Patent application number | Description | Published |
20080249284 | GENE ENCODING LABYRINTHIN, A MARKER FOR CANCER - A cDNA molecule that encodes a protein designated Labyrinthin (Lab) is isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab) or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells. | 10-09-2008 |
20100112582 | GENE ENCODING LABYRINTHIN, A MARKER FOR CANCER - A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells. | 05-06-2010 |
20100233711 | GENE ENCODING LABYRINTHIN, A MARKER FOR CANCER - A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells. | 09-16-2010 |
20110110963 | GENE ENCODING LABYRINTHIN, A MARKER FOR CANCER - A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells. | 05-12-2011 |
Patent application number | Description | Published |
20110293525 | TUMOR STEM CELLS - Tumor stem cells can be obtained by culturing a tumor cell population, and exposing the cultured tumor cell population to free radicals. In certain embodiments, the free radical agent can be a nitric oxide (NO) donor. In one embodiment, the free radical agent can be Diethylenetriamine NONOate (DETA NONOate) or agents that constitutively increase cellular nitric oxide, such as phosphodiesterase inhibitors or L-arginine, or agents that increase NO synthase in the population. The methods can further include inducing stem cells present in the population to expand and/or inducing dedifferentiation of tumor cells into tumor stem cells. Additionally, the present invention provides methods of selecting stem cells from a tumor cell population. Another aspect provides methods of screening for anti-tumor stem cell teherapeutic compounds by providing high nitric oxide (HNO) tumor cells, exposing the HNO cells to at least one compound, assessing one or more indicators of HNO cell health and determining toxicity of the compound to HNO tumor cells. | 12-01-2011 |
20110293753 | Tocotrienol Compositions - Compositional formulations are provided that comprise at least one tocotrienol or a derivative thereof, in combination with compounds derived from plant extracts. The compositions can be provided in a functionally acceptable carrier, or separately in a combined regimen. In some examples, the compositions can be effective for reducing, preventing or treating medical conditions including, for example, benign tissue growths, pre-cancerous lesions, cancer, inflammations, viral infections, bacterial infections, fungal infections, parasitic infections, impaired bodily function, or cell and tissue damage due to trauma, cell and/or tissue injury from stroke events, cell and/or tissue damage from ischemic events. The mechanism of action for cancer prevention and therapy includes telomerase and/or angiogenesis inhibition. | 12-01-2011 |
20130252236 | TUMOR STEM CELLS - Tumor stem cells can be obtained by culturing a tumor cell population, and exposing the cultured tumor cell population to free radicals. In certain embodiments, the free radical agent can be a nitric oxide (NO) donor. In one embodiment, the free radical agent can be Diethylenetriamine NONOate (DETA NONOate) or agents that constitutively increase cellular nitric oxide, such as phosphodiesterase inhibitors or L-arginine, or agents that increase NO synthase in the population. The methods can further include inducing stem cells present in the population to expand and/or inducing dedifferentiation of tumor cells into tumor stem cells. Additionally, the present invention provides methods of selecting stem cells from a tumor cell population. Another aspect provides methods of screening for anti-tumor stem cell teherapeutic compounds by providing high nitric oxide (HNO) tumor cells, exposing the HNO cells to at least one compound, assessing one or more indicators of HNO cell health and determining toxicity of the compound to HNO tumor cells. | 09-26-2013 |
Patent application number | Description | Published |
20080202899 | POWER ELECTRONIC SWITCHING DEVICE WITH LAMINATED BUS - A bus system is disclosed for use with switching devices, such as power electronic devices. The system includes generally parallel bus elements that define electrical reference planes, such as for a dc bus. The bus elements are separated from one another by insulative layers, with additional insulative layers being available for separating the system from other circuit components. Portions of the bus elements are extended or exposed to permit connection to the circuit elements, including packaged switching circuits and energy storage or filtering circuits. The bus system may be conformed to a variety of geometric configurations, and substantially reduces parasitic inductance and total loop inductance in the resulting circuitry. | 08-28-2008 |
20080266046 | Phase change cooled electrical resistor - A technique is disclosed for cooling resistive elements, such as brake resistors used in motor drives, as well as other resistors. A phase change heat spreader is thermally coupled to the resistive element and a continuous phase change cycle takes place in the heat spreader to extract heat from the resistive element. The element and heat spreader may be packaged as a modular unit or may be integrated into a system. | 10-30-2008 |
20080266803 | Phase change cooled electrical bus structure - A technique for cooling electrical bus structures is disclosed, in which a phase change heat spreader is thermally coupled to the bus. A continuous phase change cycle occurs within the heat spreader to draw heat from the bus during operation. The heat spreader may be planar, and extend over an area greater then the surface area of the bus to enhance cooling and to render the overall assembly more isothermal. The heat spreader may be placed near bus joints and circuits to remove heat caused by increased resistance at such locations. | 10-30-2008 |
Patent application number | Description | Published |
20120013283 | PARALLEL POWER INVERTER MOTOR DRIVE SYSTEM - Multiple inverter motor drives are interconnected in parallel to provide a common output to a motor. Common control circuitry is coupled to all parallel drives via optical cables and provides signals to power layer circuitry of each inverter for generation, at the power layer, of timing for gate drive signals for the respective inverter power electronic switches. The resulting timing exhibits a high degree of synchronicity such that very little imbalance occurs in the outputs of the paralleled drives, resulting in very low circulating currents. | 01-19-2012 |
