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Pyke
Adrian L. Pyke, Reading, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090013897 | System and method of improving throughput and vehicle utilization of monorail factory transport systems - Means and methods for optimizing the utilization of monorail-based vehicles carrying a work-in-progress in a clean manufacturing environment. The method includes increasing the number of pick up and drop off points on a primary or secondary monorail transportation network, to amplify the number and frequency of pick up and drop off events per vehicle per circumnavigation of the network or loop. By increasing the number of pick up and drop off events, the empty run or idle time of the corresponding vehicle will decrease, improving utilization and throughput. | 01-15-2009 |
Brendan Pyke, Western Australia AU
| Patent application number | Description | Published |
|---|---|---|
| 20110038770 | Processing Nickel Bearing Sulphides - A method of separating nickel bearing sulphides from mined ores or concentrates of mined ores that contain talc is disclosed. The method comprises treating a slurry of mined ores or concentrates of mined ores in at least one flotation stage and in at least one cleaner circuit. The method further comprises sequenced re-grinding, as described herein, of particles in the slurry. | 02-17-2011 |
| 20110039477 | Processing Nickel Bearing Sulphides - The present invention provides a method of separating nickel bearing sulphides from mined ores or concentrates of mined ores that contain talc particles is disclosed. The method comprises adjusting the Eh of a slurry of mined ores or concentrates of mined ores and making particles of nickel bearing sulphides less hydrophobic than talc particles and floating the nickel bearing sulphide particles from the slurry. | 02-17-2011 |
Brian Pyke, Langdon CA
| Patent application number | Description | Published |
|---|---|---|
| 20110140294 | Sulphur Granulation Apparatus and Process - A portable apparatus for producing sulphur granules includes a granulator with a rotatable drum having distinct zones for seed generation and product growth. The seed generation zone has an intense water spray pattern for each sulphur spray nozzle with intersecting water sprays to solidify molten sulphur and create seeds. The growth zone has a moderate, non-intersecting water spray pattern to allow sulphur nozzles to coat and grow a curtain of seeds into granules. The granulator's exhaust air is filtered either by a heated cyclone separator to recapture residual sulphur particles and moisture before venting, and/or by a granular air filter which uses the produced granules to filter the granulator's exhaust air. A two piece collar enhances maintenance of the granulator's drive system. | 06-16-2011 |
Charles Pyke, Hilleroed DK
| Patent application number | Description | Published |
|---|---|---|
| 20090004192 | Recombinant anti-epidermal growth factor receptor antibody compositions - The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies shown synergy in reduction of proliferation of representative cancer cell lines. Advantageous results have also been obtained with a composition comprising two different chimeric anti-hEGFR antibodies which show a new mechanism of action based on rapid and efficient receptor internalisation, induction of terminal differentiation and subsequent tumour eradication in an animal model. The antibodies of the invention can be manufactured in one bioreactor as a polyclonal antibody. | 01-01-2009 |
| 20100069262 | Method for Cloning Avian-Derived Antibodies - The invention relates to a procedure for linking cognate pairs of VH and VL encoding sequences from a population of avian cells enriched in particular surface antigen markers. The linking procedure involves a multiplex molecular amplification procedure capable of linking nucleotide sequences of interest in connection with the amplification (multiplex PCR). The method is particularly advantageous for the generation of cognate pair libraries as well as combinatorial libraries of antibody variable region encoding sequences from chickens or other birds. The invention also provides methods for generation of chimeric human/avian antibodies and expression libraries generated by such methods. | 03-18-2010 |
| 20110129855 | Recombinant Anti-Epidermal Growth Factor Receptor Antibody Compositions - The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies shown synergy in reduction of proliferation of representative cancer cell lines. Advantageous results have also been obtained with a composition comprising two different chimeric anti-hEGFR antibodies which show a new mechanism of action based on rapid and efficient receptor internalisation, induction of terminal differentiation and subsequent tumour eradication in an animal model. The antibodies of the invention can be manufactured in one bioreactor as a polyclonal antibody. | 06-02-2011 |
