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| 20090246852 | THERAPEUTIC USE OF ANTI-CS1 ANTIBODIES - The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists. | 10-01-2009 |
| 20100266613 | ANTI-TNF-ALPHA ANTIBODIES AND THEIR USES - The present invention relates to antibodies directed to the tumor necrosis factor alpha (“TNF-α”) and uses of such antibodies, for example to treat diseases associated with the activity and/or overproduction of TNF-α. | 10-21-2010 |
| 20100322931 | ANTI-VEGF ANTIBODIES AND THEIR USES - The present disclosure relates to antibodies directed to vascular endothelial growth factor (“VEGF”) and uses of such antibodies, for example to treat diseases associated with the activity and/or overproduction of VEGF. | 12-23-2010 |
| 20110117110 | ANTI-EGFR ANTIBODIES AND THEIR USES - The present invention relates to antibodies directed to EGFR and uses of such antibodies, for example, to treat diseases associated with the activity and/or overproduction of EGFR. | 05-19-2011 |
| 20110177095 | ANTI-HER2 ANTIBODIES AND THEIR USES - The present disclosure relates to antibodies directed to HER2 and uses of such antibodies, for example to treat diseases associated with the activity and/or overproduction of HER2. | 07-21-2011 |
| 20120064067 | THERAPEUTIC USE OF ANTI-CS1 ANTIBODIES - The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists. | 03-15-2012 |
| 20120064068 | THERAPEUTIC USE OF ANTI-CS1 ANTIBODIES - The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists. | 03-15-2012 |
| 20120064069 | THERAPEUTIC USE OF ANTI-CS1 ANTIBODIES - The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists. | 03-15-2012 |
| 20120070440 | THERAPEUTIC USE OF ANTI-CS1 ANTIBODIES - The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists. | 03-22-2012 |
| 20120135005 | ANTI-TNF-a ANTIBODIES AND THEIR USES - The present disclosure relates to antibodies directed to the tumor necrosis factor alpha (“TNF-α”) and uses of such antibodies, for example, to treat diseases associated with the activity and/or overproduction of TNF-α. | 05-31-2012 |
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| 20100326147 | LOCK MECHANISM USING ONE-WAY VALVE TO LOCK PISTON - A lock mechanism for locking at least one door of a container in a closed position includes a housing, at least one lock member at least partially enclosed within the housing, the at least one lock member comprising a first lock member configured to engage a first portion of a container to lock at least one container door in a closed position, and a latching mechanism coupled to the at least one lock member. The latching mechanism includes a fluid chamber configured to hold a fluid, a piston slidably housed within the fluid chamber, and a valve coupled to the fluid chamber and configured to be in one of two states, the two states including an open state where fluid can flow through the valve in two directions to allow the piston to be moved in two directions, and a closed state where fluid is inhibited from flowing through the valve in at least one direction to prevent the piston from moving in at least one direction. The lock mechanism further includes a lock circuit at least partially enclosed within the housing, the lock circuit including memory, and a lock controller coupled to the memory and the latching mechanism and configured to receive commands related to the operation of the lock mechanism, wherein the lock controller is configured to cause the latching mechanism to be in one of the two states in response to the received commands. | 12-30-2010 |
| 20110005282 | SENSING A SIGNAL TO SENSE SECUIRTY OF A CONTAINER - A system for sensing the security of a container includes a housing, at least two lock members coupled to the housing, the lock members configured to couple to first and second portions of the container to lock at least one container door in a closed position, a signal generator configured to generate a first signal and couple the first signal to the first portion of the container, the generated first signal having a known profile, and a lock controller configured to cause the signal generator to generate the first signal upon occurrence of a trigger event. The system further includes a signal detector configured to receive a second signal, the second signal resulting from the first signal, and a signal analyzer configured to analyze the second signal to determine a profile of the second signal, retrieve stored data representing a signal profile indicative of the lock mechanism being coupled to the first and second portions of the container, compare the profile of the second signal to the stored signal profile, and determine that a relationship between the lock mechanism and the container has changed based on the comparison. | 01-13-2011 |
