Patent application number | Description | Published |
20090291083 | BARB4 TARGET, ANTIBODY DESIGNATED BARB4, BARB4 RELATED ANTIBODIES, AND METHODS OF MAKING AND USING SAME - The invention provides antibodies, functional fragments, modified and variant forms, antibody targets, nucleic acid and other compositions. Antibodies, functional fragments, modified and variant forms, nucleic acid and other compositions are useful in treatment, diagnostic and vaccination methods. One treatment method includes inhibiting growth or proliferation of proliferating cells, such as hyperproliferative cells or inducing regression of hyperproliferative cells, such as cells of a cellular hyperproliferative disorder. | 11-26-2009 |
20110207917 | SAM-6 VARIANTS, TARGET AND METHODS OF USE - The invention provides polypeptide, nucleic acid and other compositions. Polypeptide, nucleic acid and other compositions are useful in treatment and diagnostic methods. One treatment method includes inhibiting growth or proliferation of hyperproliferative cells or inducing regression of hyperproliferative cells, such as cells of a cellular hyperproliferative disorder, or reducing levels of LDL or oxLDL. | 08-25-2011 |
20140302074 | Pat-LM1 Epitopes and Methods for Using Same - The present disclosure relates generally to epitopes of an antibody known as PAT-LM1, and methods for using said epitopes. | 10-09-2014 |
Patent application number | Description | Published |
20100322936 | LM-1 ANTIBODIES, FUNCTIONAL FRAGMENTS, LM-1 TARGET ANTIGEN, AND METHODS FOR MAKING AND USING SAME - The invention provides LM-1 antibodies, functional fragments, modified and variant forms, nucleic acid and other compositions. The invention also provides antibodies, functional fragments, modified and variant forms that bind to LM-1 antigen (e.g., NONO/nmt55). Antibodies, functional fragments, modified and variant forms, nucleic acid and other compositions are useful in treatment and diagnostic methods. One method includes treating metastasis of a neoplasia, tumor or cancer in a subject in need of treatment by administering to the subject an amount of a LM-1 antibody, an antibody that binds to LM-1 antigen, or a functional fragment thereof, effective to treat metastasis of the neoplasia, tumor or cancer in the subject. | 12-23-2010 |
20150071931 | LM-Antibodies, Functional Fragments, LM-1 Target Antigen, and Methods for Making and Using Same - The invention provides LM-1 antibodies, functional fragments, modified and variant forms, nucleic acid and other compositions. The invention also provides antibodies, functional fragments, modified and variant forms that bind to LM-1 antigen (e.g., NONO/nmt55). Antibodies, functional fragments, modified and variant forms, nucleic acid and other compositions are useful in treatment and diagnostic methods. One method includes treating metastasis of a neoplasia, tumor or cancer in a subject in need of treatment by administering to the subject an amount of a LM-1 antibody, an antibody that binds to LM-1 antigen, or a functional fragment thereof, effective to treat metastasis of the neoplasia, tumor or cancer in the subject. | 03-12-2015 |
Patent application number | Description | Published |
20130069360 | SECURITY DOCUMENT WITH INTEGRATED SECURITY DEVICE AND METHOD OF MANUFACTURE - A security document ( | 03-21-2013 |
20130093176 | HIGH REFRACTIVE INDEX COATINGS AND THEIR USE IN THE PROTECTION OF SURFACE RELIEF STRUCTURES - High refractive index coatings having metal oxide particles are disclosed. Dispersions of metal oxide particles in solvent are also disclosed. These find use in the protection of surface relief structures. In some disclosed embodiments, the coatings or dispersions contain UV-curable resins. The coatings and dispersions find application in the field of security devices and documents and tokens incorporating security devices. | 04-18-2013 |
20140042738 | SECURITY ELEMENT - A polarising security element for polarising light of a predetermined wavelength including a first dielectric material having a refractive index nb and at least one polarising region of mutually parallel segments of a second material having a refractive index np which is different from nb, the second material being a dielectric or conducting material. The segments of the second material are in contact with the first material and the segments have a width and/or an average spacing which is less than a predetermined range of wavelengths. A method of manufacturing such a security element in which a relief structure is embossed in the layer of the first dielectric material, the relief structure includes mutually parallel peaks and troughs, and the second layer of dielectric or conducting material is applied on the relief structure to form the at least one polarising region of mutually parallel segments. | 02-13-2014 |
