614 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS - PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist. | 02-18-2010 |
| 20100151492 | METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS - PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist. Methods are also disclosed for determining the efficacy of a PD-1 antagonist in a subject administered the PD-1 antagonist. In some embodiments, these methods include measuring proliferation of memory B cells in a sample from a subject administered the PD-1 antagonist. | 06-17-2010 |
| 20100279352 | Rapid Generation of Antibodies - High efficient methods for producing an antibody molecule that binds an antigen are described. The methods include obtaining a population of PBMC enriched for CD19 | 11-04-2010 |
| 20110105343 | Systems Biology Approach Predicts Immunogenicity of Vaccines - A major challenge in vaccinology is to prospectively determine vaccine efficacy. Disclosed herein are methods and compositions for identifying early expression “signatures” that predicted immune responses in humans vaccinated with a vaccine. | 05-05-2011 |
| 20110129496 | Use of mTOR Inhibitors to Enhance T Cell Immune Responses - It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog. | 06-02-2011 |
| Patent application number | Description | Published |
|---|
| 20090055349 | TABLE ELIMINATION TECHNIQUE FOR GROUP-BY QUERY OPTIMIZATION - Techniques for optimizing queries are provided. In one technique, a query optimizer determines that two tables involved in equi-joins with one other table return unique rows. The query optimizer further determines that the rows returned by one of the tables is a subset of the rows returned by the other table. The query optimizer then determines that one of the two tables involved in the equi-joins can be eliminated. In another technique, a query optimizer determines that group-by placement may be used on a query that specifies a table. The query optimizer further determines that a view that (1) replaces the table and (2) results from the group-by placement is a subset of an existing view. The query optimizer further determines that each view is unique. The query optimizer selects an execution plan that does not join any tables or views with the resulting view or with the specified table. | 02-26-2009 |
| 20090070315 | TABLE ELIMINATION OPTIMIZATIONS - Methods for transforming a query to remove redundant tables and eliminate superfluous join operations is provided. The methods provided transform queries to remove redundant tables and anti-joins, semi-joins, and outer-joins. Whether a table is redundant is determined based on a set of criteria which, if fulfilled, indicates that the removal of the table and the anti-join, semi-join, or outer-join operation does not impact query results. The removal of a redundant table from a query also results in the elimination of the anti-join, semi-join, or outer-join operation that references the removed table. | 03-12-2009 |
| 20090112793 | TECHNIQUES FOR BUSHY TREE EXECUTION PLANS FOR SNOWSTORM SCHEMA - Methods for transforming a query to simulate a bushy tree execution plan for queries containing joins in series are provided. Left deep tree execution plans are supported by most relational database systems but are inefficient at processing queries directed to databases with snowstorm schema. A snowstorm schema contains several large fact tables and many smaller dimension tables, which make reference to one another. Bushy tree execution plans can be much more efficient for processing queries to snowstorm schema. The decision to choose between left-deep and bushy tree execution plans are based on the relative costs of the two execution plans. The methods provided transform queries which are otherwise executed with left deep tree execution plans into queries which are executed with simulated bushy tree execution plans. | 04-30-2009 |
| 20090292669 | TECHNIQUE FOR REMOVING SUBQUERY USING WINDOW FUNCTIONS - Methods for transforming a query to remove redundant subqueries in HAVING clauses are provided. The methods provided transform queries that contain subqueries in HAVING clauses with tables and join conditions and filter conditions equal to tables, join conditions and filter conditions in outer query to queries that eliminate the original subquery and retain the original outer query with a single inline view using window functions. Whether this transformation can be performed depends on which tables and join and filter conditions are in the outer query and the subquery. The transformation eliminates duplicative table accesses and join operations from queries. | 11-26-2009 |
| 20100030756 | TECHNIQUES FOR COALESCING SUBQUERIES - Methods for transforming queries that contain EXISTS and NOT EXISTS subqueries are provided. The methods provided transform original queries that contain EXISTS and/or NOT EXISTS subqueries in conjunctive or disjunctive combinations into transformed queries that coalesce the original EXISTS and/or NOT EXISTS subqueries into a reduced number of EXISTS and/or NOT EXISTS subqueries, thereby eliminating duplicative table accesses and join operations. | 02-04-2010 |