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| 20100326145 | FLOATING J-HOOKS BETWEEN TWO BUSHINGS IN HOUSING WITH A SINGLE PISTON - A lock mechanism for locking at least one door of a container in a closed position includes first and second members slidably coupled to each other to move relative to each other, a latching mechanism configured to prevent the two members from moving relative to each other in at least one direction when the latching mechanism is in a locked state, and first and second lock members, each of the lock members including a first end and a second end. The first ends of the first and second lock members protrude through the body. The second end of the first lock member is coupled to the first member of the locking mechanism and the second end of the second lock member being coupled to the second member of the locking mechanism. The first ends of the first and second lock members are configured to engage portions of the container to lock the at least one container door in a closed position. The body is sized and disposed to support the first and second lock members to prevent rotation of the first and second lock members about points where the first and second lock members are attached to the first and second members of the latching mechanism. The lock mechanism further includes a lock circuit at least partially enclosed within the body. The lock circuit includes a lock controller coupled to the latching mechanism and configured to receive commands related to the operation of the lock mechanism, wherein the lock controller is configured to cause the latching mechanism to be in the locked state in response to the received commands. | 12-30-2010 |
| 20100326146 | SHIPPING CONTAINER ACTIVE LOCK RELEASE FAILSAFE - A lock mechanism to lock at least one door of a container in a closed position includes a housing enclosing at least a portion of the lock mechanism, and a lock circuit at least partially enclosed within the housing. The lock circuit includes a main power supply, a backup power supply, a plurality of subsystems, and a lock controller coupled to the main power supply and the backup power supply. The lock controller is configured to receive commands related to operation of the lock mechanism, determine a battery level remaining in the main power supply, determine if the remaining battery level is below a threshold level, and cause the lock circuit to enter a lower power mode upon determining that the remaining battery level is below the threshold level. When in the lower power mode, at least a portion of the subsystems of the lock circuit are not powered, the lock controller receives power from the main power supply, and the lock controller monitors an interface to detect a command to unlock the lock mechanism. | 12-30-2010 |
| 20100328031 | GLOBAL ASSET TRACKING ENTERPRISE SYSTEM - A system for operating a container lock mechanism includes a housing, at least two lock members, the two lock members including a first lock member configured to engage a first portion of a container and a second lock member configured to engage a second portion of the container to mount the container lock mechanism outside of the container and lock at least one container door in a closed position. The system further includes a latching mechanism coupled to the first and second lock members, a lock circuit at least partially enclosed within the housing. The lock circuit includes a first memory, a wireless module configured to receive a wireless signal and a lock controller coupled to the first memory, the wireless module and the latching mechanism and configured to receive commands related to operation of the lock mechanism, at least a portion of the commands being part of the wireless signal, to cause the latching mechanism to resist having the first and second lock members be disengaged from the first and second portions of the container when the first and second lock members are engaged to the first and second portions of the container, thereby locking the at least one container door in response to the received commands, and a battery coupled to the lock circuit and configured to provide electrical power to at least a portion of the lock circuit. | 12-30-2010 |
| 20100332359 | ACTIVE CONTAINER MANAGEMENT SYSTEM - A system for monitoring chain of custody of contents of a container includes a lock mechanism configured to lock at least one door of the container in a closed position, a housing enclosing at least a portion of the lock mechanism, and a lock circuit at least partially enclosed within the housing. The lock circuit includes a memory, a lock controller, a wireless module configured to receive information from at least one sensor associated with the container, the information regarding at least one property of the contents of the container, wherein the wireless module is configured to store the information in memory, wherein at least one of the wireless module or the sensor is powered wirelessly, and a lock controller configured to receive commands related to operation of the lock mechanism, to monitor the stored information to identify a change of state of the at least one sensor, and to generate chain of custody data to be transmitted to a remote location via the wireless module. The chain of custody data includes at least two of sensor data, an authentication code associated with the sensor, and/or an authentication code associated with the lock mechanism. | 12-30-2010 |