| 20110135636 | Recombinant Anti-Epidermal Growth Factor Receptor Antibody Compositions - The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies shown synergy in reduction of proliferation of representative cancer cell lines. Advantageous results have also been obtained with a composition comprising two different chimeric anti-hEGFR antibodies which show a new mechanism of action based on rapid and efficient receptor internalisation, induction of terminal differentiation and subsequent tumour eradication in an animal model. The antibodies of the invention can be manufactured in one bioreactor as a polyclonal antibody. | 06-09-2011 |
| 20110250203 | ANTI-CD5 ANTIBODIES - The present invention relates to the field of compositions comprising anti-CD5 antibodies. In particular, the present invention concerns an antibody composition comprising at least two anti-CD5 antibodies capable of binding distinct CD5 epitopes. The invention further concerns bi-specific molecules having the binding specificities of said antibody compositions. The invention also relates topharmaceutical compositions, use of antibody compositions and methods for manufacturing antibody compositions. The invention further relates to cell banks and a method for killing cells. | 10-13-2011 |
Jacintha Louise Pyke, Buckinghamshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20090324430 | COMPRESSORS UNITS - The invention relates to improvements in compressor units, and in particular to a modular compressor unit which has separate sections for the compressor, the controls and the air intake. The modular compressor unit comprises three separate adjoining sections, being an intake section, a compression section and a control section. The intake section comprises air intake means which provide an inlet for ambient air to be compressed and for cooling the compressor motor and comprise filters to filter air entering the intake means, noise attenuation means provided in the air intake means, and means for directing air to components in the compression section. The compression section comprises a compressor, a motor arranged to drive all compressor and all components within the unit required to cool compressed air, the motor and to remove heat from the compression section. The control section houses all the control means for operating the compressor unit. | 12-31-2009 |
Robert Pyke, New Fairfield, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20130079356 | Method for the treatment of premenstrual and other female sexual disorders - The invention relates to a method for the treatment of premenstrual and other female sexual disorders comprising the administration of a therpeutically effective amount of flibanserin. | 03-28-2013 |
Robert Pyke, Ridgefield, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20090318469 | Use of Flibanserin for the Treatment of Sexual Disorders in Females - The invention is directed to the use of flibanserin or a pharmacologically acceptable derivative thereof, for the preparation of a medical composition for the treatment of Sexual Disorder in females whereby the medication of a patient is selected to achieve a significant change (with administration of a therapeutically effective amount of flibanserin) starting from a baseline (without administration of flibanserin), the significant change being achieved within at least one primary criteria for efficacy and optionally within at least one secondary criteria of efficacy. | 12-24-2009 |
Robert Pyke US
| Patent application number | Description | Published |
|---|---|---|
| 20110105519 | Pharmaceutical Compositions for the Treatment of Sexual Disorders II - The invention relates to new pharmaceutical compositions for the treatment of sexual disorders and methods for the preparation thereof. In a preferred embodiment, the instant invention is directed to pharmaceutical combinations comprising flibanserin as one active ingredient in combination with at least one additional active ingredient for the treatment of sexual disorders and methods for the preparation thereof. | 05-05-2011 |
Ron Pyke, Bellevue, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100324878 | METHODS, SYSTEMS, AND COMPUTER PROGRAM PRODUCT FOR IMPLEMENTING HOTSPOT DETECTION, REPAIR, AND OPTIMIZATION OF AN ELECTRONIC CIRCUIT DESIGN - Disclosed are a method, a system, and a computer program product for implementing hotspot detection, repair, and optimization of an electronic circuit design, which, in some embodiments, defines, identifies criteria for hotspots/metrics or optimization objective function; performs the initial hotspot or metric prediction; identifies correction candidate(s); applies a correction candidate to the electronic circuit design; and determines whether the outcome of applying the correction candidate is acceptable. The method or the system identifies custom correction candidate(s) or custom command(s) and identifies one or more hints for the predicted hotspots or metrics; provides a single architecture to use a first model for hotspot identification/correction and a second model for design check; and provides the capability to apply a correction for a hotspot or metric, evaluate the effectiveness of the correction on the fly, and revert any changes made to the electronic circuit design by the correction. | 12-23-2010 |