Patent application number | Description | Published |
20130023056 | EARLY DETECTION OF RECURRENT BREAST CANCER USING METABOLITE PROFILING - A monitoring test for recurrent breast cancer with a high degree of sensitivity and specificity is provided that detects the presence of a panel of multiplicity of biomarkers that were identified using metabolite profiling methods. The test is capable of detecting breast cancer recurrence about a years earlier than current available monitoring diagnostic tests. The panel of biomarkers is identified using a combination of nuclear magnetic resonance (NMR) and two dimensional gas chromatography-mass spectrometry (GC×GC-MS) to produce the metabolite profiles of serum samples. The NMR and GC×GC-MS data are analyzed by multivariate statistical methods to compare identified metabolite signals between samples from patients with recurrence of breast cancer and those from patients having no evidence of disease. | 01-24-2013 |
20130046392 | SYSTEM AND METHOD FOR ATTACHING SOFT TISSUE TO AN IMPLANT - One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein the porous region exhibits a nano-textured surface, and a biocompatible polymer matrix coating the nano-textured surface. The polymer matrix coating comprises a naturally occurring extracellular matrix with biocompatible inorganic materials distributed within the matrix, or a biocompatible polymer and an osteo-inductive agent. | 02-21-2013 |
20130075259 | MICROFLUIDIC PUMPING BASED ON DIELECTROPHORESIS - This paper presents a microfluidic pumping approach using traveling-wave dielectrophoresis (tw-DEP) of microparticles. Flow is generated directly in the microfluidic devices by inducing electromechanical effects in the fluid using microelectrodes. The fluidic driving mechanisms due to the particle-fluid and particle-particle interactions under twDEP are analyzed, and the induced flow field is obtained from numerical simulations. Experimental measurements of the flow velocity in a prototype DEP micropumping device show satisfactory agreement with the numerical predications. | 03-28-2013 |
20130075377 | LASER CRYSTALLIZATION OF THIN FILMS ON VARIOUS SUBSTRATES AT LOW TEMPERATURES - A method and system are provided for crystallizing thin films with a laser system. The method includes obtaining a thin film comprising a substrate and a target layer that contains nano-scale particles and is deposited on the substrate. The heat conduction between the target layer and the substrate of the thin film is determined based on thermal input from the laser system to identify operating parameters for the laser system that cause crystallization of the nano-scale particles of the target layer in an environment at near room temperature with the substrate remaining at a temperature below the temperature of the target layer. The laser system is then operated with the determined operating parameters to generate a laser beam that is transmitted along an optical path to impinge the target layer. The laser beam is pulsed to create a localized rapid heating and cooling of the target layer. | 03-28-2013 |
20130078210 | CHITOSAN DERIVATIVES FOR INACTIVATION OF ENDOTOXINS AND SURFACE PROTECTION OF NANOPARTICLES - The present disclosure provides a polymer comprising a derivative of chitosan, wherein the derivative is zwitterionic, as well as methods of using the polymer. In addition, the present disclosure provides a nanoparticle structure comprising a derivative of chitosan and a dendrimer, as well as methods of utilizing the nanoparticle structure. | 03-28-2013 |
20130079481 | HYDROPHILIZED ANTIMICROBIAL POLYMERS - A bactericidal or antimicrobial polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal or antimicrobial in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal or antimicrobial polymers, methods for rendering materials bactericidal or antimicrobial, and methods for using bactericidal or antimicrobial compositions to kill or reduce bacterial or microbial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; fibers; paper; and/or wound dressing. | 03-28-2013 |
20130097810 | ELASTIC LOAD SUSPENSION - Elastic load suspension systems and methods are disclosed. Embodiments include handles with springs to reduce peak forces and reduce the overall energy required to carry a load. Some embodiments include handles that connect to loads, where the effective spring length statically deflects at least 2.5 and at most 18 inches, and in some embodiments approximately 5 inches, when carrying the load. Alternate embodiments include elastic suspension handles that are lightly damped, such as those with a damping ratio of at most 0.5. Still further embodiments include elastic suspension handles that elastically suspend loads and have a natural frequency that is less than the locomotive frequency of the object carrying the handle, such a less than the typical human walking frequency of 2 Hertz. | 04-25-2013 |
20130101519 | Diagnostic Method for Atherosclerosis - The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising a conjugate of a ligand and a chromophore capable of emitting light under predetermined conditions, allowing sufficient time for the ligand conjugate to bind to the activated macrophages, subjecting the blood vessels to the predetermined conditions using a catheter-based device, and identifying active plaques by detecting light emitted by the chromophore using a catheter-based device or by using an external imaging technique. The invention also relates to a similar method wherein a chemical moiety capable of emitting radiation is conjugated to the ligand. | 04-25-2013 |
20130113933 | Dietary Assessment System and Method - The present system and method provides a more precise way to record food and beverage intake than traditional methods. The present disclosure provides custom software for use in mobile computing devices that include a digital camera. Photos captured by mobile digital devices are analyzed with image processing and comparisons to certain databases to allow a user to discretely record foods eaten. Specifically, the user captures images of the meal or snack before and after eating. The foods pictured are identified. Image processing software may identify the food or provide choices for the user. Once a food is identified and volume of the food is estimated, nutrient databases are used for calculating final portion sizes and nutrient totals. | 05-09-2013 |
20130120065 | Silicon-on-Insulator High Power Amplifiers - Illustrative embodiments of power amplifiers are disclosed. In one embodiment, a power amplifier includes a plurality of transistors formed on a silicon-on-insulator (SOI) substrate such that the plurality of transistors are each electrically isolated from one another within the SOI substrate. The power amplifier also includes a plurality of biasing networks, each biasing network being configured to dynamically bias at least one of the plurality of transistors. The plurality of transistors are electrically coupled in a series stack, with an output of the power amplifier being provided across the series stack. | 05-16-2013 |