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| 20090324327 | VERTICALLY ADJUSTABLE BICYCLE ASSEMBLY - An adjustable assembly for a bicycle includes a first support having an interior surface and a second support slidably positioned within at least a portion of the first support. One of the first support and the second support is adapted to attach to a first bicycle portion, and the other of the first support and the second support is adapted to attach to a second bicycle portion. Further, the second support comprises an expansion portion configured to be moved between an expanded position and a retracted position. The expansion portion is configured to engage the interior surface of the first support when the expansion portion is in an expanded position. In addition, the first support is configured to be selectively moved relative to the second support when the expansion portion is permitted to assume a retracted position. In some embodiments, the first bicycle portion comprises a bicycle frame and the second bicycle portion comprises a bicycle saddle. In other arrangements, the first bicycle portion comprises a fork assembly and the second bicycle portion comprises a handlebar assembly. | 12-31-2009 |
| 20120091683 | BICYCLE ASSEMBLY WITH FORK AND METHOD OF MANUFACTURING - A bicycle assembly can include a bicycle fork. The bicycle fork can have a steer tube, a leg, and a crown. The bicycle fork can also include adhesive used to connect the leg to the crown. A method of manufacturing an assembly for a bicycle can include applying adhesive, to bond metal on metal, to at least one of the leg and the crown, inserting a part of the leg into a part of the crown, the parts forming a slip fit, and curing the adhesive. A similar method can also be used to attach the steer tube to the crown. | 04-19-2012 |
| 20120228906 | ADJUSTABLE ASSEMBLY FOR A BICYCLE - According to some embodiments, an adjustable assembly for a bicycle comprises a first support and a second support slidably positioned within at least a portion of the first support, such that one of the first support and the second support is adapted to attach to a first bicycle portion and the other of the first support and the second support is adapted to attach to a second bicycle portion. In some embodiments, the second support comprises an expansion portion configured to be selectively moved between an expanded position and a retracted position. In one embodiment, the expansion portion is configured to contact and engage at least one portion of the first support when the expansion portion is in an expanded position, and the first support is configured to be selectively moved relative to the second support when the expansion portion is permitted to assume a retracted position. | 09-13-2012 |
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| 20100120129 | APPARATUS FOR AND METHOD OF PROCESSING BIOLOGICAL SAMPLES - The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like. | 05-13-2010 |
| 20100285490 | DETECTION APPARATUS - The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users. | 11-11-2010 |
| 20110313143 | NUCLEIC ACID PURIFICATION APPARATUS AND METHOD - Provided herein is a clarification/binding device for the isolation of at least one target molecule from a sample. The clarification/binding device can comprise an clarification column and a binding column. The clarification column can be configured to receive the sample. Further, the clarification column can comprise a filter configured to filter at least one non-target molecule from the sample. The binding column can be configured to receive the filtered sample from the clarification column. The binding column can comprise a binding material for binding at least one target molecule. The clarification/binding device can be configured to filter the sample and bind at least one target molecule under negative pressure. Further provided herein is an apparatus for the isolation of a target molecule from a sample. The apparatus can comprise a top plate and a vacuum manifold comprising a first chamber and a second chamber. The top plate can be configured to be used with one or both of the first vacuum chamber and the second chamber of the vacuum manifold. Further provided herein are methods of use of the clarification/binding device and the vacuum apparatus and kits comprising the clarification/binding device and vacuum apparatus. | 12-22-2011 |
| 20120196304 | DETECTION APPARATUS - The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users. | 08-02-2012 |
| 20130040376 | APPARATUS FOR AND METHOD OF PROCESSING BIOLOGICAL SAMPLES - The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like. | 02-14-2013 |