20120013285 | MOTOR DRIVE COMPONENT VERIFICATION SYSTEM AND METHOD - A technique is provided for verifying the proper selection, installation, communication and operability of components in power electronic systems, such as motor drives. A processing circuit is coupled to multiple components or subsystems that identify themselves to the processing system. An identification code is stored that is compared to a similar code built based upon the information reported by the components at the time of commissioning, operation or servicing. If the comparison indicates that all components are properly installed, and communicating and operative, operation may continue. The technique may be applied in parallel motor drives at a power layer level to allow separate and parallel verification of component and component operation in the parallel drives. | 01-19-2012 |
20120013372 | POWER LAYER GENERATION OF INVERTER GATE DRIVE - Techniques include systems and methods of synchronizing multiple parallel inverters in a power converter system. In one embodiment, control circuitry is connected to a power layer interface circuitry at each of the parallel inverters, via an optical fiber interface. The system is synchronized by transmitting a synchronizing pulse to each of the inverters. Depending on the operational mode of the system, different data exchanges may occur in response to the pulse. In an off mode, power up and power down data may be exchanged between the control circuitry and the inverters. In an initiating mode, identification data may be transmitted from the inverters to the control circuitry. In an active mode, control data may be sent from the control circuitry to the inverters. In some embodiments, the inverters also transmit feedback data and/or acknowledgement signals to the control circuitry. Power layer circuitry of the inverter adjusts a local clock based upon sampled data from the control circuitry to maintain synchronicity of the inverters between synchronization pulses. | 01-19-2012 |
20120014147 | POWER LAYER GENERATION OF INVERTER GATE DRIVE SIGNALS - Solid state switches of inverters are controlled by timing signals computed in power layer interface circuitry for individual inverters. Multiple inverters may be placed in parallel with common three-phase output. Common control circuitry generates timing signals or data used to reconstruct the common signals and sends these signals to the power layer interface circuitry. A processor in a power layer interface circuitry used these signals to recomputed the timing signals. Excellent synchronicity may be provided between parallel inverters that each separately reconstruct the timing signals based upon the identical received data. | 01-19-2012 |
20120235614 | PARALLEL POWER INVERTER MOTOR DRIVE SYSTEM - Multiple inverter motor drives are interconnected in parallel to provide a common output to a motor. Common control circuitry is coupled to all parallel drives via optical cables and provides signals to power layer circuitry of each inverter for generation, at the power layer, of timing for gate drive signals for the respective inverter power electronic switches. The resulting timing exhibits a high degree of synchronicity such that very little imbalance occurs in the outputs of the paralleled drives, resulting in very low circulating currents. | 09-20-2012 |
20130154529 | MOTOR DRIVE COMPONENT VERIFICATION SYSTEM AND METHOD - A technique is provided for verifying the proper selection, installation, communication and operability of components in power electronic systems, such as motor drives. A processing circuit is coupled to multiple components or subsystems that identify themselves to the processing system. An identification code is stored that is compared to a similar code built based upon the information reported by the components at the time of commissioning, operation or servicing. If the comparison indicates that all components are properly installed, and communicating and operative, operation may continue. The technique may be applied in parallel motor drives at a power layer level to allow separate and parallel verification of component and component operation in the parallel drives. | 06-20-2013 |
20130155746 | POWER LAYER GENERATION OF INVERTER GATE DRIVE SIGNALS - Techniques include systems and methods of synchronizing multiple parallel inverters in a power converter system. In one embodiment, control circuitry is connected to a power layer interface circuitry at each of the parallel inverters, via an optical fiber interface. The system is synchronized by transmitting a synchronizing pulse to each of the inverters. Depending on the operational mode of the system, different data exchanges may occur in response to the pulse. In an off mode, power up and power down data may be exchanged between the control circuitry and the inverters. In an initiating mode, identification data may be transmitted from the inverters to the control circuitry. In an active mode, control data may be sent from the control circuitry to the inverters. In some embodiments, the inverters also transmit feedback data and/or acknowledgement signals to the control circuitry. Power layer circuitry of the inverter adjusts a local clock based upon sampled data from the control circuitry to maintain synchronicity of the inverters between synchronization pulses. | 06-20-2013 |
20140056042 | POWER LAYER GENERATION OF INVERTER GATE DRIVE SIGNALS - Solid state switches of inverters are controlled by timing signals computed in power layer interface circuitry for individual inverters. Multiple inverters may be placed in parallel with common three-phase output. Common control circuitry generates timing signals or data used to reconstruct the common signals and sends these signals to the power layer interface circuitry. A processor in a power layer interface circuitry used these signals to recomputed the timing signals. Excellent synchronicity may be provided between parallel inverters that each separately reconstruct the timing signals based upon the identical received data. | 02-27-2014 |