20140293423 | DIFFRACTIVE DEVICE - A method and apparatus for viewing or authenticating a diffractive device and a diffractive security device ( | 10-02-2014 |
20140319819 | OPTICAL SECURITY DEVICE WITH NANOPARTICLE INK - An optical security device, including a substrate ( | 10-30-2014 |
20150109647 | OPTICAL SECURITY DEVICE - An optical security device is disclosed which includes a diffraction layer having a plurality of diffraction elements and a high refractive index layer, wherein the high refractive index layer is applied on the diffraction layer such that selected regions of the diffraction layer have the corresponding diffraction elements partially uncovered by the high refractive index layer and other regions are substantially covered by the high refractive index layer. Accordingly, the optical security device has a first security feature associated with the diffraction layer and a second security feature associated with the high refractive index layer. An image is viewable from the regions of the high refractive index layer, either, covertly by placed an index matched item over the device or, overtly, through selection of the thickness of the high refractive index layer. | 04-23-2015 |
Patent application number | Description | Published |
20100076256 | CARDIAC DISEASE TREATMENT AND DEVICE - A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. | 03-25-2010 |
20100160721 | CARDIAC SUPPORT DEVICE WITH DIFFERENTIAL COMPLIANCE - A cardiac support device comprising a jacket of flexible and biocompatible material having a first axis for alignment generally parallel to a longitudinal axis of a patient's heart and a second axis that is transverse to the first axis. The material exhibits an amount of expansion in response to a force applied to the material along the first axis that is different than an amount of expansion in response to the force applied to the material along the second axis. | 06-24-2010 |
20110015558 | Isolating cardiac circulation - In a method for substantially isolating cardiac circulation from systemic circulation, flow between the coronary sinus and the right atrium is occluded. A venous collection device having a collection lumen and a support structure is located in the coronary sinus. The support structure is used to maintain patency of the coronary sinus during collection of fluid through the collection lumen. An artificial flow path is provided between the collection lumen and the one or more coronary arteries, thus isolating the cardiac circulation. According to the method, cardiac pumping for systemic circulation can be maintained during isolation of the cardiac circulation. | 01-20-2011 |
20110106193 | CARDIAC DISEASE TREATMENT AND DEVICE - A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. | 05-05-2011 |
20130184519 | CARDIAC SUPPORT DEVICE WITH DIFFERENTIAL COMPLIANCE - A cardiac support device comprising a jacket of flexible and biocompatible material having a first axis for alignment generally parallel to a longitudinal axis of a patient's heart and a second axis that is transverse to the first axis. The material exhibits an amount of expansion in response to a force applied to the material along the first axis that is different than an amount of expansion in response to the force applied to the material along the second axis. | 07-18-2013 |
20130253629 | DEVICES AND METHODS FOR PERFUSING AN ORGAN - The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region. | 09-26-2013 |
20150182684 | ISOLATING CARDIAC CIRCULATION - In a method for substantially isolating cardiac circulation from systemic circulation, flow between the coronary sinus and the right atrium is occluded. A venous collection device having a collection lumen and a support structure is located in the coronary sinus. The support structure is used to maintain patency of the coronary sinus during collection of fluid through the collection lumen. An artificial flow path is provided between the collection lumen and the one or more coronary arteries, thus isolating the cardiac circulation. According to the method, cardiac pumping for systemic circulation can be maintained during isolation of the cardiac circulation. | 07-02-2015 |
20160030714 | DEVICES AND METHODS FOR PERFUSING AN ORGAN - The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region. | 02-04-2016 |