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| 20110300159 | Sulfonated Sclerostin, antibodies, epitopes and methods for identification and use therefor - Provided are antibodies that bind to: a sulfonated epitope of the protein Sclerostin, to Sclerostin portions comprising a sulfonated amino acid and to dimerized forms of Sclerostin. Further provided are compositions and peptides comprising a sulfonated epitope of sclerostin. Also provided by this invention are methods for production of such antibodies, both active and passive, and methods for identifying antibodies specific for sulfonation sites in Sclerostin and other antibodies which discriminate between sulfonated and unsulfonated forms of sclerostin. Physical and virtual screening processes are provided in this invention for identifying compounds whichh disrupt or inhibit sulfonation and the interaction between Sclerostin and binding partners. The antibodies and compositions of the present invention are useful in diagnostic and therapeutic applications directed to Sclerostin-related disorders. | 12-08-2011 |
| 20110300160 | SULFATION OF WNT PATHWAY PROTEINS - Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a. Also provided is a composition comprising an isolated and purified Wnt pathway protein, where the protein is sulfated but not glycosylated. Additionally provided is a preparation of a Wnt pathway protein comprising at least one sulfation site and at least one glycosylation site, where all of the Wnt pathway protein in the preparation is glycosylated but not sulfated. Further provided is a composition comprising a peptide less than 75 amino acids or amino acid analogs, the peptide consisting of a fragment of a Wnt pathway protein, wherein the fragment is sulfated. A modified Wnt pathway protein comprising a sulfation site that is not present in the native Wnt pathway protein is also provided. Also provided is a method of detecting or quantifying a sulfated Wnt pathway protein in a preparation. Additionally, a modified Wnt pathway protein lacking a sulfation site that is present in the native Wnt pathway protein is provided. Also provided is methods of treating a subject having a disease exacerbated by Wnt activation. Additionally, a method of treating a subject having a disease exacerbated by Wnt inhibition is provided. | 12-08-2011 |
| 20120071399 | SULFATION OF WNT PATHWAY PROTEINS - Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment comprising Tyr43 or Tyr213. Also provided is a composition comprising a peptide comprising less than about 75 amino acids and/or amino acid analogs including an amino acid or amino acid analog capable of being sulfated, where the composition is capable of inhibiting sclerostin binding to an LRP. Further provided is a composition comprising a peptide comprising less than about 75 amino acids and/or amino acid analogs including an amino acid or amino acid analog capable of being post-translationally sulfated, where the composition is capable of inhibiting binding of a protein ligand comprising a sulfation site to its binding partner. Additionally provided is a method of enhancing a Wnt signaling pathway comprising contacting an LRP5/6 receptor in the Wnt signaling pathway with either of the above-described compositions that comprise a sequence of a sclerostin fragment or is capable of inhibiting sclerostin binding to an LRP, where the tyrosine or tyrosine analog is not sulfated, in a manner sufficient to enhance the Wnt signaling pathway. Further provided is a method of treating a subject having a disease exacerbated by inhibition of a Wnt signaling pathway comprising administering either of the above-described compositions that comprise a sequence of a sclerostin fragment or is capable of inhibiting sclerostin binding to an LRP, where the tyrosine or tyrosine analog is not sulfated, to the subject in a manner sufficient to reduce the inhibition of the Wnt signaling pathway. Also, a method of inhibiting binding of a protein ligand comprising a sulfation site to its binding partner is provided. The method comprises adding the above-described composition that is capable of inhibiting binding of a protein ligand to its binding partner to the protein ligand and its binding partner in a manner sufficient to inhibit binding of the protein ligand to its binding partner. | 03-22-2012 |
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| 20080211941 | DIGITAL CAMERA USING MULTIPLE IMAGE SENSORS TO PROVIDE IMPROVED TEMPORAL SAMPLING - A method and apparatus for capturing image data from multiple image sensors and generating an output image sequence are disclosed. The multiple image sensors capture data with one or more different characteristics, such as: staggered exposure periods, different length exposure periods, different frame rates, different spatial resolution, different lens systems, and different focal lengths. The data from multiple image sensors is processed and interleaved to generate an improved output motion sequence relative to an output motion sequence generated from an a single equivalent image sensor. | 09-04-2008 |
| 20090160941 | ENHANCING IMAGE RESOLUTION OF DIGITAL IMAGES - An imaging apparatus with adjustable imaging plane, said apparatus having mechanical, electronic or optical means to adjust the position and the orientation of the imaging plane, which successively captures a plurality of images while adjusting the imaging plane, and a method to integrate the captured images to a single high-resolution image by exploration of the mutual information not available in a single image, such as the sub-pixel observations due to the spatial misalignment, thus achieving an image resolution higher than the senor resolution. | 06-25-2009 |
| 20110267477 | RANGE MEASUREMENT USING SYMMETRIC CODED APERTURES - A method of using an image capture device to identify range information for objects in a scene includes providing an image capture device having an image sensor, a coded aperture having circular symmetry, and a lens; storing in a memory a set of blur parameters derived from range calibration data; capturing images of the scene having a plurality of objects; producing a set of reference edge images using the blur parameters from the stored set; providing a set of deblurred images using the captured image, the reference edges and each of the blur parameters from the stored set; and using the set of deblurred images to determine the range information for the objects in the scene. | 11-03-2011 |
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| 20080204538 | PRINTING ON CORRUGATED SUBSTRATES - Methods and devices for forming, such as by printing, high quality, high throughput, ultraviolet curable gel ink images on corrugated substrates for packaging applications are disclosed. The methods and devices have excellent edge acuity and do not require precoating of the substrate prior to printing or nitrogen inerting during curing. | 08-28-2008 |
| 20100086339 | System And Method For Facilitating Cutting Of Media Having A Phase Change Ink Image - A system cuts media printed with phase change ink in a manner that reduces the ink debris produced by cutting solidified ink. The system includes a heater configured to heat phase change ink on the media moving through the heater to a temperature at which the ink is malleable, the temperature being above room temperature and below a temperature at which phase change ink melts, and a cutter configured to receive the media after the media has been heated by the heater and to cut the media. The blade of the cutter may also be heated to facilitate media cutting with a reduced likelihood of solid ink debris being generated. | 04-08-2010 |
| 20100097434 | HEATED FOLDING SYSTEM FOR A PHASE CHANGE INK IMAGING DEVICE - A folding system includes a media pathway configured to transport a print substrate having phase change ink thereon. The folding system includes a folding apparatus disposed along the media pathway configured to fold the print substrate. A folding heater is configured to heat the phase change ink on the print media to a folding temperature. The folding temperature is above ambient temperature and below a melting temperature for phase change ink. | 04-22-2010 |
| 20100313788 | SOLID OR PHASE CHANGE INKS WITH IMPROVED PROPERTIES - A solid or phase change inkjet ink incorporating a polar acidic wax is described. The use of polar waxes as an ink additive improves the polarity of the ink and adhesion of the ink to paper. A method for applying the solid or phase change ink incorporating an acidic polar wax additive to form an image is also described. | 12-16-2010 |
| 20110111125 | Dithered Printing of Clear Ink to Reduce Rub and Offset - An imaging device includes a media supply and handling system configured to move media along a path. A printing system is disposed along the path that includes at least one printhead for applying melted phase-change ink of at least one color to the media to form images thereon. A fixing assembly is disposed along the path downstream of the printing system that is configured to apply heat and/or pressure to the melted phase change ink of the images on the media. A coating system is disposed along the path downstream from the spreader. The coating system includes at least one printhead for applying a clear ink on top of the images formed on the media by the printing station. | 05-12-2011 |