20130123939 | COMPOSITIONS AND METHODS FOR REPAIR OR REGENERATION OF SOFT TISSUE - Disclosed are bioscaffolds and methods for use in soft tissue repair. | 05-16-2013 |
20130124168 | COMPUTATIONALLY EFFICIENT MODELING AND SIMULATION OF LARGE SCALE SYSTEMS - A system for simulating operation of a VLSI interconnect structure having capacitive and inductive coupling between nodes thereof, including a processor, and a memory, the processor configured to perform obtaining a matrix X and a matrix Y containing different combinations of passive circuit element values for the interconnect structure, the element values for each matrix including inductance L and inverse capacitance P, obtaining an adjacency matrix A associated with the interconnect structure, storing the matrices X, Y, and A in the memory, and performing numerical integration to solve first and second equations. | 05-16-2013 |
20130136783 | HYDROPHILIZED ANTIMICROBIAL POLYMERS - A bactericidal or antimicrobial polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal or antimicrobial in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal or antimicrobial polymers, methods for rendering materials bactericidal or antimicrobial, and methods for using bactericidal or antimicrobial compositions to kill or reduce bacterial or microbial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; fibers; paper; and/or wound dressing. | 05-30-2013 |
20130144151 | System and Method For Determining Modified States of Health of Living Tissue - A phenotypic profiling method for drug/dose physiological response of living bodies utilizes feature recognition to segment the information in time-frequency tissue-response spectrograms to construct N-dimensional feature vectors. The feature vectors are used to generate a correlation matrix among a large number of different stimuli in the form of drugs, doses and conditions. Multi-dimensional scaling is applied to the correlation matrix to form a two-dimensional map of response relationships that retains rank distances from the higher-dimensionality feature matrix. The two-dimensional phenotypic profile space displays compact regions indicative of particular physiological responses, such as regions of enhanced active transport, membrane undulations and blebbing. | 06-06-2013 |
20130166002 | Wireless Magnetic Tracking - Illustrative embodiments of systems and methods for wireless magnetic tracking are disclosed. In one illustrative embodiment, a wireless magnetic tracking system may include a plurality of transmitting coils each configured to generate a magnetic field when energized, an active transponder configured to simultaneously (i) obtain measurements of the magnetic field when one of the plurality of transmitting coils is energized and (ii) transmit a wireless signal containing data concerning the measurements, and a computing device configured to (i) cause each of the plurality of transmitting coils to be sequentially energized, (ii) receive the data concerning the measurements, and (iii) determine a position and an orientation of the active transponder relative to the plurality of transmitting coils in response to the data concerning the measurements. | 06-27-2013 |
20130177570 | ANTI-HUMAN FOLATE RECEPTOR BETA ANTIBODIES AND METHODS OF USE - Human anti-human folate receptor beta antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory disorders or cancers expressing cell surface FRβ. | 07-11-2013 |
20130180969 | LASER SHOCK PEENING APPARATUSES AND METHODS - Methods and apparatuses for processing materials to enhancing the material's surface strength, improving the material's cyclic and thermal stability of microstructures, and extend the material's fatigue performance. Embodiments include laser shock peening at material temperatures that are moderately elevated (from the material's perspective) above room temperature. Alternate embodiments include laser shock peening at very cold (cryogenic) material temperatures. Still further embodiments include laser shock peening while covering the surface of the material being processed with an active agent that interacts with the laser energy and enhances the pressure exerted on the surface. | 07-18-2013 |
20130189156 | METHOD AND SYSTEM FOR TREATING PACKAGED PRODUCTS - A system and method for decontamination of product is described. An object to be treated, which may be a food product or a medical device, is placed in a substantially closed dielectric container with a working gas. The container is placed in an apparatus capable of producing a controlled electrical discharge so as to create reactive ion species within the package. The object to be treated may be exposed either the immediate products of the electrical discharge or the long lasting reactive ion species, or both, so as to treat the object to reduce or eliminate specific contaminants, which may be biological pathogens or the cause of product spoilage, or inorganic contaminants. The reactive ion species may result from an atmospheric non-equilibrium plasma (ANEP) formed by the apparatus and the treatment may be performed without significantly increasing the bulk temperature of the object being treated. | 07-25-2013 |
20130195729 | On-Demand Gas Generator - A gas generation apparatus includes a reaction vessel and a fluid reservoir. The reaction vessel has an internal container therein for a reactant material including a solid portion and a liquid portion. The internal container has a perforated upper portion suitable for containing said solid portion of said reactant material, and a solid lower portion suitable for containing said liquid portion of said reactant material. The fluid reservoir is external to the reaction vessel, and has a variable volume fluid chamber. The fluid reservoir is in fluid connection with the reaction vessel. | 08-01-2013 |
20130202012 | Highly-Reliable Micro-Electromechanical System Temperature Sensor - A micro-electromechanical system-type (MEMS) sensor arrangement for wirelessly measuring temperatures is disclosed. The MEMS sensor arrangement includes a multimorph sensor, a sensor coil coupled to the multimorph sensor, and a readout coil configured to be magnetically coupled to the sensor coil to i) energize the sensor coil, and ii) provide a readout of the natural frequency of the multimorph sensor, the sensor coil and the readout coil. | 08-08-2013 |
20130202571 | USE OF PROBIOTIC BACTERIA TO PREVENT AND TREAT LISTERIAL INFECTIONS - This invention relates to LAP-expressing probiotic bacteria and methods of use thereof to prevent and treat a pathogenic bacterial infection. | 08-08-2013 |