Patent application number | Description | Published |
20080305038 | Transport of Nano-and Macromolecular Structures Into Cytoplasm and Nucleus of Cells - The present invention refers to novel conjugate molecules and their use or the transport of nano- and macromolecular structures into cells and/or the nucleus. More particularly, the present invention refers to conjugate molecules containing a carrier, preferably thiopyridyl moieties, and a cargo moiety. Thereby, the thiopyridyl moiety is bound to the cargo moiety to act as a carrier, particularly for efficient intracellular and/or intranuclear delivery of drugs, nano-or macromolecular structures, etc. The novel conjugate molecules are provided for the manufacture of a medicament for gene therapy, apoptosis, or for the treatment of diseases such as cancer, autoimmune diseases or infectious diseases. | 12-11-2008 |
20090239939 | Combinations for introducing nucleic acids into cells - Combinations of a carrier and a complex consisting of a nucleic acid molecule and a copolymer are described, wherein the copolymer consists of an amphiphilic polymer, preferably polyethylene glycol, and a charged effector molecule, in particular a peptide or peptide derivative, as well as their use for the transfer of nucleic acid molecules into cells. | 09-24-2009 |
20100221346 | Method For Transfecting Cells Using A Magnetic Field - Described is a method for transfecting a cell comprising bringing a complex comprising vector(s) and magnetic particle(s) in contact with a cell by applying a magnetic field and methods of treatment using said method. Furthermore, described is such a complex as well as methods for making it. Finally, pharmaceutical compositions, uses of such complexes and a kit are described. The method described is particularly useful where automatizable high-throughput transfection is required for large scale screening processes. | 09-02-2010 |
Patent application number | Description | Published |
20100062952 | Copolymer based on olefinic sulphonic acids - A copolymer based on olefinic sulphonic acids as monomer component a) and an organosilicone-containing compound as reactive component b) is proposed, for which in particular 2-acrylamido-2-methylpropanesulphonic acid (AMPS®) is suitable as component a) and vinyltrimethoxysilane, vinyltriethoxysilane and trichlorosilane as component b). This copolymer, which may have a molecular weight of from 5,000 to 5,000,000 g/mol, may also comprise further reaction components c) and d) in addition to the two main components for which further reaction components (meth)acrylamides or vinyl ethers are suitable. These copolymers, which are obtainable in particular by precipitation or gel polymerizations, are used in particular in applications in construction chemistry and here especially as water retention agents and fluid loss additives in drilling fluids and for well cementing. The novel copolymers are distinguished by pronounced thermal stability, which is displayed especially under difficult pressure conditions and at high salinities. | 03-11-2010 |
20100240802 | WATER-SOLUBLE AND BIODEGRADABLE COPOLYMERS ON A POLYAMIDE BASIS AND USE THEREOF - Copolymers based on a polyamide containing at least one graft lateral chain consisting of ethylenic unsaturated compounds, in construction chemistry, as well as with the prospecting, exploiting and completion of oil-and gas deposits and with deep bore holes. | 09-23-2010 |
20100317764 | ADDITIVE FOR CEMENTING WELLS - An additive based on a polyalkylenimine and a sulphonated formaldehyde-containing condensate and its use as a fluid loss additive in the cementing of wells in the mineral oil and natural gas sector is claimed. Polyethylenimine, polypropylenimine and polybutylenimine are suitable as typical representatives of the polyalkylenimines and may also be derivatised. Preferred condensates are acetone/formaldehyde resins. Those additives according to the invention which are subjected to maturing, in particular by allowing to stand, prior to their use achieve a particularly low fluid loss value. | 12-16-2010 |
20110118382 | GRAFT COPOLYMERS, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF - A graft copolymer based on a component a) consisting of silica which has been reacted with an unsaturated silane, and a polymer component b) containing sulphonic acid is proposed. The silica used is preferably a nanosilica and the unsaturated silane is an ethylenically unsaturated alkoxysilane. The component b) is represented by a copolymer based on AMPS and a further ethylenically unsaturated monomer. The polymer according to the invention, which as a rule is a nanocomposite, is outstandingly suitable as an additive in construction chemistry applications and in the development, exploitation and completion of underground mineral oil and natural gas deposits, its effect as a water retention agent being particularly advantageous at high salinities and increased temperatures. | 05-19-2011 |
20130203951 | GRAFT COPOLYMER, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF - A graft copolymer based on a component a) consisting of silica which has been reacted with an unsaturated silane, and a polymer component b) containing sulphonic acid is proposed. The silica used is preferably a nanosilica and the unsaturated silane is an ethylenically unsaturated alkoxysilane. The component b) is represented by a copolymer based on AMPS and a further ethylenically unsaturated monomer. The polymer according to the invention, which as a rule is a nanocomposite, is outstandingly suitable as an additive in construction chemistry applications and in the development, exploitation and completion of underground mineral oil and natural gas deposits, its effect as a water retention agent being particularly advantageous at high salinities and increased temperatures. | 08-08-2013 |
Patent application number | Description | Published |
20080212912 | Radial Roller Bearing, In Particular A Single-Groove Grooved Ball Bearing - The invention relates to a radial roller bearing which is embodied as a single-grooved grooved ball bearing. The bearing bodies are embodied as spherical disks having two symmetrical, parallel lateral surfaces from a spherical base shape. According to the invention, the radial roller bearing has a larger contact surface of the spherical disk in relation to the bearing body tracks thereof as well as an increased number of bearing bodies, wherein one part of the width (b | 09-04-2008 |
20080265660 | Wheel Hub Comprising Axial Recesses Formed Between the Holes for Wheel Nuts - The invention relates to a wheel hub having a central section and a radial section which is radially connected to the central section, a bearing section which axially protrudes from the central section and is used to receive a wheel bearing, and an axially opposing receiving section for receiving a brake disk and a wheel rim. Holes for receiving wheel nuts are formed in the radial section. In order to produce an especially light wheel hub that can withstand all operating loads and provides a brake disk with a secure abutment surface under all operating conditions, the wheel hub has recesses at least between some holes, the recesses fully penetrating the wall of the radial section of the wheel hub. | 10-30-2008 |
20080267551 | Radial Antifriction Bearing, Particularly a Single-Row Grooved Antifriction Bearing or Angular Contact Antifriction Bearing - The radial antifriction bearing has an outer bearing ring, an inner bearing ring and roller bodies, which are arranged between the bearing rings, are held at uniform distances from one another in the peripheral direction by a bearing cage. The roller bodies are discs that each have two parallelly arranged lateral surfaces which are symmetrically flattened from a spherical basic shape. In order to prevent edge stresses between the discs and the raceways, at least the raceway in the inner bearing ring, on its outer edge areas, transition into a logarithmically decreasing profile. | 10-30-2008 |
20080296965 | Wheel Hub Comprising Axial Recesses Formed Between the Holes for Wheel Nuts - The invention relates to a wheel hub having a central section and a radial section which is radially connected to the central section, a bearing section which axially protrudes from the central section and is used to receive a wheel bearing, and an axially opposing receiving section for receiving a brake disk and a wheel rim. Holes for receiving wheel nuts are formed in the radial section. In order to produce an especially light wheel hub that can withstand all operating loads and provides a brake disk with a secure abutment surface under all operating conditions, the wheel hub has recesses at least between some holes, the recesses fully penetrating the wall of the radial section of the wheel hub, and at least one reinforcing means is embodied on the radial end of the wheel hub. | 12-04-2008 |
20080303339 | Wheel Hub With Axial Recesses Between the Holes For Wheel Bolts - The invention relates to a wheel hub having a central section and having a radial section which radially adjoins said central section, having a bearing section which projects axially from the central section for holding a wheel bearing and having an axially opposite holding section for holding a brake disk and a wheel rim, wherein holes for holding wheel bolts are formed in the radial section. In order to obtain a particularly light wheel hub which can withstand all operating loads and offers a reliable contact face for a brake disk under all operating conditions, it is provided that the wheel hub has recesses at least between some holes, which recesses extend completely through the wall of the radial section of the wheel hub, and that stiffening ribs are formed between the respective recesses which stiffening ribs axially thicken the radial section between the recesses. | 12-11-2008 |
20100247019 | WHEEL BEARING ARRANGEMENT FOR MOTOR VEHICLES - A wheel mounting for automotive vehicles substantially comprising a multi-row angular contact rolling bearing comprising an inner bearing ring arranged on or at least partially integrated in a hub of a wheel side-fixing flange, an outer bearing ring coaxial to the inner bearing ring and arranged in or at least partially integrated in a hub of a vehicle side-fixing flange, and a plurality of rolling elements arranged in a plurality of rows next to one another between the inner and the outer bearing rings, which rolling elements roll on defined, inclined pressure angle axes in groove-shaped raceways of the inner and the outer bearing rings and are retained uniformly spaced from one another in peripheral direction in a plurality of bearing cages wherein all the rolling elements of the angular contact rolling bearing are configured in form of ball-rollers comprising two parallel side surfaces obtained by symmetric flattening of a basic ball shape such that a width of the ball-rollers between these side surfaces is 20% to 30% smaller than a diameter of the basic ball shape. | 09-30-2010 |